Methyldithiocarbazate supplier

Name
methyldithiocarbazate
EINECS
CAS No. 5397-03-5
Article Data51
CAS DataBase
Density 1.314 g/cm³
Solubility
Melting Point 79 °C(Solv: benzene (71-43-2))
Formula C₂H₆N₂S₂
Boiling Point 207.3 °C at 760 mmHg
Molecular Weight 122.215
Flash Point 79.2 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Carbazicacid, dithio-, methyl ester (7CI,8CI);Dithiocarbazic acid methyl ester;Hydrazine-S-methylcarbodithioate;Methyl dithiocarbazate;Methylhydrazinecarbodithioate;NSC 4423;S-Methyl dithiocarbazate;S-Methylhydrazinecarbodithioate;
PSA 95.44000
LogP 1.18880

Synthetic route

: 2314-48-9
(S,S)-dimethyl trithiocarbonate

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 0℃; for 3h;	91%

: 75-15-0
carbon disulfide

: 74-88-4
methyl iodide

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
Stage #1: carbon disulfide With hydrazine hydrate; potassium hydroxide In water; isopropyl alcohol at 0 - 10℃; for 3h; Stage #2: methyl iodide In water; isopropyl alcohol at 20℃; for 4h; Cooling with ice;	90%
Stage #1: carbon disulfide With hydrazine hydrate; potassium hydroxide In water; isopropyl alcohol at 0 - 10℃; Stage #2: methyl iodide In water; isopropyl alcohol at 20℃;	86.5%
Stage #1: carbon disulfide With hydrazine hydrate; potassium hydroxide In water; isopropyl alcohol at 0 - 10℃; for 3h; Stage #2: methyl iodide In water; isopropyl alcohol at 10℃; for 1h;	64.5%

: 75-15-0
carbon disulfide

: 302-01-2
hydrazine

: 74-88-4
methyl iodide

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
With potassium hydroxide In water; isopropyl alcohol at 20℃; for 4h;	90%

...Expand

: 75-15-0
carbon disulfide

: 77-78-1
dimethyl sulfate

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
Stage #1: carbon disulfide With hydrazine hydrate; potassium hydroxide In water; isopropyl alcohol at 9 - 10℃; Stage #2: dimethyl sulfate In water; isopropyl alcohol at 12 - 15℃;	78%
Stage #1: carbon disulfide With potassium hydroxide; hydrazine In isopropyl alcohol for 3.66667h; Stage #2: dimethyl sulfate In isopropyl alcohol for 1h;	60.1%
Stage #1: carbon disulfide With hydrazine hydrate; potassium hydroxide In water; isopropyl alcohol at 10℃; for 3.66667h; Stage #2: dimethyl sulfate In water; isopropyl alcohol at 15℃;	60.1%

: 5456-21-3
S-ammonium hydrazinecarbodithiolate

: 77-78-1
dimethyl sulfate

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In water

: 5456-21-3
S-ammonium hydrazinecarbodithiolate

: 74-88-4
methyl iodide

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In water

: 74-88-4
methyl iodide

ammonium salt of dithiocarbazic acid: ammonium salt of dithiocarbazic acid

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
With ethanol

: 74-88-4
methyl iodide

dithiocarbazinate potassium: dithiocarbazinate potassium

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield

: 75-15-0
carbon disulfide

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
With potassium hydroxide; hydrazine In isopropyl alcohol

: 471-32-9
dithiocarbonic acid hydrazide

: 74-88-4
methyl iodide

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In water; isopropyl alcohol at 10℃; for 3.5h;	18.5 g
In ethanol at 0℃; for 1.5h;
for 3.5h; Cooling with ice;
In water; isopropyl alcohol for 3h; Cooling with ice;

: 26648-11-3
potassium hydrazine carbodithioate

: 74-88-4
methyl iodide

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In ethanol
In ethanol at 0℃; for 5h;
With potassium hydroxide at 10℃;

: 75-15-0
carbon disulfide

: 7803-57-8
hydrazine hydrate

: 74-88-4
methyl iodide

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
With potassium hydroxide at 0 - 5℃;

...Expand

: CH3N2S2(1-)*Na(1+)

: 74-88-4
methyl iodide

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In water; isopropyl alcohol for 1.5h; Cooling with ice;

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: malonic acid ethyl ester 5-oxo-pentyl ester

: malonic acid ethyl ester 5-(methylsulfanylthiocarbonyl-hydrazono)-pentyl ester

Conditions

Conditions	Yield
In ethanol for 10h; Heating;	100%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 1-(3-((2-methoxyethoxy)methyl)pyridin-2-yl)ethan-1-one

: methyl (E)-2-(1-(3-((2-methoxyethoxy)methyl)pyridin-2-yl)ethylidene)hydrazine-1-carbodithioate

Conditions

Conditions	Yield
In isopropyl alcohol at 60℃;	100%

: 1271-55-2
acetylferrocene

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: methyl 2-(1-ferrocenylethylidene)hydrazinecarbodithioate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20 - 80℃; for 1.16667h;	98.1%
With methanesulfonic acid; choline chloride at 80℃;	93.6%
In ethanol addn. of S-methyldithiocarbazate in hot anhydrous ethanol to a soln. of formylferrocene in same solvent; refluxing for 1 h; cooling;; filtration of crystals; washing with cold ethanol; drying in vac.; elem. anal.;;	92%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 50901-42-3
pyridazine-4-carbaldehyde

: N'-[1-Pyridazin-4-yl-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In isopropyl alcohol at 65 - 70℃; for 1h;	98%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 23787-80-6
methyl 2-(3-methylpyrazinyl) ketone

: methyl 2-[1-(3-methyl-2-pyrazinyl)ethylidene]hydrazinecarbodithioate

Conditions

Conditions	Yield
In isopropyl alcohol at 65 - 70℃; for 1h;	98%

: 12093-10-6
ferrocenecarboxaldehyde

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: formylferrocene hydrazinodithioformate methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20 - 80℃; for 1.08333h;	97.5%
In ethanol addn. of S-methyldithiocarbazate in hot anhydrous ethanol to a soln. of formylferrocene in same solvent; refluxing for 1 h; cooling;; filtration of crystals; washing with cold ethanol; drying in vac.; elem. anal.;;	96%
In ethanol for 2h; Reflux; Inert atmosphere; Schlenk technique;	95%
With methanesulfonic acid; choline chloride at 80℃;	91.2%
In isopropyl alcohol Reflux;

: 58022-21-2
1-acetylisoquinoline

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 85748-38-5
methyl 3-<1-(1-isoquinolinyl)ethylidene>hydrazinecarbodithioate

Conditions

Conditions	Yield
In ethanol for 0.416667h; Heating;	97%

: 21240-56-2
9-methyl-9H-carbazole-3-carbaldehyde

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: C16H15N3S2

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 60℃; for 1.08333h; Green chemistry;	96.8%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 50901-46-7
Methyl 4-pyridazinyl ketone

: 124436-43-7
N'-[1-Pyridazin-4-yl-eth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In isopropyl alcohol at 65 - 70℃; for 1h;	96%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 104688-94-0
Oxo-p-tolylamino-dithioacetic acid methyl ester

: 104689-05-6
5-Methylsulfanyl-[1,3,4]thiadiazole-2-carboxylic acid p-tolylamide

Conditions

Conditions	Yield
In ethanol Heating;	95%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 22047-27-4
1-(5-methylpyrazin-2-yl)ethanone

: methyl 2-[1-(5-methyl-2-pyrazinyl)ethylidene]hydrazinecarbodithioate

Conditions

Conditions	Yield
In isopropyl alcohol at 65 - 70℃; for 1h;	95%

: 1003-29-8
2-pyrrole aldehyde

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 685567-52-6
[((1E)-1-aza-2-pyrol-2-ylvinyl)amino]phenylmethylthiomethane-1-thione

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; for 2h;	95%

: 487-89-8
Indole-3-carboxaldehyde

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 685567-53-7
methyl (E)-2-((1H-indol-3-yl)methylene)hydrazine-1-carbodithioate

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; for 2h;	95%

: cobalt(II) chloride hexahydrate

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: Co(3+)*3NH2NC(S)SCH3(1-)=[Co(NH2NC(S)SCH3)3]

Conditions

Conditions	Yield
In water 3 equiv. of ligand; elem. anal.;	95%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 4-methoxy-5-oxo-5H-furo[3,2-g][1]benzopyran-6-carboxaldehyde

: 1131893-26-9
C15H12N2O4S2

Conditions

Conditions	Yield
In isopropyl alcohol at 20℃; for 2h;	95%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 67073-96-5
methyl 4-(6-methylpyrimidinyl) ketone

: methyl 2-[1-(6-methyl-4-pyrimidinyl)ethylidene]hydrazinecarbodithioate

Conditions

Conditions	Yield
In isopropyl alcohol at 65 - 70℃; for 1h;	94%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 7310-95-4
2-Hydroxy-5-methylisophthalaldehyde

: 705251-42-9
CH3C6H2OH(CHNNHCSSCH3)2

Conditions

Conditions	Yield
In methanol for 4h; Reflux;	93.8%
In methanol for 4h; Reflux;	93.8%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 1181214-29-8
4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzaldehyde

: 1392735-19-1
(E)-methyl 2-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzylidene)hydrazinecarbodithioate

Conditions

Conditions	Yield
In ethanol at 80℃; for 3h;	93%
In ethanol at 80℃; for 3h;	93%
In ethanol at 80℃; for 3h;	93%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 76-05-1
trifluoroacetic acid

: 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole

Conditions

Conditions	Yield
In toluene at 10 - 20℃; for 2h;	93%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 54117-37-2
9-benzyl-9H-carbazole-3-carbaldehyde

: C22H19N3S2

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃;	92.3%

: 2525-16-8
O-methylcaprolactim

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 18596-83-3
N'-Azepan-(2E)-ylidene-hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In methanol for 1h; Ambient temperature;	92%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 2,2-Dimethoxy-azepane

: 18596-83-3
N'-Azepan-(2E)-ylidene-hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In methanol for 1h; Ambient temperature;	92%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 3-(1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazole-4 carbaldehyde

: methyl 2-((3-(1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazine-1-carbodithioate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃;	92%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 67707-09-9
9-butyl-9H-carbazole-3-carbaldehyde

: C19H21N3S2

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃;	92%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 1122-63-0
1-(pyridazin-3-yl)ethan-1-one

: 124436-48-2
N'-[1-Pyridazin-3-yl-eth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester

Conditions

Conditions	Yield
In isopropyl alcohol at 65 - 70℃; for 1h;	91%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 26518-71-8
6-acetyl-4H-benzo[1,4]oxazin-3-one

: 113769-59-8
Methyl 3-<(3-oxo-2H,1,4-benzoxazin-6-yl)-ethylidene>hydrazinecarbodithioate

Conditions

Conditions	Yield
With acetic acid In ethanol for 1h; Heating;	91%

: 50-00-0
formaldehyd

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 5720-07-0
4-methoxyphenylboronic acid

: 3-(4-methoxybenzyl)-5-(methylthio)-2,3-dihydro-1,3,4-thiadiazole

Conditions

Conditions	Yield
In dichloromethane; water at 60℃; for 12h; Sealed tube;	91%

...Expand

: 574-17-4
1-acetyl-1H-indole-2,3-dione

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 78344-53-3
S-methyl ester of 1-acetylisatin 3-dithiocarboxyhydrazone

Conditions

Conditions	Yield
With acetic acid for 1h;	90.3%

: 5397-03-5
hydrazinecarbodithioic acid methyl ester

: 90-02-8
salicylaldehyde

: 133978-98-0, 26151-73-5
methyl 2-(2-hydroxybenzylidene)hydrazinecarbodithioate

Conditions

Conditions	Yield
In ethanol	90%
In ethanol for 12h; Reflux;	68%
In methanol Reflux;	61%

Methyldithiocarbazate Specification

The Methyldithiocarbazate is an organic compound with the formula C₂H₆N₂S₂. The IUPAC name of this chemical is methyl N-aminocarbamodithioate. With the CAS registry number 5397-03-5, it is also named as Dithiocarbazic acid methyl ester. The classification codes are TSCA Flag P [A commenced PMN (Premanufacture Notice) substance];
TSCA Flag S [Substance is identified in a proposed or final SNUR (Significant New Use Rule) under TSCA]. In addition, the molecular weight is 122.21.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.39; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.39; (4)ACD/LogD (pH 7.4): 0.38; (5)ACD/BCF (pH 5.5): 1.17; (6)ACD/BCF (pH 7.4): 1.15; (7)ACD/KOC (pH 5.5): 38.89; (8)ACD/KOC (pH 7.4): 38.23; (9)#H bond acceptors: 2; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 63.87 Å²; (13)Index of Refraction: 1.645; (14)Molar Refractivity: 33.73 cm³; (15)Molar Volume: 92.9 cm³; (16)Polarizability: 13.37×10^-24 cm³; (17)Surface Tension: 66.8 dyne/cm; (18)Density: 1.314 g/cm³; (19)Flash Point: 79.2 °C; (20)Enthalpy of Vaporization: 44.36 kJ/mol; (21)Boiling Point: 207.3 °C at 760 mmHg; (22)Vapour Pressure: 0.227 mmHg at 25°C.

Uses of Methyldithiocarbazate: It can react with furfural to get furfurylidene-hydrazinecarbodithioic acid methyl ester. This reaction which is a kind of condensation needs solvent ethanol by heating. The reaction time is 1 hours. The yield is 50%.

Methyldithiocarbazate can react with furfural to get furfurylidene-hydrazinecarbodithioic acid methyl ester

People can use the following data to convert to the molecule structure.
1. SMILES:S=C(SC)NN
2. InChI:InChI=1/C2H6N2S2/c1-6-2(5)4-3/h3H2,1H3,(H,4,5)
3. InChIKey:ILAXBOIRSPXAMM-UHFFFAOYAV

Product Name

methyldithiocarbazate

Synthetic route

Methyldithiocarbazate Specification

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