Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiry70458-92-3;149676-40-4 Pefloxacin product Name Pefloxacin Synonyms RB-1589; Pefloxacine Mesylate Dihydrate; Pefloxacine Methansulfonate Dihydr
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J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryPefloxacin CAS NO.70458-92-3Appearance:powder Storage:Dry and ventilated Package:according to customers' requirements Application:intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according t
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
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inquiryHigh qualityAppearance:White powder Storage:Room temperature Package:Aluminum bag Application:Used in producing API Transportation:By air Port:Beijing
1-methyl-piperazine
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
A
Pefloxacin
Conditions | Yield |
---|---|
In water for 13h; Heating; | A 90% B n/a |
In dimethylsulfoxide-d6 at 120 - 130℃; | A 82 % Spectr. B 18 % Spectr. |
formaldehyd
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Pefloxacin
Conditions | Yield |
---|---|
With formic acid Heating; | 85% |
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
tetra-n-butylammoniumfluoride trihydrate
Pefloxacin
Conditions | Yield |
---|---|
In water; acetonitrile | 85% |
1-methyl-piperazine
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Pefloxacin
Conditions | Yield |
---|---|
at 130 - 140℃; for 5h; | 68% |
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
methyl iodide
Pefloxacin
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 80 - 90℃; for 2h; | 30% |
1-methyl-piperazine
6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Pefloxacin
Conditions | Yield |
---|---|
Yield given. Multistep reaction; | |
In dimethyl sulfoxide at 40℃; Rate constant; or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution); |
methyl bromide
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
Pefloxacin
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 80 - 90℃; for 2h; |
Conditions | Yield |
---|---|
With sodium hydroxide 1.) DMSO, 110 deg C, 2 h; 2.) reflux, 1 h; Yield given; |
3-chloro-4-fluorophenylamine
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 100 percent / 2 h / 120 - 130 °C 2: diphenyl ether / 1 h / Heating 3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 4: 90 percent / 2N NaOH / 2 h / Heating 5: 66 percent / 5 h / 130 - 140 °C 6: 85 percent / 87percent HCOOH / Heating View Scheme | |
Multi-step reaction with 6 steps 1: 100 percent / 2 h / 120 - 130 °C 2: diphenyl ether / 1 h / Heating 3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 4: 90 percent / 2N NaOH / 2 h / Heating 5: 66 percent / 5 h / 130 - 140 °C 6: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 5 steps 1: 100 percent / 2 h / 120 - 130 °C 2: diphenyl ether / 1 h / Heating 3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 4: 90 percent / 2N NaOH / 2 h / Heating 5: 68 percent / 5 h / 130 - 140 °C View Scheme |
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 66 percent / 5 h / 130 - 140 °C 2: 85 percent / 87percent HCOOH / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 66 percent / 5 h / 130 - 140 °C 2: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C View Scheme |
1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 90 percent / 2N NaOH / 2 h / Heating 2: 66 percent / 5 h / 130 - 140 °C 3: 85 percent / 87percent HCOOH / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 90 percent / 2N NaOH / 2 h / Heating 2: 66 percent / 5 h / 130 - 140 °C 3: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 2 steps 1: 90 percent / 2N NaOH / 2 h / Heating 2: 68 percent / 5 h / 130 - 140 °C View Scheme |
ethyl 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2N NaOH / 2 h / Heating 2: 85 percent / 87percent HCOOH / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 2N NaOH / 2 h / Heating 2: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C View Scheme |
diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: diphenyl ether / 1 h / Heating 2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 3: 90 percent / 2N NaOH / 2 h / Heating 4: 66 percent / 5 h / 130 - 140 °C 5: 85 percent / 87percent HCOOH / Heating View Scheme | |
Multi-step reaction with 5 steps 1: diphenyl ether / 1 h / Heating 2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 3: 90 percent / 2N NaOH / 2 h / Heating 4: 66 percent / 5 h / 130 - 140 °C 5: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 4 steps 1: diphenyl ether / 1 h / Heating 2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 3: 90 percent / 2N NaOH / 2 h / Heating 4: 68 percent / 5 h / 130 - 140 °C View Scheme |
7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 2: 90 percent / 2N NaOH / 2 h / Heating 3: 66 percent / 5 h / 130 - 140 °C 4: 85 percent / 87percent HCOOH / Heating View Scheme | |
Multi-step reaction with 4 steps 1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 2: 90 percent / 2N NaOH / 2 h / Heating 3: 66 percent / 5 h / 130 - 140 °C 4: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C View Scheme | |
Multi-step reaction with 3 steps 1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C 2: 90 percent / 2N NaOH / 2 h / Heating 3: 68 percent / 5 h / 130 - 140 °C View Scheme |
6-Fluoro-4-hydroxy-7-piperazin-1-yl-quinoline-3-carboxylic acid ethyl ester
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: K2CO3 / dimethylformamide / 2 h / 60 - 90 °C 2: 2N NaOH / 2 h / Heating 3: 85 percent / 87percent HCOOH / Heating View Scheme | |
Multi-step reaction with 3 steps 1: K2CO3 / dimethylformamide / 2 h / 60 - 90 °C 2: 2N NaOH / 2 h / Heating 3: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C View Scheme |
N-ethyl-3,4-difluoroaniline
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 62 percent / 0.5 h / 90 - 100 °C 2: 71 percent / PPA / toluene / 0.58 h / 100 °C 3: dimethylsulfoxide / 40 °C / or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution) View Scheme |
N-(3,4-Difluorphenyl)-N-ethyl-formamid
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 77 percent / conc. HCl / H2O / 2 h / Heating 2: 62 percent / 0.5 h / 90 - 100 °C 3: 71 percent / PPA / toluene / 0.58 h / 100 °C 4: dimethylsulfoxide / 40 °C / or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution) View Scheme |
N-(3,4-Difluorphenyl)-N-ethyl-aminomethylen-meldrumsaeure
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 71 percent / PPA / toluene / 0.58 h / 100 °C 2: dimethylsulfoxide / 40 °C / or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution) View Scheme |
3,4-difluoroaniline
Pefloxacin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 72.5 percent / conc. H2SO4 / 1.5 h / 175 °C 2: 77 percent / conc. HCl / H2O / 2 h / Heating 3: 62 percent / 0.5 h / 90 - 100 °C 4: 71 percent / PPA / toluene / 0.58 h / 100 °C 5: dimethylsulfoxide / 40 °C / or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution) View Scheme |
1-methyl-piperazine
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
pyrographite
Pefloxacin
Conditions | Yield |
---|---|
In acetic acid; dimethyl sulfoxide |
Pefloxacin
Conditions | Yield |
---|---|
With ammonia In water |
Conditions | Yield |
---|---|
In methanol for 24h; Reflux; | 91% |
Conditions | Yield |
---|---|
In methanol for 24h; Reflux; | 86% |
Conditions | Yield |
---|---|
Stage #1: Pefloxacin With potassium hydroxide In methanol for 0.5h; Stage #2: methanol; 1,10-Phenanthroline; copper(II) choride dihydrate for 0.333333h; | 85% |
Pefloxacin
1,1'-carbonyldiimidazole
Conditions | Yield |
---|---|
In acetonitrile Solvent; Reflux; | 83.5% |
hydrogen bromide
Pefloxacin
pefloxancindium tetrabromidozincate
Conditions | Yield |
---|---|
In hydrogen bromide aq. HBr; pefloxacin dissolved in 6 M HBr; ZnO was slowly added to molar ratio Zn:pefloxacin = 2:1; solvent evapd.; crystals were obtained; elem. anal.; | 83% |
Conditions | Yield |
---|---|
In methanol for 24h; Reflux; | 82% |
Conditions | Yield |
---|---|
In methanol for 24h; Reflux; | 80% |
Pefloxacin
1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-2,3-dihydroquinolin-4(1Η)-one
Conditions | Yield |
---|---|
With sodium tetrahydroborate; toluene-4-sulfonic acid In methanol at 65℃; for 0.5h; | 76.2% |
Stage #1: Pefloxacin With methanol; sodium tetrahydroborate at 0℃; for 1h; Stage #2: With toluene-4-sulfonic acid at 60 - 65℃; for 0.5h; | 76.3% |
vanadium(IV) fluoride
Pefloxacin
Conditions | Yield |
---|---|
In methanol methanolic soln. of VF4 added to methanolic soln. of C17H22O3N3F dropwise with stirring, mixt. had pH 3, refluxed for 2 h, kept overnight with stirring at room temp.; solvent removed on a rotary apparatus under reduced pressure; recrystn. (MeOH/n-hexane, 1/1); elem. anal.; | 76% |
Conditions | Yield |
---|---|
Stage #1: Pefloxacin With potassium hydroxide In methanol for 0.5h; Stage #2: methanol; copper(II) choride dihydrate for 0.5h; | 75% |
Conditions | Yield |
---|---|
Stage #1: Pefloxacin With potassium hydroxide In methanol for 0.5h; Stage #2: methanol; [2,2]bipyridinyl; copper(II) choride dihydrate for 0.333333h; | 75% |
Conditions | Yield |
---|---|
In methanol for 24h; Reflux; | 74% |
Conditions | Yield |
---|---|
With sulfuric acid for 12h; Reflux; | 73% |
di(pyridin-2-yl)amine
Pefloxacin
Conditions | Yield |
---|---|
Stage #1: Pefloxacin With potassium hydroxide In methanol for 0.5h; Stage #2: di(pyridin-2-yl)amine; copper(II) choride dihydrate In methanol for 0.333333h; | 70% |
Conditions | Yield |
---|---|
With CH3ONa In methanol CH3OH soln. of Cu salt added to CH3OH soln. of bipyridyl amine (1:1), treated with 1 equiv. of levofloxacin in CH3OH, pH adjusted to 6.2 (CH3ONa), refluxed for 1 h; concd., washed (cold CH3OH, ether), dried (vac.), elem. anal.; | 68% |
Conditions | Yield |
---|---|
With CH3ONa In methanol CH3OH soln. of Cu salt added to CH3OH soln. of bipyridyl amine (1:1), treated with 1 equiv. of pefloxacin in CH3OH, pH adjusted to 6.2 (CH3ONa),refluxed for 1 h; concd., washed (cold CH3OH, ether), dried (vac.), elem. anal.; | 63% |
water
Pefloxacin
Conditions | Yield |
---|---|
With sodium methylate In methanol for 3h; pH=Ca. 6.8; Reflux; | 61.2% |
[tris(triphenylphosphine) ruthenium(III) trichloride]
Pefloxacin
Conditions | Yield |
---|---|
With sodium methylate In methanol; toluene Reflux; | 57.9% |
Pefloxacin
3-(diphenylphosphino)propionic acid
Conditions | Yield |
---|---|
In methanol for 10h; pH=Ca. 6.8; Reflux; | 57.32% |
[tris(triphenylphosphine) ruthenium(III) trichloride]
Pefloxacin
Conditions | Yield |
---|---|
With sodium methylate; triethylamine; lithium chloride In methanol; toluene Reflux; | 53.8% |
Conditions | Yield |
---|---|
In water at 80℃; | 53% |
Pefloxacin
3-(diphenylphosphino)propionic acid
Conditions | Yield |
---|---|
With sodium methylate In methanol for 3h; pH=Ca. 6.8; Reflux; | 52.3% |
Conditions | Yield |
---|---|
With water at 80℃; | 43% |
3-(1-amino-5-mercapto-1H-[1,3,4]triazol-2-yl)-1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4(1H)quinolinone
Pefloxacin
Conditions | Yield |
---|---|
With dmap; trichlorophosphate at 20℃; Reflux; | 34% |
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