1. Introduction of Metformin hydrochloride
Metformin hydrochloride is one kind of crystalline solid or white powder. The IUPAC Name of this chemical is 3-(Diaminomethylidene)-1,1-dimethylguanidine hydrochloride. Besides, Metformin hydrochloride belongs to Intermediates & Fine Chemicals; Pharmaceuticals; API's; Miscellaneous Compounds. In addition, Metformin hydrochloride Classification Code is Antidiabetic; Drug / Therapeutic Agent; Skin / Eye Irritant. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether and chloroform.
2. Properties of Metformin hydrochloride
Physical properties about Metformin hydrochloride are:
(1)Molecular Weight: 165.62; (2)H bond acceptors: 5; (3)H bond donors: 5; (4)Freely Rotating Bonds: 1; (5)Polar Surface Area: 34.44 Å2; (6)Merck: 13,5963; (7)Flash Point: 89.3 °C; (8)Enthalpy of Vaporization: 46.06 kJ/mol; (9)Boiling Point: 224.1 °C at 760 mmHg; (10)Vapour Pressure: 0.0929 mmHg at 25°C; (11)Melting point: 223-226 °C; (12)Appearance: Crystalline Solid; (13)Prisms from water, mp 232 deg C; (14)Crystals from propanol, mp 218-220 deg C; (15)H-Bond Donor: 4; (16)H-Bond Acceptor: 1.
3. Structure Descriptors of Metformin hydrochloride
(1)InChI: InChI=1/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
(2)Smiles: C(NC(N)=N)(N(C)C)=N.Cl
(3)Canonical SMILES : CN(C)C(=N)N=C(N)N.Cl
(4)InChIKey: OETHQSJEHLVLGH-UHFFFAOYSA-N
4. Toxicity of Metformin hydrochloride
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | intramuscular | 200mg/kg (200mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 474, 1960. | |
guinea pig | LD50 | intraperitoneal | 200mg/kg (200mg/kg) | Toxicology and Applied Pharmacology. Vol. 2, Pg. 474, 1960. | |
guinea pig | LD50 | oral | 500mg/kg (500mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
guinea pig | LD50 | subcutaneous | 150mg/kg (150mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
mouse | LD50 | intraperitoneal | 420mg/kg (420mg/kg) | Drugs in Japan Vol. 6, Pg. 841, 1982. | |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04012, | |
mouse | LD50 | oral | 1450mg/kg (1450mg/kg) | Drugs in Japan Vol. 6, Pg. 841, 1982. | |
mouse | LD50 | subcutaneous | 225mg/kg (225mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
rabbit | LD50 | oral | 350mg/kg (350mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
rabbit | LD50 | subcutaneous | 150mg/kg (150mg/kg) | Drugs in Japan Vol. -, Pg. 1193, 1990. | |
rat | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | French Demande Patent Document. Vol. #2220256, | |
rat | LD50 | oral | 1gm/kg (1000mg/kg) | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 934, 1989. | |
rat | LD50 | subcutaneous | 300mg/kg (300mg/kg) | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 934, 1989. |
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