Product Name

  • Name

    L-Alaninol

  • EINECS 220-388-7
  • CAS No. 2749-11-3
  • Article Data105
  • CAS DataBase
  • Density 0.943 g/cm3
  • Solubility Completely miscible in water
  • Melting Point -2 °C
  • Formula C3H9NO
  • Boiling Point 174.5 °C at 760 mmHg
  • Molecular Weight 75.1106
  • Flash Point 83.9 °C
  • Transport Information UN 2735 8/PG 2
  • Appearance Colorless liquid
  • Safety 26-36/37/39-45-36
  • Risk Codes 34-36/37/38
  • Molecular Structure Molecular Structure of 2749-11-3 (L-Alaninol)
  • Hazard Symbols IrritantXi,CorrosiveC
  • Synonyms 1-Propanol,2-amino-, (S)-;((S)-2-Hydroxy-1-methylethyl)amine;(+)-2-Aminopropanol;(+)-Alaninol;(2S)-2-Amino-1-propanol;(S)-2-Amino-1-propanol;(S)-Alaninol;2-(S)-Amino-propan-1-ol;L-(+)-Alaninol;
  • PSA 46.25000
  • LogP 0.02620

Synthetic route

L-alanin
56-41-7

L-alanin

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;97%
With lithium aluminium tetrahydride In tetrahydrofuran Heating;95%
With sulfuric acid; hydrogen In water at 39.84℃; under 60006 Torr; Concentration; Reagent/catalyst;93.7%
L-tartaric acid L-2-aminopropanol

L-tartaric acid L-2-aminopropanol

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 20℃; Reagent/catalyst;92.2%
(-)-(3R,5S)-5-methyl-3-phenylmorpholin-2-one
157985-07-4

(-)-(3R,5S)-5-methyl-3-phenylmorpholin-2-one

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol under 112509 Torr; for 72h;89%
With hydrogen; palladium on activated charcoal In methanol under 114000 Torr; for 72h; Hydrogenolysis; ring cleavage; methanolysis;89%
L-Alanine methyl ester
10065-72-2

L-Alanine methyl ester

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With lithium aluminium tetrahydride78%
With lithium aluminium tetrahydride In tetrahydrofuran for 4h; Heating;30%
With hydrogen; Nishimura catalyst <(45.9% Rh/19.9% Pt) oxide> In methanol at 25℃; under 75007.5 Torr;
(S)-alanine ethyl ester hydrochloride
1115-59-9

(S)-alanine ethyl ester hydrochloride

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With lithium aluminium tetrahydride74%
With sodium tetrahydroborate In ethanol Heating;16.9%
cyclo(L-Ala-L-Ala)
5845-61-4

cyclo(L-Ala-L-Ala)

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With C24H20ClN2OPRu; potassium tert-butylate; hydrogen In tetrahydrofuran at 110℃; under 2280.15 - 30402 Torr; for 48h; Inert atmosphere; Schlenk technique; Autoclave;65%
(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 12h; Reflux; Inert atmosphere;51.1%
L-alanin
56-41-7

L-alanin

A

(S)-Alaninol
2749-11-3

(S)-Alaninol

B

isopropylamine
75-31-0

isopropylamine

Conditions
ConditionsYield
With phosphoric acid; hydrogen In water at 79.84℃; under 7500.75 - 60006 Torr; for 4h; Concentration; Reagent/catalyst;A 42.2%
B n/a
With sulfuric acid; hydrogen In water at 79.84℃; under 60006 Torr; for 2h; Catalytic behavior; Autoclave;
(Z,E)-2-amino-6-chloro-9-[(2-carbethoxycyclopropylidene)methyl]purine
200434-95-3

(Z,E)-2-amino-6-chloro-9-[(2-carbethoxycyclopropylidene)methyl]purine

A

(S)-Alaninol
2749-11-3

(S)-Alaninol

B

anti-2-amino-6-chloro-N9-(2-hydroxymethylcyclopropylidenemethyl)purine
200435-01-4

anti-2-amino-6-chloro-N9-(2-hydroxymethylcyclopropylidenemethyl)purine

Conditions
ConditionsYield
With diisobutylaluminium hydride In tetrahydrofuran; cyclohexane at 0℃; for 2h;A 41.8%
B 23.3%
L-Alanine ethyl ester
3082-75-5

L-Alanine ethyl ester

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With lithium aluminium tetrahydride; diethyl ether
With lithium aluminium tetrahydride
(S)-butyl 2-aminopropanoate
2885-02-1, 44924-99-4, 50833-19-7

(S)-butyl 2-aminopropanoate

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With 1,4-dioxane; copper oxide-chromium oxide at 150℃; under 102971 Torr;
(S)-N-benzylalaninol
6940-80-3

(S)-N-benzylalaninol

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With oxalic acid; palladium Hydrogenolise;
With oxalic acid; palladium Hydrogenolise;
(S)-(-)-N-(benzyloxycarbonyl)alaninol
6429-44-3, 61425-27-2, 87905-97-3, 66674-16-6

(S)-(-)-N-(benzyloxycarbonyl)alaninol

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol
With hydrogen; palladium on activated charcoal In tetrahydrofuran; methanol under 760 Torr; for 3h; Ambient temperature;
L-alanine amide
7324-05-2

L-alanine amide

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With ammonia; sodium In methanol dry-ice-cooled; Yield given;
2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione
70058-19-4

2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With hydrazine hydrate In ethanol at 60℃; for 1.25h;
(S)-(-)-2--1-propanol
83197-71-1

(S)-(-)-2--1-propanol

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With sodium hydroxide at 80℃; for 2h;
(S)-(-)-2-propyl acetate
110418-24-1

(S)-(-)-2-propyl acetate

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With sodium hydroxide at 80℃; for 2h;
ergometrinine

ergometrinine

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With hydrogenchloride
ergometrine

ergometrine

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With hydrogenchloride
diethyl ether
60-29-7

diethyl ether

L-Alanine ethyl ester
3082-75-5

L-Alanine ethyl ester

LiAlH4

LiAlH4

(S)-Alaninol
2749-11-3

(S)-Alaninol

diethyl ether
60-29-7

diethyl ether

Z-Ala-SMe
545390-96-3

Z-Ala-SMe

Raney nickel

Raney nickel

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
anschliessendes Eindampfen mit wss. HCl;
L-alanin
56-41-7

L-alanin

A

(S)-Alaninol
2749-11-3

(S)-Alaninol

B

(R)-2-aminopropan-1-ol
35320-23-1

(R)-2-aminopropan-1-ol

Conditions
ConditionsYield
With phosphoric acid; hydrogen In water at 100℃; under 51714.8 Torr; for 6h; Product distribution; Further Variations:; Temperatures; Pressures;
methanolic sodium methoxide

methanolic sodium methoxide

Re2O7

Re2O7

L-alanin
56-41-7

L-alanin

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With H2; RuO2 In methanol; aqueous H2SO4; water
L-alanin
56-41-7

L-alanin

ruthenium
7440-18-8

ruthenium

(S)-Alaninol
2749-11-3

(S)-Alaninol

indan-1,2,3-trione hydrate
485-47-2

indan-1,2,3-trione hydrate

L-alanine methyl ester hydrochloride
2491-20-5

L-alanine methyl ester hydrochloride

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
With sodium borohydrid In water
2-Amino-1-propanol
6168-72-5

2-Amino-1-propanol

(S)-Alaninol
2749-11-3

(S)-Alaninol

Conditions
ConditionsYield
Stage #1: With titanium(IV) isopropylate; (R,R)-TADDOL In diphenylether at 90℃; for 1h;
Stage #2: 2-Amino-1-propanol In diphenylether at 90℃; for 0.166667h; Product distribution / selectivity;
n/a
(S)-Alaninol
2749-11-3

(S)-Alaninol

2-ammoniopropyl sulfate
114080-83-0

2-ammoniopropyl sulfate

Conditions
ConditionsYield
With sulfuric acid In water at 50 - 110℃; for 2.5h;100%
With chlorosulfonic acid In acetonitrile at 25 - 40℃;95%
With sulfuric acid67%
(S)-Alaninol
2749-11-3

(S)-Alaninol

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-2-t-butoxycarbonylaminopropan-1-ol
79069-13-9

(S)-2-t-butoxycarbonylaminopropan-1-ol

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane at 20℃; for 3h;100%
With triethylamine In methanol at 20℃; for 12h;100%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 12h;100%
(S)-Alaninol
2749-11-3

(S)-Alaninol

4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

(2S)-2-methyl-1-[(4-nitrophenyl)sulfonyl]aziridine
374783-78-5

(2S)-2-methyl-1-[(4-nitrophenyl)sulfonyl]aziridine

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 5h;100%
In pyridine; dichloromethane at 0 - 20℃;98%
(S)-Alaninol
2749-11-3

(S)-Alaninol

ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

N-(S)-(2-hydroxy-1-methylethyl)-2,2.2-trifluoroacetamide
107011-25-6

N-(S)-(2-hydroxy-1-methylethyl)-2,2.2-trifluoroacetamide

Conditions
ConditionsYield
In acetonitrile100%
benzyl 4-oxo-1-piperidinecarboxylate
19099-93-5

benzyl 4-oxo-1-piperidinecarboxylate

(S)-Alaninol
2749-11-3

(S)-Alaninol

phenylmethyl 4-{[(1S)-2-hydroxy-1-methylethyl]amino}-1-piperidinecarboxylate
1237840-86-6

phenylmethyl 4-{[(1S)-2-hydroxy-1-methylethyl]amino}-1-piperidinecarboxylate

Conditions
ConditionsYield
Stage #1: benzyl 4-oxo-1-piperidinecarboxylate; (S)-Alaninol With acetic acid In methanol for 0.25h;
Stage #2: With methanol; sodium cyanoborohydride for 72h;
100%
2,4-dichloroquinazoline
607-68-1

2,4-dichloroquinazoline

(S)-Alaninol
2749-11-3

(S)-Alaninol

C11H12ClN3O

C11H12ClN3O

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran100%
(S)-Alaninol
2749-11-3

(S)-Alaninol

2-nitrophenyl isocyanate
3320-86-3

2-nitrophenyl isocyanate

N-[(2S)-1-Hydroxypropan-2-yl]-N'-(2-nitrophenyl)urea

N-[(2S)-1-Hydroxypropan-2-yl]-N'-(2-nitrophenyl)urea

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;100%
5-methylthiophene-2-carboxaldehyde
13679-70-4

5-methylthiophene-2-carboxaldehyde

(S)-Alaninol
2749-11-3

(S)-Alaninol

C9H13NOS

C9H13NOS

Conditions
ConditionsYield
In benzene for 4h; Reflux; Dean-Stark;100%
5-ethyl-thiophene-2-carbaldehyde
36880-33-8

5-ethyl-thiophene-2-carbaldehyde

(S)-Alaninol
2749-11-3

(S)-Alaninol

C10H15NOS

C10H15NOS

Conditions
ConditionsYield
In benzene for 4h; Reflux; Dean-Stark;100%
(S)-Alaninol
2749-11-3

(S)-Alaninol

ethyl acetate
141-78-6

ethyl acetate

2,3,4,5-tetrafluorobenzoyl chloride
94695-48-4

2,3,4,5-tetrafluorobenzoyl chloride

formic acid ethyl ester
109-94-4

formic acid ethyl ester

ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
106939-34-8

ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate

Conditions
ConditionsYield
Stage #1: ethyl acetate; formic acid ethyl ester With sodium hydride In toluene
Stage #2: (S)-Alaninol; 2,3,4,5-tetrafluorobenzoyl chloride In toluene at 20℃; Reflux;
Stage #3: With potassium fluoride In N,N-dimethyl-formamide Reflux;
99.4%
(S)-Alaninol
2749-11-3

(S)-Alaninol

benzaldehyde
100-52-7

benzaldehyde

C10H12FN
1187926-68-6

C10H12FN

Conditions
ConditionsYield
Stage #1: (S)-Alaninol; benzaldehyde With toluene-4-sulfonic acid In toluene at 20℃; for 2h;
Stage #2: With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at -78 - 20℃;
99%
(S)-Alaninol
2749-11-3

(S)-Alaninol

2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate
80149-80-0

2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate

(S)-2-[2-(trimethylsilylethoxy)carbonylamino]propan-1-ol
181767-52-2

(S)-2-[2-(trimethylsilylethoxy)carbonylamino]propan-1-ol

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane for 24h; Ambient temperature;98%
phthalic anhydride
85-44-9

phthalic anhydride

(S)-Alaninol
2749-11-3

(S)-Alaninol

2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione
70058-19-4

2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
at 140℃;98%
With triethylamine In toluene for 3h; Condensation; Heating;94%
at 200℃; for 3h;93%
(S)-Alaninol
2749-11-3

(S)-Alaninol

1-(2,4-dinitrophenyl)-3-methylpyridinium chloride
6526-37-0

1-(2,4-dinitrophenyl)-3-methylpyridinium chloride

1-((S)-2-Hydroxy-1-methyl-ethyl)-3-methyl-pyridinium; chloride

1-((S)-2-Hydroxy-1-methyl-ethyl)-3-methyl-pyridinium; chloride

Conditions
ConditionsYield
In butan-1-ol for 0.166667h; Zincke's reaction; microwave irradiation;98%
2-fluoro-5-nitrobenzaldehyde diethylacetal
773850-31-0

2-fluoro-5-nitrobenzaldehyde diethylacetal

(S)-Alaninol
2749-11-3

(S)-Alaninol

(2S)-aminopropyl-[2-(1,1-bis-ethoxymethyl)-4-nitrophenyl]ether
773850-38-7

(2S)-aminopropyl-[2-(1,1-bis-ethoxymethyl)-4-nitrophenyl]ether

Conditions
ConditionsYield
With sodium hydride In 1,2-dimethoxyethane at 20℃;98%
(S)-Alaninol
2749-11-3

(S)-Alaninol

2,2'-di(bromomethyl)-1,1'-binaphthalene
54130-90-4, 86631-56-3, 37803-02-4

2,2'-di(bromomethyl)-1,1'-binaphthalene

C25H23NO

C25H23NO

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 16h; Reflux;98%
(S)-Alaninol
2749-11-3

(S)-Alaninol

ethyl 3-(3-amino-4-(cyclohexyl(isobutyl)amino)phenyl)butanoate

ethyl 3-(3-amino-4-(cyclohexyl(isobutyl)amino)phenyl)butanoate

1,1'-Thiocarbonyldiimidazole
6160-65-2

1,1'-Thiocarbonyldiimidazole

ethyl 3-(4-(cyclohexyl(isobutyl)amino)-3-(3-((S)-1-hydroxypropan-2-yl)thioureido)phenyl)butanoate

ethyl 3-(4-(cyclohexyl(isobutyl)amino)-3-(3-((S)-1-hydroxypropan-2-yl)thioureido)phenyl)butanoate

Conditions
ConditionsYield
Stage #1: ethyl 3-(3-amino-4-(cyclohexyl(isobutyl)amino)phenyl)butanoate; 1,1'-Thiocarbonyldiimidazole In dichloromethane at 0 - 20℃; for 4h;
Stage #2: (S)-Alaninol In dichloromethane
98%
(S)-Alaninol
2749-11-3

(S)-Alaninol

C11H17NO3S

C11H17NO3S

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran at 20℃;98%
ethyl 8-bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
69585-94-0

ethyl 8-bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate

(S)-Alaninol
2749-11-3

(S)-Alaninol

(S)-8-bromo-N-(1-hydroxypropan-2-yl)-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxamide

(S)-8-bromo-N-(1-hydroxypropan-2-yl)-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxamide

Conditions
ConditionsYield
at 90℃; Sealed tube;98%
(S)-Alaninol
2749-11-3

(S)-Alaninol

Allyl chloroformate
2937-50-0

Allyl chloroformate

C7H13NO3

C7H13NO3

Conditions
ConditionsYield
With sodium carbonate In water; ethyl acetate at 20 - 25℃; for 1h;97.3%
N-(Benzyloxycarbonyloxy)succinimide
13139-17-8

N-(Benzyloxycarbonyloxy)succinimide

(S)-Alaninol
2749-11-3

(S)-Alaninol

(S)-(-)-N-(benzyloxycarbonyl)alaninol
6429-44-3, 61425-27-2, 87905-97-3, 66674-16-6

(S)-(-)-N-(benzyloxycarbonyl)alaninol

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane; water at 20℃; for 12h; Large scale;97%
With triethylamine In tetrahydrofuran for 2h;92%
In 1,4-dioxane; water for 12h;90%
With TEA In tetrahydrofuran for 1h; Ambient temperature; Yield given;
In dichloromethane at 20℃; for 2h;
(S)-Alaninol
2749-11-3

(S)-Alaninol

benzyl bromide
100-39-0

benzyl bromide

(S)-2-(N,N-dibenzylamino)-1-propanol
60479-65-4

(S)-2-(N,N-dibenzylamino)-1-propanol

Conditions
ConditionsYield
With potassium carbonate In water; acetone for 10h; Heating;97%
With potassium carbonate Alkylation;83%
With potassium carbonate In acetonitrile at 0 - 20℃;69.1%
With potassium iodide In N,N-dimethyl-formamide at 80℃;
With potassium carbonate
2-mesitylenesulphonyl chloride
773-64-8

2-mesitylenesulphonyl chloride

(S)-Alaninol
2749-11-3

(S)-Alaninol

(2S)-N-(2,4,6-trimethylbenzenesulfonyl)-2-aminopropanol
1032477-02-3

(2S)-N-(2,4,6-trimethylbenzenesulfonyl)-2-aminopropanol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 18h;97%
(S)-Alaninol
2749-11-3

(S)-Alaninol

3-iodochlorobenzene
625-99-0

3-iodochlorobenzene

(S)-2-{(3-chlorophenyl)amino}propan-1-ol
1114547-42-0

(S)-2-{(3-chlorophenyl)amino}propan-1-ol

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide In ethylene glycol; isopropyl alcohol at 80℃; for 24h;97%
With potassium phosphate; copper(l) iodide In ethylene glycol; isopropyl alcohol at 80℃; for 24h; Ullmann-Goldberg Substitution; Inert atmosphere;97%
(S)-Alaninol
2749-11-3

(S)-Alaninol

3,5-bistrifluoromethylphenylisothiocyanate
23165-29-9

3,5-bistrifluoromethylphenylisothiocyanate

N-(2S)-3-hydroxypropan-2-yl-N'-(3,5-bis-(trifluoro-methyl)phenyl)-thiourea
1312749-57-7

N-(2S)-3-hydroxypropan-2-yl-N'-(3,5-bis-(trifluoro-methyl)phenyl)-thiourea

Conditions
ConditionsYield
In dichloromethane at 40℃; for 3h;97%
(S)-Alaninol
2749-11-3

(S)-Alaninol

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one
1450657-28-9

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one

(1S)-Ν-(1-methyl-1-hydroxymethylmethyl)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-vinylamine

(1S)-Ν-(1-methyl-1-hydroxymethylmethyl)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-vinylamine

Conditions
ConditionsYield
Stage #1: 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one With toluene-4-sulfonic acid In methanol at 5 - 15℃; Inert atmosphere; Molecular sieve;
Stage #2: (S)-Alaninol In methanol at 10℃; Inert atmosphere; Molecular sieve;
96.7%
(S)-Alaninol
2749-11-3

(S)-Alaninol

2-Fluorobenzoyl chloride
393-52-2

2-Fluorobenzoyl chloride

(1'S)-2-fluoro-N-<1-(hydroxymethyl)ethyl>benzamide
111904-32-6

(1'S)-2-fluoro-N-<1-(hydroxymethyl)ethyl>benzamide

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane for 1.5h;96%
With sodium hydroxide In dichloromethane; water for 1h; Ambient temperature;73%
(S)-Alaninol
2749-11-3

(S)-Alaninol

4-pentynoic acid
6089-09-4

4-pentynoic acid

Pent-4-ynoic acid ((S)-2-hydroxy-1-methyl-ethyl)-amide

Pent-4-ynoic acid ((S)-2-hydroxy-1-methyl-ethyl)-amide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In dichloromethane Ambient temperature;96%
(S)-Alaninol
2749-11-3

(S)-Alaninol

N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

[(1S)-[(1S)-2-hydroxy-1-methylethylcarbamoyl]-2-phenylethyl]carbamic acid tert-butyl ester

[(1S)-[(1S)-2-hydroxy-1-methylethylcarbamoyl]-2-phenylethyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 23℃; for 15h;96%

L-Alaninol Chemical Properties

The Molecular Structure of L-Alaninol (CAS NO.2749-11-3):

Empirical Formula: C3H9NO
Molecular Weight: 75.1097 
IUPAC Name: 2-aminopropan-1-ol  
Appearance: Colorless liquid
Nominal Mass: 75 Da
Average Mass: 75.1097 Da
Monoisotopic Mass: 75.068414 Da 
Index of Refraction: 1.439
Molar Refractivity: 20.97 cm3
Molar Volume: 79.6 cm3
Surface Tension: 35.7 dyne/cm
Density: 0.943 g/cm3
Flash Point: 83.9 °C
Enthalpy of Vaporization: 47.83 kJ/mol
Boiling Point: 174.5 °C at 760 mmHg
Vapour Pressure: 0.373 mmHg at 25°C 
Storage temp: 2-8°C
Sensitive: Hygroscopic
Product Categories: Pharmaceutical Intermediates;Pharmaceutical Raw Materials;Alcohols and Derivatives;Amino Alcohols;Alanine [Ala, A];Amino Alcohols (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Chiral Compound;Amino alcohols
InChI
InChI=1/C3H9NO/c1-3(4)2-5/h3,5H,2,4H2,1H3 
Smiles
N[C@@H](CO)C 
Synonyms: EINECS 220-388-7 ; (+)-2-Aminopropan-1-ol ; L-(+)-alaninol;l-alaninol ; L-(+)-2-amino propanol ; L-2-amino-propanol ; H-l-ala-ol ; H-alaninol ; H-ala-ol 

L-Alaninol Safety Profile

Hazard Codes: IrritantXiCorrosiveC
Risk Statements: 34-36/37/38 
R34: Causes burns
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36/37/39-45-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36: Wear suitable protective clothing
RIDADR: UN 2735 8/PG 2
WGK Germany: 3
F: 10-23 
F 10: Keep under argon
F 23: Sensitive to air
HazardClass: 8
PackingGroup: III

L-Alaninol Specification

HANDLING and STORAGE about L-Alaninol (CAS NO.2749-11-3):
Handling: Wash thoroughly after handling. Use only in a well-ventilated area.Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not get on skin or in eyes. Do not ingest or inhale. Handle under an inert atmosphere. Store protected from air. Discard contaminated shoes. Do not pressurize, cut, weld, braze,solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible  substances. Corrosives area. Do not expose to air.Store under an inert atmosphere.
FIRST AID MEASURES
Eyes:Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.

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