N-(3-Aminopropyl)cyclohexylamine supplier

Name
N-(3-AMINOPROPYL)CYCLOHEXYLAMINE
EINECS 222-001-7
CAS No. 3312-60-5
Article Data10
CAS DataBase
Density 0.914 g/cm³
Solubility 5000g/L at 20℃
Melting Point -17--15 °C(lit.)
Formula C₉H₂₀N₂
Boiling Point 238.735 °C at 760 mmHg
Molecular Weight 156.271
Flash Point 112.298 °C
Transport Information UN 2735 8/PG 2
Appearance Pale yellow clear liquid
Safety 26-27-28-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols Xi, C
Synonyms 1,3-Propanediamine,N-cyclohexyl- (6CI,7CI,8CI,9CI);(Cyclohexylamino)propylamine;1-(Cyclohexylamino)-3-aminopropane;3-(Cyclohexylamino)-1-propylamine;3-Amino-1-(cyclohexylamino)propane;Laromin C252;N-(3-Aminopropyl)-N-cyclohexylamine;N-(3-Aminopropyl)cyclohexanamine;N-Cyclohexyl-1,3-diaminopropane;N-Cyclohexyl-1,3-propanediamine;N-Cyclohexyl-1,3-propylenediamine;N-Cyclohexyltrimethylenediamine;NSC 87572;Polycat 352;
PSA 38.05000
LogP 2.34870

Synthetic route

: 198712-51-5
N-cyclohexyl-1,3-propanediamino-N,N'-bis(trimethylmethanesulfonamide)

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; methoxybenzene In dichloromethane at 20℃; for 2.5h; desulfonation;	67%

: 702-03-4
3-cyclohexylaminopropionitrile

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

Conditions

Conditions	Yield
With ammonia; nickel at 120℃; under 128714 Torr; Hydrogenation;
With lithium aluminium tetrahydride
With hydrogen; nickel In methanol
With lithium aluminium tetrahydride In diethyl ether at 0℃;

: 702-03-4
3-cyclohexylaminopropionitrile

A: 80638-40-0
bis-(N-cyclohexyl-3-aminopropyl)amine

B: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

Conditions

Conditions	Yield
With nickel Hydrogenation;

: 3956-37-4
1-Cyclohexyl-1-(β-cyanethyl)-hydrazin

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

Conditions

Conditions	Yield
With hydrogen; nickel In methanol

: 108-91-8
cyclohexylamine

: 107-13-1
acrylonitrile

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

Conditions

Conditions	Yield
(i) EtOH, (ii) LiAlH4; Multistep reaction;

: 108-91-8
cyclohexylamine

Co2(CO)8: Co2(CO)8

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethyl methyl ether / 78 °C 2: LiAlH4 / diethyl ether / 0 °C View Scheme

: 108-91-8
cyclohexylamine

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: Raney nickel; ethanolic ammonia / 120 °C / 128714 Torr / Hydrogenation View Scheme

: 6498-34-6
cyclohexylhydrazine

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol 2: H2 / Raney-Ni / methanol View Scheme

: 108-91-8
cyclohexylamine

sodium chloro sulfate: sodium chloro sulfate

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: LiAlH4 View Scheme

: 1829-34-1
2-hydroxy-3-bromobenzaldehyde

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 1451054-32-2
2-bromo-6-[(3-cyclohexylaminopropylimino)methyl]phenol

Conditions

Conditions	Yield
In methanol at 20℃; for 1h;	100%
In methanol at 20℃;	91%
for 1h; Reflux;	83%
In ethanol for 1h; Reflux;	80%

: 5-benzoyl-3-(cyclopent-1-en-1-yl)-5-phenyl-1,5-dihydro-4H-pyrazol-4-one

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 52289-18-6
N-Cyclohexyl-N'-benzoyltrimethylen-1,3-diamin

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.5h; regioselective reaction;	99%

: 874903-63-6
4-chloro-2-(2-furyl)-pyrimido[5,4-c]cinnoline

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: N-cyclohexyl-N'-[2-(2-furyl)pyrimido[5,4-c]cinnolin-4-yl]propane-1,3-diamine

Conditions

Conditions	Yield
In ethanol for 0.333333h; Heating;	95%

: 874903-59-0
4-chloro-2-phenyl-pyrimido[5,4-c]cinnoline

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: N-cyclohexyl-N'-[2-phenyl-pyrimido[5,4-c]cinnolin-4-yl]propane-1,3-diamine

Conditions

Conditions	Yield
In ethanol for 0.333333h; Heating;	95%

: 81761-75-3
4-Methyl-5,5-dioxo-1-p-tolyl-4,5-dihydro-1H-5λ6-thia-1,2,4-triaza-cyclopenta[a]naphthalene-3-carboxylic acid methyl ester

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 4-Methyl-5,5-dioxo-1-p-tolyl-4,5-dihydro-1H-5λ6-thia-1,2,4-triaza-cyclopenta[a]naphthalene-3-carboxylic acid (3-cyclohexylamino-propyl)-amide

Conditions

Conditions	Yield
for 2h; Heating;	90%

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: tetramethylammonium trifluoromethanethiolate

: 39148-52-2
1-cyclohexyltetrahydropyrimidine-2(1H)-thione

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.166667h;	89%

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: N-(3-cyclohexylamino-propyl)-2-nitro-benzenesulfonamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran at 20℃; Substitution;	88%

: (2,5-dioxopyrrolidin-1-yl)(E)-3-(2-fluorophenyl)-2-propenoate

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: (E)-N-[3-(cyclohexylamino)propyl]-3-(2-fluorophenyl)-2-propenamide

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; for 1h;	84%

: 6336-42-1
2-amino-9-benzyl-6-chloro-9H-purine

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: N6-[3-(cyclohexylamino)propyl]-9-phenylmethyl-9H-purine-2,6-diamine

Conditions

Conditions	Yield
In ethanol at 60℃; for 24h;	82%

: 5-(4-chloro-benzenesulfonylamino)-1-(2-chloro-benzyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 5-(4-chloro-benzenesulfonylamino)-1-(2-chloro-benzyl)-1H-imidazole-4-carboxylic acid (3-cyclohexylamino-propyl)-amide

Conditions

Conditions	Yield
at 100℃; for 8h;	81%

: 128459-09-6
N-acetyl-N-methoxyacetamide

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 128459-11-0
N-[3-(cyclohexylamino)propyl]-acetamide

Conditions

Conditions	Yield
In water for 20.3h; Ambient temperature;	80%

: 24964-64-5
3-Cyanobenzaldehyde

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 917021-48-8
C17H25N3

Conditions

Conditions	Yield
Stage #1: 3-Cyanobenzaldehyde; N-(3-aminopropyl)cyclohexylamine In methanol at 60℃; for 18h; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 0.5h;	80%

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 944934-09-2
2-[(3-cyclohexylaminopropylimino)methyl]-6-methoxyphenol

Conditions

Conditions	Yield
In methanol for 3h; Reflux;	79%

: 3764-01-0
2,4,6-trichloropyrimidine

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: C24H42ClN5

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 60℃;	75%

: 81761-78-6
1-(4-Chloro-phenyl)-4-methyl-5,5-dioxo-4,5-dihydro-1H-5λ6-thia-1,2,4-triaza-cyclopenta[a]naphthalene-3-carboxylic acid methyl ester

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 1-(4-Chloro-phenyl)-4-methyl-5,5-dioxo-4,5-dihydro-1H-5λ6-thia-1,2,4-triaza-cyclopenta[a]naphthalene-3-carboxylic acid (3-cyclohexylamino-propyl)-amide

Conditions

Conditions	Yield
for 2h; Heating;	74%

: 5-[bis-(4-chlorophenylsulfonyl)-amino]-1-(2,6-dichlorophenylmethyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 5-(4-chloro-benzenesulfonylamino)-1-(2,6-dichloro-benzyl)-1H-imidazole-4-carboxylic acid (3-cyclohexylamino-propyl)-amide

Conditions

Conditions	Yield
at 100℃; for 8h;	72%

: 81-25-4
cholic acid

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: N-[3-(cyclohexylamino)propyl]cholanamide

Conditions

Conditions	Yield
Stage #1: cholic acid With triethylamine In tetrahydrofuran for 0.166667h; Cooling; Stage #2: With chloroformic acid ethyl ester In tetrahydrofuran at 20℃; for 0.166667h; Cooling; Stage #3: N-(3-aminopropyl)cyclohexylamine In tetrahydrofuran for 3h;	72%

: 24424-99-5
di-tert-butyl dicarbonate

: 81172-89-6
terephthalaldehyde mono(diethylacetal)

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: C31H52N2O6

Conditions

Conditions	Yield
Stage #1: terephthalaldehyde mono(diethylacetal); N-(3-aminopropyl)cyclohexylamine In methanol at 70℃; for 6h; Inert atmosphere; Molecular sieve; Stage #2: With sodium tetrahydroborate at 0 - 20℃; for 3h; Inert atmosphere; Stage #3: di-tert-butyl dicarbonate With sodium carbonate In water; tert-butyl alcohol at 20℃; for 12h; Inert atmosphere;	71%

...Expand

: 105-07-7
4-cyanobenzaldehyde

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 917021-03-5
C17H25N3

Conditions

Conditions	Yield
Stage #1: 4-cyanobenzaldehyde; N-(3-aminopropyl)cyclohexylamine In methanol at 60℃; for 6h; Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 0.5h;	70%
Stage #1: 4-cyanobenzaldehyde; N-(3-aminopropyl)cyclohexylamine In methanol at 65℃; for 6h; Molecular sieve; Stage #2: With methanol; sodium tetrahydroborate at 20℃; Molecular sieve;

: 81761-76-4
1-(2-Chloro-phenyl)-4-methyl-5,5-dioxo-4,5-dihydro-1H-5λ6-thia-1,2,4-triaza-cyclopenta[a]naphthalene-3-carboxylic acid methyl ester

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 1-(2-Chloro-phenyl)-4-methyl-5,5-dioxo-4,5-dihydro-1H-5λ6-thia-1,2,4-triaza-cyclopenta[a]naphthalene-3-carboxylic acid (3-cyclohexylamino-propyl)-amide

Conditions

Conditions	Yield
for 2h; Heating;	69%

: 5-(4-chloro-benzenesulfonylamino)-1-phenethyl-1H-imidazole-4-carboxylic acid ethyl ester

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 5-(4-chloro-benzenesulfonylamino)-1-phenethyl-1H-imidazole-4-carboxylic acid (3-cyclohexylamino-propyl)-amide

Conditions

Conditions	Yield
at 120℃; for 48h;	69%

: 93256-54-3
2-amino-7-benzyl-6-chloro-7H-purine

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: N6-[3-(cyclohexylamino)propyl]-7-phenylmethyl-7H-purine-2,6-diamine

Conditions

Conditions	Yield
at 100℃; for 3h;	69%

: 874903-61-4
4-chloro-2-(2-methoxyphenyl)-pyrimido[5,4-c]cinnoline

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: N-cyclohexyl-N'-[2-(2-methoxyphenyl)-pyrimido[5,4-c]cinnolin-4-yl]propane-1,3-diamine

Conditions

Conditions	Yield
In ethanol for 0.333333h; Heating;	66%

: 5-(4-chloro-benzenesulfonylamino)-1-(4-phenyl-butyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 5-(4-chloro-benzenesulfonylamino)-1-(4-phenyl-butyl)-1H-imidazole-4-carboxylic acid (3-cyclohexylamino-propyl)-amide

Conditions

Conditions	Yield
at 120℃; for 5h;	66%

: 5-(4-chloro-benzenesulfonylamino)-1-(3-chloro-benzyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 5-(4-chloro-benzenesulfonylamino)-1-(3-chloro-benzyl)-1H-imidazole-4-carboxylic acid (3-cyclohexylamino-propyl)-amide

Conditions

Conditions	Yield
at 120℃; for 3h;	65%

: 33233-67-9
4-(tert-Butoxycarbonylaminomethyl)benzoic acid

: 3312-60-5
N-(3-aminopropyl)cyclohexylamine

: 917021-35-3
C22H35N3O3

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25℃; for 18h;	65%

N-(3-Aminopropyl)cyclohexylamine Specification

The 1,3-Propanediamine,N1-cyclohexyl-, with the CAS registry number 3312-60-5, is also known as 3-(Cyclohexylamino)propylamine. It belongs to the product categories of Nitrogen Compounds; Organic Building Blocks; Polyamines. Its EINECS registry number is 222-001-7. This chemical's molecular formula is C₉H₂₀N₂ and molecular weight is 156.27. What's more, its IUPAC name and systematic name are the same which is called N-Cyclohexylpropane-1,3-diamine. Additionally, it should be preserved hermetically and put in a cool, dry place. It is pale yellow clear liquid.

Physical properties about 1,3-Propanediamine,N1-cyclohexyl-: (1)ACD/LogP: 1.27; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.83; (4)ACD/LogD (pH 7.4): -2.67; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 6.48 Å²; (13)Index of Refraction: 1.484; (14)Molar Refractivity: 48.92 cm³; (15)Molar Volume: 170.9 cm³; (16)Surface Tension: 35.3 dyne/cm; (17)Density: 0.91 g/cm³; (18)Flash Point: 112.3 °C; (19)Enthalpy of Vaporization: 47.56 kJ/mol; (20)Boiling Point: 238.7 °C at 760 mmHg; (21)Vapour Pressure: 0.0417 mmHg at 25 °C; (22)Melting point: -17--15 °C.

Preparation of 1,3-Propanediamine,N1-cyclohexyl-: It can be obtained by 2-Methyl-propane-2-sulfonic acid cyclohexyl-[3-(2-methyl-propane-2-sulfonylamino)-propyl]-amide. The reaction occurs with reagents Anisole and Trifluoromethanesulfonic acid at temperature of 20 °C for 2.5 hours. The yield is 67 %.

1,3-Propanediamine,N1-cyclohexyl- can be obtained by 2-Methyl-propane-2-sulfonic acid cyclohexyl-[3-(2-methyl-propane-2-sulfonylamino)-propyl]-amide

Uses of 1,3-Propanediamine,N1-cyclohexyl-: it is used to produce other chemicals. For example, it can react with Formaldehyde to get 1-Cyclohexylhexahydropyrimidine. The reaction occurs with reagent H₂O at ambient temperature for 1 hour. The yield is 56.7 %.

1,3-Propanediamine,N1-cyclohexyl- can react with Formaldehyde to get 1-Cyclohexylhexahydropyrimidine

When you are dealing with this chemical, you should be very careful. This chemical is inflammation to the skin or other mucous membranes and may destroy living tissue on contacting. What’s more, it may cause burns. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And in case of contacting with eyes or skin, you should take off immediately all contaminated clothing and rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: N(CCCN)C1CCCCC1
(2) InChI: InChI=1/C9H20N2/c10-7-4-8-11-9-5-2-1-3-6-9/h9,11H,1-8,10H2
(3) InChIKey: ITZPOSYADVYECJ-UHFFFAOYAP

Product Name

N-(3-AMINOPROPYL)CYCLOHEXYLAMINE

Synthetic route

N-(3-Aminopropyl)cyclohexylamine Specification

Related Products

Hot Products