• Name

  Methanedisulphonic acid

• EINECS 207-966-4
• CAS No. 503-40-2
• Article Data60
• CAS DataBase
• Density 2.145 g/cm³
• Solubility 2458g/L(25 oC)
• Melting Point 107-109oC
• Formula CH₄O₆S₂
• Boiling Point 263℃ at 101.3kPa
• Molecular Weight 176.171
• Flash Point
• Transport Information
• Appearance white powder
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Methionicacid;Methanedisulfonic acid;
• PSA 125.50000
• LogP 0.88110

Synthetic route

75-09-2

dichloromethane

calcium methanedisulfonate

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
Stage #1: dichloromethane With calcium sulfite In water at 180℃; for 10h; Autoclave; Stage #2: calcium methanedisulfonate With sulfuric acid In water at 80℃; for 2h; Reagent/catalyst; Temperature;	89%

74-95-3

1,2-dibromomethane

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
Stage #1: 1,2-dibromomethane With potassium sulfite; tetrabutylammomium bromide; potassium iodide In water at 80 - 90℃; for 88h; Stage #2: With hydrogenchloride In water at 90℃; for 2h; Stage #3: With barium(II) chloride In water at 20 - 90℃; for 2h;	84.7%

18555-26-5

methylene trithiocarbonate

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With nitric acid

60-35-5

acetamide

123-43-3

sulfoacetic acid

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfuric acid

60-35-5

acetamide

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide bis zum Entweichen von schwefliger Saeure;
With sulfuric acid; sulfur trioxide at 210℃;

849585-22-4

LACTIC ACID

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide bis zur Entwicklung von schwefliger Saeure, dann Saettigen mit BaCO3;
With sulfuric acid; sulfur trioxide

64-67-5

diethyl sulfate

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide

75-75-2

methanesulfonic acid

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide at 140℃;
With aminosulfonic acid at 25 - 150℃; for 3h; Reagent/catalyst; Temperature;

60-29-7

diethyl ether

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide

75-47-8

iodoform

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With potassium sulfite at 150℃;

22063-28-1

dimethyl methanedisulfonate

64-17-5

ethanol

A

60-29-7

diethyl ether

B

503-40-2

methanedisulfonic acid

...Expand

64-17-5

ethanol

5799-68-8

methanedisulfonyl chloride

503-40-2

methanedisulfonic acid

67-66-3

chloroform

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With potassium sulfite at 180℃;

6317-18-6

bis(thiocyanato)methane

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid bei der elektrolytischen Oxydation;
durch Hypochlorite;

123-43-3

sulfoacetic acid

A

50-00-0

formaldehyd

B

110-04-3

ethane-1,2-disulphonic acid

C

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
bei der elektrolytischen Oxydation von sulfoessigsauren Salzen,und Kochen der angesaeuerten Loesung (Entwicklung von CO2,H2SO4,CO,SO2,Aethylen);

...Expand

123-43-3

sulfoacetic acid

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfuric acid at 75 - 80℃; bei der elektrolytischen Oxydation an PbO2;
With water at 75 - 80℃; bei der elektrolytischen Oxydation an Platin;

86147-56-0

oxo-ethane-1,1-disulfonic acid

A

64-18-6

formic acid

B

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With alkali

500878-39-7

disulfoacetic acid

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
durch thermische Zersetzung;

579-10-2

N-acetyl-N-methylaniline

A

503-40-2

methanedisulfonic acid

B

70916-29-9

N-methylorthanilic acid

Conditions

Conditions	Yield
With sulfuric acid at 140 - 150℃;

108-24-7

acetic anhydride

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide at 120℃; durch Zufuegen von Eisessig und weiteres Erhitzen auf 120grad;

64-19-7

acetic acid

A

123-43-3

sulfoacetic acid

B

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With chlorosulfonic acid unter Kuehlung und Erhitzen des Reaktionsgemisches dann auf 140grad;

64-19-7

acetic acid

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With chlorosulfonic acid unter Kuehlung und Erhitzen des Reaktionsgemisches dann auf 140grad;

67-64-1

acetone

A

503-40-2

methanedisulfonic acid

B

2-oxo-propane-1,1,3,3-tetrasulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide
With methanol; sulfuric acid; sulfur trioxide

123-43-3

sulfoacetic acid

75-05-8

acetonitrile

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfuric acid

74-86-2

acetylene

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide ueber mehrere Stufen;
With sulfuric acid

74-86-2

acetylene

A

503-40-2

methanedisulfonic acid

B

prop-1-ene-1,1-disulfonic acid

Conditions

Conditions	Yield
With sulfuric acid

74-86-2

acetylene

A

503-40-2

methanedisulfonic acid

B

86147-56-0

oxo-ethane-1,1-disulfonic acid

Conditions

Conditions	Yield
With sulfuric acid entstehen noch Sulfaten wie HO3SOCH(OH)CH(SO3H)2, welche bei der Spaltung mit Salzsaeure ebenfalls Acetaldehyddisulfonsaeure liefern;

5799-68-8

methanedisulfonyl chloride

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
(hydrolysis);

diazo-methanedisulfonic acid

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
With piperidine

methanedisulfonic acid sodium salt

503-40-2

methanedisulfonic acid

Conditions

Conditions	Yield
(i) aq. HCl, BaCl2, (ii) aq. H2SO4; Multistep reaction;

616-47-7

1-methyl-1H-imidazole

503-40-2

methanedisulfonic acid

N-methylimidazolium sulphomethylsulfonate

Conditions

Conditions	Yield
In water at 20℃; for 6h;	99%

503-40-2

methanedisulfonic acid

silver carbonate

71608-87-2

disilver methanedisulfonate

Conditions

Conditions	Yield
In water addn. of Ag2CO3 to an aq. soln. of the sulfonic acid; filtn., evapd. in vac., dried in vac. at 50°C; elem. anal.;	98%
In water exclusion of light; filtn., pptn. on evapn., drying (vac., 50°C); elem. anal.;	98%
In water (N2); Schlenk technique; aq. soln. of acid was added dropwise into stirred aq. soln. of Ag salt at 20°C; filtered through Celite; stirredat 20°C for 1 h; evapd. (vac.); dried at 50°C in vac.;	84%
In water

503-40-2

methanedisulfonic acid

92975-18-3

[(chlorosulfonyl)oxy]methyl sulfurochloridate

99591-74-9

methylene methane disulfonate

Conditions

Conditions	Yield
Stage #1: methanedisulfonic acid With poly(4-vinylpyridine) In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: [(chlorosulfonyl)oxy]methyl sulfurochloridate In 1,2-dichloro-ethane at 55℃; for 5h; Reagent/catalyst; Temperature;	92%

50-00-0

formaldehyd

503-40-2

methanedisulfonic acid

99591-74-9

methylene methane disulfonate

Conditions

Conditions	Yield
With acetic anhydride; phosphorus trichloride at 120℃; for 5h; Reagent/catalyst; Temperature; Time;	88.72%
In toluene at 120℃; for 2h; Temperature; Solvent;	81.2%
With phosphorus pentoxide In 1,2-dichloro-ethane at 84℃; for 2h;	76.52%
With phosphorus pentoxide at 120℃; for 1h;	47%

67-56-1

methanol

503-40-2

methanedisulfonic acid

115-10-6

Dimethyl ether

Conditions

Conditions	Yield
at 120℃;

64-17-5

ethanol

503-40-2

methanedisulfonic acid

60-29-7

diethyl ether

Conditions

Conditions	Yield
at 140℃; man destilliert kontinuerlich der gebildete Aether ueber;
at 140℃;

123-51-3

i-Amyl alcohol

503-40-2

methanedisulfonic acid

A

71-23-8

propan-1-ol

B

513-35-9

2-methyl-but-2-ene

C

544-01-4

isopentyl ether

D

78-83-1

2-methyl-propan-1-ol

...Expand

503-40-2

methanedisulfonic acid

5799-68-8

methanedisulfonyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride
With phosphorus pentachloride
With phosphorus pentachloride

Methanedisulphonic acid Chemical Properties

Methanedisulphonic acid Uses