IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 121.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Methylazoxymethanol acetate( CAS No.592-62-1) is also called (methyl-onn-azoxy)-methanoacetate(ester); (methyl-onn-azoxy)methanol,acetate(ester); (methyl-onn-azoxy)methanol,acetateester;aceticacid,(methyl-onn-azoxy)methylester; cycasinacetate; mamac; mamacetate; methylazoxymethanolacetate. Methylazoxymethanol acetate, MAM, is a neurotoxin and carcinogen which reduces DNA synthesis used in making animal models of neurological diseases including schizophrenia and epilepsy. Methylazoxymethyl acetate is used as a potent alkylating agent. It is an azo compound. Azo, compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids.
Physical properties about Methylazoxymethanol acetate are: (1)ACD/LogP: 0.691; (2)#H bond acceptors:5; (3)#Freely Rotating Bonds: 3; (4)Index of Refraction:1.463; (5)Molar Refractivity: 30.708 cm3; (6)Molar Volume: 111.513 cm3; (7)Polarizability: 12.174 10-24cm3; (8)Surface Tension: 38.6980018615723 dyne/cm; (9)Density: 1.185 g/cm3; (10)Flash Point: 62.153 °C; (11)Enthalpy of Vaporization: 41.544 kJ/mol; (12)Boiling Point: 179.158 °C at 760 mmHg; (13)Vapour Pressure: 0.954999983310699 mmHg at 25°C
You can still convert the following datas into molecular structure:
(1)InChI=1S/C4H8N2O3/c1-4(7)9-3-5-6(2)8/h3H2,1-2H3/b6-5+;
(2)InChIKey=BELPJCDYWUCHKF-AATRIKPKSA-N;
(3)SmilesC(OC\N=[N+](/C)[O-])(C)=O
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 105mg/kg (105mg/kg) | JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979. | |
mouse | LD50 | intravenous | 10mg/kg (10mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04566, | |
mouse | LDLo | oral | 35mg/kg (35mg/kg) | Cancer Research. Vol. 30, Pg. 801, 1970. | |
rat | LDLo | intraperitoneal | 50mg/kg (50mg/kg) | Chemico-Biological Interactions. Vol. 17, Pg. 291, 1977. |
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