N-BOC-D-Arginine hydrochloride supplier

Name
N-BOC-L-Arginine hydrochloride
EINECS 237-295-2
CAS No. 35897-34-8
Density 1.28 g/cm³
Solubility Slightly soluble in water.
Melting Point
Formula C₁₁H₂₃ClN₄O₄
Boiling Point 494 °C at 760 mmHg
Molecular Weight 310.781
Flash Point 252.6 °C
Transport Information
Appearance
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms L-Arginine,N²-[(1,1-dimethylethoxy)carbonyl]-, monohydrochloride (9CI);N-tert-Butoxycarbonyl-L-argininehydrochloride;N2-tert-Butyloxycarbonyl-L-arginine monohydrochloride;NSC334363;Boc-Arg-OH·HCl·H2O;
PSA 137.53000
LogP 2.61140

Synthetic route

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 138401-29-3
tert-butyl 4'-<(2-n-butyl-4-oxo-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate

: tert-butyl 4'-<<2-n-butyl-4-oxo-8--1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate hydrochloride

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide for 18h;	95%

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 100-01-6
4-nitro-aniline

: 99306-64-6
N-(t-butoxycarbonyl)-L-arginine p-nitroanilide hydrochloride

Conditions

Conditions	Yield
With pyridine; trichlorophosphate at -15℃;	91%

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 154445-78-0
2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride

: (S)-2-(tert-butoxycarbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water; acetone at 5℃; for 1h; Temperature;	82%

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 134393-23-0
N,N'-bis(4-nitrophenyl)phospheneimidous amide

: 99306-64-6
N-(t-butoxycarbonyl)-L-arginine p-nitroanilide hydrochloride

Conditions

Conditions	Yield
With pyridine at 40℃; for 4h;	75%

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: obeticholic acid

: C38H68N8O6

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;	72.3%

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: obeticholic acid

: C32H56N4O5

Conditions

Conditions	Yield
Stage #1: obeticholic acid With sodium hydride In tetrahydrofuran for 2h; Stage #2: Nα-t-butoxycarbonyl-arginine hydrochloride With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃;	71.4%

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 501-53-1
benzyl chloroformate

: 51219-18-2
N7-<(benzyloxy)carbonyl>-N2-<(tert-butoxy)carbonyl>-L-arginine

Conditions

Conditions	Yield
With sodium hydroxide	70%

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 128719-07-3
D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine methyl ester hydrochloride

: 128719-16-4
N-tert-butoxycarbonyl-L-arginyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucine methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 4℃;	60.2%

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 67605-64-5
5-(4-aminophenyl)-10,15,20-triphenylporphyrin

: Nα-Boc-Arg-NH-TPP hydrochloride

Conditions

Conditions	Yield
With pyridine; dmap; phosphorus trichloride at -15℃; for 1h; Condensation;	56%

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 68762-02-7
(S)-2-[(R)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-4-methyl-pentanoic acid methyl ester; hydrochloride

: 128719-64-2
N-tert-butoxycarbonyl-L-arginyl(HCl)-D-tryptophyl-L-leucine methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 4℃;	54%

: 50903-47-4
perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 42538-64-7
Boc-glycine cesium salt

: 3392-10-7
tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester

: 64-19-7
acetic acid

: Boc-Gly-Pro-Arg-Gly-Gly-OH acetate

Conditions

Conditions	Yield
Multistep reaction;	36%

...Expand

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 141663-87-8
Ala-D-Trp-Phe-D-Pro-Pro-OMe hydrochloride

: Boc-Arg-Ala-D-Trp-Phe-D-Pro-Pro-OMe

Conditions

Conditions	Yield
With triethylamine; dicyclohexyl-carbodiimide 1.) DMF, 10 min, 2.) DMF, 20 deg C, 2 h; Yield given. Multistep reaction;

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 141636-75-1
Boc-Ala-D-Trp-Phe-D-Pro-Pro-NHMe hydrochloride

: 141636-53-5
Boc-Arg-Ala-D-Trp-Phe-D-Pro-Pro-NMe

Conditions

Conditions	Yield
With triethylamine; dicyclohexyl-carbodiimide 1.) DMF, 10 min, 2.) DMF, 20 deg C, 2 h; Yield given. Multistep reaction;

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 94770-24-8
{(S)-2-[(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-3-methyl-butyrylamino]-4-methyl-pentanoylamino}-acetic acid methyl ester; compound with trifluoro-acetic acid

: 105220-35-7
Boc-Arg(HCl)-Lys(Z)-Val-Leu-Gly-OCH3

Conditions

Conditions	Yield
With N-ethylmorpholine;; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 18h; pH=7; Yield given;

: 3392-07-2
tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 42538-64-7
Boc-glycine cesium salt

: 3392-10-7
tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester

: Nα-tert-butoxycarbonylglycylprolylarginylglycylglycine

Conditions

Conditions	Yield
Yield given. Multistep reaction;

...Expand

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 69355-83-5
Pro-Lys(Boc)-Pro-OMe

: 82565-76-2
Boc-Arg-Pro-Lys(Boc)-Pro-OMe

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0 - 8℃; for 19h; Yield given;

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 195716-40-6
(R)-N-(4-Aminomethyl-phenyl)-2-(N',N''-dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionamide

: 195717-52-3
((S)-1-{4-[(R)-2-(N',N''-Dicyclohexyl-guanidino)-3-naphthalen-2-yl-propionylamino]-benzylcarbamoyl}-4-guanidino-butyl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide

: 124-22-1
n-Dodecylamine

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: ((S)-1-Dodecylcarbamoyl-4-guanidino-butyl)-carbamic acid tert-butyl ester; hydrochloride

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1) DMF, 25 deg C, 30 min; 2) DMF, 25 deg C, overnight; Yield given. Multistep reaction;

: 2016-42-4
tetradecylamine

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: ((S)-4-Guanidino-1-tetradecylcarbamoyl-butyl)-carbamic acid tert-butyl ester; hydrochloride

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1) DMF, 25 deg C, 30 min; 2) DMF, 25 deg C, overnight; Yield given. Multistep reaction;

: 143-27-1
hexadecylamine

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: ((S)-4-Guanidino-1-hexadecylcarbamoyl-butyl)-carbamic acid tert-butyl ester; hydrochloride

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1) DMF, 25 deg C, 30 min; 2) DMF, 25 deg C, overnight; Yield given. Multistep reaction;

: 2016-57-1
1-aminodecane

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: ((S)-1-Decylcarbamoyl-4-guanidino-butyl)-carbamic acid tert-butyl ester; hydrochloride

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine 1) DMF, 25 deg C, 30 min; 2) DMF, 25 deg C, overnight; Yield given. Multistep reaction;

: 75-77-4
chloro-trimethyl-silane

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: C14H30N4O4Si

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 40℃; for 1.5h; silylation;

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 128797-22-8
(S)-2-tert-Butoxycarbonylamino-3-[4-(diphenyl-phosphinoyloxy)-phenyl]-propionic acid

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

Boc-Gly-OH, Boc-Lys(Fmoc)-OH, Boc-Pro-OH, Boc-Lys(Fmoc)-Pac-resin: Boc-Gly-OH, Boc-Lys(Fmoc)-OH, Boc-Pro-OH, Boc-Lys(Fmoc)-Pac-resin

: 77739-20-9
alpha-Neoendorphin (Porcine)

Conditions

Conditions	Yield
Yield given. Multistep reaction;

...Expand

: 50903-47-4
perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 42538-64-7
Boc-glycine cesium salt

: 3392-10-7
tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester

Boc-Gly-ONSu: Boc-Gly-ONSu

: Nα-tert-butoxycarbonylglycylprolylarginylglycylglycine

Conditions

Conditions	Yield
Yield given. Multistep reaction;

...Expand

: 50903-47-4
perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 42538-64-7
Boc-glycine cesium salt

: 50903-54-3
N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine pentafluorophenyl ester

Boc-Arg(Bzl)-OPfp 2 Boc-Pro-OPfp: Boc-Arg(Bzl)-OPfp 2 Boc-Pro-OPfp

: H-Arg-Pro-Pro-Gly-Phe-Ser(OBzl)-Phe-Arg-Gly-Gly trihydrobromide

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 67-56-1
methanol

: 50903-47-4
perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 42538-64-7
Boc-glycine cesium salt

: 3392-10-7
tert-butoxycarbonyl-L-proline N-hydroxysuccinimide ester

protohemin IX 6(7)-mono-N-succinimide ester: protohemin IX 6(7)-mono-N-succinimide ester

: Nα-[6-(protohemin IX)-yl]-Gly-Pro-Arg-Gly-Gly-OMe

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 67-56-1
methanol

: 50903-47-4
perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 42538-64-7
Boc-glycine cesium salt

: 50903-54-3
N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanine pentafluorophenyl ester

Boc-Arg(Bzl)-OPfp 2 Boc-Pro-OPfpprotohemin IX: Boc-Arg(Bzl)-OPfp 2 Boc-Pro-OPfpprotohemin IX

: Nα-[6-(protohemin IX)-yl]-Arg-Pro-Pro-Gly-Phe-Ser(Bzl)-Phe-Arg-Gly-Gly-OMe

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 17462-58-7
isobutyl chloroformate

: C12H21ClN4O5

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at -10℃; Anhydride formation;

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: 56-81-5
glycerol

A: rac-1-O-(Nα-tert-butoxycarbonyl-L-argininyl)glycerol hydrochloride

B: rac-2-O-(Nα-Boc-L-arginyl)glycerol hydrochloride

Conditions

Conditions	Yield
With DL-dithiothreitol; papain In various solvent(s) at 50℃; for 24h; Title compound not separated from byproducts.;

...Expand

: 47292-14-8
[1]naphthylmethyl-[2]naphthylmethyl-amine

: 35897-34-8
Nα-t-butoxycarbonyl-arginine hydrochloride

: [4-guanidino-1-(naphthalen-2-ylmethyl-naphthalen-1-ylmethyl-carbamoyl)-butyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate In N,N-dimethyl-formamide for 20h;

N-BOC-D-Arginine hydrochloride Specification

The L-Arginine,N²-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride (1:1), with the CAS registry number 35897-34-8, is also known as Boc-Arg-OH hydrochloride. It belongs to the product categories of Amino Acids; Arginine [Arg, R]; Boc-Amino Acids and Derivative; Amino Acids (N-Protected); Biochemistry; Boc-Amino Acids; Boc-Amino Acid series; Amino Hydrochloride. Its EINECS registry number is 237-295-2. This chemical's molecular formula is C₁₁H₂₃ClN₄O₄ and molecular weight is 310.78. What's more, its IUPAC name is called 5-(Diaminomethylideneamino)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid. It should be kept in a sealed, cool and dry place.

Physical properties about L-Arginine,N²-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride (1:1) are: (1)ACD/LogP: 0.49; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -1.97; (4)ACD/LogD (pH 7.4): -2.01; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 8; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 8; (12)Polar Surface Area: 74.68 Å²; (13)Flash Point: 252.6 °C; (14)Enthalpy of Vaporization: 83.35 kJ/mol; (15)Boiling Point: 494 °C at 760 mmHg; (16)Vapour Pressure: 4.17E-11 mmHg at 25°C.

When you are dealing with this chemical, you should be very careful. The gas of this chemical can not be breathed. Therefore, you should avoid contacting with skin and eyes.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(OC(C)(C)C)N[C@H](C(=O)O)CCC/N=C(\N)N.Cl
(2) InChI: InChI=1/C11H22N4O4.ClH/c1-11(2,3)19-10(18)15-7(8(16)17)5-4-6-14-9(12)13;/h7H,4-6H2,1-3H3,(H,15,18)(H,16,17)(H4,12,13,14);1H/t7-;/m0./s1
(3) InChIKey: HDELGKMVZYHPPB-FJXQXJEOBE

Product Name

N-BOC-L-Arginine hydrochloride

Synthetic route

N-BOC-D-Arginine hydrochloride Specification

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