N-(1-Naphthyl)ethylenediamine dihydrochloride supplier

Name
N-(1-Naphthyl)ethylenediamine dihydrochloride
EINECS 215-981-2
CAS No. 1465-25-4
Density
Solubility soluble in water
Melting Point 200 °C
Formula C₁₂H₁₆Cl₂N₂
Boiling Point 370.7 °C at 760 mmHg
Molecular Weight 259.178
Flash Point 209.7 °C
Transport Information
Appearance white to beige or pink powder
Safety 26-37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 1,2-Ethanediamine,N-1-naphthalenyl-, dihydrochloride (9CI);Ethylenediamine, N-1-naphthyl-, dihydrochloride(6CI,7CI,8CI);Bratton-Marshall reagent;N-1-Naphthylethylenediamine dihydrochloride;NEDA;NEDA(amine);Reagents, Bratton-Marshall;N(1-Naphthl)ethylenediamine dihydrochloride;1,2-ethanediamine, N1-1-naphthalenyl-, hydrochloride (1:2);N-(1-Naphthyl)-1,2-ethanediamine dihydrochloride;N-(1-Naphthyl)ethane-1,2-diamine dihydrochloride;N-(1-Naphthyl)ethylenediamine 2HCl;N-(1-naphthyl)-ethylenediamine dihydrochloride;
PSA 38.05000
LogP 4.58770

Synthetic route

: 383-63-1
ethyl trifluoroacetate,

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 895775-85-6
2,2,2-trifluoro-N-(2-(naphthalen-1-ylamino)ethyl)acetamide

Conditions

Conditions	Yield
With water; N-ethyl-N,N-diisopropylamine In acetonitrile Reflux;	86%

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 1077-28-7, 62-46-4
Thioctic acid

: 1151851-91-0
5-[1,2]dithiolan-3-yl-pentanoic acid [2-(naphthalene-1-ylamino)ethyl]amide

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane	85%

: 1835-49-0
tetrafluoroterephthalonitrile

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: C20H13F3N4

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Sonication;	80%

: 10025-99-7
potassium tetrachloroplatinate(II)

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 467218-94-6
((1-naphthyl)-NH2CH2CH2NH3)PtCl4

Conditions

Conditions	Yield
In water 1 equiv. of N-compd. in aq. soln. (30 °C) was added to warm (40 °C) of Pt-compd. under stirring; soln. was allowed to stand at 0 °C for 20 min, ppt. was filtered off, washed with small amt. of H2O and ether, dried in vac.;	75%

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 122-51-0
orthoformic acid triethyl ester

: C13H12N2*ClH

Conditions

Conditions	Yield
Heating;	66%

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 708-06-5
2-hydroxynaphthalene-1-carbaldehyde

: C23H20N2O

Conditions

Conditions	Yield
With acetic acid In ethanol Reflux;	65%
With acetic acid In ethanol at 85℃; for 12h;	52%

: 100-34-5
benzene diazonium chloride

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 132472-74-3
N-(4-phenylazo-[1]naphthyl)-ethylenediamine

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 87790-97-4
N-Aminoethyl-1,4-naphthylendiamin

Conditions

Conditions	Yield
With sodium sulfanilate; acetic acid; zinc 2.) 1,4-dioxane; Multistep reaction;

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

N--ethylenediamine monohydrochloride: N--ethylenediamine monohydrochloride

Conditions

Conditions	Yield
beim Erhitzen unter vermindertem Druck;

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 5'-Amino-3-methanesulfonyl-1'-methyl-4,5-dihydro-3H,1'H-[1,2']biimidazolyl-2-one

: 5'-[4-(2-amino-ethylamino)-naphthalen-1-ylazo]-3-methanesulfonyl-1'-methyl-4,5-dihydro-3H,1'H-[1,2']biimidazolyl-2-one; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Conditions

Conditions	Yield
Stage #1: 5'-Amino-3-methanesulfonyl-1'-methyl-4,5-dihydro-3H,1'H-[1,2']biimidazolyl-2-one With hydrogenchloride; sodium nitrite Stage #2: N-(1-naphthyl)ethylenediamine dihydrochloride

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 247193-74-4
2-(4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid

: 10-{[2-(naphthalen-1-ylamino)-ethylcarbamoyl]-methyl}-1,4,7,10tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h;

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: N-[2-(naphthalen-1-ylamino)-ethyl]-2-(1,4,7,10tetraaza-cyclododec-1-yl)-acetamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N; HOBt; DCC / tetrahydrofuran / 24 h / 20 °C 2: 1.0 g / HCl / methanol / 20 °C View Scheme

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 87790-99-6
6-Acetylamino-benzochinoxalin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) sulfanilic acid sodium salt, 2.) Zn, acetic acid / 2.) 1,4-dioxane 2: PDC / dimethylformamide / 0.25 h 3: pyridine View Scheme

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 87790-98-5
6-Amino-benzoquinoxaline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) sulfanilic acid sodium salt, 2.) Zn, acetic acid / 2.) 1,4-dioxane 2: PDC / dimethylformamide / 0.25 h View Scheme

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 551-09-7
N-(1-naphthyl)ethylenediamine

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane

: 22302-59-6
3-chloro-N-(naphthalen-1-yl)propanamide

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 71-36-3
butan-1-ol

: 3-[(1-naphthylamino)ethylamino]-N-(1-naphthyl)propionamide dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; potassium iodide; potassium carbonate

...Expand

: 67-56-1
methanol

: 832-89-3
2-chloro-N-(1-naphthyl)acetamide

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 71-36-3
butan-1-ol

: [2-(1-naphthylamino)ethylamino]-N-(1-naphthyl)acetamide monohydrochloride monohydrate

Conditions

Conditions	Yield
With hydrogenchloride; potassium iodide; potassium carbonate In hexane	1.5 g (39.1%)

...Expand

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 121221-07-6
3-(α-chloroacetylamino)quinoline

: 2-(1-naphthylamino)ethylamino-N-(3-quinolyl)acetamide dihydrochloride monohydrate

Conditions

Conditions	Yield
With hydrogenchloride; potassium iodide; potassium carbonate In N-methyl-acetamide

: 121221-08-7
5-(α-chloroacetylamino)quinoline

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: [2-(1-naphthylamino)ethylamino]-N-(5-quinolyl)acetamide dihydrochloride monohydrate

Conditions

Conditions	Yield
With hydrogenchloride; potassium iodide; potassium carbonate In N-methyl-acetamide	4 g (22.5%)

: 22302-58-5
2-chloro-N-(naphthalen-1-yl)propanamide

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 2-[2-(1-naphthylamino)ethylamino]-N-(1-naphthyl)propionamide monohydrate

Conditions

Conditions	Yield
With potassium iodide; potassium carbonate In acetonitrile

: 33544-33-1
N-(5-quinoxalyl)-2-chloroacetamide

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: [2-(1-naphthylamino)ethylamino]-N-(5-quinoxalyl)-acetamide dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; potassium iodide; potassium carbonate In N-methyl-acetamide

: 7623-09-8
2-chloropropionyl chloride

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: N-[(1-naphthylamino)ethyl]-2-chloropropionamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran

: 1465-25-4
N-(1-naphthyl)ethylenediamine dihydrochloride

: 501-53-1
benzyl chloroformate

: 1146411-78-0
phenylmethyl [2-(1-naphthalenylamino)ethyl]-carbamate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;

N-(1-Naphthyl)ethylenediamine dihydrochloride Consensus Reports

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-168 ,1979. . Reported in EPA TSCA Inventory.

N-(1-Naphthyl)ethylenediamine dihydrochloride Specification

The N-1-Naphthylethylene diamine dihydrochloride, with the CAS registry number 1465-25-4 and EINECS registry number 215-981-2, has the systematic name of N-(naphthalen-1-yl)ethane-1,2-diamine dihydrochloride. It is a kind of white to beige or pink powder which is light sensitive and hygroscopic. And the molecular formula of this chemical is C₁₂H₁₆Cl₂N₂.

The physical properties of N-1-Naphthylethylene diamine dihydrochloride are as followings: (1)ACD/LogP: 1.95; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.06; (4)ACD/LogD (pH 7.4): 0.14; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 4.28; (9)#H bond acceptors: 2; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 6.48 Å²; (13)Flash Point: 209.7 °C; (14)Enthalpy of Vaporization: 61.77 kJ/mol; (15)Boiling Point: 370.7 °C at 760 mmHg; (16)Vapour Pressure: 1.08E-05 mmHg at 25°C.

Preparation of N-1-Naphthylethylene diamine dihydrochloride: It can be prepared from α-bromonaphthalene and quadrol with heating and pressurization, and then salify it by adding hydrochloric acid.

N-1-Naphthylethylene diamine dihydrochloride be prepared from α-bromonaphthalene and quadrol with heating and pressurization(step1), and then salify it by adding hydrochloric acid

N-1-Naphthylethylene diamine dihydrochloride be prepared from α-bromonaphthalene and quadrol with heating and pressurization, and then salify it by adding hydrochloric acid(step2)

Uses of N-1-Naphthylethylene diamine dihydrochloride: It can be used as a reagent for the determination of sulfonamides, and visualization reagent in photometry.

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin, and it is also harmful if swallowed. Therefore, you had better take the following instructions: Wear suitable gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl.Cl.c1cccc2cccc(NCCN)c12
(2)InChI: InChI=1/C12H14N2.2ClH/c13-8-9-14-12-7-3-5-10-4-1-2-6-11(10)12;;/h1-7,14H,8-9,13H2;2*1H
(3)InChIKey: MZNYWPRCVDMOJG-UHFFFAOYAW

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	150mg/kg (150mg/kg)		National Technical Information Service. Vol. AD691-490,

Product Name

N-(1-Naphthyl)ethylenediamine dihydrochloride

Synthetic route

N-(1-Naphthyl)ethylenediamine dihydrochloride Consensus Reports

N-(1-Naphthyl)ethylenediamine dihydrochloride Specification

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