Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran Heating; | 97% |
With lithium aluminium tetrahydride In tetrahydrofuran Heating; | 95% |
With sulfuric acid; hydrogen In water at 39.84℃; under 60006 Torr; Concentration; Reagent/catalyst; | 93.7% |
(S)-Alaninol
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol at 20℃; Reagent/catalyst; | 92.2% |
(-)-(3R,5S)-5-methyl-3-phenylmorpholin-2-one
(S)-Alaninol
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol under 112509 Torr; for 72h; | 89% |
With hydrogen; palladium on activated charcoal In methanol under 114000 Torr; for 72h; Hydrogenolysis; ring cleavage; methanolysis; | 89% |
L-Alanine methyl ester
(S)-Alaninol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride | 78% |
With lithium aluminium tetrahydride In tetrahydrofuran for 4h; Heating; | 30% |
With hydrogen; Nishimura catalyst <(45.9% Rh/19.9% Pt) oxide> In methanol at 25℃; under 75007.5 Torr; |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride | 74% |
With sodium tetrahydroborate In ethanol Heating; | 16.9% |
Conditions | Yield |
---|---|
With C24H20ClN2OPRu; potassium tert-butylate; hydrogen In tetrahydrofuran at 110℃; under 2280.15 - 30402 Torr; for 48h; Inert atmosphere; Schlenk technique; Autoclave; | 65% |
L-alanine hydrochloride
(S)-Alaninol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 12h; Reflux; Inert atmosphere; | 51.1% |
Conditions | Yield |
---|---|
With phosphoric acid; hydrogen In water at 79.84℃; under 7500.75 - 60006 Torr; for 4h; Concentration; Reagent/catalyst; | A 42.2% B n/a |
With sulfuric acid; hydrogen In water at 79.84℃; under 60006 Torr; for 2h; Catalytic behavior; Autoclave; |
(Z,E)-2-amino-6-chloro-9-[(2-carbethoxycyclopropylidene)methyl]purine
A
(S)-Alaninol
B
anti-2-amino-6-chloro-N9-(2-hydroxymethylcyclopropylidenemethyl)purine
Conditions | Yield |
---|---|
With diisobutylaluminium hydride In tetrahydrofuran; cyclohexane at 0℃; for 2h; | A 41.8% B 23.3% |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; diethyl ether | |
With lithium aluminium tetrahydride |
(S)-butyl 2-aminopropanoate
(S)-Alaninol
Conditions | Yield |
---|---|
With 1,4-dioxane; copper oxide-chromium oxide at 150℃; under 102971 Torr; |
Conditions | Yield |
---|---|
With oxalic acid; palladium Hydrogenolise; | |
With oxalic acid; palladium Hydrogenolise; |
(S)-(-)-N-(benzyloxycarbonyl)alaninol
(S)-Alaninol
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol | |
With hydrogen; palladium on activated charcoal In tetrahydrofuran; methanol under 760 Torr; for 3h; Ambient temperature; |
Conditions | Yield |
---|---|
With ammonia; sodium In methanol dry-ice-cooled; Yield given; |
2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione
(S)-Alaninol
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol at 60℃; for 1.25h; |
(S)-(-)-2--1-propanol
(S)-Alaninol
Conditions | Yield |
---|---|
With sodium hydroxide at 80℃; for 2h; |
(S)-(-)-2-propyl acetate
(S)-Alaninol
Conditions | Yield |
---|---|
With sodium hydroxide at 80℃; for 2h; |
(S)-Alaninol
Conditions | Yield |
---|---|
With hydrogenchloride |
(S)-Alaninol
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
anschliessendes Eindampfen mit wss. HCl; |
Conditions | Yield |
---|---|
With phosphoric acid; hydrogen In water at 100℃; under 51714.8 Torr; for 6h; Product distribution; Further Variations:; Temperatures; Pressures; |
Conditions | Yield |
---|---|
With H2; RuO2 In methanol; aqueous H2SO4; water |
indan-1,2,3-trione hydrate
L-alanine methyl ester hydrochloride
(S)-Alaninol
Conditions | Yield |
---|---|
With sodium borohydrid In water |
Conditions | Yield |
---|---|
Stage #1: With titanium(IV) isopropylate; (R,R)-TADDOL In diphenylether at 90℃; for 1h; Stage #2: 2-Amino-1-propanol In diphenylether at 90℃; for 0.166667h; Product distribution / selectivity; | n/a |
(S)-Alaninol
2-ammoniopropyl sulfate
Conditions | Yield |
---|---|
With sulfuric acid In water at 50 - 110℃; for 2.5h; | 100% |
With chlorosulfonic acid In acetonitrile at 25 - 40℃; | 95% |
With sulfuric acid | 67% |
(S)-Alaninol
di-tert-butyl dicarbonate
(S)-2-t-butoxycarbonylaminopropan-1-ol
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane at 20℃; for 3h; | 100% |
With triethylamine In methanol at 20℃; for 12h; | 100% |
With triethylamine In tetrahydrofuran at 0 - 20℃; for 12h; | 100% |
(S)-Alaninol
4-Nitrobenzenesulfonyl chloride
(2S)-2-methyl-1-[(4-nitrophenyl)sulfonyl]aziridine
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; for 5h; | 100% |
In pyridine; dichloromethane at 0 - 20℃; | 98% |
(S)-Alaninol
ethyl trifluoroacetate,
N-(S)-(2-hydroxy-1-methylethyl)-2,2.2-trifluoroacetamide
Conditions | Yield |
---|---|
In acetonitrile | 100% |
benzyl 4-oxo-1-piperidinecarboxylate
(S)-Alaninol
phenylmethyl 4-{[(1S)-2-hydroxy-1-methylethyl]amino}-1-piperidinecarboxylate
Conditions | Yield |
---|---|
Stage #1: benzyl 4-oxo-1-piperidinecarboxylate; (S)-Alaninol With acetic acid In methanol for 0.25h; Stage #2: With methanol; sodium cyanoborohydride for 72h; | 100% |
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran | 100% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; | 100% |
Conditions | Yield |
---|---|
In benzene for 4h; Reflux; Dean-Stark; | 100% |
Conditions | Yield |
---|---|
In benzene for 4h; Reflux; Dean-Stark; | 100% |
(S)-Alaninol
ethyl acetate
2,3,4,5-tetrafluorobenzoyl chloride
formic acid ethyl ester
ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate
Conditions | Yield |
---|---|
Stage #1: ethyl acetate; formic acid ethyl ester With sodium hydride In toluene Stage #2: (S)-Alaninol; 2,3,4,5-tetrafluorobenzoyl chloride In toluene at 20℃; Reflux; Stage #3: With potassium fluoride In N,N-dimethyl-formamide Reflux; | 99.4% |
Conditions | Yield |
---|---|
Stage #1: (S)-Alaninol; benzaldehyde With toluene-4-sulfonic acid In toluene at 20℃; for 2h; Stage #2: With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at -78 - 20℃; | 99% |
(S)-Alaninol
2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate
(S)-2-[2-(trimethylsilylethoxy)carbonylamino]propan-1-ol
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane for 24h; Ambient temperature; | 98% |
phthalic anhydride
(S)-Alaninol
2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
at 140℃; | 98% |
With triethylamine In toluene for 3h; Condensation; Heating; | 94% |
at 200℃; for 3h; | 93% |
Conditions | Yield |
---|---|
In butan-1-ol for 0.166667h; Zincke's reaction; microwave irradiation; | 98% |
2-fluoro-5-nitrobenzaldehyde diethylacetal
(S)-Alaninol
(2S)-aminopropyl-[2-(1,1-bis-ethoxymethyl)-4-nitrophenyl]ether
Conditions | Yield |
---|---|
With sodium hydride In 1,2-dimethoxyethane at 20℃; | 98% |
(S)-Alaninol
2,2'-di(bromomethyl)-1,1'-binaphthalene
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 16h; Reflux; | 98% |
Conditions | Yield |
---|---|
Stage #1: ethyl 3-(3-amino-4-(cyclohexyl(isobutyl)amino)phenyl)butanoate; 1,1'-Thiocarbonyldiimidazole In dichloromethane at 0 - 20℃; for 4h; Stage #2: (S)-Alaninol In dichloromethane | 98% |
Conditions | Yield |
---|---|
With potassium hydroxide In tetrahydrofuran at 20℃; | 98% |
ethyl 8-bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
(S)-Alaninol
Conditions | Yield |
---|---|
at 90℃; Sealed tube; | 98% |
Conditions | Yield |
---|---|
With sodium carbonate In water; ethyl acetate at 20 - 25℃; for 1h; | 97.3% |
N-(Benzyloxycarbonyloxy)succinimide
(S)-Alaninol
(S)-(-)-N-(benzyloxycarbonyl)alaninol
Conditions | Yield |
---|---|
With potassium carbonate In 1,4-dioxane; water at 20℃; for 12h; Large scale; | 97% |
With triethylamine In tetrahydrofuran for 2h; | 92% |
In 1,4-dioxane; water for 12h; | 90% |
With TEA In tetrahydrofuran for 1h; Ambient temperature; Yield given; | |
In dichloromethane at 20℃; for 2h; |
Conditions | Yield |
---|---|
With potassium carbonate In water; acetone for 10h; Heating; | 97% |
With potassium carbonate Alkylation; | 83% |
With potassium carbonate In acetonitrile at 0 - 20℃; | 69.1% |
With potassium iodide In N,N-dimethyl-formamide at 80℃; | |
With potassium carbonate |
2-mesitylenesulphonyl chloride
(S)-Alaninol
(2S)-N-(2,4,6-trimethylbenzenesulfonyl)-2-aminopropanol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 18h; | 97% |
(S)-Alaninol
3-iodochlorobenzene
(S)-2-{(3-chlorophenyl)amino}propan-1-ol
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide In ethylene glycol; isopropyl alcohol at 80℃; for 24h; | 97% |
With potassium phosphate; copper(l) iodide In ethylene glycol; isopropyl alcohol at 80℃; for 24h; Ullmann-Goldberg Substitution; Inert atmosphere; | 97% |
(S)-Alaninol
3,5-bistrifluoromethylphenylisothiocyanate
N-(2S)-3-hydroxypropan-2-yl-N'-(3,5-bis-(trifluoro-methyl)phenyl)-thiourea
Conditions | Yield |
---|---|
In dichloromethane at 40℃; for 3h; | 97% |
(S)-Alaninol
1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one
Conditions | Yield |
---|---|
Stage #1: 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one With toluene-4-sulfonic acid In methanol at 5 - 15℃; Inert atmosphere; Molecular sieve; Stage #2: (S)-Alaninol In methanol at 10℃; Inert atmosphere; Molecular sieve; | 96.7% |
(S)-Alaninol
2-Fluorobenzoyl chloride
(1'S)-2-fluoro-N-<1-(hydroxymethyl)ethyl>benzamide
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane for 1.5h; | 96% |
With sodium hydroxide In dichloromethane; water for 1h; Ambient temperature; | 73% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In dichloromethane Ambient temperature; | 96% |
(S)-Alaninol
N-tert-butoxycarbonyl-L-phenylalanine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 23℃; for 15h; | 96% |
The Molecular Structure of L-Alaninol (CAS NO.2749-11-3):
Empirical Formula: C3H9NO
Molecular Weight: 75.1097
IUPAC Name: 2-aminopropan-1-ol
Appearance: Colorless liquid
Nominal Mass: 75 Da
Average Mass: 75.1097 Da
Monoisotopic Mass: 75.068414 Da
Index of Refraction: 1.439
Molar Refractivity: 20.97 cm3
Molar Volume: 79.6 cm3
Surface Tension: 35.7 dyne/cm
Density: 0.943 g/cm3
Flash Point: 83.9 °C
Enthalpy of Vaporization: 47.83 kJ/mol
Boiling Point: 174.5 °C at 760 mmHg
Vapour Pressure: 0.373 mmHg at 25°C
Storage temp: 2-8°C
Sensitive: Hygroscopic
Product Categories: Pharmaceutical Intermediates;Pharmaceutical Raw Materials;Alcohols and Derivatives;Amino Alcohols;Alanine [Ala, A];Amino Alcohols (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Chiral Compound;Amino alcohols
InChI
InChI=1/C3H9NO/c1-3(4)2-5/h3,5H,2,4H2,1H3
Smiles
N[C@@H](CO)C
Synonyms: EINECS 220-388-7 ; (+)-2-Aminopropan-1-ol ; L-(+)-alaninol;l-alaninol ; L-(+)-2-amino propanol ; L-2-amino-propanol ; H-l-ala-ol ; H-alaninol ; H-ala-ol
Hazard Codes: XiC
Risk Statements: 34-36/37/38
R34: Causes burns
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36/37/39-45-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36: Wear suitable protective clothing
RIDADR: UN 2735 8/PG 2
WGK Germany: 3
F: 10-23
F 10: Keep under argon
F 23: Sensitive to air
HazardClass: 8
PackingGroup: III
HANDLING and STORAGE about L-Alaninol (CAS NO.2749-11-3):
Handling: Wash thoroughly after handling. Use only in a well-ventilated area.Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not get on skin or in eyes. Do not ingest or inhale. Handle under an inert atmosphere. Store protected from air. Discard contaminated shoes. Do not pressurize, cut, weld, braze,solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Do not expose to air.Store under an inert atmosphere.
FIRST AID MEASURES
Eyes:Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
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