Methylmalonic acid supplier

Name
2-Methylpropanedioic acid
EINECS 208-219-5
CAS No. 516-05-2
Article Data55
CAS DataBase
Density 1.402 g/cm³
Solubility Soluble in water
Melting Point 128-130 °C(lit.)
Formula C₄H₆O₄
Boiling Point 334.4 °C at 760 mmHg
Molecular Weight 118.089
Flash Point 170.2 °C
Transport Information
Appearance white crystals
Safety 26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms CPD-546;Propanedioic acid, methyl-;2-methylpropanedioic acid;2-methylpropanedioate;Propanedioic acid, methyl- (9CI);2-Methylmalonic acid;methylpropanedioic acid;4-02-00-01932 (Beilstein Handbook Reference);Malonic acid, methyl-;1, 1-Ethanedicarboxylic acid;Isosuccinic acid;
PSA 74.60000
LogP -0.20830

Synthetic route

: 609-08-5
Diethyl methylmalonate

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 1h; Ambient temperature;	99%
With potassium hydroxide In water at 0 - 20℃; for 60h;	71%
With potassium hydroxide In ethanol; water for 4h; Heating;

: 38330-80-2
monomethyl monopotassium malonate

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With concentrated hydrochloric acid In water	96%
With hydrogenchloride In hexane; dichloromethane	84.8%

: 34812-95-8
1,3-di-tert-butyl 2-methylpropanedioate

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol; dichloromethane at 20℃; for 3h; Solvent;	84%

: 609-02-9
methyl-malonic acid dimethylester

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
In water; toluene	81%
With sodium hydroxide In methanol at 20℃;
With water; sodium hydroxide In methanol at 80℃; for 1h;

: 632-07-5
2-cyanopropanoic acid

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 39619-07-3
2-methylmalonyl dichloride

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 2163-42-0
2-methyl-1.3-propanediol

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With nitric acid

: 381-97-5
(2RS)-3,3,3-trifluoro-2-methylpropanoic acid

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 2-cyano-3-imino-4-methyl-glutaric acid-1-ethyl ester

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 141-82-2
malonic acid

B: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
Kochen;

...Expand

: 2-cyano-3-imino-4-methyl-glutaric acid diethyl ester

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 141-82-2
malonic acid

B: 516-05-2
methyl-propanedioic acid

...Expand

: 2-cyano-3-imino-2,4,4-trimethyl-glutaric acid diethyl ester

: furan-2,3,5(4H)-trione pyridine (1:1)

A: 516-05-2
methyl-propanedioic acid

B: 595-46-0
2,2-dimethylmalonic acid

Conditions

Conditions	Yield
Erhitzen;

...Expand

: 98020-11-2
methyl-malonyl bromide

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With water

: 79-03-8
propionyl chloride

: 503-38-8
trichloromethyl chloroformate

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
at 225℃; folgendes Verseifen mit Wasser;
at 225℃; im Rohr; und folgende Hydrolyse;
at 225℃; folgendes Verseifen mit Wasser;

: 151-50-8
potassium cyanide

: 535-11-5, 41978-69-2
Ethyl 2-bromopropionate

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With ethanol ueber mehreren Stufen;

: 15601-92-0
2-methyl-3-oxo-3-(phenylamino)propanoic acid

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With sodium hydroxide Heating;

: 74-85-1
ethene

: 124-38-9
carbon dioxide

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
1.) Al, AlCl3, methylcyclohexane, 3 atm, 90-95 deg C, 12h; 2.) methylcyclohexane, 75 atm, 80 deg C; Multistep reaction;

: 141-82-2
malonic acid

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With sodium bromate; sulfuric acid; cerium (IV) sulfate In water at 25℃; Mechanism;

: 24161-56-6
ethyl 2-nitrophenyl methylmalonate

A: 64-17-5
ethanol

B: 516-05-2
methyl-propanedioic acid

C: 88-75-5
2-hydroxynitrobenzene

Conditions

Conditions	Yield
With pH = 8.00 In water at 23℃; under 750.06 Torr; Mechanism; Rate constant; pressure-dependence of rates of elimination; activation parameter for hydrolysis: ΔV(excit.); var. press.;

...Expand

: 69858-40-8
3,3-Dihydroxy-2-methyl-acrylic acid

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With cis-nitrous acid; chloride In water at 25℃; Equilibrium constant;

: 75-00-3
chloroethane

: 124-38-9
carbon dioxide

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With sodium; Petroleum ether at 110℃; unter Druck;

: 2163-42-0
2-methyl-1.3-propanediol

: 7697-37-2
nitric acid

: 516-05-2
methyl-propanedioic acid

: 124-38-9
carbon dioxide

: 627-44-1
diethylmercury

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With sodium; Petroleum ether at 110℃; unter Druck;

: 381-97-5
(2RS)-3,3,3-trifluoro-2-methylpropanoic acid

aqueous NaOH-solution: aqueous NaOH-solution

: 516-05-2
methyl-propanedioic acid

isosuccinic acid amide: isosuccinic acid amide

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
With sodium hydroxide

: 2163-42-0
2-methyl-1.3-propanediol

KMnO4: KMnO4

: 516-05-2
methyl-propanedioic acid

: 2-cyano-3-imino-2,4-dimethyl-glutaric acid diethyl ester

strong KOH-solution: strong KOH-solution

: 516-05-2
methyl-propanedioic acid

Conditions

Conditions	Yield
Erhitzen;

: 34762-17-9
ethyl 3-bromo-2-(ethoxycarbonyl)propionate

: 64-19-7
acetic acid

zinc: zinc

: 516-05-2
methyl-propanedioic acid

...Expand

: 872822-99-6
4-cyano-2-methyl-3-oxo-valeric acid ethyl ester

alkali, aqueous: alkali, aqueous

A: 516-05-2
methyl-propanedioic acid

B: 802294-64-0
propionic acid

Conditions

Conditions	Yield
Hydrolysis;

...Expand

: 75-00-3
chloroethane

: 124-38-9
carbon dioxide

sodium: sodium

ligroine: ligroine

A: 516-05-2
methyl-propanedioic acid

B: 802294-64-0
propionic acid

Conditions

Conditions	Yield
at 110℃; under 11032.6 Torr;

...Expand

: 90-46-0
9-hydroxyxanthene

: 516-05-2
methyl-propanedioic acid

: 150330-35-1
(±)-2-(9H-xanthen-9-yl)propanoic acid

Conditions

Conditions	Yield
With pyrrolidine; isopropyl alcohol; potassium hydroxide In toluene for 24h; Reflux;	99%
With pyridine

: 33342-17-5
5-(4'-fluorophenyl)furan-2-carbaldehyde

: 516-05-2
methyl-propanedioic acid

: (E)-2-methyl-3-(5-(4-fluorophenyl)furan-2-yl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 3h; Knoevenagel Condensation; Reflux;	96.7%

: 516-05-2
methyl-propanedioic acid

: disilver methylmalonate

Conditions

Conditions	Yield
With sodium hydroxide; nitric acid; silver nitrate In methanol; water	96.7%

: 516-05-2
methyl-propanedioic acid

: 853311-16-7
4-(4-methylphenyl)thiophene-2-carbaldehyde

: (E)-2-methyl-3-(4-(4-methylphenyl)thiophen-2-yl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 3h; Knoevenagel Condensation; Reflux;	96.1%

: 110-89-4
piperidine

: tert-butyl (+/-)-trans-2,2-dimethyl-3-formylcyclopropanecarboxylate

: 516-05-2
methyl-propanedioic acid

: 1195315-35-5
tert-butyl (+/-)-trans-2,2-dimethyl-3-{2-carboxy-(E)-1-propenyl}cyclopropanecarboxylate

Conditions

Conditions	Yield
In pyridine; diethyl ether; hexane; ethyl acetate	96%
In pyridine; diethyl ether; hexane; ethyl acetate	94.1%

...Expand

: 26170-87-6
4-phenylthiophene-2-carbaldehyde

: 516-05-2
methyl-propanedioic acid

: 941281-24-9
(E)-2-methyl-3-(4-phenylthiophen-2-yl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 3h; Knoevenagel Condensation; Reflux;	95.5%

: 516-05-2
methyl-propanedioic acid

: 94940-17-7
3-methyl-2-methylthio-6-(tetra-O-acetyl-β-D-glucopyranosylamino)pyrimidin-4(3H)-one

: 135112-04-8
3,4,7,8-tetrahydro-5-hydroxy-3,6-dimethyl-2-methylthio-4,7-dioxo-8-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)pyrido<2,3-d>pyrimidine

Conditions

Conditions	Yield
With acetic anhydride at 100℃; for 1h;	95%

: 516-05-2
methyl-propanedioic acid

: 24424-99-5
di-tert-butyl dicarbonate

: 34812-95-8
1,3-di-tert-butyl 2-methylpropanedioate

Conditions

Conditions	Yield
With dmap In diethyl ether; tert-butyl alcohol at 23℃; for 48h; Inert atmosphere;	95%

: 516-05-2
methyl-propanedioic acid

: calcium 2-methylmalonate

Conditions

Conditions	Yield
With calcium hydroxide In water at 70℃; for 5h;	95%

: 516-05-2
methyl-propanedioic acid

: 107-18-6
allyl alcohol

: 150193-37-6
2-methylmalonic acid diallyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene Heating;	92%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 3.08333h;

: 516-05-2
methyl-propanedioic acid

: 34035-05-7
5-(4-tolyl)-2-furaldehyde

: (E)-2-methyl-3-(5-(4-methylphenyl)furan-2-yl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 3h; Knoevenagel Condensation; Reflux;	92%

: 516-05-2
methyl-propanedioic acid

: 4-(4-fluorophenyl)furan-2-carbaldehyde

: (E)-2-methyl-3-(4-(4-fluorophenyl)furan-2-yl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 3h; Knoevenagel Condensation; Reflux;	91.3%

: 91-16-7
1,2-dimethoxybenzene

: 516-05-2
methyl-propanedioic acid

: 738616-34-7
5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione

Conditions

Conditions	Yield
In dichloromethane at 22℃; for 18h;	91%
With Eaton’s reagent In dichloromethane at 22℃; for 18h; Inert atmosphere;	66%

: 871700-54-8
1-(2-fluoro-4-iodophenyl)-3-(4-methoxybenzyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione

: 516-05-2
methyl-propanedioic acid

: 871700-55-9
1-(2-fluoro-4-iodophenyl)-5-hydroxy-3-(4-methoxybenzyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione

Conditions

Conditions	Yield
With acetic anhydride at 90 - 100℃; for 4h;	90.7%

: 516-05-2
methyl-propanedioic acid

: 4-(3,4-methylene-dioxyphenyl)thiophene-2-carbaldehyde

: (E)-2-methyl-3-(4-(3,4-methylene-dioxyphenyl)thiophen-2-yl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 3h; Knoevenagel Condensation; Reflux;	90.6%

: 516-05-2
methyl-propanedioic acid

: 71-36-3
butan-1-ol

: 52886-83-6
dibutyl 2-methylmalonate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 3.08333h;	90%

: 516-05-2
methyl-propanedioic acid

: 67-63-0
isopropyl alcohol

: diisopropyl 2-methylmalonate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 3.08333h;	90%

: 516-05-2
methyl-propanedioic acid

: 108-93-0
cyclohexanol

: 73742-26-4
dicyclohexyl 2-methylmalonate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 3.08333h;	90%

: 109-86-4
2-methoxy-ethanol

: 516-05-2
methyl-propanedioic acid

: bis(2-methoxyethyl) 2-methylmalonate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 3.08333h;	90%

: 516-05-2
methyl-propanedioic acid

: 4-(4-nitrophenyl)thiophene-2-carbaldehyde

: (E)-2-methyl-3-(4-(4-nitrophenyl)thiophen-2-yl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 3h; Knoevenagel Condensation; Reflux;	89.4%

: 516-05-2
methyl-propanedioic acid

: 88-06-2
2,4,6-Trichlorophenol

: 15781-71-2
bis(2,4,6-trichlorophenyl) 2-methylmalonate

Conditions

Conditions	Yield
With trichlorophosphate for 5h; Reflux;	89.11%
With trichlorophosphate Reflux;

: 75105-48-5
N,N'-dimesitylformamidine

: 516-05-2
methyl-propanedioic acid

: 1051375-11-1
1,3-dimesityl-5-methyl-6-oxo-6H-pyrimidinium-4-olate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h; Inert atmosphere;	89%
With triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 0℃; Schlenk technique; Inert atmosphere;	89%

: 553-26-4
4,4'-bipyridine

: zinc(II) nitrate hexahydrate

: 516-05-2
methyl-propanedioic acid

: [Zn2(4,4′-bpy)(Memal)2(H2O)2]n

Conditions

Conditions	Yield
With sodium carbonate In methanol; water three parts sepd. by water interphases: aq. soln. of MeCH(CO2H)2 and Na2CO3 at the bottom, soln. of Zn nitrate in the middle region and soln. ofbipyridine in MeOH on the top; sysztem stored at room temp. for a few w k; crystals collected; washed with H2O/EtOH; air dried; elem. anal.;	89%

...Expand

: 516-05-2
methyl-propanedioic acid

: 2919-20-2
1,1-di(p-tolyl)ethylene

: 2-carboxy-2-methyl-4,4-bis(4-methylphenyl)-4-butanolide

Conditions

Conditions	Yield
With manganese triacetate In acetic acid at 100℃; for 0.05h;	88%

: 516-05-2
methyl-propanedioic acid

: 4-(6-fluoropyridin-3-yl)furan-2-carbaldehyde

: (E)-2-methyl-3-(4-(6-fluoropyridin-3-yl)furan-2-yl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 3h; Knoevenagel Condensation; Reflux;	87.7%

: 516-05-2
methyl-propanedioic acid

: 55591-35-0
1,1'-(4-nitro-phenylmethanediyl)-bis-piperidine

: 13048-77-6, 949-98-4, 13048-76-5
(E)-2-methyl-3-(4-nitrophenyl)acrylic acid

Conditions

Conditions	Yield
for 96h; Ambient temperature;	87%

: 553-26-4
4,4'-bipyridine

: cobalt(II) nitrate hexahydrate

: 516-05-2
methyl-propanedioic acid

: [Co(II)2(4,4'-bipyridine)(methylmalonate(2-))2(H2O)2]

Conditions

Conditions	Yield
With sodium carbonate In methanol; water three parts sepd. by water interphases: aq. soln. of MeCH(CO2H)2 and Na2CO3 at the bottom, soln. of CoCl2*6H2O in the middle region and soln. ofbipyridine in MeOH on the top; system stored at room temp. for a few wk; crystals collected; washed with H2O/EtOH; air dried; elem. anal.;	87%

...Expand

: 516-05-2
methyl-propanedioic acid

: 94940-33-7
Acetic acid (2R,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(2-methoxy-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-tetrahydro-pyran-3-yl ester

: 4-Acetoxy-3-methyl-7-methoxy-5-(2,3,4,6-tetra-O-acetyl-β-D-glucyopyranosylamino)pyrano<2,3-d>pyrimidin-2-one

Conditions

Conditions	Yield
With acetic anhydride at 100℃; for 1h;	86%

Methylmalonic acid Chemical Properties

The molecular formula of Methylmalonic acid(516-05-2) is C₄H₆O₄ and its formula weight is 118.09.
The density of Methylmalonic acid(516-05-2) is 1.45 and it has a melting point of 128-130 °C(lit.).
The chemical synonyms of Methylmalonic acid(516-05-2) are METHYLMALONIC ACID;METHYLPROPANEDIOIC ACID;2-METHYLPROPANEDIOIC ACID;PROPANEDIOIC ACID, METHYL-;1,1-Ethanedicarboxylic acid;1,1-ethanedicarboxylicacid;2-Methylmalonic acid;2-methylmalonicacid
The molecular structure of Methylmalonic acid(516-05-2):

Methylmalonic acid Toxicity Data With Reference

RTECS#: CAS# 516-05-2: OO1400000
LD50/LC50: RTECS: Not available.
Carcinogenicity: Methylmalonic acid - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: See actual entry in RTECS for complete information.

Methylmalonic acid Safety Profile

Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
RTECS OO1400000

Methylmalonic acid Specification

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Strong oxidants.
Incompatibilities with Other Materials Not available
Hazardous Decomposition Products Irritating and toxic fumes and gases.
Hazardous Polymerization Hazardous Polymerization

Product Name

2-Methylpropanedioic acid

Synthetic route

Methylmalonic acid Chemical Properties

Methylmalonic acid Toxicity Data With Reference

Methylmalonic acid Safety Profile

Methylmalonic acid Specification

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