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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Pefloxacin Manufacturer/High quality/Best price/In stock

Cas:70458-92-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Pefloxacin mesylate Cas 70458-92-3 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Package:1kg/foil bag, 25kg/drum or as you require

Hot selling high quality Pefloxacin mesylate Cas 70458-92-3 with top purity low price

Cas:70458-92-3

Min.Order:1 Kilogram

FOB Price: $205.0

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Pefloxacin 70458-92-3 GMP Manufacturer

Cas:70458-92-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Pefloxacin

Cas:70458-92-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c

Pefloxacin CAS:70458-92-3

Cas:70458-92-3

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 70458-92-3 with best quality

Cas:70458-92-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

70458-92-3;149676-40-4 Pefloxacin product Name Pefloxacin Synonyms RB-1589; Pefloxacine Mesylate Dihydrate; Pefloxacine Methansulfonate Dihydr

Pefloxacin;Pefloxacine Mesylate Dihydrate

Cas:70458-92-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Pefloxacin 70458-92-3

Cas:70458-92-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Pefloxacin CAS:70458-92-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Pefloxacin CAS:70458-92-3

Cas:70458-92-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Pefloxacin

Cas:70458-92-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Pefloxacin

Cas:70458-92-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Pefloxacin;Pefloxacine Mesylate Dihydrate

Cas:70458-92-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

Pefloxacin CAS NO.70458-92-3Appearance:powder Storage:Dry and ventilated Package:according to customers' requirements Application:intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according t

Pefloxacin CAS NO.70458-92-3

Cas:70458-92-3

Min.Order:1 Gram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:antibacterial;DNA gyrase inhibitor Transportation:BY AIR Port:S

Pefloxacin

Cas:70458-92-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Pefloxacin

Cas:70458-92-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Pefloxacin

Cas:70458-92-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Pefloxacin

Cas:70458-92-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Other

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Manufacturers

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Other

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

99% up by HPLC Pefloxacin 70458-92-3

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

BOC Sciences

GMP factory Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Api, inhibitor, and fine chemicals for more

Pefloxacin Mesylate cas 70458-92-3

Cas:70458-92-3

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

High qualityAppearance:White powder Storage:Room temperature Package:Aluminum bag Application:Used in producing API Transportation:By air Port:Beijing

Pefloxacin

Cas:70458-92-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

1-methyl-piperazine
109-01-3

1-methyl-piperazine

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
68077-26-9

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

A

Pefloxacin
70458-92-3

Pefloxacin

B

7-Chloro-1-ethyl-6-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-Chloro-1-ethyl-6-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions
ConditionsYield
In water for 13h; Heating;A 90%
B n/a
In dimethylsulfoxide-d6 at 120 - 130℃;A 82 % Spectr.
B 18 % Spectr.
formaldehyd
50-00-0

formaldehyd

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
With formic acid Heating;85%
4-(t-butyldimethylsilyl)-1-methyl piperazine

4-(t-butyldimethylsilyl)-1-methyl piperazine

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
68077-26-9

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

tetra-n-butylammoniumfluoride trihydrate
22206-57-1

tetra-n-butylammoniumfluoride trihydrate

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
In water; acetonitrile85%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
68077-26-9

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
at 130 - 140℃; for 5h;68%
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

methyl iodide
74-88-4

methyl iodide

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 80 - 90℃; for 2h;30%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
70032-25-6

6,7-difluoro-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Yield given. Multistep reaction;
In dimethyl sulfoxide at 40℃; Rate constant; or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution);
methyl bromide
74-83-9

methyl bromide

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 80 - 90℃; for 2h;
1-methyl-piperazine
109-01-3

1-methyl-piperazine

C16H14BClFNO7

C16H14BClFNO7

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
With sodium hydroxide 1.) DMSO, 110 deg C, 2 h; 2.) reflux, 1 h; Yield given;
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 100 percent / 2 h / 120 - 130 °C
2: diphenyl ether / 1 h / Heating
3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
4: 90 percent / 2N NaOH / 2 h / Heating
5: 66 percent / 5 h / 130 - 140 °C
6: 85 percent / 87percent HCOOH / Heating
View Scheme
Multi-step reaction with 6 steps
1: 100 percent / 2 h / 120 - 130 °C
2: diphenyl ether / 1 h / Heating
3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
4: 90 percent / 2N NaOH / 2 h / Heating
5: 66 percent / 5 h / 130 - 140 °C
6: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1: 100 percent / 2 h / 120 - 130 °C
2: diphenyl ether / 1 h / Heating
3: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
4: 90 percent / 2N NaOH / 2 h / Heating
5: 68 percent / 5 h / 130 - 140 °C
View Scheme
7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
68077-26-9

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 66 percent / 5 h / 130 - 140 °C
2: 85 percent / 87percent HCOOH / Heating
View Scheme
Multi-step reaction with 2 steps
1: 66 percent / 5 h / 130 - 140 °C
2: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester
70458-94-5

1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / 2N NaOH / 2 h / Heating
2: 66 percent / 5 h / 130 - 140 °C
3: 85 percent / 87percent HCOOH / Heating
View Scheme
Multi-step reaction with 3 steps
1: 90 percent / 2N NaOH / 2 h / Heating
2: 66 percent / 5 h / 130 - 140 °C
3: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1: 90 percent / 2N NaOH / 2 h / Heating
2: 68 percent / 5 h / 130 - 140 °C
View Scheme
ethyl 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate
74011-47-5

ethyl 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2N NaOH / 2 h / Heating
2: 85 percent / 87percent HCOOH / Heating
View Scheme
Multi-step reaction with 2 steps
1: 2N NaOH / 2 h / Heating
2: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate
70032-30-3

diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: diphenyl ether / 1 h / Heating
2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
3: 90 percent / 2N NaOH / 2 h / Heating
4: 66 percent / 5 h / 130 - 140 °C
5: 85 percent / 87percent HCOOH / Heating
View Scheme
Multi-step reaction with 5 steps
1: diphenyl ether / 1 h / Heating
2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
3: 90 percent / 2N NaOH / 2 h / Heating
4: 66 percent / 5 h / 130 - 140 °C
5: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
Multi-step reaction with 4 steps
1: diphenyl ether / 1 h / Heating
2: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
3: 90 percent / 2N NaOH / 2 h / Heating
4: 68 percent / 5 h / 130 - 140 °C
View Scheme
7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester
70458-93-4

7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
2: 90 percent / 2N NaOH / 2 h / Heating
3: 66 percent / 5 h / 130 - 140 °C
4: 85 percent / 87percent HCOOH / Heating
View Scheme
Multi-step reaction with 4 steps
1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
2: 90 percent / 2N NaOH / 2 h / Heating
3: 66 percent / 5 h / 130 - 140 °C
4: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
Multi-step reaction with 3 steps
1: 90 percent / K2CO3 / dimethylformamide / 10 h / 80 - 90 °C
2: 90 percent / 2N NaOH / 2 h / Heating
3: 68 percent / 5 h / 130 - 140 °C
View Scheme
6-Fluoro-4-hydroxy-7-piperazin-1-yl-quinoline-3-carboxylic acid ethyl ester
75001-56-8

6-Fluoro-4-hydroxy-7-piperazin-1-yl-quinoline-3-carboxylic acid ethyl ester

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: K2CO3 / dimethylformamide / 2 h / 60 - 90 °C
2: 2N NaOH / 2 h / Heating
3: 85 percent / 87percent HCOOH / Heating
View Scheme
Multi-step reaction with 3 steps
1: K2CO3 / dimethylformamide / 2 h / 60 - 90 °C
2: 2N NaOH / 2 h / Heating
3: 30 percent / Et3N / dimethylformamide / 2 h / 80 - 90 °C
View Scheme
N-ethyl-3,4-difluoroaniline
136491-15-1

N-ethyl-3,4-difluoroaniline

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 62 percent / 0.5 h / 90 - 100 °C
2: 71 percent / PPA / toluene / 0.58 h / 100 °C
3: dimethylsulfoxide / 40 °C / or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution)
View Scheme
N-(3,4-Difluorphenyl)-N-ethyl-formamid
136491-16-2

N-(3,4-Difluorphenyl)-N-ethyl-formamid

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 77 percent / conc. HCl / H2O / 2 h / Heating
2: 62 percent / 0.5 h / 90 - 100 °C
3: 71 percent / PPA / toluene / 0.58 h / 100 °C
4: dimethylsulfoxide / 40 °C / or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution)
View Scheme
N-(3,4-Difluorphenyl)-N-ethyl-aminomethylen-meldrumsaeure
136491-17-3

N-(3,4-Difluorphenyl)-N-ethyl-aminomethylen-meldrumsaeure

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 71 percent / PPA / toluene / 0.58 h / 100 °C
2: dimethylsulfoxide / 40 °C / or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution)
View Scheme
3,4-difluoroaniline
3863-11-4

3,4-difluoroaniline

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 72.5 percent / conc. H2SO4 / 1.5 h / 175 °C
2: 77 percent / conc. HCl / H2O / 2 h / Heating
3: 62 percent / 0.5 h / 90 - 100 °C
4: 71 percent / PPA / toluene / 0.58 h / 100 °C
5: dimethylsulfoxide / 40 °C / or over the mixed anhydrides with BF3 or BBr3 (facilitate the aromatic substitution)
View Scheme
1-methyl-piperazine
109-01-3

1-methyl-piperazine

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
68077-26-9

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

pyrographite
7440-44-0

pyrographite

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
In acetic acid; dimethyl sulfoxide
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)-3-quinolinecarboxylic acid methanesulfonate dihydrate

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methyl-1-piperazinyl)-3-quinolinecarboxylic acid methanesulfonate dihydrate

Pefloxacin
70458-92-3

Pefloxacin

Conditions
ConditionsYield
With ammonia In water
RuCl2*3H2O

RuCl2*3H2O

water
7732-18-5

water

Pefloxacin
70458-92-3

Pefloxacin

[Ru(PEF)Cl2(H2O)2]*5H2O

[Ru(PEF)Cl2(H2O)2]*5H2O

Conditions
ConditionsYield
In methanol for 24h; Reflux;91%
iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

water
7732-18-5

water

Pefloxacin
70458-92-3

Pefloxacin

[Fe(PEF)Cl2(H2O)2]*5H2O

[Fe(PEF)Cl2(H2O)2]*5H2O

Conditions
ConditionsYield
In methanol for 24h; Reflux;86%
methanol
67-56-1

methanol

1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

copper(II) choride dihydrate

copper(II) choride dihydrate

Pefloxacin
70458-92-3

Pefloxacin

C29H27ClCuFN5O3*CH4O*2H2O

C29H27ClCuFN5O3*CH4O*2H2O

Conditions
ConditionsYield
Stage #1: Pefloxacin With potassium hydroxide In methanol for 0.5h;
Stage #2: methanol; 1,10-Phenanthroline; copper(II) choride dihydrate for 0.333333h;
85%
Pefloxacin
70458-92-3

Pefloxacin

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-3-(1H-imidazole-1-formyl)quinoline-4(1H)-one

1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-3-(1H-imidazole-1-formyl)quinoline-4(1H)-one

Conditions
ConditionsYield
In acetonitrile Solvent; Reflux;83.5%
hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

Pefloxacin
70458-92-3

Pefloxacin

zinc(II) oxide

zinc(II) oxide

pefloxancindium tetrabromidozincate
1368704-55-5

pefloxancindium tetrabromidozincate

Conditions
ConditionsYield
In hydrogen bromide aq. HBr; pefloxacin dissolved in 6 M HBr; ZnO was slowly added to molar ratio Zn:pefloxacin = 2:1; solvent evapd.; crystals were obtained; elem. anal.;83%
water
7732-18-5

water

Pefloxacin
70458-92-3

Pefloxacin

zinc(II) chloride
7646-85-7

zinc(II) chloride

[Zn(PEF)Cl(H2O)]

[Zn(PEF)Cl(H2O)]

Conditions
ConditionsYield
In methanol for 24h; Reflux;82%
copper(II) chloride hydrate

copper(II) chloride hydrate

water
7732-18-5

water

Pefloxacin
70458-92-3

Pefloxacin

[Cu(PEF)2]*4H2O

[Cu(PEF)2]*4H2O

Conditions
ConditionsYield
In methanol for 24h; Reflux;80%
Pefloxacin
70458-92-3

Pefloxacin

1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-2,3-dihydroquinolin-4(1Η)-one
110719-52-3

1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-2,3-dihydroquinolin-4(1Η)-one

Conditions
ConditionsYield
With sodium tetrahydroborate; toluene-4-sulfonic acid In methanol at 65℃; for 0.5h;76.2%
Stage #1: Pefloxacin With methanol; sodium tetrahydroborate at 0℃; for 1h;
Stage #2: With toluene-4-sulfonic acid at 60 - 65℃; for 0.5h;
76.3%
vanadium(IV) fluoride
10049-16-8

vanadium(IV) fluoride

Pefloxacin
70458-92-3

Pefloxacin

difluorovanadium(IV) di(1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinoline carboxylate)

difluorovanadium(IV) di(1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinoline carboxylate)

Conditions
ConditionsYield
In methanol methanolic soln. of VF4 added to methanolic soln. of C17H22O3N3F dropwise with stirring, mixt. had pH 3, refluxed for 2 h, kept overnight with stirring at room temp.; solvent removed on a rotary apparatus under reduced pressure; recrystn. (MeOH/n-hexane, 1/1); elem. anal.;76%
methanol
67-56-1

methanol

copper(II) choride dihydrate

copper(II) choride dihydrate

Pefloxacin
70458-92-3

Pefloxacin

C35H42CuF2N6O7

C35H42CuF2N6O7

Conditions
ConditionsYield
Stage #1: Pefloxacin With potassium hydroxide In methanol for 0.5h;
Stage #2: methanol; copper(II) choride dihydrate for 0.5h;
75%
methanol
67-56-1

methanol

[2,2]bipyridinyl
366-18-7

[2,2]bipyridinyl

copper(II) choride dihydrate

copper(II) choride dihydrate

Pefloxacin
70458-92-3

Pefloxacin

C27H27ClCuFN5O3*0.5CH4O*4H2O

C27H27ClCuFN5O3*0.5CH4O*4H2O

Conditions
ConditionsYield
Stage #1: Pefloxacin With potassium hydroxide In methanol for 0.5h;
Stage #2: methanol; [2,2]bipyridinyl; copper(II) choride dihydrate for 0.333333h;
75%
K2PtCl4

K2PtCl4

water
7732-18-5

water

Pefloxacin
70458-92-3

Pefloxacin

[Pt(PEF)Cl(H2O)]*3H2O

[Pt(PEF)Cl(H2O)]*3H2O

Conditions
ConditionsYield
In methanol for 24h; Reflux;74%
methanol
67-56-1

methanol

Pefloxacin
70458-92-3

Pefloxacin

pefloxacin

pefloxacin

Conditions
ConditionsYield
With sulfuric acid for 12h; Reflux;73%
di(pyridin-2-yl)amine
1202-34-2

di(pyridin-2-yl)amine

copper(II) choride dihydrate

copper(II) choride dihydrate

Pefloxacin
70458-92-3

Pefloxacin

C27H28ClCuFN6O3*2H2O

C27H28ClCuFN6O3*2H2O

Conditions
ConditionsYield
Stage #1: Pefloxacin With potassium hydroxide In methanol for 0.5h;
Stage #2: di(pyridin-2-yl)amine; copper(II) choride dihydrate In methanol for 0.333333h;
70%
copper(II) choride dihydrate

copper(II) choride dihydrate

water
7732-18-5

water

levofloxacin
100986-85-4

levofloxacin

Pefloxacin
70458-92-3

Pefloxacin

(levofloxacin)(bipyridyl amine)CuCl2*5H2O

(levofloxacin)(bipyridyl amine)CuCl2*5H2O

Conditions
ConditionsYield
With CH3ONa In methanol CH3OH soln. of Cu salt added to CH3OH soln. of bipyridyl amine (1:1), treated with 1 equiv. of levofloxacin in CH3OH, pH adjusted to 6.2 (CH3ONa), refluxed for 1 h; concd., washed (cold CH3OH, ether), dried (vac.), elem. anal.;68%
di(pyridin-2-yl)amine
1202-34-2

di(pyridin-2-yl)amine

copper(II) choride dihydrate

copper(II) choride dihydrate

water
7732-18-5

water

Pefloxacin
70458-92-3

Pefloxacin

pefloxaci

pefloxaci

Conditions
ConditionsYield
With CH3ONa In methanol CH3OH soln. of Cu salt added to CH3OH soln. of bipyridyl amine (1:1), treated with 1 equiv. of pefloxacin in CH3OH, pH adjusted to 6.2 (CH3ONa),refluxed for 1 h; concd., washed (cold CH3OH, ether), dried (vac.), elem. anal.;63%
copper(II) choride dihydrate

copper(II) choride dihydrate

C9H6ClN3OS2

C9H6ClN3OS2

water
7732-18-5

water

Pefloxacin
70458-92-3

Pefloxacin

C26H24ClCuFN6O4S2*H2O

C26H24ClCuFN6O4S2*H2O

Conditions
ConditionsYield
With sodium methylate In methanol for 3h; pH=Ca. 6.8; Reflux;61.2%
[tris(triphenylphosphine) ruthenium(III) trichloride]
30050-39-6, 23311-38-8

[tris(triphenylphosphine) ruthenium(III) trichloride]

Pefloxacin
70458-92-3

Pefloxacin

[Ru(pefloxacin-(1H))(PPh3)2Cl2]

[Ru(pefloxacin-(1H))(PPh3)2Cl2]

Conditions
ConditionsYield
With sodium methylate In methanol; toluene Reflux;57.9%
oxovanadium(IV) sulfate

oxovanadium(IV) sulfate

Pefloxacin
70458-92-3

Pefloxacin

3-(diphenylphosphino)propionic acid
2848-01-3

3-(diphenylphosphino)propionic acid

C30H29FN3O6PV

C30H29FN3O6PV

Conditions
ConditionsYield
In methanol for 10h; pH=Ca. 6.8; Reflux;57.32%
[tris(triphenylphosphine) ruthenium(III) trichloride]
30050-39-6, 23311-38-8

[tris(triphenylphosphine) ruthenium(III) trichloride]

Pefloxacin
70458-92-3

Pefloxacin

[Ru(pefloxacin-(1H))(PPh3)3Cl]

[Ru(pefloxacin-(1H))(PPh3)3Cl]

Conditions
ConditionsYield
With sodium methylate; triethylamine; lithium chloride In methanol; toluene Reflux;53.8%
4,6-dihydroxy-2-mercaptopyrimidine
504-17-6

4,6-dihydroxy-2-mercaptopyrimidine

Pefloxacin
70458-92-3

Pefloxacin

pefloxacinium 2-thiobarbiturate

pefloxacinium 2-thiobarbiturate

Conditions
ConditionsYield
In water at 80℃;53%
copper(II) choride dihydrate

copper(II) choride dihydrate

Pefloxacin
70458-92-3

Pefloxacin

3-(diphenylphosphino)propionic acid
2848-01-3

3-(diphenylphosphino)propionic acid

C32H33CuFN3O5P*H2O

C32H33CuFN3O5P*H2O

Conditions
ConditionsYield
With sodium methylate In methanol for 3h; pH=Ca. 6.8; Reflux;52.3%
BARBITURIC ACID
67-52-7

BARBITURIC ACID

Pefloxacin
70458-92-3

Pefloxacin

bis(pefloxacinium 2-thiobarbiturate) hydrate

bis(pefloxacinium 2-thiobarbiturate) hydrate

Conditions
ConditionsYield
With water at 80℃;43%
3-(1-amino-5-mercapto-1H-[1,3,4]triazol-2-yl)-1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4(1H)quinolinone
1215036-45-5

3-(1-amino-5-mercapto-1H-[1,3,4]triazol-2-yl)-1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4(1H)quinolinone

Pefloxacin
70458-92-3

Pefloxacin

C37H40F2N10O2S*2ClH

C37H40F2N10O2S*2ClH

Conditions
ConditionsYield
With dmap; trichlorophosphate at 20℃; Reflux;34%

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