IUPAC Name: 1,5-Dimethyl-3-methylidene-4-oxo-6-oxabicyclo[3.1.0]hexane-2-carboxylic acid
Synonyms of Methylenomycin A (CAS NO.52775-76-5): 6-Oxabicyclo(3.1.0)hexane-2-carboxylic acid, 1,5-dimethyl-3-methylene-4-oxo-, (1S-(1-alpha,2-alpha,5-alpha))-
CAS NO: 52775-76-5
Molecular Formula: C9H10O4
Molecular Weight : 182.173300 g/mol
Molecular Structure:
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 55.9 Å2
Index of Refraction: 1.546
Molar Refractivity: 42.66 cm3
Molar Volume: 134.7 cm3
Surface Tension: 48.2 dyne/cm
Density: 1.35 g/cm3
Flash Point: 141.2 °C
Enthalpy of Vaporization: 64.27 kJ/mol
Boiling Point: 341.2 °C at 760 mmHg
Vapour Pressure: 1.49E-05 mmHg at 25°C
Methylenomycin A (CAS NO.52775-76-5) is effective against both Gram-negative and Gram-positive bacteria.
Methylenomycin A (CAS NO.52775-76-5) is a cyclopentanoid antibiotic produced by Streptomyces coelicolor A3(2).Methylenomycins are naturally produced in two variants: A and B.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 75mg/kg (75mg/kg) | Journal of Antibiotics. Vol. 27, Pg. 400, 1974. | |
mouse | LD50 | intravenous | 156mg/kg (156mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 6, Pg. 45, 1981. | |
mouse | LD50 | oral | 1500mg/kg (1500mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1267, 1978. |
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. When Methylenomycin A (CAS NO.52775-76-5) is heated to decomposition, it emits acrid smoke and irritating fumes.
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