Product Name

Stability

    Stable, but may decompose in the presence of water ormoisture. Incompatible with water, strong bases, strong oxidizing agents.

Toxicology

    May be fatal if swallowed, inhaled or absorbed through
  • Melting Point 31-34 °C
  • Formula CH3 Cl2 O P
  • Boiling Point 163 °C(lit.)
  • Molecular Weight 132.914
  • Flash Point >110°C
  • Transport Information UN 3390 6
  • Appearance solid
  • Safety Poison by inhalation. A corrosive irritant to the eyes, skin, and mucous membranes. When heated to decomposition it emits toxic fumes of Cl and POx. See also CHLORIDES.
  • Risk Codes 14-26-34
  • Molecular Structure Molecular Structure of 676-97-1 (METHYLPHOSPHONIC DICHLORIDE)
  • Hazard Symbols VeryT+
  • Synonyms Phosphonicdichloride, methyl- (8CI,9CI); Dichloromethylphosphine oxide;Methanephosphonodichloridic acid; Methanephosphonyl chloride; Methanephosphonyldichloride; Methylphosphonic acid dichloride; Methylphosphonic dichloride;Methylphosphonic dichoride; Methylphosphonodichloridic acid; Methylphosphonylchloride; Methylphosphonyl dichloride
  • PSA 26.88000
  • LogP 2.28690

Synthetic route

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

methylene chloride
74-87-3

methylene chloride

Conditions
ConditionsYield
With thionyl chloride; N-Formylpiperidine for 19h; Heating; various conditions and cactalasts investigated;A 99.2%
B n/a
methylphosphonic acid bis(trimethylsilyl) ester
18279-83-9

methylphosphonic acid bis(trimethylsilyl) ester

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

Conditions
ConditionsYield
With phosphorus pentachloride In tetrachloromethane for 1h; Ambient temperature;A 98%
B n/a
dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide for 4h; Reagent/catalyst; Reflux;96.4%
With thionyl chloride92.8%
With calcium fluoride; thionyl chloride for 20h; Substitution; Heating;92.8%
methylphosphonic acid bis(trimethylsilyl) ester
18279-83-9

methylphosphonic acid bis(trimethylsilyl) ester

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

C

o-phenylene chlorophosphate
1499-17-8

o-phenylene chlorophosphate

Conditions
ConditionsYield
With CPTA 86.5%
B n/a
C n/a
methylphosphonic acid
993-13-5

methylphosphonic acid

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With phosphorus pentachloride for 14h; Chlorination; Heating;81%
With thionyl chloride80%
With phosphorus pentachloride In tetrachloromethane at 45℃; for 12h;
With 1-chloro-1-(dimethylamino)-2-methyl-1-propene In chloroform at 50℃; for 0.0833333h;86 % Spectr.
With thionyl chloride
1,3-dichloro-2-butene
926-57-8

1,3-dichloro-2-butene

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

1,2-dichloroethyl phosphorodichloridate
34838-28-3

1,2-dichloroethyl phosphorodichloridate

C

acetyl chloride
75-36-5

acetyl chloride

D

chloromethylphosphonic dichloride
1983-26-2

chloromethylphosphonic dichloride

E

phosphoryl chloride

phosphoryl chloride

Conditions
ConditionsYield
With oxygen; phosphorus trichloride at -10 - 10℃; Product distribution; Mechanism;A n/a
B 80%
C n/a
D n/a
E n/a
With oxygen; phosphorus trichloride at -10 - 10℃; Title compound not separated from byproducts;A n/a
B 80%
C n/a
D n/a
E n/a
With oxygen; phosphorus trichloride at -10 - 10℃;A n/a
B 80%
C n/a
D n/a
E n/a
methylthiophosphonic acid

methylthiophosphonic acid

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With pyridine; thionyl chloride for 4h; Heating;75%
dimethyl methylphosphonothionate
681-06-1

dimethyl methylphosphonothionate

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With pyridine; thionyl chloride for 4h; Heating;71%
O,O-diethyl methanephosphonothionate
6996-81-2

O,O-diethyl methanephosphonothionate

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With pyridine; thionyl chloride for 4h; Heating;65%
methyl-thiophosphonic acid O,O'-dipropyl ester
25371-75-9

methyl-thiophosphonic acid O,O'-dipropyl ester

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With pyridine; thionyl chloride for 4h; Heating;62%
methyl dichlorophosphite
3279-26-3

methyl dichlorophosphite

O-(methylchloroformoimino)methyldichlorophosphonium chloride
143800-66-2

O-(methylchloroformoimino)methyldichlorophosphonium chloride

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

methylene chloride
74-87-3

methylene chloride

C

acetonitrile
75-05-8

acetonitrile

D

POCl3

POCl3

Conditions
ConditionsYield
In diethyl ether at 30℃; for 1h;A 9.8%
B n/a
C n/a
D n/a
In diethyl ether at 30℃; for 1h;A 9.8 g
B n/a
C n/a
D n/a
Dimethoxymethane
109-87-5

Dimethoxymethane

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With nickel(II) iodide; phosphorus trichloride at 250℃;
diisopropyl methanephosphonate
1445-75-6

diisopropyl methanephosphonate

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With thionyl chloride
dibutyl methylphosphonate
2404-73-1

dibutyl methylphosphonate

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With phosphorus pentachloride; chlorine
bis(2-chloroethyl) methylphosphonate
2799-58-8

bis(2-chloroethyl) methylphosphonate

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

methyl-phosphonic acid-(2-chloro-ethyl ester)-chloride
25789-17-7

methyl-phosphonic acid-(2-chloro-ethyl ester)-chloride

Conditions
ConditionsYield
With phosphorus pentachloride
methylphosphinic acid
4206-94-4

methylphosphinic acid

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With phosphorus pentachloride
formaldehyd
50-00-0

formaldehyd

methyldichlorophosphane
676-83-5

methyldichlorophosphane

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

chloromethyl(methyl)phosphinic chloride
26350-26-5

chloromethyl(methyl)phosphinic chloride

Conditions
ConditionsYield
at 200℃; for 2h;
methyldichlorophosphane
676-83-5

methyldichlorophosphane

1,1-dichloro-1-nitrosoethane
677-23-6

1,1-dichloro-1-nitrosoethane

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
at 100℃; Yield given;
methyldichlorophosphane
676-83-5

methyldichlorophosphane

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

chloromethyl(methyl)phosphinic chloride
26350-26-5

chloromethyl(methyl)phosphinic chloride

Conditions
ConditionsYield
With formaldehyd at 200℃; for 2h;
4,4-dimethyl-2-pentyne
999-78-0

4,4-dimethyl-2-pentyne

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

tert-butyl phosphinyl dichloride
4707-95-3

tert-butyl phosphinyl dichloride

C

(2-chloro-5,5-dimethyl-3-penten-3-yl)phosphonic dichloride

(2-chloro-5,5-dimethyl-3-penten-3-yl)phosphonic dichloride

Conditions
ConditionsYield
With oxygen; phosphorus trichloride Yield given. Yields of byproduct given;
O-(Trimethylsilyl)acetohydroxamoyl chloride
86260-81-3

O-(Trimethylsilyl)acetohydroxamoyl chloride

O-(methylchloroformoimino)methyldichlorophosphonium chloride
143800-66-2

O-(methylchloroformoimino)methyldichlorophosphonium chloride

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

C

acetonitrile
75-05-8

acetonitrile

Conditions
ConditionsYield
A 1.5 g
B n/a
C n/a
propenyl chloride
590-21-6

propenyl chloride

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

1,2,2-trichloroethyl phosphorodichloridate
32830-83-4

1,2,2-trichloroethyl phosphorodichloridate

C

1,2-dichloropropyl phosphorodichloridate

1,2-dichloropropyl phosphorodichloridate

D

phosphoryl chloride

phosphoryl chloride

Conditions
ConditionsYield
With oxygen; phosphorus trichloride at -10 - 10℃; Product distribution; Mechanism;
compound of trichloro-methyl-phosphonium chloride with AlCl3

compound of trichloro-methyl-phosphonium chloride with AlCl3

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With water
2-chloropropene
557-98-2

2-chloropropene

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

acetyl chloride
75-36-5

acetyl chloride

C

chloromethyl phosphorodichloridate

chloromethyl phosphorodichloridate

D

chloromethylphosphonic dichloride
1983-26-2

chloromethylphosphonic dichloride

E

phosphoryl chloride

phosphoryl chloride

Conditions
ConditionsYield
With oxygen; phosphorus trichloride at -10 - 10℃; Title compound not separated from byproducts;
With oxygen; phosphorus trichloride at -10 - 10℃; Product distribution; Mechanism;
methylene chloride
74-87-3

methylene chloride

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
Stage #1: methylene chloride With aluminium trichloride; phosphorus trichloride at 25℃; under 3420 Torr; for 2h;
Stage #2: With water In dichloromethane at 0℃;
10.1 g
With phosphorus trichloride In acetonitrile at 30 - 80℃; Autoclave;
methyldichlorophosphane
676-83-5

methyldichlorophosphane

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With oxygen
With sulfuryl dichloride at 0 - 30℃; for 2.41667h; Temperature; Sealed tube;130.7 g
methyl phosphine chloride
20502-96-9

methyl phosphine chloride

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Conditions
ConditionsYield
With phosphorus; iodine; chlorine; phosphorus trichloride at 50 - 70℃; for 5h; Temperature; Autoclave;
methanol
67-56-1

methanol

A

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

B

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

Conditions
ConditionsYield
With phosphorus trichloride at 70℃;
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

2,2-dimethyl-3-(methylamino)propan-1-ol
16047-86-2

2,2-dimethyl-3-(methylamino)propan-1-ol

2,3,5,5-Tetramethyl-[1,3,2]oxazaphosphinane 2-oxide

2,3,5,5-Tetramethyl-[1,3,2]oxazaphosphinane 2-oxide

Conditions
ConditionsYield
With triethylamine In benzene for 20h; Ambient temperature;100%
1-(2-cyanoethyl)aziridine
1072-66-8

1-(2-cyanoethyl)aziridine

methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

N-(2-cyanoethyl)-N-(2-chloroethyl)-P-methylphosphonamidic chloride
76081-09-9

N-(2-cyanoethyl)-N-(2-chloroethyl)-P-methylphosphonamidic chloride

Conditions
ConditionsYield
In benzene at 20℃;99%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

p-cresol
106-44-5

p-cresol

O,O-di-4-methylphenyl methylphosphonate
60146-74-9

O,O-di-4-methylphenyl methylphosphonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; Cooling with ice;99%
With triethylamine In dichloromethane at 20℃; for 1h;70%
at 160℃; for 6h;65%
With triethylamine In benzene at 50 - 60℃; for 6h;56%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

propan-1-ol
71-23-8

propan-1-ol

methylphosphonic acid dipropyl ester
6410-56-6

methylphosphonic acid dipropyl ester

Conditions
ConditionsYield
With aluminum oxide at 20℃;98%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

acrylic acid
79-10-7

acrylic acid

2-carboxyethyl-methyl-phosphinic acid
15090-23-0

2-carboxyethyl-methyl-phosphinic acid

Conditions
ConditionsYield
Stage #1: methylphosphonic acid dichloroanhydride; acrylic acid at 60 - 80℃; Inert atmosphere;
Stage #2: With water In acetone for 0.166667h; Solvent; Reflux;
98%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

1-ethynyl-4-fluorobenzene
766-98-3

1-ethynyl-4-fluorobenzene

bis((4-fluorophenyl)ethynyl)(methyl)phosphine oxide

bis((4-fluorophenyl)ethynyl)(methyl)phosphine oxide

Conditions
ConditionsYield
Stage #1: 1-ethynyl-4-fluorobenzene With isopropylmagnesium bromide In tetrahydrofuran; 2-methyltetrahydrofuran at -20℃; for 4h; Inert atmosphere;
Stage #2: methylphosphonic acid dichloroanhydride In tetrahydrofuran; 2-methyltetrahydrofuran at -20℃; for 4h;
98%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

O-ethylethylthiophosphonic acid
7776-66-1

O-ethylethylthiophosphonic acid

bis(ethylethoxythiophosphonyl)methylphosphonate
118016-49-2, 118016-53-8, 118099-73-3

bis(ethylethoxythiophosphonyl)methylphosphonate

Conditions
ConditionsYield
With triethylamine In diethyl ether 1.) -45 deg C, 1 h, 2.) 20 deg C, 1 h;97.2%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

isopropyl alcohol
67-63-0

isopropyl alcohol

diisopropyl methanephosphonate
1445-75-6

diisopropyl methanephosphonate

Conditions
ConditionsYield
With aluminum oxide at 20℃;97%
With N,N-diethylaniline
With pyridine
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

methoxydimethylsilyl cyanide
23272-12-0

methoxydimethylsilyl cyanide

A

methyl (cyano)methylphosphonate
101153-04-2

methyl (cyano)methylphosphonate

B

dimethylsilicon dichloride
75-78-5

dimethylsilicon dichloride

Conditions
ConditionsYield
at 40 - 45℃; for 0.0833333h;A 87.6%
B 97%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

4-chloro-phenol
106-48-9

4-chloro-phenol

O,O-di-4-chlorophenyl methylphosphonate
6395-59-1

O,O-di-4-chlorophenyl methylphosphonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; Cooling with ice;97%
With triethylamine In dichloromethane at 20℃; for 1h;77%
With triethylamine In benzene at 50 - 60℃; for 6h;68%
at 160℃; for 6h;64%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

ethanol
64-17-5

ethanol

Diethyl methylphosphonate
683-08-9

Diethyl methylphosphonate

Conditions
ConditionsYield
With aluminum oxide at 20℃;97%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

2,2,3,3,4,4,5,5-octafluoropentan-1-ol
355-80-6

2,2,3,3,4,4,5,5-octafluoropentan-1-ol

bis(1H,1H,5H-octafluoropentyl) methylphosphonate
65611-29-2

bis(1H,1H,5H-octafluoropentyl) methylphosphonate

Conditions
ConditionsYield
With lithium chloride for 2.5h; bath temperature 170 - 195 deg C;96.8%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

(R,R)-TADDOL
93379-48-7

(R,R)-TADDOL

(3aR,8aR)-tetrahydro-2,2,6-trimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin 6-oxide
1399829-81-2

(3aR,8aR)-tetrahydro-2,2,6-trimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-e][1,3,2]dioxaphosphepin 6-oxide

Conditions
ConditionsYield
Stage #1: (R,R)-TADDOL With n-butyllithium In tetrahydrofuran at -78 - 20℃; for 1h;
Stage #2: methylphosphonic acid dichloroanhydride In tetrahydrofuran at -78 - 20℃; for 3.5h;
96%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

(±)-6-hydroxy-2,5,7,8-tetramethyl chroman-2-carboxylic acid hexadecyl ester

(±)-6-hydroxy-2,5,7,8-tetramethyl chroman-2-carboxylic acid hexadecyl ester

(±)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid hexadecyl ester-6-methylphosphonyl chloride ester

(±)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid hexadecyl ester-6-methylphosphonyl chloride ester

Conditions
ConditionsYield
With triethylamine In diethyl ether at 20℃; for 8h; Inert atmosphere; Large scale;96%
With triethylamine In diethyl ether at 20℃; for 8h; Inert atmosphere;96%
With caesium carbonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere;
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

methanol
67-56-1

methanol

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

Conditions
ConditionsYield
With aluminum oxide at 20℃;95%
With triethylamine80%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

N-allyl (L)-leucine methyl ester
73270-65-2

N-allyl (L)-leucine methyl ester

C3H5NHCHC4H9CO2CH3POClCH2
384824-23-1

C3H5NHCHC4H9CO2CH3POClCH2

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane Substitution; Heating;95%
With dmap; triethylamine In dichloromethane Substitution; Heating;
With dmap; triethylamine In dichloromethane Heating;
With dmap; triethylamine In dichloromethane Heating;
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

[(14)N]-p-nitrophenol

[(14)N]-p-nitrophenol

(14)N-bis(p-nitrophenyl) methylphosphonate

(14)N-bis(p-nitrophenyl) methylphosphonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; Cooling with ice;95%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

isobutyl hydrogen methylphosphonite
25296-66-6

isobutyl hydrogen methylphosphonite

Conditions
ConditionsYield
With ammonia In cyclohexane at -10℃; for 2h;95%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

tert-butylamine
75-64-9

tert-butylamine

P-methyl-N-t-butylphosphonamidic chloride
88652-78-2

P-methyl-N-t-butylphosphonamidic chloride

Conditions
ConditionsYield
In diethyl ether for 40h; Ambient temperature;94%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

phenol
108-95-2

phenol

diphenyl methylphosphonate
7526-26-3

diphenyl methylphosphonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; Cooling with ice;94%
With triethylamine In dichloromethane for 1h; Ambient temperature;86%
With triethylamine In dichloromethane at 0 - 20℃; for 3h;86%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

Allylbenzylamine
4383-22-6

Allylbenzylamine

C11H15ClNOP
920526-03-0

C11H15ClNOP

Conditions
ConditionsYield
Stage #1: methylphosphonic acid dichloroanhydride With dmap; triethylamine In dichloromethane at 20℃; for 0.25h;
Stage #2: Allylbenzylamine In dichloromethane at 40℃; for 3h;
94%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

tetrafluoroethane-β-sultone
697-18-7

tetrafluoroethane-β-sultone

chlorosulfuric acid trifluorovinyl ester
923-15-9

chlorosulfuric acid trifluorovinyl ester

Conditions
ConditionsYield
In dichloromethane at -10°C;94%
In dichloromethane at -10°C;94%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

ethanol
64-17-5

ethanol

ethyl methylphosphinate
16391-07-4

ethyl methylphosphinate

Conditions
ConditionsYield
With ammonia In cyclohexane at -10℃; for 1h;93.3%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

4-nitro-phenol
100-02-7

4-nitro-phenol

O,O-di-4-nitrophenyl methylphosphonate
6395-57-9

O,O-di-4-nitrophenyl methylphosphonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; Cooling with ice;93%
With triethylamine In dichloromethane at 20℃; for 4h; Cooling with ice;91%
With triethylamine In dichloromethane at 20℃; for 4h; Cooling with ice;91%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

bis(2,2,2-trifluoroethyl)(methyl)phosphonate
757-95-9

bis(2,2,2-trifluoroethyl)(methyl)phosphonate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 10 - 30℃; for 2.5h; Inert atmosphere;93%
With triethylamine In tetrahydrofuran for 2h; Ambient temperature;92%
With lithium chloride for 4h; bath temperature 160 deg C;85%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

rac-octan-2-ol
4128-31-8

rac-octan-2-ol

di(methylheptyl)methylphosphonate
76341-63-4

di(methylheptyl)methylphosphonate

Conditions
ConditionsYield
With hydrogenchloride at 30 - 85℃; for 4.25h;93%
methylphosphonic acid dichloroanhydride
676-97-1

methylphosphonic acid dichloroanhydride

hexan-1-ol
111-27-3

hexan-1-ol

n-hexyl methylphosphinate
85187-13-9

n-hexyl methylphosphinate

Conditions
ConditionsYield
With ammonia In cyclohexane at 0℃; for 3h;92.8%

Methylphosphonic dichloride Chemical Properties

IUPAC:  Dichlorophosphorylmethane 
 Methyl phosphonic dichloride (676-97-1) is also called for 4-04-00-03509 (Beilstein Handbook Reference) ; BRN 1071305 ; EINECS 211-634-4 ; HSDB 6329 ; Methanephosphonyl chloride ; Phosphonic dichloride, methyl- ; Phosphonic dichloride, P-methyl- ; Phosphonic dichloride, methyl- ; NA9206 ; 228052_ALDRICH ; 64262_FLUKA and so on.
Molecular Formula: CH3Cl2OP
Molecular Weight: 132.91
EINECS: 211-634-4
Melting Point: 31-34°C
Density: 1.445 g/cm3
Flash Point: 44.1°C   
Boiling Point: 163°C at 760 mmHg
LogP: ACD/LogP: 0.26
XLogP: 0.80
ALOGPS: 0.67
ACD/LogD (pH 5.5): 0.26 
ACD/LogD (pH 7.4): 0.26 
ACD/BCF (pH 5.5): 1 
ACD/BCF (pH 7.4): 1 
ACD/KOC (pH 5.5): 32.79 
ACD/KOC (pH 7.4): 32.79 
H bond acceptors: 1 
H bond donors: 0 
Freely Rotating Bonds: 0
Heavy Atom Count: 5
Formal Charge: 0
Complexity: 64
Isotope Atom Count: 0
Defined Atom StereoCenter Count: 0
Undefined Atom StereoCenter Count: 0
Defined Bond StereoCenter Count: 0
Undefined Bond StereoCenter Count: 0
Covalently-Bonded Unit Count: 1
Index of Refraction: 1.419 
Molar Refractivity: 23.25 cm3 
Molar Volume: 91.9 cm3 
Surface Tension: 33.3 dyne/cm     
Vapour Pressure: 2.76 mmHg at 25°C 
Enthalpy of Vaporization: 38.31 kJ/mol
The molecular structure of  Methyl phosphonic dichloride (676-97-1) :

Methylphosphonic dichloride Toxicity Data With Reference

 

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LC50 inhalation 26ppm/4H (26ppm) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
American Industrial Hygiene Association Journal. Vol. 25, Pg. 470, 1964.

Methylphosphonic dichloride Consensus Reports

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Methylphosphonic dichloride Safety Profile

Poison by inhalation. A corrosive irritant to the eyes, skin, and mucous membranes. When heated to decomposition it emits toxic fumes of Cl and POx. See also CHLORIDES.

Hazard Codes:  T+
Risk Statements:  14-26-34
R14: Reacts violently with water
R26: Very Toxic by inhalation
R34: Causes burns 
Safety Statements:  26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR:  UN 3390 6.1/PG 1
WGK Germany:  3
F10:  Keep under argon
HazardClass:  6.1
PackingGroup:  I
RTECS:  TA1840000

Methylphosphonic dichloride Standards and Recommendations

DOT Classification:  6.1; Label: Poison, Corrosive

Methylphosphonic dichloride Specification

1.Treatment of Methyl phosphonic dichloride (676-97-1) in Wastewater,see as follows :
Total removal:                    2.60  percent
Total biodegradation:         0.09  percent
Total sludge adsorption:     1.75  percent
Total to air:                        0.76  percent
(using 10000 hr Bio P,A,S)
2.Reactivity Profile
 Methyl phosphonic dichloride (676-97-1) is incompatible with water, strong oxidizing, agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts.

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