Product Details Overview Quick Details Pro Name;Ruxolitinib free base CAS NO:941678-49-5 Purity:high purity Application: API Appearance:normal MF: C17H18N6 Place of Origin: Jiangsu China Package & Delivery Time package D
Cas:941678-49-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryQianyu Unique advantages of high purity CAS941678-49-5 Ruxolitinib Our Advantages A. International Top level Technology Our company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the f
Cas:941678-49-5
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryLower price, sample is available,large stock in warehouse.Best service, high quality and reasonable price.If you are looking for the material's manufacturer or supplier in China, Sibian chemical is your best choice. Storage:Sealed drying(25℃) Pa
Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:941678-49-5
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryItems Standard Result Assay (Ursolic acid) 98%min -------------------------------------------------------------------------------
Cas:941678-49-5
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryDescription Ruxolitinib (INCB018424) is a JAK inhibitor of JAK1 (IC50 = 2.7 nM), JAK2 (IC50 = 4.5 nM), and JAK3 (IC50 = 322 nM). JAKs, or Janus-associated kinases, are tyrosine k
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:941678-49-5
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryRuxolitinib CAS No.:941678-49-5 Name: Ruxolitinib Synonyms: INCB-018424; (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile Molecular Structure Molecular Formula
Cas:941678-49-5
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience 2. Free samples will be provided,ensure specifications and quality are right for customer 3. Customers will receive the most professional techn
Cas:941678-49-5
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:941678-49-5
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:941678-49-5
Min.Order:1 Kilogram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:941678-49-5
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
Cas:941678-49-5
Min.Order:1 Kilogram
FOB Price: $7.0 / 10.0
Type:Trading Company
inquiryName: Ruxolitinib Synonyms: (betar)-beta-cyclopentyl-4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazole-1-propanenitrile CAS:941678-49-5 MF: C17H18N6 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kg
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:941678-49-5
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:941678-49-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:941678-49-5
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:941678-49-5
Min.Order:1 Gram
FOB Price: $1.0 / 5.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:941678-49-5
Min.Order:1 Gram
FOB Price: $789.0 / 864.0
Type:Trading Company
inquiryRuxolitinib CAS:941678-49-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:941678-49-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:941678-49-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Superiority We can customize and synthesize products that other suppliers may not be able to provide. 1. best service, high quality and reasonable way for his produccts from many recent effective packing way.best s
Cas:941678-49-5
Min.Order:100 Kilogram
Negotiable
Type:Trading Company
inquiryAppearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda
Cas:941678-49-5
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryQ1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo
Cas:941678-49-5
Min.Order:0
Negotiable
Type:Trading Company
inquiry(R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
ruxolitinib
Conditions | Yield |
---|---|
With water; sodium hydroxide In methanol at 20℃; Product distribution / selectivity; | 100% |
With sodium hydroxide; water In methanol at 20℃; for 15h; |
(3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
ruxolitinib
Conditions | Yield |
---|---|
Stage #1: (3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile With boron trifluoride diethyl etherate In acetonitrile at 60 - 70℃; for 5h; Stage #2: With ammonium hydroxide; water In acetonitrile at 20℃; for 12h; | 92.1% |
Stage #1: (3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile With lithium tetrafluoroborate; water In acetonitrile Inert atmosphere; Reflux; Stage #2: With ammonia; water at 5 - 20℃; pH=9 - 10; Inert atmosphere; optical yield given as %ee; | 84% |
With trifluoroacetic acid In dichloromethane for 6h; | 58% |
ruxolitinib
Conditions | Yield |
---|---|
With trichlorophosphate In 1-methyl-pyrrolidin-2-one; dichloromethane at 20 - 30℃; for 3h; | 77.3% |
(3R)-3-cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile
4-chloro-1H-pyrrolo[2,3-d]pyrimidine
ruxolitinib
Conditions | Yield |
---|---|
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 20 - 95℃; Product distribution / selectivity; Inert atmosphere; | 64.3% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 100℃; for 21h; Suzuki coupling; Inert atmosphere; | |
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,4-dioxane; water at 120℃; for 24h; Inert atmosphere; | 0.84 g |
ruxolitinib
Conditions | Yield |
---|---|
With trifluoroacetic acid; trifluoroacetic anhydride In toluene at 100℃; for 1h; | 61% |
(3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
A
ruxolitinib
B
C18H20N6O
Conditions | Yield |
---|---|
With lithium tetrafluoroborate; water In acetonitrile Inert atmosphere; Reflux; | |
With lithium tetrafluoroborate; water In acetonitrile at 12 - 80℃; |
(R)-3-(4-bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanecarbonitrile
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 24 h / 20 - 90 °C / Inert atmosphere 2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 24 h / 120 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -15 - 5 °C / Inert atmosphere 1.2: -5 - 5 °C / Inert atmosphere 2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 50 - 60 °C / Inert atmosphere 3.1: hydrogenchloride / tetrahydrofuran; water / 20 °C / Reflux View Scheme |
C18H20N6O
ruxolitinib
Conditions | Yield |
---|---|
With ammonia; water In acetonitrile at 0 - 20℃; Product distribution / selectivity; | n/a |
4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C 2: ethanol; hexane / Resolution of racemate 3: trifluoroacetic acid / dichloromethane / 6 h View Scheme | |
Multi-step reaction with 3 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C 2: Resolution of racemate 3: trifluoroacetic acid / dichloromethane / 6 h View Scheme | |
Multi-step reaction with 4 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 26 h / 60 - 80 °C / Inert atmosphere 2: acetonitrile; tetrahydrofuran; acetone / 50 - 80 °C / Large scale 3: sodium hydroxide / ethyl acetate; water / 0 °C 4: lithium tetrafluoroborate / acetonitrile; water / 11 h / 0.8 - 27 °C View Scheme |
3-cyclopentaneacrylonitrile
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C 2: ethanol; hexane / Resolution of racemate 3: trifluoroacetic acid / dichloromethane / 6 h View Scheme | |
Multi-step reaction with 3 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C 2: Resolution of racemate 3: trifluoroacetic acid / dichloromethane / 6 h View Scheme | |
Multi-step reaction with 4 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 26 h / 60 - 80 °C / Inert atmosphere 2: acetonitrile; tetrahydrofuran; acetone / 50 - 80 °C / Large scale 3: sodium hydroxide / ethyl acetate; water / 0 °C 4: lithium tetrafluoroborate / acetonitrile; water / 11 h / 0.8 - 27 °C View Scheme |
3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol; hexane / Resolution of racemate 2: trifluoroacetic acid / dichloromethane / 6 h View Scheme | |
Multi-step reaction with 2 steps 1: Resolution of racemate 2: trifluoroacetic acid / dichloromethane / 6 h View Scheme | |
Multi-step reaction with 3 steps 1: acetonitrile; tetrahydrofuran; acetone / 50 - 80 °C / Large scale 2: sodium hydroxide / ethyl acetate; water / 0 °C 3: lithium tetrafluoroborate / acetonitrile; water / 11 h / 0.8 - 27 °C View Scheme |
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 2.5 h / 0 - 20 °C 1.2: 2 h / 0 - 20 °C 2.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 1.75 h / 20 °C 3.1: ammonium hydroxide; iodine / tetrahydrofuran; water / 0.5 h / 20 °C / Darkness 4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 24 h / 20 - 90 °C / Inert atmosphere 5.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 24 h / 120 °C / Inert atmosphere View Scheme |
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 1.75 h / 20 °C 2: ammonium hydroxide; iodine / tetrahydrofuran; water / 0.5 h / 20 °C / Darkness 3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 24 h / 20 - 90 °C / Inert atmosphere 4: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 24 h / 120 °C / Inert atmosphere View Scheme |
(3R)-3-(4-bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanal
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonium hydroxide; iodine / tetrahydrofuran; water / 0.5 h / 20 °C / Darkness 2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 24 h / 20 - 90 °C / Inert atmosphere 3: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 24 h / 120 °C / Inert atmosphere View Scheme |
cyclopentylallene
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; JoSPOPhos SL-J688-2; pyridinium p-toluenesulfonate / toluene / 16 h / 80 °C / Inert atmosphere; Schlenk technique; Sealed tube 2.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 2.5 h / 0 - 20 °C 2.2: 2 h / 0 - 20 °C 3.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 1.75 h / 20 °C 4.1: ammonium hydroxide; iodine / tetrahydrofuran; water / 0.5 h / 20 °C / Darkness 5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / dimethyl sulfoxide / 24 h / 20 - 90 °C / Inert atmosphere 6.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 24 h / 120 °C / Inert atmosphere View Scheme |
cyclopentanealdehyde
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: potassium tert-butylate / tetrahydrofuran / 0 °C / Inert atmosphere 1.2: 0 - 30 °C / Inert atmosphere 2.1: acetonitrile / 30 °C 3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 30 °C 4.1: (1S,2R)-1-amino-2-indanol / isopropyl alcohol / 20 °C 5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere 5.2: 0.5 h 6.1: phosphorus pentoxide / tetrahydrofuran / 60 - 70 °C / Inert atmosphere 7.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -15 - 5 °C / Inert atmosphere 7.2: -5 - 5 °C / Inert atmosphere 8.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 50 - 60 °C / Inert atmosphere 9.1: hydrogenchloride / tetrahydrofuran; water / 20 °C / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C 1.2: 64 h / 0 - 20 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C 3.1: trifluoroacetic acid / dichloromethane / 6 h View Scheme |
3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetonitrile / 20 - 70 °C 2: sodium hydroxide / water; ethyl acetate / 20 - 25 °C / pH 9.5 - 10 View Scheme |
ruxolitinib
Conditions | Yield |
---|---|
With sodium hydroxide In water; ethyl acetate at 20 - 25℃; pH=9.5 - 10; |
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / ethyl acetate; water / 0 °C 2: lithium tetrafluoroborate / acetonitrile; water / 11 h / 0.8 - 27 °C View Scheme |
4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
A
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C 2: trifluoroacetic acid / dichloromethane / 6 h View Scheme |
3-cyclopentaneacrylonitrile
A
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C 2: trifluoroacetic acid / dichloromethane / 6 h View Scheme |
3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
A
ruxolitinib
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane for 6h; Overall yield = 58 %; Overall yield = 2.68 g; |
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 50 - 60 °C / Inert atmosphere 2: hydrogenchloride / tetrahydrofuran; water / 20 °C / Reflux View Scheme |
ruxolitinib
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 20℃; Reflux; |
2,6-dichloro-pyrimidine carbaldehyde
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: ammonia / toluene; methanol / 2 h / 60 °C 2.1: potassium tert-butylate / tetrahydrofuran / 1 h / -5 - 0 °C / Inert atmosphere 2.2: 30 h / 20 °C / Inert atmosphere 3.1: dmap / ethyl acetate / 2 h / 45 - 50 °C 4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 50 - 60 °C / Inert atmosphere 5.1: hydrogenchloride / tetrahydrofuran; water / 20 °C / Reflux View Scheme |
Cyclopentyl bromide
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: magnesium; iodine / tetrahydrofuran / 30 - 40 °C / Inert atmosphere 1.2: 1 h / 10 - 30 °C / Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 0 °C / Inert atmosphere 2.2: 0 - 30 °C / Inert atmosphere 3.1: acetonitrile / 30 °C 4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 30 °C 5.1: (1S,2R)-1-amino-2-indanol / isopropyl alcohol / 20 °C 6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere 6.2: 0.5 h 7.1: phosphorus pentoxide / tetrahydrofuran / 60 - 70 °C / Inert atmosphere 8.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -15 - 5 °C / Inert atmosphere 8.2: -5 - 5 °C / Inert atmosphere 9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 50 - 60 °C / Inert atmosphere 10.1: hydrogenchloride / tetrahydrofuran; water / 20 °C / Reflux View Scheme |
4-amino-6-chloro-pyrimidine-5-carbaldehyde
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium tert-butylate / tetrahydrofuran / 1 h / -5 - 0 °C / Inert atmosphere 1.2: 30 h / 20 °C / Inert atmosphere 2.1: dmap / ethyl acetate / 2 h / 45 - 50 °C 3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 50 - 60 °C / Inert atmosphere 4.1: hydrogenchloride / tetrahydrofuran; water / 20 °C / Reflux View Scheme |
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dmap / ethyl acetate / 2 h / 45 - 50 °C 2: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 50 - 60 °C / Inert atmosphere 3: hydrogenchloride / tetrahydrofuran; water / 20 °C / Reflux View Scheme |
methyl 3-cyclopentylacrylate
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: acetonitrile / 30 °C 2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 30 °C 3.1: (1S,2R)-1-amino-2-indanol / isopropyl alcohol / 20 °C 4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere 4.2: 0.5 h 5.1: phosphorus pentoxide / tetrahydrofuran / 60 - 70 °C / Inert atmosphere 6.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -15 - 5 °C / Inert atmosphere 6.2: -5 - 5 °C / Inert atmosphere 7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 50 - 60 °C / Inert atmosphere 8.1: hydrogenchloride / tetrahydrofuran; water / 20 °C / Reflux View Scheme |
ruxolitinib
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 30 °C 2.1: (1S,2R)-1-amino-2-indanol / isopropyl alcohol / 20 °C 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere 3.2: 0.5 h 4.1: phosphorus pentoxide / tetrahydrofuran / 60 - 70 °C / Inert atmosphere 5.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -15 - 5 °C / Inert atmosphere 5.2: -5 - 5 °C / Inert atmosphere 6.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; water / 50 - 60 °C / Inert atmosphere 7.1: hydrogenchloride / tetrahydrofuran; water / 20 °C / Reflux View Scheme |
ruxolitinib
Conditions | Yield |
---|---|
With phosphoric acid In water; ethyl acetate at 50℃; for 1h; | 95% |
ruxolitinib
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In ethanol at 50℃; | 89% |
ruxolitinib
Conditions | Yield |
---|---|
With hydrogenchloride In water; ethyl acetate at 20 - 50℃; for 1h; | 88% |
ruxolitinib
citric acid
Conditions | Yield |
---|---|
In methanol at 50℃; for 1h; Solvent; | 85% |
ruxolitinib
ruxolitinib phosphate
Conditions | Yield |
---|---|
With phosphoric acid In dichloromethane; isopropyl alcohol at 20℃; Product distribution / selectivity; Reflux; | 84% |
With phosphoric acid In isopropyl alcohol at 20℃; for 2h; Heating / reflux; | |
With phosphoric acid In isopropyl alcohol at 20℃; Heating; | 171.7 mg |
ruxolitinib
benzenesulfonic acid
Conditions | Yield |
---|---|
In isopropyl alcohol at 60℃; | 81% |
In acetonitrile at 50℃; for 1h; Solvent; | 49% |
L-Tartaric acid
ruxolitinib
Conditions | Yield |
---|---|
In ethanol at 50℃; | 79% |
ruxolitinib
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In ethanol at 50℃; for 1h; Solvent; | 78% |
hydrogenchloride
ruxolitinib
Conditions | Yield |
---|---|
In ethanol; water at 50℃; for 1h; Solvent; | 77% |
ethanesulfonic acid
ruxolitinib
Conditions | Yield |
---|---|
In methanol at 50℃; for 1h; Solvent; | 75% |
ruxolitinib
toluene-4-sulfonic acid
Conditions | Yield |
---|---|
In methanol at 50℃; for 1h; Solvent; | 75% |
ruxolitinib
naphthalene-2-sulfonate
Conditions | Yield |
---|---|
In methanol at 50℃; for 1h; Solvent; | 73% |
ruxolitinib
4-chloro-benzenesulfonic acid
Conditions | Yield |
---|---|
In methanol at 50℃; for 1h; Solvent; | 72% |
ruxolitinib
Conditions | Yield |
---|---|
With hydrogen bromide In ethanol; water at 50℃; for 17h; Cooling; | 71% |
ruxolitinib
hydrogen bromide
Conditions | Yield |
---|---|
In methanol at 50℃; for 1h; Solvent; | 70% |
L-Tartaric acid
ruxolitinib
Conditions | Yield |
---|---|
In ethanol at 50℃; for 1h; Solvent; | 70% |
ruxolitinib
benzoic acid
Conditions | Yield |
---|---|
In methanol at 50℃; for 1h; Solvent; | 60% |
ruxolitinib
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h; | 30% |
ruxolitinib
maleic acid
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile maleic acid salt
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; for 2.5h; Heating / reflux; | |
In isopropyl alcohol at 20℃; Heating; | 173 mg |
ruxolitinib
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile sulfuric acid salt
Conditions | Yield |
---|---|
With sulfuric acid In acetonitrile at 20℃; for 2h; Heating / reflux; | |
With sulfuric acid In acetonitrile at 20℃; Heating; | 180 mg |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View