• Name

  Mometasone furoate

• EINECS 617-501-0
• CAS No. 83919-23-7
• Article Data15
• CAS DataBase
• Density 1.37 g/cm³
• Solubility
• Melting Point 218-220°C
• Formula C₂₇H₃₀Cl₂O₆
• Boiling Point 655.5 °C at 760 mmHg
• Molecular Weight 521.438
• Flash Point 350.2 °C
• Transport Information
• Appearance Powder
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Elocon (TN);Rimelon;Ecural;9,21-Dichloro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17-(2-furoate);Nosorex;Sch 32088;[(9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate;Elocone;Mometasone furoate [USAN:JAN];Pregna-1,4-diene-3,20-dione,9,21-dichloro- 17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16- methyl-,(11a,16R)-;Danitin;Elocon;Mometasone furoate (JAN/USP);Flumeta;Nasonex;
• PSA 113.02000
• LogP 6.32690

Synthetic route

C27H31ClO7

83919-23-7

Mometasone furoate

Conditions

Conditions	Yield
With N-chloro-succinimide; sulfur dioxide In dichloromethane at 10℃; for 0.5h;	98.2%

C28H31ClO6

83919-23-7

Mometasone furoate

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In dichloromethane; water at 20 - 25℃; for 5h;	96%

9,11-epoxide mometasone furoate

83919-23-7

Mometasone furoate

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water at 5 - 25℃; for 9h; Temperature;	93.8%
With hydrogenchloride; acetic acid In water at -2 - 6℃; for 5h; Temperature;	23.22 g

C34H36O9S

83919-23-7

Mometasone furoate

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In dichloromethane at -5 - 40℃; for 13h; Concentration;	93%

83881-09-8

9,11-Epoxidemometasone furoate

83919-23-7

Mometasone furoate

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water at -5 - 5℃; for 3h;	86%
With hydrogenchloride In acetic acid for 3h; Ambient temperature;	83%
With hydrogenchloride; acetic acid In water at 0 - 5℃;	68.1 g

83880-65-3

21-chloro-16α-methyl-17α-hydroxy-1,4,9(11)-pregnatriene-3,20-dione 17-(2'-furoate)

A

83919-23-7

Mometasone furoate

B

83880-66-4

17α-hydroxy-16α-methyl-9α,11β,21-trichloro-1,4-pregnadiene-3,20-dione 17-(2'-furoate)

Conditions

Conditions	Yield
With perchloric acid; 1,3-dichloro-5,5-dimethylhydantoin In tetrahydrofuran for 4h; Ambient temperature;	A 65% B 9%

527-69-5

2-furancarbonyl chloride

83881-08-7

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

A

83919-23-7

Mometasone furoate

B

(Z)-9α,21-dichloro-20-<(2'-furanylcarbonyl)oxyl>-11β-hydroxy-16α,17β-dimethyl-18-norpregna-1,4,13,20-tetraen-3-one

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Multistep reaction;

...Expand

83881-09-8

9,11-Epoxidemometasone furoate

A

83919-23-7

Mometasone furoate

B

Furan-2-carboxylic acid (1R,2R,4S,6R,7aS)-6-chloro-1-(2-chloro-acetyl)-4-[2-(5-hydroxy-2-methyl-phenyl)-ethyl]-2,7a-dimethyl-5-oxo-octahydro-inden-1-yl ester

C

Furan-2-carboxylic acid (E)-2-chloro-1-((8S,9R,10S,11S,16R,17R)-9-chloro-11-hydroxy-10,16,17-trimethyl-3-oxo-6,7,8,9,10,11,12,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-vinyl ester

Conditions

Conditions	Yield
With hydrogenchloride In dichloromethane for 1.5h; Ambient temperature;
With hydrogenchloride In dichloromethane for 1.5h; Mechanism; Ambient temperature;

...Expand

527-69-5

2-furancarbonyl chloride

83919-23-7

Mometasone furoate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature 2: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature View Scheme

24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

83919-23-7

Mometasone furoate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 69 percent / 4-DMAP, CH3SO2Cl / CH2Cl2 / 4 h / Heating 2: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature 3: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature View Scheme
Multi-step reaction with 3 steps 1: 69 percent / 4-DMAP / CH2Cl2 / 4 h / Heating 2: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature 3: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature View Scheme

83881-08-7

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

83919-23-7

Mometasone furoate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature 2: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature View Scheme

83919-23-7

Mometasone furoate

132160-74-8

Furan-2-carboxylic acid (6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloro-acetyl)-6,11-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester

Conditions

Conditions	Yield
With selenium(IV) oxide In 1,4-dioxane at 100℃; for 39h;	73.7%

83919-23-7

Mometasone furoate

A

9,11-epoxide mometasone furoate

B

C27H27ClO5

Conditions

Conditions	Yield
With simulated lung fluid In phosphate buffer at 37℃; for 72h; pH=7.4; Kinetics; Product distribution; Further Variations:; pH-values;

83919-23-7

Mometasone furoate

134429-30-4

C27H29ClO7

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 73.7 percent / SeO2 / dioxane / 39 h / 100 °C 2: 38.5 percent / 0.01N aq. NaOH / methanol / 0.08 h / Ambient temperature View Scheme

Mometasone furoate Chemical Properties

Mometasone furoate Uses

Mometasone furoate Toxicity Data With Reference