Product Name

  • Name

    Isopropyl chloroformate

  • EINECS 203-563-2
  • CAS No. 108-23-6
  • Article Data20
  • CAS DataBase
  • Density 1.116 g/cm3
  • Solubility
  • Melting Point -81oC
  • Formula C4H7ClO2
  • Boiling Point 108.3 °C at 760 mmHg
  • Molecular Weight 122.551
  • Flash Point 25 °C
  • Transport Information UN 3286 3/PG 2
  • Appearance clear colorless volatile liquid
  • Safety 26-36/37/39-45-62
  • Risk Codes 11-34-48/20-63-65-67
  • Molecular Structure Molecular Structure of 108-23-6 (Isopropyl chloroformate)
  • Hazard Symbols FlammableF,CorrosiveC
  • Synonyms Formicacid, chloro-, isopropyl ester (6CI,7CI,8CI);1-Methylethyl chloroformate;2-Propyl chloroformate;Chloroformic acid isopropyl ester;Isopropoxycarbonylchloride;Isopropyl carbonochloridate;Isopropyl chlorocarbonate;Isopropylchloroformate;
  • PSA 26.30000
  • LogP 1.77020

Synthetic route

phosgene
75-44-5

phosgene

isopropyl alcohol
67-63-0

isopropyl alcohol

isopropyl chloroformate
108-23-6

isopropyl chloroformate

Conditions
ConditionsYield
In neat (no solvent, gas phase) 150°C;55%
at 150℃; in der Dampfphase;
isopropyl alcohol
67-63-0

isopropyl alcohol

trichloromethyl chloroformate
503-38-8

trichloromethyl chloroformate

A

hydrogenchloride
7647-01-0

hydrogenchloride

B

phosgene
75-44-5

phosgene

C

isopropyl chloroformate
108-23-6

isopropyl chloroformate

D

isopropyl-trichloromethyl carbonate

isopropyl-trichloromethyl carbonate

...Expand
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

isopropyl alcohol
67-63-0

isopropyl alcohol

isopropyl chloroformate
108-23-6

isopropyl chloroformate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Ice bath; Inert atmosphere;
isopropyl formate
625-55-8

isopropyl formate

isopropyl chloroformate
108-23-6

isopropyl chloroformate

Conditions
ConditionsYield
With chlorine Kinetics; Mechanism; Photolysis; Inert atmosphere;
(1r,4r)-4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid
27687-12-3

(1r,4r)-4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid

isopropyl chloroformate
108-23-6

isopropyl chloroformate

C20H27NO6

C20H27NO6

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at -20℃; for 1h;100%
isopropyl chloroformate
108-23-6

isopropyl chloroformate

(2S,4R)-2-azidomethyl-4-tritylsulfanylpyrrolidine
393792-04-6

(2S,4R)-2-azidomethyl-4-tritylsulfanylpyrrolidine

(2S,4R)-2-azidomethyl-4-tritylsulfanylpyrrolidine-1-carboxylic acid isopropyl ester
844476-72-8

(2S,4R)-2-azidomethyl-4-tritylsulfanylpyrrolidine-1-carboxylic acid isopropyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 48h;100%
4-methoxypyridine
620-08-6

4-methoxypyridine

isopropyl chloroformate
108-23-6

isopropyl chloroformate

allylmagnesium bromide
1730-25-2

allylmagnesium bromide

C12H17NO3
1003847-45-7

C12H17NO3

Conditions
ConditionsYield
Stage #1: 4-methoxypyridine; isopropyl chloroformate; allylmagnesium bromide In tetrahydrofuran at -40℃;
Stage #2: Acidic aqueous solution;		100%
...Expand
2-(2-chloro-5-[1,4]diazepan-1-yl-phenyl)-1H-benzoimidazole
1160834-05-8

2-(2-chloro-5-[1,4]diazepan-1-yl-phenyl)-1H-benzoimidazole

isopropyl chloroformate
108-23-6

isopropyl chloroformate

N,N-dimethylethylenediamine
108-00-9

N,N-dimethylethylenediamine

4-[3-(1H-benzoimidazol-2-yl)-4-chloro-phenyl]-[1,4]diazepane-1-carboxylic acid (2-dimethylamino-ethyl)-amide
1160829-74-2

4-[3-(1H-benzoimidazol-2-yl)-4-chloro-phenyl]-[1,4]diazepane-1-carboxylic acid (2-dimethylamino-ethyl)-amide

Conditions
ConditionsYield
Stage #1: isopropyl chloroformate; N,N-dimethylethylenediamine With triethylamine In 1,4-dioxane at 20℃; for 1h;
Stage #2: 2-(2-chloro-5-[1,4]diazepan-1-yl-phenyl)-1H-benzoimidazole In 1,4-dioxane at 150℃; for 1h; Microwave irradiation;		100%
...Expand
1,4-butenediol
6117-80-2

1,4-butenediol

isopropyl chloroformate
108-23-6

isopropyl chloroformate

(Z)-1,4-bis(i-propoxycarbonyloxy)-2-butene
783368-59-2

(Z)-1,4-bis(i-propoxycarbonyloxy)-2-butene

Conditions
ConditionsYield
With pyridine In dichloromethane at 5 - 20℃; for 4h; Inert atmosphere;100%
octahydro-[1]pyrindin-4-one; hydrochloride
120641-01-2

octahydro-[1]pyrindin-4-one; hydrochloride

isopropyl chloroformate
108-23-6

isopropyl chloroformate

C12H19NO3
1246734-21-3

C12H19NO3

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water; toluene at 0 - 20℃;100%
6-fluoro-1H-indole-2-carboxylic acid ethyl ester
348-37-8

6-fluoro-1H-indole-2-carboxylic acid ethyl ester

isopropyl chloroformate
108-23-6

isopropyl chloroformate

2-ethyl 1-isopropyl 6-fluoro-1H-indole-1,2-dicarboxylate
912959-93-4

2-ethyl 1-isopropyl 6-fluoro-1H-indole-1,2-dicarboxylate

Conditions
ConditionsYield
Stage #1: 6-fluoro-1H-indole-2-carboxylic acid ethyl ester With sodium hydride In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: isopropyl chloroformate In tetrahydrofuran; toluene at 20℃;		100%
(3Z)-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonylxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

(3Z)-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonylxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

isopropyl chloroformate
108-23-6

isopropyl chloroformate

(3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione
1308721-98-3

(3Z)-1-isopropyloxycarbonyl-6-[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenylmethyl]-3-[[4,5-dimethoxy-3-methyl-2-(4-methylphenylsulfonyloxy)phenyl]methylene]-4-(4-methoxyphenylmethyl)piperazine-2,5-dione

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 25℃; for 23h; Cooling with ice;100%
With dmap; triethylamine In dichloromethane at 25℃; for 23h;
salicylaldehyde
90-02-8

salicylaldehyde

isopropyl chloroformate
108-23-6

isopropyl chloroformate

2-(isopropoxycarbonyloxy)benzaldehyde
1296132-70-1

2-(isopropoxycarbonyloxy)benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In toluene; acetonitrile at 28℃; for 1h;100%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 20h;100%
With pyridine In dichloromethane; toluene at -25℃; for 2.33333h; Cooling with acetone-dry ice;
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

isopropyl chloroformate
108-23-6

isopropyl chloroformate

4-formylphenyl isopropyl carbonate
1296131-08-2

4-formylphenyl isopropyl carbonate

Conditions
ConditionsYield
With pyridine In dichloromethane; toluene at 0℃; for 2h;100%
O-(3-(1-cyclohexenyl)-2-propynyl)hydroxylamine
1287768-81-3

O-(3-(1-cyclohexenyl)-2-propynyl)hydroxylamine

isopropyl chloroformate
108-23-6

isopropyl chloroformate

isopropyl (3-(1-cyclohexenyl)-2-propynyl)oxycarbamate
1287768-95-9

isopropyl (3-(1-cyclohexenyl)-2-propynyl)oxycarbamate

Conditions
ConditionsYield
Stage #1: O-(3-(1-cyclohexenyl)-2-propynyl)hydroxylamine With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 0.5h;
Stage #2: isopropyl chloroformate In 1,4-dioxane; water for 1h;		100%
(R)-methyl 2-(tert-butoxycarbonylamino)-3-(4-((1r,4S)-4-(1-methylpiperidin-4-yloxy)cyclohexyloxy)phenyl)propanoate

(R)-methyl 2-(tert-butoxycarbonylamino)-3-(4-((1r,4S)-4-(1-methylpiperidin-4-yloxy)cyclohexyloxy)phenyl)propanoate

isopropyl chloroformate
108-23-6

isopropyl chloroformate

isopropyl 4-((1R,4r)-4-(4-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenoxy)cyclohexyloxy)piperidine-1-carboxylate

isopropyl 4-((1R,4r)-4-(4-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropyl)phenoxy)cyclohexyloxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Cooling with ice;100%
C19H22N2O6S

C19H22N2O6S

isopropyl chloroformate
108-23-6

isopropyl chloroformate

isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate
1104442-28-5

isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane; toluene at 20℃; for 1h; Inert atmosphere;100%
(S)-(6-bromo-2-methyl-3,4-dihydroquinoxalin-1(2H)-yl)(cyclopropyl)methanone

(S)-(6-bromo-2-methyl-3,4-dihydroquinoxalin-1(2H)-yl)(cyclopropyl)methanone

isopropyl chloroformate
108-23-6

isopropyl chloroformate

(S)-isopropyl 7-bromo-4-(cyclopropanecarbonyl)-3-methyl-3,4-dihydroquinoxaline-1(2H)carboxylate

(S)-isopropyl 7-bromo-4-(cyclopropanecarbonyl)-3-methyl-3,4-dihydroquinoxaline-1(2H)carboxylate

Conditions
ConditionsYield
With pyridine In 1,2-dichloro-ethane; toluene at 0 - 20℃; for 1.5h;100%
isopropyl chloroformate
108-23-6

isopropyl chloroformate

isobutyric acid hydrazide
3619-17-8

isobutyric acid hydrazide

C8H16N2O3

C8H16N2O3

Conditions
ConditionsYield
With sodium carbonate In methanol at 15 - 20℃;100%
(R)-tert-butyl 2-(aminooxy)butanoate

(R)-tert-butyl 2-(aminooxy)butanoate

isopropyl chloroformate
108-23-6

isopropyl chloroformate

(R)-tert-butyl 2-(isopropoxycarbonylaminooxy)butanoate

(R)-tert-butyl 2-(isopropoxycarbonylaminooxy)butanoate

Conditions
ConditionsYield
With pyridine In acetonitrile at 20℃; for 1h; Cooling with ice;100%
2-[1-(5-methylpyridin-3-yl)methyl-1H-pyrazole[3,4-b]pyridin-3-yl]-4,5,6-pyrimidine triamine

2-[1-(5-methylpyridin-3-yl)methyl-1H-pyrazole[3,4-b]pyridin-3-yl]-4,5,6-pyrimidine triamine

isopropyl chloroformate
108-23-6

isopropyl chloroformate

4,6-diamino-2-[1-(5-methylpyridin-3-yl)methyl-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidylamino isopropyl formate

4,6-diamino-2-[1-(5-methylpyridin-3-yl)methyl-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidylamino isopropyl formate

Conditions
ConditionsYield
With pyridine at 20℃; for 2h; Cooling with ice;100%
With pyridine at 20℃; for 2h;100%
(2S,3S,4S,5S)-3-tert-butyl-4-(5-tert-butyl-2-methoxybenzylamino)-5-(2-isopropylphenyl)pyrrolidine-2-carboxylic acid ethyl ester

(2S,3S,4S,5S)-3-tert-butyl-4-(5-tert-butyl-2-methoxybenzylamino)-5-(2-isopropylphenyl)pyrrolidine-2-carboxylic acid ethyl ester

isopropyl chloroformate
108-23-6

isopropyl chloroformate

(2S,3S,4S,5S)-3-tert-butyl-4-(5-tert-butyl-2-methoxybenzylamino)-5-(2-isopropylphenyl)-pyrrolidine-1,2-dicarboxylic acid 2-ethyl ester 1-isopropyl ester

(2S,3S,4S,5S)-3-tert-butyl-4-(5-tert-butyl-2-methoxybenzylamino)-5-(2-isopropylphenyl)-pyrrolidine-1,2-dicarboxylic acid 2-ethyl ester 1-isopropyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane for 1h;100%
(2S,3S,4S,5S)-ethyl 3-(tert-butyl)-4-(((5-cyclobutyl-2-methoxypyridin-3-yl)methyl)amino)-5-(2-isopropylphenyl)pyrrolidine-2-carboxylate

(2S,3S,4S,5S)-ethyl 3-(tert-butyl)-4-(((5-cyclobutyl-2-methoxypyridin-3-yl)methyl)amino)-5-(2-isopropylphenyl)pyrrolidine-2-carboxylate

isopropyl chloroformate
108-23-6

isopropyl chloroformate

(2S,3S,4S,5S)-2-ethyl 1-isopropyl 3-(tert-butyl)-4-(((5-cyclobutyl-2-methoxypyridin-3-yl)methyl)amino)-5-(2-isopropylphenyl)pyrrolidine-1,2-dicarboxylate

(2S,3S,4S,5S)-2-ethyl 1-isopropyl 3-(tert-butyl)-4-(((5-cyclobutyl-2-methoxypyridin-3-yl)methyl)amino)-5-(2-isopropylphenyl)pyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane; toluene at 45℃;100%
(2S,3R,4S,5S)-ethyl 3-(tert-butyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

(2S,3R,4S,5S)-ethyl 3-(tert-butyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

isopropyl chloroformate
108-23-6

isopropyl chloroformate

(2S,3R,4S,5S)-2-ethyl 1-isopropyl 3-(tert-butyl)-4-nitro-5-phenylpyrrolidine-1,2-dicarboxylate

(2S,3R,4S,5S)-2-ethyl 1-isopropyl 3-(tert-butyl)-4-nitro-5-phenylpyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane; toluene at 20℃; for 4.05h;100%
7-chloro-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepine-2-thione

7-chloro-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepine-2-thione

isopropyl chloroformate
108-23-6

isopropyl chloroformate

isopropyl 7-chloro-2-thioxo-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate

isopropyl 7-chloro-2-thioxo-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;100%
With triethylamine In dichloromethane at 0 - 20℃;
(2S,3R,4S,5S)-ethyl 3-(tert-butyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

(2S,3R,4S,5S)-ethyl 3-(tert-butyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

isopropyl chloroformate
108-23-6

isopropyl chloroformate

(2S,3R,4S,5S)-2-ethyl 1-isopropyl 3-(tert-butyl)-4-nitro-5-phenylpyrrolidine-1,2-dicarboxylate

(2S,3R,4S,5S)-2-ethyl 1-isopropyl 3-(tert-butyl)-4-nitro-5-phenylpyrrolidine-1,2-dicarboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane; toluene at 20℃; for 3h;100%
4-[3-(difluoromethyl)-4-[[5-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino]pyrazol-1-yl]benzoic acid

4-[3-(difluoromethyl)-4-[[5-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino]pyrazol-1-yl]benzoic acid

isopropyl chloroformate
108-23-6

isopropyl chloroformate

isopropoxycarbonyl 4-[3-(difluoromethyl)-4-[[5-[(1R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino]pyrazol-1-yl]benzoate

isopropoxycarbonyl 4-[3-(difluoromethyl)-4-[[5-[(1R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carbonyl]amino]pyrazol-1-yl]benzoate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃; for 0.5h;100%
isopropyl chloroformate
108-23-6

isopropyl chloroformate

2-aminomethyl-1,4-di-phenylmethyl piperazine
116163-33-8, 1035052-05-1, 1035052-07-3

2-aminomethyl-1,4-di-phenylmethyl piperazine

1,4-dibenzyl-2-(isopropyloxycarbonylaminomethyl)piperazine
253873-06-2

1,4-dibenzyl-2-(isopropyloxycarbonylaminomethyl)piperazine

Conditions
ConditionsYield
With triethylamine In toluene99.6%
With triethylamine In toluene at 20℃; for 2h;67%
N-[4-(N'-methylsulfonylamino)-phenylethoxy]-phthalimide
727690-24-6

N-[4-(N'-methylsulfonylamino)-phenylethoxy]-phthalimide

isopropyl chloroformate
108-23-6

isopropyl chloroformate

N-{[4-(N'-isopropyloxy-N'-methylsulfonyl)amino]-phenylethoxy}-phthalimide
727690-25-7

N-{[4-(N'-isopropyloxy-N'-methylsulfonyl)amino]-phenylethoxy}-phthalimide

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 1h;99.2%
1'-(4-methoxybenzyl)spiro[azetidine-3,3-dihydroindoline]-2'-one

1'-(4-methoxybenzyl)spiro[azetidine-3,3-dihydroindoline]-2'-one

isopropyl chloroformate
108-23-6

isopropyl chloroformate

isopropyl 1'-(4-methoxybenzyl)-2-oxospiro[azetidine-3,3-dihydroindoline]-1-carboxylate

isopropyl 1'-(4-methoxybenzyl)-2-oxospiro[azetidine-3,3-dihydroindoline]-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;99.1%
With triethylamine In dichloromethane at 20℃; for 1h; Cooling with ice;460 mg
isopropyl chloroformate
108-23-6

isopropyl chloroformate

diisopropyl peroxydicarbonate
105-64-6

diisopropyl peroxydicarbonate

Conditions
ConditionsYield
With sodium hydroxide; dihydrogen peroxide99%
With sodium hydroxide; dihydrogen peroxide In water at 15℃; Product distribution / selectivity;94%
With dihydrogen peroxide; potassium hydroxide In water at 5 - 50℃; for 0.0766667h; Flow reactor;74.7%
With sodium peroxide
With sodium hydroxide; dihydrogen peroxide
isopropyl chloroformate
108-23-6

isopropyl chloroformate

benzylamine
100-46-9

benzylamine

isopropyl N-benzylcarbamate
5338-49-8

isopropyl N-benzylcarbamate

Conditions
ConditionsYield
In tetrahydrofuran; water; acetone at 0 - 20℃; for 2h;99%
With sodium hydrogencarbonate In tetrahydrofuran; water at 0 - 20℃; Inert atmosphere;89%
for 2h; cooling;41%
isopropyl chloroformate
108-23-6

isopropyl chloroformate

(3-amino-5-chloro-benzyl)-{6-[2-(5-ethyl-4-methyl-thiazol-2-yl)-ethyl]-4-methanesulfonyl-pyridin-2-yl}-carbamic acid tert-butyl ester
693225-88-6

(3-amino-5-chloro-benzyl)-{6-[2-(5-ethyl-4-methyl-thiazol-2-yl)-ethyl]-4-methanesulfonyl-pyridin-2-yl}-carbamic acid tert-butyl ester

(3-chloro-5-isopropoxycarbonylamino-benzyl)-{6-[2-(5-ethyl-4-methyl-thiazol-2-yl)-ethyl]-4-methanesulfonyl-pyridin-2-yl}-carbamic acid tert-butyl ester
693225-89-7

(3-chloro-5-isopropoxycarbonylamino-benzyl)-{6-[2-(5-ethyl-4-methyl-thiazol-2-yl)-ethyl]-4-methanesulfonyl-pyridin-2-yl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With dmap In chloroform at 20℃; for 2h;99%
methyl 2-amino-5-methyl-4-trifluoromethylbenzoate
872624-53-8

methyl 2-amino-5-methyl-4-trifluoromethylbenzoate

isopropyl chloroformate
108-23-6

isopropyl chloroformate

methyl 2-(N-isopropoxycarbonylamino)-5-methyl-4-trifluromethylbenzoate
872624-54-9

methyl 2-(N-isopropoxycarbonylamino)-5-methyl-4-trifluromethylbenzoate

Conditions
ConditionsYield
With pyridine In dichloromethane; toluene at 0 - 20℃; for 2h;99%

Isopropyl chloroformate Chemical Properties

Product Name: Isopropyl chloroformate
The MF of Isopropyl chloroformate (108-23-6) is C4H7ClO2.
                            
The MW of Isopropyl chloroformate (108-23-6) is 122.55.
Synonyms: 1-methylethylchloroformate ; carbonochlorideacid , 1-methylethylester ; isopropylchloroformatesolution ; Carbonochloridicacid , 1-methylester ; chlorocarbonicacidisopropylester ; chloro-formicaciisopropylester  ; isopropylchloromethanoate ; isopropylesterkyselinychlormravenci 
Product Categories: CHLOROFORMATES;Acid Halides;Carbonyl Compounds;Organic Building Blocks
EINECS: 203-563-2
Flash Point: 25 °C 
Boiling Point: 108.3 °C
density: 0.892 g/mL at 25 °C
refractive index: n20/D 1.485(lit.)
storage temp: 2-8°C

Isopropyl chloroformate Uses

    Isopropyl chloroformate (108-23-6) is used as PVC resin, when used as a polymerization initiator, but also used as pesticide intermediates, ore flotation agents.

Isopropyl chloroformate Toxicity Data With Reference

1.   

skn-rbt 500 mg

   IHFCAY    Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1.
2.   

eye-rbt 500 mg SEV

   IHFCAY    Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1.
3.   

orl-rat LD50:1070 mg/kg

   IHFCAY    Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1.
4.   

ihl-rat LCLo:200 ppm/5H

   BJIMAG    British Journal of Industrial Medicine. 27 (1970),1.
5.   

orl-mus LD50:178 mg/kg

   37ASAA    Kirk-Othmer Encyclopedia of Chemical Technology. 4 (1978),758.
6.   

ihl-mus LD50:299 ppm/1H

   37ASAA    Kirk-Othmer Encyclopedia of Chemical Technology. 4 (1978),758.
7.   

skn-mus LD50:12 mg/kg

   37ASAA    Kirk-Othmer Encyclopedia of Chemical Technology. 4 (1978),758.
8.   

skn-rbt LD50:11,300 mg/kg

   IHFCAY    Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1.

Isopropyl chloroformate Consensus Reports

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Isopropyl chloroformate Safety Profile

A poison by skin contact and ingestion. Moderately toxic by inhalation. Ingestion of even small amounts can be fatal. A skin and severe eye irritant. Inhalation of a small amount can cause immediate lachrymation, coughing, choking, and respiratory distress. Death may result from pulmonary edema which may not appear for several hours after exposure. A dangerous fire and moderate explosion hazard when exposed to heat, spark, or flame. Self-reactive. Iron salts may catalyze a potentially explosive thermal decomposition. Incompatible with water, iron, metal salts, acids, alkalies, amines, alcohols. Stable under refrigeration below 20°, but one reference (1973) reports that it has exploded while stored in a refrigerator. Present-day formulations appear to be more stable. Temperatures above 20° can cause decomposition. When heated to decomposition it emits acrid smoke and fumes.
Safety information of Isopropyl chloroformate (108-23-6):
Hazard Codes  F,C
Risk Statements  11-34-48/20-63-65-67
R11: Highly Flammable
R34: Causes burns
R48/20: Harmful: danger of serious damage to health by prolonged exposure through inhalation
R63: Possible risk of harm to the unborn child
R65: Harmful: May cause lung damage if swallowed
R67: Vapors may cause drowsiness and dizziness 
Safety Statements  26-36/37/39-45-62
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S62: If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label 
RIDADR  UN 3286 3/PG 2
WGK Germany  2
RTECS  LQ6475000
F  10-19
HazardClass  6.1(a)
PackingGroup  I

Isopropyl chloroformate Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid, Corrosive, Poison

Isopropyl chloroformate Specification

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

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