Methyl chloroacetate supplier

Name
Methyl chloroacetate
EINECS 202-501-1
CAS No. 96-34-4
Article Data71
CAS DataBase
Density 1.167 g/cm³
Solubility water: 28 g/L (20 °C)
Melting Point -33 °C
Formula C₃H₅ClO₂
Boiling Point 132.2 °C at 760 mmHg
Molecular Weight 108.525
Flash Point 51.7 °C
Transport Information UN 2295 6.1/PG 1
Appearance clear colourless liquid
Safety 26-37/39-45-36-16
Risk Codes 10-23/25-41-40-36/37/38
Molecular Structure
Hazard Symbols T,Xi,F
Synonyms Aceticacid, chloro-, methyl ester (6CI,8CI,9CI);Chloroacetic acid methyl ester;Methyl 2-chloroacetate;Methyl monochloracetate;Methyl a-chloroacetate;Monochloroacetic acid methyl ester;NSC 2635;
PSA 26.30000
LogP 0.39820

Synthetic route

: 6832-16-2
methyl diazoacetate

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With titanium tetrachloride; acrylic acid methyl ester In dichloromethane at 20℃; for 0.0333333h; Inert atmosphere;	96%
With hydrogenchloride In water

: 67-56-1
methanol

: 79-11-8
chloroacetic acid

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
F-4SK (H form) In dichloromethane at 41℃; for 15h;	94%
With iron(III) sulfate; sulfuric acid for 1h; Heating;	94%
With sulfuric acid for 6h; Fischer–Speier Esterification; Reflux;	89%

: 6832-16-2
methyl diazoacetate

: 292638-85-8
acrylic acid methyl ester

A: 19255-80-2
5-methoxycarbonyl-pyrazoline-3-carboxylic acid methyl ester

B: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With ethylaluminum dichloride In hexane; dichloromethane at 20℃; for 0.0666667h; Inert atmosphere;	A 90% B 5%
With tin(IV) chloride In dichloromethane at 20℃; for 0.0333333h; Inert atmosphere;	A 10% B 85%

...Expand

: 6832-16-2
methyl diazoacetate

: 292638-85-8
acrylic acid methyl ester

A: 19255-80-2
5-methoxycarbonyl-pyrazoline-3-carboxylic acid methyl ester

B: 1262030-04-5
dimethyl 1-(2-methoxy-2-oxoethyl)-4,5-dihydro-1H-pyrazole-3,5-dicarboxylate

C: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With gallium(III) trichloride In dichloromethane at 20℃; for 0.0833333h; Inert atmosphere;	A 15% B 76% C 5%

...Expand

: trans-3,5-bis-(chloromethyl)-3,5-dimethoxy-1,2,4-trioxolane

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With hydrogenchloride In chloroform-d1 for 24h; Ambient temperature;	72%

: 616-42-2
dimethylsulfite

: 79-11-8
chloroacetic acid

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
sulfuric acid In methanol Heating;	51%

: 124-41-4
sodium methylate

: 3,5-Dichloro-3,5-bis-chloromethyl-[1,2,4]trioxolane

A: 96-34-4
methyl chloroacetate

B: cis-3,5-bis-(chloromethyl)-3,5-dimethoxy-1,2,4-trioxolane

: trans-3,5-bis-(chloromethyl)-3,5-dimethoxy-1,2,4-trioxolane

Conditions

Conditions	Yield
With silver tetrafluoroborate; lithium fluoride In methanol; diethyl ether at 0℃; for 0.5h; Yield given;	A n/a B 6% C 10%
With silver tetrafluoroborate; lithium fluoride In methanol; diethyl ether at 0℃; for 0.5h;	A n/a B 6% C 10%
With silver tetrafluoroborate; lithium fluoride In diethyl ether at 0℃; for 30h;	A n/a B 6% C 10%

...Expand

: 67-66-3
chloroform

: 6832-16-2
methyl diazoacetate

A: 20618-07-9
methyl 2,3,3-trichloropropanoate

B: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
UV-Licht.Irradiation;
im UV-Licht;

...Expand

: 67-56-1
methanol

: 42345-82-4
(E)-1,2-dichloro-1-ethoxy-ethene

: 96-34-4
methyl chloroacetate

: 67-56-1
methanol

: 42345-82-4
(E)-1,2-dichloro-1-ethoxy-ethene

A: 96-34-4
methyl chloroacetate

B: 105-39-5
chloroacetic acid ethyl ester

...Expand

: 79-11-8
chloroacetic acid

: 77-78-1
dimethyl sulfate

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
at 200℃;
With tetra(n-butyl)ammonium hydrogensulfate; sodium sulfate In water at 55℃; Methylation; esterification;

: 67-56-1
methanol

: 79-04-9
chloroacetyl chloride

: 96-34-4
methyl chloroacetate

: 109-88-6, 16436-83-2, 16436-85-4
magnesium methanolate

: 79-04-9
chloroacetyl chloride

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With Petroleum ether

: 67-56-1
methanol

: 79-07-2
Chloroacetamide

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With boron trifluoride

: 67-56-1
methanol

: 78-88-6
2,3-Dichloroprop-1-ene

A: 107-31-3
Methyl formate

B: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With ozone 1.) -78 deg C, 2.) room temperature, 15 h; Title compound not separated from byproducts;	A 66 % Spectr. B 80 % Spectr.

...Expand

: 67-56-1
methanol

: 683-51-2
2-chloro-2-propenal

A: 553-90-2
Dimethyl oxalate

B: 96-35-5
glycolic acid methyl ester

C: 89-91-8
Methyl dimethoxyacetate

D: 96-34-4
methyl chloroacetate

E: 298-12-4
Glyoxilic acid

Conditions

Conditions	Yield
With ozone at -78℃; Product distribution; ozonolysis;	A 18 % Spectr. B 14 % Spectr. C 44 % Spectr. D 1 % Spectr. E 18 % Spectr.

...Expand

: 67-56-1
methanol

: 683-70-5
3-chloro-but-3-en-2-one

A: 553-90-2
Dimethyl oxalate

B: 96-35-5
glycolic acid methyl ester

C: 79-20-9
acetic acid methyl ester

D: 10076-48-9
methyl 2,2-dimethoxypropionate

E: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With ozone at -78℃; Product distribution; ozonolysis;

...Expand

: 67-56-1
methanol

: 777-84-4
chloroacetic acid 4-nitrophenyl ester

A: 100-02-7
4-nitro-phenol

B: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
pyridine at 25.1℃; Rate constant; also with other bases (3-methylpyridine, 4-methylpyridine, 2,6-dimethylpyridine, imidazole, 2-methylimidazole); kobs, k1, k2;

...Expand

: 67-56-1
methanol

: 95684-29-0
2-chloro-1-hydroxyethyl 2-chloro-1-methoxyethyl peroxide

A: 97-97-2
chloroacetaldehyde dimethyl acetal

B: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With hydrogenchloride In chloroform-d1 1.) 40 deg C, 16 h, 2.) 60 deg C, 12 h; Yield given. Yields of byproduct given;

...Expand

: 79-43-6
dichloro-acetic acid

: 3,5-Dichloro-3,5-bis-chloromethyl-[1,2,4]trioxolane

A: 116-54-1
dichloroacetic acid methyl ester

B: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
1) CDCl3, 60 deg C, 7 d; 2) 30 min; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 97-97-2
chloroacetaldehyde dimethyl acetal

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With ozone In ethyl acetate at -78℃; Rate constant;

: 67-56-1
methanol

: 30274-77-2
oxoproline TMS

: 79-04-9
chloroacetyl chloride

A: 75-77-4
chloro-trimethyl-silane

B: 98062-50-1
N-chloroacetylpyroglutamic acid

C: 96-34-4
methyl chloroacetate

D: 4931-66-2, 54571-66-3, 64700-65-8
methyl 5-oxopyrrolidine-2-carboxylate

Conditions

Conditions	Yield
Product distribution;

...Expand

: 67-56-1
methanol

: 105-39-5
chloroacetic acid ethyl ester

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
acrylonitrile; triphenylphosphine at 25℃; for 0.5h;	100 % Chromat.
With HZnPS-1, porous sulfonated zinc phosphonate material at 24.84℃; for 24h;	588 mg

: 67-56-1
methanol

: 105-39-5
chloroacetic acid ethyl ester

A: 64-17-5
ethanol

B: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With imobilized subtilisin on an alumina-phosphate In n-heptane at 22℃; Kinetics;
Stage #1: methanol; chloroacetic acid ethyl ester at 59.84℃; for 0.25h; Stage #2: With hybrid supermicroporous iron(III) phosphonate nanoparticle (HFeP-1-3) at 59.84℃; for 6h;

...Expand

: 20667-76-9, 20667-77-0, 21124-13-0
3-methyl-1-p-tolyltriazene

: 79-11-8
chloroacetic acid

A: 106-49-0
p-toluidine

B: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
In acetone at 25℃; Rate constant;

...Expand

: 79-11-8
chloroacetic acid

: 74-88-4
methyl iodide

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With tetraethylammonium tosylate 1.) DMF, room temperature, electrolysis, 2.) DMF; Yield given. Multistep reaction;

: 95684-29-0
2-chloro-1-hydroxyethyl 2-chloro-1-methoxyethyl peroxide

A: 97-97-2
chloroacetaldehyde dimethyl acetal

B: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With hydrogenchloride In methanol; chloroform-d1 1.) 40 deg C, 16 h, 2.) 60 deg C, 12 h; Yield given. Yields of byproduct given;

: 3,5-Dichloro-3,5-bis-chloromethyl-[1,2,4]trioxolane

: 96-34-4
methyl chloroacetate

Conditions

Conditions	Yield
With deuteromethanol; triphenylphosphine; 1,1,2,2-tetrachloroethane In chloroform-d1 at -60℃;	92 % Spectr.

: (+/-)-2-chloroacetoxy-2'-hydroxy-1,1'-binaphthyl

: 18531-94-7
(+)-2,2'-dihydroxy-1,1'-binaphthyl

: 602-09-5, 18531-94-7, 18531-99-2, 41024-90-2
(-)-2,2'-dihydroxy-1,1'-binaphthyl

C: 96-34-4
methyl chloroacetate

: (S)-(-)-2-chloroacetoxy-2'-hydroxy-1,1'-binaphthyl

Conditions

Conditions	Yield
With methanol; lipase from Pseudomonas sp In di-isopropyl ether at 40℃; for 5.2h; Yield given. Title compound not separated from byproducts;
With methanol; lipase from Pseudomonas sp In di-isopropyl ether at 40℃; for 5.2h; Yield given;

...Expand

: 96-34-4
methyl chloroacetate

: 5199-50-8
methyl 2-iodoacetate

Conditions

Conditions	Yield
With sodium iodide In acetone Finkelstein reaction;	100%
With ethanol; potassium iodide
With potassium iodide In acetone
With sodium iodide In acetone at 20℃; for 0.333333h;
With sodium iodide In acetone for 0.333333h;

: 27160-23-2
dimethyl formamidomalonate

: 96-34-4
methyl chloroacetate

: 2-Formylamino-2-methoxycarbonyl-succinic acid dimethyl ester

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; for 0.5h;	100%

: 96-34-4
methyl chloroacetate

: 85666-09-7
E-3-m-hydroxystyrylpyridine

: 79131-35-4
4-[(E)-2-(3-Hydroxy-phenyl)-vinyl]-1-methoxycarbonylmethyl-pyridinium; chloride

Conditions

Conditions	Yield
In methanol for 10h; Heating;	100%

: 96-34-4
methyl chloroacetate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 2-Acetylamino-2-ethoxycarbonyl-succinic acid 1-ethyl ester 4-methyl ester

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In N,N-dimethyl-formamide at 100 - 110℃; for 0.5h;	100%

: 123-08-0
4-hydroxy-benzaldehyde

: 96-34-4
methyl chloroacetate

: 73620-18-5
methyl (4-formylphenoxy)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 5h;	100%
With potassium carbonate; sodium iodide In acetone for 12h; Heating / reflux;	66.1%
With iodine; potassium carbonate; toluene-4-sulfonic acid In water; toluene

: 3659-97-0
1-methylparabanic acid

: 96-34-4
methyl chloroacetate

: 1040062-24-5
N-methyl-N'-carbmethoxymethyl parabanic acid

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 16h; Sonication;	100%

: 96-34-4
methyl chloroacetate

: 105-07-7
4-cyanobenzaldehyde

: 1323412-89-0
(Z)-2-chloro-3-(4-cyanophenyl)acrylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: methyl chloroacetate; 4-cyanobenzaldehyde With titanium tetrachloride In dichloromethane at 20℃; for 0.666667h; Aldol Condensation; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at 20 - 30℃; Aldol Condensation; Inert atmosphere; stereoselective reaction;	100%

: 1448725-57-2
N-((5-chloro-1H-indazol-3-yl)methyl)-1-(4-((2-oxopyridin-1(2H)-yl)methyl)benzyl)-1H-pyrazole-4-carboxamide

: 96-34-4
methyl chloroacetate

: methyl 2-(5-chloro-3-((1-(4-((2-oxopyridin-1(2H)-yl)methyl)benzyl)-1H-pyrazole-4-carboxamido)methyl)-1H-indazol-1-yl)acetate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 50℃;	100%

: 4-[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 96-34-4
methyl chloroacetate

: methyl {4-[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-3,3,3-trifluoropropyl]-3-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 20℃; for 4h; Reflux;	100%

: 1539-42-0
bis[(2-pyridyl)methyl]amine

: 96-34-4
methyl chloroacetate

: N,N-bis(2-pyridylmethyl)glycine methyl ester

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile at 50℃; for 3h;	100%

: 60964-09-2
2,6-dichloro-4-hydroxybenzaldehyde

: 96-34-4
methyl chloroacetate

: 616195-97-2
methyl 2-(3,5-dichloro-4-formylphenoxy)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 2h;	99.9%

: 96-34-4
methyl chloroacetate

: 18156-74-6
1-(Trimethylsilyl)imidazole

: 1,3-bis(2-methoxy-2-oxoethyl)-1H-imidazole-3-ium chloride

Conditions

Conditions	Yield
at 60℃; for 24h;	99%
at 60℃; for 24h;	99.7%
at 60℃; for 24h;	99.7%
In neat liquid at 60℃; for 24h;	99.7%
at 60℃; for 24h; Inert atmosphere;	97%

: 96-34-4
methyl chloroacetate

: 1-(3,4-dichloro-phenyl)-propylamine; hydrochloride

: 847448-34-4
[1-(3,4-dichloro-phenyl)-propylamino]-acetic acid methyl ester

Conditions

Conditions	Yield
With triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 64h;	99.7%
With triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 44h;	99.7%
With triethylamine In N,N-dimethyl-formamide at 20℃; for 64h;	99.7%

: 96-34-4
methyl chloroacetate

: 120-83-2
2,4-dichlorophenol

: 1928-38-7
methyl 2,4-dichlorophenoxyacetate

Conditions

Conditions	Yield
With potassium fluoride; potassium iodide at 120℃; for 24h; Reagent/catalyst; Time;	99.2%
Stage #1: 2,4-dichlorophenol With potassium carbonate In water; chlorobenzene at 125℃; for 2h; Stage #2: methyl chloroacetate In water; chlorobenzene at 120 - 146℃; for 4h; Reagent/catalyst; Temperature; Concentration; Solvent;	98.5%
Stage #1: 2,4-dichlorophenol With potassium carbonate In water; chlorobenzene at 125℃; for 2h; Stage #2: methyl chloroacetate In water; chlorobenzene at 120℃; for 4h; Solvent; Concentration; Reagent/catalyst; Temperature;	98.5%

: 96-34-4
methyl chloroacetate

: 1816-92-8
Methyl azidoacetate

Conditions

Conditions	Yield
With sodium azide In N,N-dimethyl-formamide at 60℃; for 24h;	99%
With sodium azide In acetonitrile for 20h; Heating;	93%
With sodium azide In N,N-dimethyl-formamide at 20℃; for 4h;	88%

: 616-47-7
1-methyl-1H-imidazole

: 96-34-4
methyl chloroacetate

: methyl 2-(3-methyl-1H-imidazolium-1-yl)acetate chloride

Conditions

Conditions	Yield
at 20℃; for 1h;	99%
for 1h; Sonication;	97%
at 20℃; for 1.5h;

: 96-34-4
methyl chloroacetate

: 1122-91-4
4-bromo-benzaldehyde

: 1376214-50-4
(Z)-3-(4-bromophenyl)-2-chloroacrylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: methyl chloroacetate; 4-bromo-benzaldehyde With titanium tetrachloride In dichloromethane at 20℃; for 0.666667h; Aldol Condensation; Inert atmosphere; Stage #2: With triethylamine In dichloromethane at 20 - 30℃; Aldol Condensation; Inert atmosphere; stereoselective reaction;	99%

: 22948-02-3
3-aminothiophenol

: 96-34-4
methyl chloroacetate

: methyl 2-((3-aminophenyl)thio)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 3.5h; Inert atmosphere;	99%

: 3',5-diallyl-4'-((1-benzyl-1H-1,2,3-triazol-4-yl)methoxy)-[1,1'-biphenyl]-2-ol

: 96-34-4
methyl chloroacetate

: C31H31N3O4

Conditions

Conditions	Yield
With caesium carbonate; triethylamine; potassium iodide In acetone at 20℃; for 24h; Microwave irradiation;	99%

: 19402-71-2
potassium 1-naphtholate

: 96-34-4
methyl chloroacetate

: 118688-52-1
(naphthalen-1-yloxy)acetic acid methyl ester

Conditions

Conditions	Yield
at 120℃; for 2h; Time;	98.9%

: 96-34-4
methyl chloroacetate

: 102-28-3
m-acetamide aniline

: m-acetylamino-N,N-di(methylacetate)aniline

Conditions

Conditions	Yield
Stage #1: methyl chloroacetate; m-acetamide aniline With sodium carbonate at 90 - 100℃; for 2h; Stage #2: With sodium bromide; zinc at 105 - 110℃; for 2h; Catalytic behavior; Time;	98.6%

: 96-34-4
methyl chloroacetate

: 16091-26-2
N-Benzoyl-m-phenylendiamin

: m-benzoylamino-N,N-di(methylacetate)aniline

Conditions

Conditions	Yield
Stage #1: methyl chloroacetate; N-Benzoyl-m-phenylendiamin With sodium carbonate at 100 - 105℃; for 2h; Stage #2: With sodium bromide; zinc at 110 - 130℃; for 3h;	98.4%

: 96-34-4
methyl chloroacetate

: 108-95-2
phenol

: 2065-23-8
methyl 2-phenoxyacetate

Conditions

Conditions	Yield
Stage #1: phenol With potassium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene; 2-methyl-propan-1-ol; water at 138℃; for 1h; Stage #2: methyl chloroacetate In 5,5-dimethyl-1,3-cyclohexadiene; 2-methyl-propan-1-ol; water at 120 - 135℃; for 6h; Solvent; Temperature; Reagent/catalyst;	98.15%
With potassium carbonate at 150℃; for 10h; Temperature; Reagent/catalyst;	97.6%
Stage #1: phenol With sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene; water; butan-1-ol at 140℃; for 1h; Stage #2: methyl chloroacetate at 146℃; for 6h; Solvent; Reagent/catalyst; Temperature;	97.5%

: 140-89-6
potassium ethyl xanthogenate

: 96-34-4
methyl chloroacetate

: 123972-89-4
ethoxyrhiocarbonylsulfanylacetic acid methyl ester

Conditions

Conditions	Yield
In acetonitrile at 0 - 20℃; for 2h;	98%
In acetone at 0 - 20℃;	83%
With ethanol

: 128-44-9
saccharin sodium salt

: 96-34-4
methyl chloroacetate

: 6639-62-9
methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide

Conditions

Conditions	Yield
In DMF (N,N-dimethyl-formamide) at 115 - 120℃; for 1.5 - 2h; Industry scale;	98%
In N,N-dimethyl-formamide for 0.05h; Microwave irradiation;	96.2%
In N,N-dimethyl-formamide at 110 - 120℃; for 3h;	96%

: 555-16-8
4-nitrobenzaldehdye

: 96-34-4
methyl chloroacetate

: 19202-48-3, 108492-48-4, 117083-58-6, 139618-61-4, 143004-35-7
Methyl trans-3-(4-nitrophenyl)oxirane-2-carboxylate

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; Darzens Condensation;	98%
With potassium tert-butylate In diethyl ether for 20h;	69%
With sodium methylate In methanol 1.) 0 deg C, 2 h, 2.) room temperature, 3 h;	65%

: 14752-66-0
sodium p-chlorobenzenesulphinate

: 96-34-4
methyl chloroacetate

: 15446-25-0
methyl 4-chlorophenylsulphinylacetate

Conditions

Conditions	Yield
	98%
In N,N-dimethyl-formamide at 120℃; for 3h;	98%
In N,N-dimethyl-formamide at 45 - 115℃; for 3h;	98%

: 2929-96-6
2,2'-thiobis<4-methylphenol>

: 96-34-4
methyl chloroacetate

: 882304-68-9
2,2'-sulfinyl bis[methy(4-methylphenoxyacetate)]

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetone for 24h; Reflux;	98%
With potassium carbonate; potassium iodide In acetone for 24h; Reflux;	98%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide; acetonitrile at 20℃; for 24h;	95%
With potassium carbonate; potassium iodide In acetone Heating;

: 81-83-4
1,8-Naphthalimide

: 96-34-4
methyl chloroacetate

: 135980-44-8
methyl (1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)acetate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 70℃; for 1h;	98%

: 96-34-4
methyl chloroacetate

: 122-52-1
triethyl phosphite

: 1067-74-9
Methyl diethylphosphonoacetate

Conditions

Conditions	Yield
at 135℃; for 10h;	98%

Methyl chloroacetate Chemical Properties

IUPAC Name: Methyl 2-chloroacetate
Synonyms of Methyl chloroacetate (CAS NO.96-34-4): AI3-39185 ; Acetic acid, chloro-, methyl ester ; CCRIS 7749 ; Chloroacetic acid methyl ester ; EINECS 202-501-1 ; HSDB 5303 ; Methyl alpha-chloroacetate ; Methyl chloroethanoate ; Methyl monochloracetate ; Methyl monochloroacetate ; Methylester kyseliny chloroctove ; Methylester kyseliny chloroctove [Czech] ; Monochloroacetic acid methyl ester ; NSC 2635 ; Acetic acid, 2-chloro-, methyl ester ; Methyl chloroacetate [UN2295] [Poison] ; UN2295
CAS NO: 96-34-4
Molecular Formula of Methyl chloroacetate (CAS NO.96-34-4): C₃H₅ClO₂
Molecular Weight: 108.5236
Molecular Structure:

Melting Point: -33 °C
ProductCategories: Organics ; Alpha sort ; H-MAlphabetic ; M ; META - METH ; Pesticides&Metabolites ;C2 to C5 ; Carbonyl Compounds ; Esters ; 500 Series Drinking Water Methods ; EPA ; Method 552
Polar Surface Area: 26.3 Å²
Index of Refraction: 1.4
Molar Refractivity: 22.57 cm³
Molar Volume: 92.9 cm³
Surface Tension: 28.4 dyne/cm
Density of Methyl chloroacetate (CAS NO.96-34-4): 1.167 g/cm³
Flash Point: 51.7 °C
Enthalpy of Vaporization: 39.23 kJ/mol
Boiling Point: 132.2 °C at 760 mmHg
Vapour Pressure: 8.97 mmHg at 25°C

Methyl chloroacetate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	oral	240mg/kg (240mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
mouse	LC50	inhalation	1gm/m3/2H (1000mg/m3)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 82, 1982.
mouse	LD50	oral	240mg/kg (240mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 82, 1982.
rat	LCLo	inhalation	250ppm/7H (250ppm)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Toxicology and Applied Pharmacology. Vol. 19, Pg. 1, 1971.
rat	LD16	subcutaneous	560mg/kg (560mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 82, 1982.

Methyl chloroacetate Consensus Reports

Methyl chloroacetate (CAS NO.96-34-4) Market Research Report 2009

Methyl chloroacetate Safety Profile

Hazard Codes: Toxic T, Irritant Xi,F
Risk Statements: 10-23/25-41-40-36/37/38
R10: Flammable.
R23/25: Toxic by inhalation and if swallowed.
R41: Risk of serious damage to the eyes.
R40: Limited evidence of a carcinogenic effect.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39-45-36-16
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39: Wear suitable gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36: Wear suitable protective clothing.
S16: Keep away from sources of ignition.
RIDADR: UN 2295 6.1/PG 1
WGK Germany: 2
RTECS: AF9500000
F: 19
HazardClass: 6.1
PackingGroup: I
Hazardous Substances Data: 96-34-4(Hazardous Substances Data)

Product Name

Methyl chloroacetate

Synthetic route

Methyl chloroacetate Chemical Properties

Methyl chloroacetate Toxicity Data With Reference

Methyl chloroacetate Consensus Reports

Methyl chloroacetate Safety Profile

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