Methyl carbazate supplier | CasNO.6294-89-9

Name
Methyl carbazate
EINECS 228-560-3
CAS No. 6294-89-9
Article Data24
CAS DataBase
Density 1.162 g/cm³
Solubility Soluble in water
Melting Point 70-73 °C(lit.)
Formula C₂H₆N₂O₂
Boiling Point 230.906 °C at 760 mmHg
Molecular Weight 90.0818
Flash Point 86.129 °C
Transport Information UN 2811
Appearance white to pink crystalline platelets
Safety 26-36/37/39-22-45
Risk Codes 36/37/38-48-23/25
Molecular Structure
Hazard Symbols Xi, T
Synonyms Carbazicacid, methyl ester (8CI);(Methoxycarbonyl)hydrazide;Carbomethoxyhydrazide;Methyl hydrazinecarboxylate;Methyl hydrazinoformate;
PSA 64.35000
LogP 0.30730

Synthetic route

: 7803-57-8
hydrazine hydrate

: 616-38-6
carbonic acid dimethyl ester

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
at 20℃;	96%

: 616-38-6
carbonic acid dimethyl ester

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With hydrazine hydrate at 20 - 50℃; for 20.33h;	95%
With hydrazine hydrate	95%
With hydrazine hydrate at 20 - 50℃; for 24.5h;	94%

: 616-38-6
carbonic acid dimethyl ester

A: 6294-89-9
hydrazinecarboxylic acid methyl ester

B: 497-18-7
carbonodihydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) at 80℃; Temperature;	A 53% B 35%

: 14442-53-6
N-nitro-carbamide acid methylester

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With acetic acid Electrolysis.durch Reduktion an einer verzinnten Kupferkathode;

: 14442-53-6
N-nitro-carbamide acid methylester

: 64-19-7
acetic acid

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
Reduktion an einer verzinnten Kupferkathode.Electrolysis;

: 79-22-1
methyl chloroformate

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With methanol; hydrazine hydrate

: 76529-39-0
methyl (phenylseleno)formate

A: 6294-89-9
hydrazinecarboxylic acid methyl ester

B: 1666-13-3
diphenyl diselenide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at -10 - 20℃;

: S-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)O-methyl carbonothioate

A: 6294-89-9
hydrazinecarboxylic acid methyl ester

B: 22478-90-6
3-benzyl-4-phenyl-5-mercapto-1,2,4-triazole

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol; water at 20 - 60℃; for 10h;

: 61985-23-7
methyl 1-imidazolecarboxylate

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With hydrazine hydrate In dichloromethane at 0 - 20℃; for 1h;

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 534-07-6
1,3-Dichloroacetone

: 87595-89-9
methyl 2-[2-chloro-1-(chloromethyl)ethylidene]-1-hydrazinecarboxylate

Conditions

Conditions	Yield
In diethyl ether for 15h; Ambient temperature;	100%
In methanol at 23℃; for 4h;	54%
for 3h; Ambient temperature; Yield given;
In methanol at 23℃; for 4h;

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 298-12-4
Glyoxilic acid

: 332868-35-6
[(methoxycarbonyl)hydrazono]acetic acid

Conditions

Conditions	Yield
In water for 7h;	100%

: 700-58-3
2-Adamantanone

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 544419-63-8
C12H18N2O2

Conditions

Conditions	Yield
With acetic acid In methanol for 1h; Reflux;	100%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 67-64-1
acetone

: 21732-11-6
methyl-2,3-diaza-4-methyl-4-acetoxypent-2-enoate

Conditions

Conditions	Yield
With magnesium sulfate for 6.5h; Reflux; Inert atmosphere;	100%
With magnesium sulfate In acetone for 2h; Inert atmosphere; Reflux;	87.8%
With acetic acid In methanol at 25 - 65℃; Molecular sieve;
With acetic acid at 20℃; for 24h;

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: C5H11N3O3

Conditions

Conditions	Yield
With sodium hydroxide In ethyl acetate at 50℃; for 16h; Reagent/catalyst;	100%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 107-14-2
chloroacetonitrile

: N'-(1-amino-2-chloroethylidene)hydrazine carboxylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: chloroacetonitrile With sodium In methanol at 0 - 20℃; for 0.5h; Stage #2: hydrazinecarboxylic acid methyl ester With acetic acid In methanol at 20℃; for 0.666667h;	99.4%
Stage #1: chloroacetonitrile With sodium methylate In methanol at 0 - 20℃; for 0.75h; Stage #2: hydrazinecarboxylic acid methyl ester With acetic acid In methanol at 20℃; for 0.5h;

: 7803-57-8
hydrazine hydrate

: 616-38-6
carbonic acid dimethyl ester

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
at 20℃;	96%

: 616-38-6
carbonic acid dimethyl ester

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With hydrazine hydrate at 20 - 50℃; for 20.33h;	95%
With hydrazine hydrate	95%
With hydrazine hydrate at 20 - 50℃; for 24.5h;	94%

: 616-38-6
carbonic acid dimethyl ester

A: 6294-89-9
hydrazinecarboxylic acid methyl ester

B: 497-18-7
carbonodihydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In neat (no solvent) at 80℃; Temperature;	A 53% B 35%

: 14442-53-6
N-nitro-carbamide acid methylester

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With acetic acid Electrolysis.durch Reduktion an einer verzinnten Kupferkathode;

: 14442-53-6
N-nitro-carbamide acid methylester

: 64-19-7
acetic acid

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
Reduktion an einer verzinnten Kupferkathode.Electrolysis;

: 79-22-1
methyl chloroformate

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With methanol; hydrazine hydrate

: 76529-39-0
methyl (phenylseleno)formate

A: 6294-89-9
hydrazinecarboxylic acid methyl ester

B: 1666-13-3
diphenyl diselenide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at -10 - 20℃;

: S-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)O-methyl carbonothioate

A: 6294-89-9
hydrazinecarboxylic acid methyl ester

B: 22478-90-6
3-benzyl-4-phenyl-5-mercapto-1,2,4-triazole

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol; water at 20 - 60℃; for 10h;

: 61985-23-7
methyl 1-imidazolecarboxylate

: 6294-89-9
hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With hydrazine hydrate In dichloromethane at 0 - 20℃; for 1h;

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 534-07-6
1,3-Dichloroacetone

: 87595-89-9
methyl 2-[2-chloro-1-(chloromethyl)ethylidene]-1-hydrazinecarboxylate

Conditions

Conditions	Yield
In diethyl ether for 15h; Ambient temperature;	100%
In methanol at 23℃; for 4h;	54%
for 3h; Ambient temperature; Yield given;
In methanol at 23℃; for 4h;

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 298-12-4
Glyoxilic acid

: 332868-35-6
[(methoxycarbonyl)hydrazono]acetic acid

Conditions

Conditions	Yield
In water for 7h;	100%

: 700-58-3
2-Adamantanone

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 544419-63-8
C12H18N2O2

Conditions

Conditions	Yield
With acetic acid In methanol for 1h; Reflux;	100%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 67-64-1
acetone

: 21732-11-6
methyl-2,3-diaza-4-methyl-4-acetoxypent-2-enoate

Conditions

Conditions	Yield
With magnesium sulfate for 6.5h; Reflux; Inert atmosphere;	100%
With magnesium sulfate In acetone for 2h; Inert atmosphere; Reflux;	87.8%
With acetic acid In methanol at 25 - 65℃; Molecular sieve;
With acetic acid at 20℃; for 24h;

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: C5H11N3O3

Conditions

Conditions	Yield
With sodium hydroxide In ethyl acetate at 50℃; for 16h; Reagent/catalyst;	100%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 107-14-2
chloroacetonitrile

: N'-(1-amino-2-chloroethylidene)hydrazine carboxylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: chloroacetonitrile With sodium In methanol at 0 - 20℃; for 0.5h; Stage #2: hydrazinecarboxylic acid methyl ester With acetic acid In methanol at 20℃; for 0.666667h;	99.4%
Stage #1: chloroacetonitrile With sodium methylate In methanol at 0 - 20℃; for 0.75h; Stage #2: hydrazinecarboxylic acid methyl ester With acetic acid In methanol at 20℃; for 0.5h;

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 141-97-9
ethyl acetoacetate

: 356102-30-2
3-methoxycarbonylhydrazonoacetic acid ethyl ester

Conditions

Conditions	Yield
In ethanol at 20℃; for 10.5h;	99%
In ethanol at 20℃; for 10.5h;	99%
In ethanol at 20℃;	98%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 58085-33-9, 60135-02-6, 51388-67-1
α-phenylcinnamoyl chloride

: 1194791-09-7
methyl 2-[(2E)-(2,3-diphenyl)prop-2-enoyl]hydrazinecarboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	99%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 35086-79-4, 95602-71-4
cinnamoyl chloride

: 1194791-02-0
methyl 2-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]hydrazinecarboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	99%

: 50-00-0
formaldehyd

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 99132-70-4
N'-Methylene-hydrazinecarboxylic acid methyl ester

Conditions

Conditions	Yield
With triethylamine In methanol for 2h; Heating;	98%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 622-58-2
p-Tolylisocyanate

: C10H13N3O3

Conditions

Conditions	Yield
In benzene for 0.333333h;	98%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 102252-89-1
3-amino-1-(4-methoxyphenyl)but-2-en-1-one

: 254734-22-0
methyl 4,5-dihydro-5-hydroxy-5-(4-methoxyphenyl)-3-methylpyrazole-1-carboxylate

Conditions

Conditions	Yield
With acetic acid In ethanol at 20℃; for 24h; Cycloaddition;	98%

: 31021-02-0
2-phenylmethylenecyclohexan-1-one

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: N-(methoxycarbonyl)-N'-(2-phenylmethylenecyclohexylidene)-hydrazine

Conditions

Conditions	Yield
In ethanol	98%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 28424-61-5, 73186-06-8, 119924-24-2
(2E)-3-(2-thiophenyl)-2-propenoyl chloride

: 1194790-95-8
methyl 2-[(2E)-3-(2-thienyl)prop-2-enoyl]hydrazinecarboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	98%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 53901-95-4, 108608-06-6, 58523-18-5
p-acetoxycinnamoyl chloride

: 1194790-88-9
methyl 2-[(2E)-3-(4-acetoxyphenyl)prop-2-enoyl]hydrazinecarboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	98%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 7-nitro-1H-benzo[b][1,4]diazepine-2,4(3H,5H)-dithione

: 2-nitro-9H-bis[l,2,4]triazolo[4,3-a: 3',4'-d][I,5]benzodiazepine

Conditions

Conditions	Yield
In butan-1-ol at 130℃; for 48h;	98%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 121557-79-7
Ethyl <<2-(4-t-Butylphenyl)-1-thioxoethyl>thio>acetate

: 114373-67-0
2-[2-[4-(1,1-dimethylethyl)phenyl]-1-thioxoethyl]hydrazinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
In dichloromethane for 2h; Heating;	97%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 108-94-1
cyclohexanone

: 14702-42-2
methoxycarbonylhydrazone of cyclohexanone

Conditions

Conditions	Yield
With acetic acid In methanol for 0.5h; Heating;	97%
	91%
With acetic acid In methanol for 6h; Heating; Yield given;
With acetic acid In methanol at 25 - 65℃; Molecular sieve;

: 1118-66-7
4-amino-3-penten-2-one

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 53921-04-3
methyl 3,5-dimethyl-1H-pyrazole-1-carboxylate

Conditions

Conditions	Yield
With acetic acid In ethanol at 20℃; for 110h; Cyclization; condensation;	97%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 102252-95-9
3-amino-1-(4-nitrophenyl)-2-buten-1-one

: methyl 4,5-dihydro-5-hydroxy-3-methyl-5-(4-nitrophenyl)pyrazole-1-carboxylate

Conditions

Conditions	Yield
With acetic acid In ethanol at 20℃; for 24h; Dehydration; condensation;	97%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 169559-48-2
[perfluoro(sulfanyl)vinyl]-diiron complex

: 436162-67-3
[(Fe(CO)3)2( μ-S(CH3)C(CF3)C β (NHNHC(O)OMe) C α (NHNHC(O)OMe))]

Conditions

Conditions	Yield
In dichloromethane room temp., 2 hs, (Ar); filtration (deoxygenated silica gel), vac. evapn., crystn. (pentane), elem. anal.;	97%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 119924-22-0
(E)-3-(thien-3-yl)acryloyl chloride

: 1194790-97-0
methyl 2-[(2E)-3-(2-thienyl)prop-2-enoyl]hydrazinecarboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	97%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 121557-83-3
Ethyl <<2-(3-Methoxyphenyl)-1-thioxoethyl>thio>acetate

: 114373-92-1
2-[2-(3-methoxyphenyl)-1-thioxoethyl]hydrazinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
In dichloromethane for 2h; Heating;	96%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 114373-99-8
[[1-thioxo-2-[3-(trifluoromethyl)phenyl]ethyl]thio]acetic acid, ethyl ester

: 114373-96-5
2-[1-thioxo-2-[3-(trifluoromethyl)phenyl]ethyl]hydrazinecarboxylic acid, methyl ester

Conditions

Conditions	Yield
In dichloromethane for 2h; Heating;	96%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 93222-85-6
2-<(nitrooxy)methyl>quinoxaline 1,4-dioxide

: 6804-07-5
carbadox

Conditions

Conditions	Yield
In dichloromethane	96%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 67130-27-2
ethyl-2 benzothiazine-3,1 thione-4

: 83389-34-8
(2-Ethyl-4-thioxo-4H-quinazolin-3-yl)-carbamic acid methyl ester

Conditions

Conditions	Yield
In ethanol; benzene for 4h; Heating;	96%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 23652-90-6, 80012-15-3, 1128-85-4
3-amino-1-phenylbut-2-en-1-one

: 254734-23-1
methyl 4,5-dihydro-5-hydroxy-3-methyl-5-phenylpyrazole-1-carboxylate

Conditions

Conditions	Yield
With acetic acid In ethanol at 20℃; for 18h; Cyclization; condensation;	96%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 35086-87-4, 38449-13-7
(E)-2-methyl-3-phenylacryloyl chloride

: 1194791-06-4
methyl 2-[(2E)-(2-methyl-3-phenyl)prop-2-enoyl]hydrazinecarboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	96%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 98-86-2
acetophenone

: methyl (E)-2-(1-phenylethylidene)hydrazine-1-carboxylate

Conditions

Conditions	Yield
With acetic acid In ethanol; water for 0.5h; Reflux;	96%

: 6294-89-9
hydrazinecarboxylic acid methyl ester

: 611-70-1
phenyl isopropyl ketone

: methyl (E)-2-(2-methyl-1-phenylpropylidene)hydrazine-1-carboxylate

Conditions

Conditions	Yield
With acetic acid In ethanol Reflux;	96%

Methyl carbazate Consensus Reports

Methyl carbazate is reported in EPA TSCA Inventory.

Methyl carbazate Specification

The Methyl carbazate, with the CAS registry number 6294-89-9, is also known as Methoxycarbonylhydrazine. It belongs to the product categories of Amines; Isotope Labelled Compounds. Its EINECS number is 228-560-3. This chemical's molecular formula is C₂H₆N₂O₂ and molecular weight is 90.08. What's more, its systematic name is Methyl hydrazinecarboxylate.

Physical properties of Methyl carbazate are: (1)ACD/LogP: -0.719; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.72; (4)ACD/LogD (pH 7.4): -0.72; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 9.64; (8)ACD/KOC (pH 7.4): 9.67; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 64.35 Å²; (13)Index of Refraction: 1.435; (14)Molar Refractivity: 20.22 cm³; (15)Molar Volume: 77.525 cm³; (16)Polarizability: 8.016×10^-24cm³; (17)Surface Tension: 38.8 dyne/cm; (18)Density: 1.162 g/cm³; (19)Flash Point: 86.129 °C; (20)Enthalpy of Vaporization: 46.755 kJ/mol; (21)Boiling Point: 230.906 °C at 760 mmHg; (22)Vapour Pressure: 0.06 mmHg at 25°C.

Uses of Methyl carbazate: it can be used to produce benzylidene-carbazic acid methyl ester by heating. It will need reagent acetic acid and solvent methanol with the reaction time of 30 min. The yield is about 90%.

Methyl carbazate can be used to produce benzylidene-carbazic acid methyl ester by heating

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. It it toxic by inhalation and if swallowed. It has a danger of serious damage to health by prolonged exposure. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing, gloves and eye/face protection. You should not breathe dust. In case of accident or if you feel unwell, you must seek medical advice immediately (show the label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OC)NN
(2)Std. InChI: InChI=1S/C2H6N2O2/c1-6-2(5)4-3/h3H2,1H3,(H,4,5)
(3)Std. InChIKey: WFJRIDQGVSJLLH-UHFFFAOYSA-N

Product Name

Methyl carbazate

Synthetic route

Methyl carbazate Consensus Reports

Methyl carbazate Specification

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