• Name

  Liothyronine sodium

• EINECS 200-223-5
• CAS No. 55-06-1
• Article Data1
• CAS DataBase
• Density
• Solubility Partly miscible in water. Soluble in dimethyl sulfoxide, methanol, sodium hydroxide and ethanol. Practically insoluble in most other organic solvents.
• Melting Point 205 °C (dec.)(lit.)
• Formula C₁₅H₁₁I₃NNaO₄
• Boiling Point 563.5 °C at 760 mmHg
• Molecular Weight 672.96
• Flash Point 294.6 °C
• Transport Information
• Appearance white to beige powder
• Safety 22-24/25-36
• Risk Codes 20/21/22
• Molecular Structure
• Hazard Symbols Xn
• Synonyms Alanine,3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, monosodium salt, L- (8CI);L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (9CI);3,3',5-Triiodo-L-thyronine sodium salt;3,3',5-Triiodothyronine sodium salt;3,5,3'-Triiodo-L-thyronine monosodium salt;Basoprocin;Cynomel;Cyomel;Cytobin;Cytomel;Cytomel sodium;Cytomine;Ibiothyron;L-Triiodothyroninesodium salt;Liothyroniinde sodium salt;Liothyroninesodium;Sodium 3,3',5-triiodo-L-thyronine;Sodium 3,5,3'-triiodothyronine;Sodium L-3,3',5-triiodothyronine;Sodium L-triiodothyronine;Sodium T3;Sodiumliothyronine;Sodium triiodo-L-thyronine;Sodium triiodothyronine;T3 Sodiumsalt;Tertroxin;Triiodothyronine sodium salt;Triostat;Triothyrone;
• PSA 95.61000
• LogP 3.31830

Synthetic route

1041-01-6, 534-51-0, 5563-89-3, 299-82-1

3,5-diiodo-L-thyronine

55-06-1

liothyronine sodium

Conditions

Conditions	Yield
With iodine; ethylamine; sodium iodide In water at 0 - 22℃; for 7h; Large scale;

bismuth (III) nitrate pentahydrate

55-06-1

liothyronine sodium

bismuth triiodothyronine

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 18h;	91%

55-06-1

liothyronine sodium

1417654-45-5

(S)-4-(4-(2-amino-3-hydroxypropyl)-2,6-diiodophenoxy)-2-iodophenol

Conditions

Conditions	Yield
With lithium borohydride; chloro-trimethyl-silane In tetrahydrofuran; 1,4-dioxane at 0℃; Inert atmosphere;	61%

55-06-1

liothyronine sodium

3,5-diiodo-N-[[(carboxymethyl)[2-[(carboxymethyl)[2-[bis(carboxymethyl)amino]ethyl]amino]ethyl]amino]acetyl]-O-[3-iodo-4-(sulfooxy)phenyl]-l-tyrosine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic acid / water / Large scale 2.1: chlorosulfonic acid / N,N-dimethyl acetamide / 4.67 h / -5 - 5 °C / Inert atmosphere 2.2: 1.5 h / Inert atmosphere 3.1: N,N-dimethyl acetamide; water / 4.5 h / 80 °C 3.2: 0.33 h / 25 °C View Scheme

55-06-1

liothyronine sodium

6893-02-3

triiodothyronine

Conditions

Conditions	Yield
With acetic acid In water Large scale;

55-06-1

liothyronine sodium

C36H47I3N4O14S2

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic acid / water / Large scale 2.1: chlorosulfonic acid / N,N-dimethyl acetamide / 4.67 h / -5 - 5 °C / Inert atmosphere 2.2: 1.5 h / Inert atmosphere 3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0 - 20 °C View Scheme

Liothyronine sodium Chemical Properties

Liothyronine sodium Uses

Liothyronine sodium Safety Profile

Liothyronine sodium Specification