Methyl propyl ether supplier

Name
1 -Methoxypropane
EINECS 209-158-7
CAS No. 557-17-5
Article Data39
CAS DataBase
Density 0.734 g/cm³
Solubility
Melting Point
Formula C4H10 O
Boiling Point 40.1 °C at 760 mmHg
Molecular Weight 74.1228
Flash Point °C
Transport Information
Appearance
Safety 16-33
Risk Codes 11
Molecular Structure
Hazard Symbols
Synonyms Ether,methyl propyl (6CI,7CI,8CI); 1-Methoxypropane; Methyl n-propyl ether; Methylpropyl ether; Metopryl; Neothyl; Propyl methyl ether; a-Methoxypropane
PSA 9.23000
LogP 1.04280

Synthetic route

: 186581-53-3, 908094-01-9
diazomethane

: 628-32-0
ethylpropylether

A: 115-10-6
Dimethyl ether

B: 540-67-0
ethyl methyl ether

C: 557-17-5
methyl propyl ether

D: 625-54-7
2-butyl ethyl ether

Conditions

Conditions	Yield
Product distribution; Mechanism; Ambient temperature; Irradiation;	A n/a B 2.4% C 4.4% D 93.2%

...Expand

: 628-32-0
ethylpropylether

: 14621-84-2
diazomethane-d2

A: 115-10-6
Dimethyl ether

B: 540-67-0
ethyl methyl ether

C: 557-17-5
methyl propyl ether

D: 625-54-7
2-butyl ethyl ether

Conditions

Conditions	Yield
Product distribution; Mechanism; Ambient temperature; Irradiation; deuterium distribution;	A n/a B 3.3% C 4.2% D 92.5%

...Expand

: 627-41-8
propargyl alcohol methyl ether

A: 557-17-5
methyl propyl ether

B: 627-40-7
methylallylether

Conditions

Conditions	Yield
With hydrogen; palladium dichloride In N,N-dimethyl-formamide under 18751.5 Torr; for 0.666667h; Product distribution; Ambient temperature; various time;	A 2% B 68.4%
Stage #1: propargyl alcohol methyl ether With pyridine In toluene for 0.166667h; Glovebox; Stage #2: With hydrogen In toluene at 120℃; under 37503.8 Torr; for 12h; Glovebox;

: 540-67-0
ethyl methyl ether

: 14621-84-2
diazomethane-d2

A: 60-29-7
diethyl ether

B: 598-53-8
isopropyl methyl ether

C: 74-85-1
ethene

D: 115-10-6
Dimethyl ether

E: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
Product distribution; Mechanism; Ambient temperature; Irradiation; deuterium distribution;	A 29.7% B 17.9% C n/a D 37.2% E 15.2%

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 540-67-0
ethyl methyl ether

A: 60-29-7
diethyl ether

B: 598-53-8
isopropyl methyl ether

C: 74-85-1
ethene

D: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
Product distribution; Mechanism; Ambient temperature; Irradiation;	A 34% B 33.2% C n/a D 32.8%

...Expand

: Methylethyl((trimethylsilyl)methyl)oxonium Tetrafluoroborate

A: 60-29-7
diethyl ether

B: 74-85-1
ethene

C: 115-10-6
Dimethyl ether

D: 557-17-5
methyl propyl ether

E: 420-56-4
trimethylsilyl fluoride

F usual alkylation products: usual alkylation products

Conditions

Conditions	Yield
With cesium fluoride Product distribution; Mechanism;	A 1.2% B 3.9% C 2.9% D 0.02% E n/a F n/a

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 71-23-8
propan-1-ol

: 557-17-5
methyl propyl ether

: 67-56-1
methanol

: 71-23-8
propan-1-ol

: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
With naphthalene-2-sulfonate at 122 - 126℃;
With benzenesulfonic acid at 122 - 126℃;
With naphthalene-2-sulfonate at 122 - 126℃;
With benzenesulfonic acid at 122 - 126℃;

: 115-10-6
Dimethyl ether

: 111-43-3
Dipropyl ether

: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
With aluminum oxide; silica gel; zirconium(IV) oxide at 230℃; under 44130.5 Torr;

: 6819-41-6
sodium n-propoxide

: 74-88-4
methyl iodide

: 557-17-5
methyl propyl ether

: 67-56-1
methanol

: 34557-54-5
methane

: 14604-48-9
vinyl cation

A: 187737-37-7
propene

B: 463-49-0
1,2-propanediene

C: 557-17-5
methyl propyl ether

D: 627-40-7
methylallylether

Conditions

Conditions	Yield
at 100℃; under 60 - 720 Torr; Product distribution; Kinetics; Thermodynamic data; labelled with tritium; -ΔH;

...Expand

: 67-56-1
methanol

: 88125-57-9
C30H28N(1+)*BF4(1-)

: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
at 150℃; Yield given;
at 150℃; Rate constant; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.);

: 2465-56-7
methylene

: 628-32-0
ethylpropylether

A: 187737-37-7
propene

B: 74-85-1
ethene

C: 540-67-0
ethyl methyl ether

D: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
at 20℃; Kinetics; Irradiation;
at 100℃; Kinetics; Irradiation;

...Expand

: 4-Chloro-phenol; compound with 1-methoxy-propane

A: 557-17-5
methyl propyl ether

B: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
In cyclohexane at 20℃; Equilibrium constant;

: 89909-38-6
Methylethyl-n-propyloxonium Tetrafluoroborate

A: 60-29-7
diethyl ether

B: 115-10-6
Dimethyl ether

C: 540-67-0
ethyl methyl ether

D: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
With potassium hydroxide In various solvent(s) for 0.5h; Product distribution; Ambient temperature;

...Expand

: 97-93-8
triethylaluminum

: 107-30-2
chloromethyl methyl ether

A: 74-84-0
ethane

B: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 60℃; for 2h;

...Expand

: 96-10-6
diethylaluminium chloride

: 107-30-2
chloromethyl methyl ether

A: 74-84-0
ethane

B: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 80℃; for 2h;

...Expand

: 107-30-2
chloromethyl methyl ether

: 2397-68-4
sodium tetraethylaluminate

A: 74-84-0
ethane

B: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
In tetrahydrofuran at 60℃; for 5h;

...Expand

: 80426-24-0
trimethyl (3-methoxypropyl)tin

A: 109-99-9
tetrahydrofuran

B: 557-17-5
methyl propyl ether

C: 540-47-6
cyclopropyl methyl ether

Conditions

Conditions	Yield
With benzophenone In benzene at 22℃; for 72h; Irradiation; further reagents (PhCOMe, (t-BuO)2, FeCl3); Yield given. Yields of byproduct given;

...Expand

: 71-23-8
propan-1-ol

: 77-78-1
dimethyl sulfate

: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In chlorobenzene 1.) ice bath, 1h, 2.) water bath, 2h;

: 71-23-8
propan-1-ol

: 74-88-4
methyl iodide

: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
With sodium hydride 1.) 4 h, reflux, 2.) 0.5 h at 20 deg C, reflux, 1 h; Multistep reaction;
Stage #1: propan-1-ol With sodium hydride In dimethyl sulfoxide Stage #2: methyl iodide In dimethyl sulfoxide at 20℃; for 5h; Further stages.;

: 67-56-1
methanol

: n-propyl 2-nitrobenzenesulfonate

: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
at 40 - 70℃; Rate constant; Thermodynamic data; Ea, ΔF(excit.), ΔH(excit.), -ΔS(excit.);

: 930-22-3
epoxybutene

A: 106-88-7
ethyloxirane

B: 123-73-9
trans-Crotonaldehyde

C: 557-17-5
methyl propyl ether

D: 627-40-7
methylallylether

E: 123-72-8
butyraldehyde

F: 106-97-8
n-butane

Conditions

Conditions	Yield
With hydrogen; silica gel; palladium at -0.15℃; under 150.012 Torr; Product distribution; Mechanism; also ethyloxirane; also with duterium; also over Pt-SiO2; var. temp. and time;

...Expand

: 67-56-1
methanol

: 71-23-8
propan-1-ol

dehydrated alum: dehydrated alum

A: 115-10-6
Dimethyl ether

B: 557-17-5
methyl propyl ether

C: 111-43-3
Dipropyl ether

Conditions

Conditions	Yield
at 180 - 185℃; analog reagiert mit Alkohol;

...Expand

CH2ClOCH3: CH2ClOCH3

Zn(C2H5)2: Zn(C2H5)2

: 557-17-5
methyl propyl ether

: 67-56-1
methanol

: 71-23-8
propan-1-ol

A: 557-17-5
methyl propyl ether

B dimethyl ether and dipropyl ether: dimethyl ether and dipropyl ether

Conditions

Conditions	Yield
With aluminum oxide at 180 - 185℃;

...Expand

: 67-56-1
methanol

: 106-94-5
propyl bromide

: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
With 1,3,5-triphenylverdazyl at 25℃; Kinetics; Further Variations:; Reaction partners; Temperatures;

: 71-23-8
propan-1-ol

A: 74-84-0
ethane

B: 74-98-6
propane

C: 557-17-5
methyl propyl ether

D: 111-43-3
Dipropyl ether

Conditions

Conditions	Yield
With sulfided Ni-Mo; hydrogen at 180℃; under 51714.8 Torr; Product distribution; Further Variations:; Temperatures;

...Expand

: 111-43-3
Dipropyl ether

A: 71-23-8
propan-1-ol

B: 74-98-6
propane

C: 115-10-6
Dimethyl ether

D: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
With sulfided Ni-Mo; hydrogen at 180℃; under 51714.8 Torr; Product distribution; Further Variations:; Temperatures;

...Expand

: 942-01-8
1,2,3,4-tetrahydrocarbazole

: 557-17-5
methyl propyl ether

A: 1140-49-4
1-propyl-1,2,3,4-tetrahydrocarbazole

B: 10257-86-0
1-ethyl-1,2,3,4-tetrahydrocarbazole

C: 1-butyl-1,2,3,4-tetrahydrocarbazole

D: 1-pentyl-1,2,3,4-tetrahydrocarbazole

Conditions

Conditions	Yield
With n-butyllithium; potassium tert-butylate In hexane Ambient temperature;	A n/a B 60% C n/a D n/a

...Expand

: 557-17-5
methyl propyl ether

: 56252-55-2
bis(2,6-di-tert-butyl-4-methylphenoxide)methylaluminum

: ((CH3)(CH2)2OMe) methylaluminium bis(2,6-di-tert-butyl-4-methylphenoxide) complex

Conditions

Conditions	Yield
With tert-butyl methyl ether In hexane addn. of methyl propyl ether and t-butyl methyl ether and MAD (hexane, room temp.), pptn., standing (1 h), heating, redissoln., standing (3 h, room temp.); filtration, elem. anal.;	60%

: 557-17-5
methyl propyl ether

: 14621-84-2
diazomethane-d2

A: 628-28-4
butyl methyl ether

B: 6795-87-5
2-butyl methyl ether

C: 115-10-6
Dimethyl ether

D: 628-32-0
ethylpropylether

E: 625-44-5
isobutyl methyl ether

Conditions

Conditions	Yield
Product distribution; Mechanism; Ambient temperature; Irradiation; deuterium distribution;	A 32.1% B 20.6% C 4.4% D 23% E 19.9%

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 557-17-5
methyl propyl ether

A: 628-28-4
butyl methyl ether

B: 6795-87-5
2-butyl methyl ether

C: 628-32-0
ethylpropylether

D: 625-44-5
isobutyl methyl ether

Conditions

Conditions	Yield
Product distribution; Mechanism; Ambient temperature; Irradiation;	A 29.8% B 19.6% C 31.4% D 19.2%

...Expand

: 557-17-5
methyl propyl ether

: methyl aluminium (2+); chloride-propylate

Conditions

Conditions	Yield
With aluminium trichloride; aluminium

: 557-17-5
methyl propyl ether

: 3294-58-4
phenyl(bromodichloromethyl)mercury

: 24165-85-3
1,1-dichloro-2-methoxy-butane

Conditions

Conditions	Yield
In benzene

: 557-17-5
methyl propyl ether

: 110-56-5
1,4-dichlorobutane

: 14860-82-3
1-chloro-4-propoxybutane

Conditions

Conditions	Yield
(i) SbF5, SO2, (ii) /BRN= 1730899/; Multistep reaction;

: 557-17-5
methyl propyl ether

: 1972-28-7
diethylazodicarboxylate

: C10H20N2O5

Conditions

Conditions	Yield
Irradiation;

: 557-17-5
methyl propyl ether

: 1972-28-7
diethylazodicarboxylate

: C10H20N2O5

Conditions

Conditions	Yield
Irradiation;

: 557-17-5
methyl propyl ether

: 106-48-9
4-chloro-phenol

: 4-Chloro-phenol; compound with 1-methoxy-propane

Conditions

Conditions	Yield
In cyclohexane at 20℃; Equilibrium constant;

Methyl propyl ether Chemical Properties

Molecule structure of Methyl propyl ether (CAS NO.557-17-5) :

IUPAC Name: 1-methoxypropane
Molecular Weight: 74.1216 g/mol
Molecular Formula: C₄H₁₀O
Density: 0.734 g/cm³
Boiling Point: 40.1 °C at 760 mmHg
Index of Refraction: 1.36
Molar Refractivity: 22.32 cm³
Molar Volume: 100.9 cm³
Polarizability: 8.85×10^-24 cm³
Surface Tension: 19 dyne/cm
Enthalpy of Vaporization: 26.75 kJ/mol
log P (octanol-water): 1.21
Water Solubility: 3.05E+04 mg/L
Vapor Pressure: 465 mm Hg
Henry's Law Constant: 1.49E-03 atm-m³/mole
Atmospheric OH Rate Constant: 1.13E-11 cm³/molecule-sec
XLogP3: 1.2
H-Bond Acceptor: 1
Rotatable Bond Count: 2
Exact Mass: 74.073165
MonoIsotopic Mass; 74.073165
Topological Polar Surface Area: 9.2
Heavy Atom Count: 5
Complexity: 13.1
Canonical SMILES: CCCOC
InChI: InChI=1S/C4H10O/c1-3-4-5-2/h3-4H2,1-2H3
InChIKey: VNKYTQGIUYNRMY-UHFFFAOYSA-N
EINECS: 209-158-7

Methyl propyl ether Uses

Methyl propyl ether (CAS NO.557-17-5) is an ether once used as a general anaesthetic. It is also used as an alternative to diethyl ether because of its greater potency. Its use as an anaesthetic has since been supplanted by modern halogenated ethers which are much less flammable. Methyl propyl ether (CAS NO.557-17-5) also can be used as a solvent and to make other chemicals.

Methyl propyl ether Toxicity Data With Reference

ihl-mus LC50:259 mg/m3/15M

ANESAV Anesthesiology. 11 (1950),455.

Methyl propyl ether Safety Profile

A poison by inhalation. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating vapors.
Risk Statements: 11
R11:Highly flammable.
Safety Statements: 16-33
S16:Keep away from sources of ignition.
S33:Take precautionary measures against static discharges.
RIDADR: 2612
RTECS: KO2280000
HazardClass: 3.1
PackingGroup: II

Methyl propyl ether Standards and Recommendations

DOT Classification: 3; Label: Flammable Liquid

Methyl propyl ether Specification

Methyl propyl ether (CAS NO.557-17-5) is also called 1-Methoxypropane ; Methyl n-propyl ether ; Metopryl
Neothyl ; alpha-Methoxy propane ; Propane, 1-methoxy- ; Propane, 1-methoxy- (9CI) . Methyl propyl ether (CAS NO.557-17-5) is a colorless volatile liquid with an ether-like odor. It is less dense than water and insoluble in water. Vapors heavier than air. May be narcotic by inhalation in high concentrations. Methyl propyl ether (CAS NO.557-17-5) is highly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously. A mixture of liquid air and diethyl ether exploded spontaneously. Ethers, such as Methyl propyl ether (CAS NO.557-17-5) , can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution. Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated.

Product Name

1 -Methoxypropane

Synthetic route

Methyl propyl ether Chemical Properties

Methyl propyl ether Uses

Methyl propyl ether Toxicity Data With Reference

Methyl propyl ether Safety Profile

Methyl propyl ether Standards and Recommendations

Methyl propyl ether Specification

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