Methyl fluoroacetate supplier

Name
Methyl fluoroacetate
EINECS 207-218-7
CAS No. 453-18-9
Article Data16
CAS DataBase
Density 1.17 g/cm³
Solubility
Melting Point -40 °C
Formula C₃H₅FO₂
Boiling Point 104.5 °C at 760 mmHg
Molecular Weight 92.0699
Flash Point 17.6 °C
Transport Information UN 3272
Appearance Colorless, transparent liquid
Safety 16-26-36
Risk Codes 10-36/37/38
Molecular Structure
Hazard Symbols T
Synonyms 4-02-00-00447 (Beilstein Handbook Reference);Fluoroacetic acid, methyl ester;methyl 2-fluoroacetate;Methylester kyseliny fluoroctove [Czech];TL 551;Fluoroacetic acid methyl ester;Methyl fluoro-acetate;
PSA 26.30000
LogP 0.12890

Synthetic route

: 557-31-3
3-ethoxyprop-1-ene

: 181224-33-9
Methyl fluoroiodoacetate

A: 453-18-9
methyl fluoroacetate

B: 5-Ethoxy-2-fluoro-4-iodo-pentanoic acid methyl ester

Conditions

Conditions	Yield
With iron In tetrahydrofuran for 12h; Heating;	A 9 % Spectr. B 82%

...Expand

: 181224-33-9
Methyl fluoroiodoacetate

A: 453-18-9
methyl fluoroacetate

B: Propionic acid 1-fluoro-2-(4-iodomethyl-tetrahydro-furan-3-yl)-ethyl ester

Conditions

Conditions	Yield
With Allyl ether; iron In tetrahydrofuran for 13h; Heating;	A 11 % Spectr. B 81%

: 96-34-4
methyl chloroacetate

: 453-18-9
methyl fluoroacetate

Conditions

Conditions	Yield
With potassium fluoride; tetrabutylammomium bromide for 1.25h; Heating;	79%
With acetamide; potassium fluoride at 100 - 110℃; for 3h; Substitution;	30%
With acetamide; potassium fluoride at 100 - 110℃; for 3h; Substitution;	30%

: 107-13-1
acrylonitrile

: 181224-33-9
Methyl fluoroiodoacetate

A: 453-18-9
methyl fluoroacetate

B: 4-Cyano-2-fluoro-butyric acid methyl ester

Conditions

Conditions	Yield
With [2,2]bipyridinyl; chromium chloride; iron In methanol at 70 - 80℃; for 10h;	A 14 % Spectr. B 74%

...Expand

: 292638-85-8
acrylic acid methyl ester

: 181224-33-9
Methyl fluoroiodoacetate

A: 453-18-9
methyl fluoroacetate

B: 7766-74-7
Dimethyl 2-fluoropentanedioate

Conditions

Conditions	Yield
With [2,2]bipyridinyl; chromium chloride; iron In methanol at 70 - 80℃; for 11h;	A 17 % Spectr. B 71%

...Expand

: 67-56-1
methanol

: 640-19-7
fluoroacetamide

: 453-18-9
methyl fluoroacetate

Conditions

Conditions	Yield
With boron trifluoride

: 5199-50-8
methyl 2-iodoacetate

: 453-18-9
methyl fluoroacetate

Conditions

Conditions	Yield
With silver fluoride at 170℃;
With mercury(II) fluoride at 170℃;

: 96-32-2
bromoacetic acid methyl ester

: 453-18-9
methyl fluoroacetate

Conditions

Conditions	Yield
With thallium(I) fluoride; ethanol
With potassium fluoride; acetylacetone Irradiation.UV-Licht;

: 67-56-1
methanol

: 116-15-4
perfluoropropylene

: 453-18-9
methyl fluoroacetate

Conditions

Conditions	Yield
With carbon dioxide; sodium In acetone

: 67-56-1
methanol

: 359-06-8
monofluoroacetyl chloride

: 453-18-9
methyl fluoroacetate

: 64-17-5
ethanol

: 96-32-2
bromoacetic acid methyl ester

Tlf: Tlf

: 453-18-9
methyl fluoroacetate

...Expand

: 77-78-1
dimethyl sulfate

sodium-fluoroacetate: sodium-fluoroacetate

: 453-18-9
methyl fluoroacetate

: 453-18-9
methyl fluoroacetate

: allyl S-(5-amido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonicacid)-(2→6)-2-acetamido-2-deoxy-6-thio-α-Dgalactopyranoside

: allyl S-(5-fluoroacetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-2-acetamido-2-deoxy-6-thio-α-D-galactopyranoside

Conditions

Conditions	Yield
With triethylamine In methanol Inert atmosphere; Reflux;	100%

: 453-18-9
methyl fluoroacetate

: 62-74-8
sodium fluoroacetate

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran for 2h; Reflux;	94%

: 196929-85-8
(R)-N-benzylidene-2-methylpropane-2-sulfinamide

: 453-18-9
methyl fluoroacetate

: (RS,2R,3S)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)-3-phenylpropionic acid methyl ester

Conditions

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran at -80℃; for 0.5h; Inert atmosphere;	88%
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	85%

: 5418-86-0
tris(methylthio)methane

: 453-18-9
methyl fluoroacetate

: 3-Fluoro-1,1,1-tris-methylsulfanyl-propan-2-one

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane 1.) -95 deg C, 2 h, 2.) -95 deg C, 5 min;	87%

: 453-18-9
methyl fluoroacetate

: allyl 4-O-(5-amino-3,5-dideoxy-α-D-neuraminopyranosyl)-2-acetylamino-2-deoxy-α-D-galactopyranoside

: 1263480-77-8
C22H35FN2O14

Conditions

Conditions	Yield
With triethylamine In methanol at 20℃; Inert atmosphere; Cooling with ice;	85%
With triethylamine In methanol at 20℃; Inert atmosphere; Cooling with ice;

: 453-18-9
methyl fluoroacetate

: 507469-89-8
(R)-(-)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide

A: C14H19ClFNO3S

B: (RS,2R,3S)-3-(4-chlorophenyl)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)propionic acid methyl ester

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A n/a B 83%
With potassium tert-butylate In tetrahydrofuran at 30℃; for 0.5h; Inert atmosphere; Overall yield = 83 %;	A n/a B n/a

...Expand

: 31469-15-5
1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

: 7677-24-9
trimethylsilyl cyanide

: 453-18-9
methyl fluoroacetate

: methyl 3-cyano-4-fluoro-2,2-dimethyl-3-trimethylsilyloxybutanoate

Conditions

Conditions	Yield
With gallium(III) iodide In dichloromethane at 20℃; for 5h;	82%

...Expand

: 453-18-9
methyl fluoroacetate

: 1547490-94-7
C17H17Cl2NOS

A: (RS,2R)-3,3-bis(4-chlorophenyl)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)propionic acid methyl ester

B: C20H22Cl2FNO3S

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A 82% B n/a

...Expand

: 453-18-9
methyl fluoroacetate

: (S)-5-(aminomethyl)-3-(3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)oxazolidin-2-one

: (S)-2-fluoro-N-((3-(3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Conditions

Conditions	Yield
In 2,2,2-trifluoroethanol at 80℃; for 15h;	81%

: 453-18-9
methyl fluoroacetate

: 1015198-46-5
C12H17NOS

A: C15H22FNO3S

B: (RS,2R,3S)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)-3-p-tolylpropionic acid methyl ester

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A n/a B 80%
With sodium hexamethyldisilazane In tetrahydrofuran; dichloromethane at -20℃; for 0.5h; Inert atmosphere; Overall yield = 80 %; Overall yield = 252 mg;	A n/a B n/a

...Expand

: 50-00-0
formaldehyd

: 453-18-9
methyl fluoroacetate

: 2343-89-7
methyl 2-fluoroprop-2-enoate

Conditions

Conditions	Yield
Stage #1: methyl fluoroacetate With Dimethyl oxalate; sodium methylate In dimethyl sulfoxide at 15 - 25℃; for 1h; Inert atmosphere; Stage #2: formaldehyd With 2,6-di-tert-butyl-4-methyl-phenol In dimethyl sulfoxide at 20 - 35℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere;	79.3%
Stage #1: methyl fluoroacetate With Dimethyl oxalate; sodium methylate In methanol; pentane at 20 - 25℃; for 24.25h; Claisen Condensation; Stage #2: formaldehyd In pentane at 5 - 10℃; for 5h; Concentration; Reagent/catalyst; Temperature; Time;	58%

: 453-18-9
methyl fluoroacetate

: (R)-2-methyl-N-(3-(trifluoromethyl)benzylidene)propane-2-sulfinamide

A: (RS,2R,3S)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)-3-(3-trifluoromethylphenyl)propionic acid methyl ester

B: C15H19F4NO3S

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A 77% B n/a

...Expand

: 453-18-9
methyl fluoroacetate

: 1208989-34-7
2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide

A: C15H22FNO3S

B: (RS,2R,3S)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)-3-o-tolylpropionic acid methyl ester

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A n/a B 76%
With potassium hexamethylsilazane In tetrahydrofuran; N,N-dimethyl-formamide at -40℃; for 0.5h; Inert atmosphere; Overall yield = 88 %; Overall yield = 277 mg;	A n/a B n/a

...Expand

: 453-18-9
methyl fluoroacetate

: (R)-N-(4-bromobenzylidene)-2-methylpropane-2-sulfinamide

A: (RS,2R,3S)-3-(4-bromophenyl)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)propionic acid tert-butyl ester

B: C14H19BrFNO3S

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A 76% B n/a

...Expand

: 453-18-9
methyl fluoroacetate

: C24H41NO18

: C26H42FNO19

Conditions

Conditions	Yield
With triethylamine In methanol at 0 - 50℃; Inert atmosphere;	75%

: 453-18-9
methyl fluoroacetate

: C12H17NOS

A: C15H22FNO3S

B: (RS,2R,3S)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)-3-m-tolylpropionic acid methyl ester

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A n/a B 74%
With sodium t-butanolate In tetrahydrofuran at 10℃; for 0.5h; Inert atmosphere; Overall yield = 74 %; Overall yield = 233 mg;	A n/a B n/a

...Expand

: 453-18-9
methyl fluoroacetate

: 935263-24-4
(R)-(-)-N-(4-cyanobenzylidene)-2-methylpropane-2-sulfinamide

A: (RS,2R,3S)-3-(4-cyanophenyl)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)propionic acid methyl ester

B: C15H19FN2O3S

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A 71% B n/a

...Expand

: 891782-22-2
N-tert-butylsulfinyl ketoimine

: 453-18-9
methyl fluoroacetate

A: C20H24FNO3S

B: C20H24FNO3S

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A 71% B n/a

...Expand

: 453-18-9
methyl fluoroacetate

: 507469-91-2
(RS)-N-[(2-naphthyl)methylidene]-2-methyl-2-propanesulfinamide

: (RS,2R,3S)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)-3-naphthalen-2-ylpropionic acid methyl ester

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	70%
With potassium hexamethylsilazane In tetrahydrofuran; N,N-dimethyl-formamide at -40℃; for 0.5h; Inert atmosphere;	n/a

: 453-18-9
methyl fluoroacetate

: 1015198-59-0
N-t-butylsulfinyl-2-pyridinyl carboxaenamine

A: (RS,2R,3S)-2-fluoro-3-(2-methylpropane-2-sulfinylamino)-3-pyridin-2-ylpropionic acid methyl ester

B: C13H19FN2O3S

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 0.5h; Inert atmosphere; diastereoselective reaction;	A 70% B n/a

...Expand

: 496-15-1
1-indoline

: 453-18-9
methyl fluoroacetate

: 2-fluoro-1-(indolin-1-yl)ethanone

Conditions

Conditions	Yield
at 80℃; for 12h;	70%

: 553-90-2
Dimethyl oxalate

: 453-18-9
methyl fluoroacetate

: 52328-05-9
O-methylisourea hemisulfate

: C7H7FN2O4

Conditions

Conditions	Yield
Stage #1: Dimethyl oxalate; methyl fluoroacetate With sodium methylate In toluene at 25℃; for 2h; Stage #2: O-methylisourea hemisulfate With sodium methylate In toluene at 35℃; for 8h;	70%

...Expand

: 453-18-9
methyl fluoroacetate

: allyl 6-O-(5-amino-3,5-dideoxy-α-D-neuraminopyranosyl)-2-amino-2-deoxy-α-D-galactopyranoside

: 1263481-00-0
C22H34F2N2O14

Conditions

Conditions	Yield
With triethylamine In methanol at 20℃; Inert atmosphere; Cooling with ice;	67%

: 453-18-9
methyl fluoroacetate

: trans-4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)ethyl]cyclohexylamine hydrochloride

: trans-N-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperidin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide

Conditions

Conditions	Yield
Stage #1: methyl fluoroacetate With potassium trimethylsilonate In 1,4-dioxane at 20℃; Stage #2: trans-4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)ethyl]cyclohexylamine hydrochloride With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 4h;	66.7%

: 453-18-9
methyl fluoroacetate

: trans-4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride

: 1395922-18-5
N-trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-2-fluoro-acetamide

Conditions

Conditions	Yield
Stage #1: methyl fluoroacetate With potassium trimethylsilonate In 1,4-dioxane at 20℃; Stage #2: trans-4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 20℃; for 4h;	66.7%

Methyl fluoroacetate Specification

The Methyl fluoroacetate, with the CAS registry number 453-18-9, is also known as Acetic acid, fluoro-, methyl ester. It belongs to the product category of Fluoro-Aliphatics. Its EINECS registry number is 207-218-7. This chemical's molecular formula is C₃H₅FO₂ and molecular weight is 92.07. Its IUPAC name is called methyl 2-fluoroacetate. This chemical's classification codes are Agricultural Chemical; Human Data; Rodenticide.

Physical properties of Methyl fluoroacetate: (1)ACD/LogP: -0.16; (2)ACD/LogD (pH 5.5): -0.16; (3)ACD/LogD (pH 7.4): -0.16; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 19.4; (7)ACD/KOC (pH 7.4): 19.4; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.332; (11)Molar Refractivity: 17.88 cm³; (12)Molar Volume: 86.9 cm³; (13)Surface Tension: 20.7 dyne/cm; (14)Density: 1.058 g/cm³; (15)Flash Point: 17.6 °C; (16)Enthalpy of Vaporization: 34.35 kJ/mol; (17)Boiling Point: 104.5 °C at 760 mmHg; (18)Vapour Pressure: 30.8 mmHg at 25°C.

Preparation of Methyl fluoroacetate: can be produced by the reaction of methyl chloroacetate and potassium fluoride.

ClCH₂COOCH₃+KF→FCH₂COOCH₃+KCl

Uses: Methyl fluoroacetate can be used as a medicine, pesticide and dye intermediate.It also can be used as the basic raw materials for fluorine, fluoride cyproterone piperidine acid, 5-fluorouracil, fluoro glycosides, furans fluoro-piperidine and double lamivudine 5-fluoro-4-hydroxy-pyrimidine drugs, but also as pesticides and perfume intermediate body.

When you are using this chemical, please be cautious about it as the following:
This chemical is toxic. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: COC(=O)CF
(2)InChI: InChI=1S/C3H5FO2/c1-6-3(5)2-4/h2H2,1H3
(3)InChIKey: RJBYSQHLLIHSLT-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LC50	inhalation	25mg/m³/10M (25mg/m³)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. PB158-508,
cat	LD50	intravenous	200ug/kg (0.2mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	National Technical Information Service. Vol. PB158-508,
cat	LD50	oral	300ug/kg (0.3mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
cat	LD50	subcutaneous	300ug/kg (0.3mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
chicken	LDLo	intravenous	15mg/kg (15mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
dog	LC50	inhalation	25mg/m³/10M (25mg/m³)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
dog	LD50	intravenous	60ug/kg (0.06mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
dog	LD50	oral	100ug/kg (0.1mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. PB158-508,
dog	LD50	subcutaneous	100ug/kg (0.1mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	National Technical Information Service. Vol. PB158-508,
domestic animals - goat/sheep	LC50	inhalation	200mg/m³/10M (200mg/m³)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
domestic animals - goat/sheep	LD50	intramuscular	600ug/kg (0.6mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
domestic animals - goat/sheep	LD50	intravenous	600ug/kg (0.6mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
domestic animals - goat/sheep	LD50	oral	1mg/kg (1mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	National Technical Information Service. Vol. PB158-508,
domestic animals - goat/sheep	LD50	subcutaneous	1mg/kg (1mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
frog	LD50	subcutaneous	100ug/kg (0.1mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. PB158-508,
frog	LD50	unreported	300mg/kg (300mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
guinea pig	LC50	inhalation	100mg/m³/10M (100mg/m³)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of the Chemical Society. Vol. -, Pg. 1773, 1948.
guinea pig	LD50	intraperitoneal	350ug/kg (0.35mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
guinea pig	LD50	oral	500ug/kg (0.5mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	National Technical Information Service. Vol. PB158-508,
guinea pig	LD50	subcutaneous	200ug/kg (0.2mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
hamster	LD50	intraperitoneal	2500ug/kg (2.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
horse/donkey	LD50	intramuscular	500ug/kg (0.5mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
man	TDLo	oral	650ug/kg (0.65mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	National Technical Information Service. Vol. PB158-508,
monkey	LC50	inhalation	800mg/m³/10M (800mg/m³)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. PB158-508,
monkey	LD50	intravenous	4mg/kg (4mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
monkey	LD50	oral	10mg/kg (10mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. PB158-508,
monkey	LD50	subcutaneous	10mg/kg (10mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	National Technical Information Service. Vol. PB158-508,
monkey	LD50	unreported	> 50mg/kg (50mg/kg)		Pharmacological Reviews. Vol. 1, Pg. 383, 1949.
mouse	LC50	inhalation	3200mg/m³/10M (3200mg/m³)		Nature. Vol. 160, Pg. 179, 1947.
mouse	LD50	intraperitoneal	7500ug/kg (7.5mg/kg)		Journal of Organic Chemistry. Vol. 21, Pg. 883, 1956.
mouse	LD50	intravenous	17mg/kg (17mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
mouse	LD50	oral	5mg/kg (5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. PB158-508,
mouse	LD50	parenteral	6mg/kg (6mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of the Chemical Society. Vol. -, Pg. 1279, 1949.
mouse	LD50	subcutaneous	5mg/kg (5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	National Technical Information Service. Vol. PB158-508,
pig	LD50	intraperitoneal	400ug/kg (0.4mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
rabbit	LC50	inhalation	25mg/m³/10M (25mg/m³)		Nature. Vol. 160, Pg. 179, 1947.
rabbit	LD50	intravenous	200ug/kg (0.2mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
rabbit	LD50	oral	500ug/kg (0.5mg/kg)	BEHAVIORAL: COMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	National Technical Information Service. Vol. PB158-508,
rabbit	LD50	skin	20mg/kg (20mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of the Chemical Society. Vol. -, Pg. 1773, 1948.
rabbit	LD50	subcutaneous	300ug/kg (0.3mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	National Technical Information Service. Vol. PB158-508,
rat	LC50	inhalation	300mg/m³/10M (300mg/m³)		Nature. Vol. 160, Pg. 179, 1947.
rat	LD50	intramuscular	2500ug/kg (2.5mg/kg)		Nature. Vol. 160, Pg. 179, 1947.
rat	LD50	oral	3500ug/kg (3.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	National Technical Information Service. Vol. PB158-508,
rat	LD50	subcutaneous	5mg/kg (5mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.

Product Name

Methyl fluoroacetate

Synthetic route

Methyl fluoroacetate Specification

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