N-Boc-L-tert-Leucine supplier

Name
N-Boc-L-tert-Leucine
EINECS 613-118-8
CAS No. 62965-35-9
Article Data44
CAS DataBase
Density 1.063 g/cm³
Solubility
Melting Point 118-121 °C
Formula C₁₁H₂₁NO₄
Boiling Point 350 °C at 760 mmHg
Molecular Weight 231.292
Flash Point 165.5 °C
Transport Information
Appearance white crystalline powder
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Boc-Tle-OH;(2S)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutanoicacid;(S)-2-(((tert-Butoxy)carbonyl)amino)-3,3-dimethylbutanoic acid;(S)-2-tert-Butoxycarbonylamino-3,3-dimethylbutyric acid;BOC-L-tert-leucine;
PSA 75.63000
LogP 2.40130

Synthetic route

: 20859-02-3
L-tert-Leucine

: 24424-99-5
di-tert-butyl dicarbonate

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
With triethylamine In methanol at 0 - 5℃;	100%
With triethylamine In methanol at 0 - 5℃;	100%
With sodium hydroxide In 1,4-dioxane at 20℃; for 12h;	100%

NaHSO4·H2O: NaHSO4·H2O

: 20859-02-3
L-tert-Leucine

: 24424-99-5
di-tert-butyl dicarbonate

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water	99%
With triethylamine In 1,4-dioxane; water	99%

...Expand

: D,L-N-Boc-t-leucine methyl ester

A: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

B: 153960-35-1
N-Boc-D-tert-leucine methyl ester

Conditions

Conditions	Yield
With Bacillus licheniformis In water at 35℃; for 23h; pH=7.8;	A 93% B n/a
With Bacillus licheniformis In water at 35℃; for 18h; pH=7.8;	A n/a B 82%

: 153645-26-2
N-Boc-L-tert-leucinol

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Isopropyl acetate; sodium hydrogencarbonate; sodium bromide at 0 - 25℃;	73%

: C14H21F6NO4

A: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

B: 124655-17-0
(R)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

Conditions

Conditions	Yield
With C28H30N3O2(1+)*Br(1-); sodium hydroxide In chloroform at 0℃; for 24h;	A 52% B n/a

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 20859-02-3
L-tert-Leucine

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane

: 20859-02-3
L-tert-Leucine

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water for 4h; Ambient temperature;

: 335628-21-2
(4S,5R)-3-tert-butoxycarbonyl-4-tert-butyl-5-methoxy-2-oxazolidinone

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
With potassium hydroxide; potassium permanganate In water; tert-butyl alcohol

: D,L-N-Boc-t-leucine methyl ester

A: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

B: 124655-17-0
(R)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

C: 153960-35-1
N-Boc-D-tert-leucine methyl ester

Conditions

Conditions	Yield
With subtilisin In water at 35℃; for 18h; pH=7.5;

...Expand

: D,L-N-Boc-t-leucine methyl ester

A: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

B: 153960-35-1
N-Boc-D-tert-leucine methyl ester

C: 176504-88-4
2-tert-butoxycarbonylamino-3,3-dimethylbutyric acid methyl ester

Conditions

Conditions	Yield
With subtilisin In water at 35℃; for 15h; pH=7.5;

...Expand

: 335627-81-1
(4S,5R)-4-tert-butyl-5-methoxy-2-oxazolidinone

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N; DMAP / CH2Cl2 / 2 h / 20 °C 2: KMnO4; KOH / 2-methyl-propan-2-ol; H2O View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

: 58482-93-2
tert-butylaminoacetic acid

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
In tetrahydrofuran; sodium hydroxide

t-butoxycarbonyl-anhydride: t-butoxycarbonyl-anhydride

: 20859-02-3
L-tert-Leucine

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In 1,4-dioxane; water; ethyl acetate

: 1203546-60-4
(S)-ethyl 3,3-dimethyl-2-[(S)-phenylmethanesulfinamido]butanoate

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / methanol 2: triethylamine 3: lithium hydroxide / water View Scheme

: (E)-[(S)-2-methylpropane-2-sulfinylimino]acetic acid ethyl ester

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrahydrofuran / 12 h / -20 - 20 °C / Inert atmosphere 2: hydrogenchloride / methanol 3: triethylamine 4: lithium hydroxide / water View Scheme

: 1465120-76-6
C13H25NO4

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
With lithium hydroxide In water

: 24424-99-5
di-tert-butyl dicarbonate

: 69557-34-2
ethyl (S)-2-amino-3,3-dimethylbutanoate

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine 2: lithium hydroxide / water View Scheme

: (S)-ethyl 2-[butanesulfinamido]-3,3-dimethylbutanoate

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: thionyl chloride / methanol 2: triethylamine 3: lithium hydroxide / water View Scheme

: 152488-38-5
(R)-1-chloro-3,3-dimethyl-2-butanol

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 15 h / -5 - 5 °C / Heating 2: hydrogenchloride; water / 15 h / Reflux 3: sodium hydroxide / water; ethanol / 40 - 50 °C 4: sodium hydrogencarbonate; sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Isopropyl acetate; sodium hypochlorite / 0 - 25 °C View Scheme

: C10H16ClNO2

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride; water / 15 h / Reflux 2: sodium hydroxide / water; ethanol / 40 - 50 °C 3: sodium hydrogencarbonate; sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Isopropyl acetate; sodium hypochlorite / 0 - 25 °C View Scheme

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 372199-21-8
(S)-tert-butyl (1-amino-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Conditions

Conditions	Yield
With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	100%
With 4-methyl-morpholine; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -20℃; for 0.5h; Stage #2: With ammonium hydroxide In tetrahydrofuran at -20 - 20℃;
With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 630421-45-3
(2S,4R)-methyl 1-{(S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoyl}-4-hydroxypyrrolidine-2-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0 - 20℃;	100%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 16h;	98%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h;	92%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 100-39-0
benzyl bromide

: 154092-61-2
(S)-benzyl 2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 72h;	100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0 - 22℃; for 3.5h;	98%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0 - 20℃; for 3.08333h;	93%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 72h;

: 918662-07-4
4R-(7-methoxy-2-pyrazol-1-yl-quinolin-4-yloxy)-pyrrolidine-2S-carboxylic acid methyl ester hydrochloride

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 918662-09-6
1-(2S-tert-butoxycarbonylamino-3,3-dimethylbutyryl)-4R-(7-methoxy-2-pyrazol-1-yl-quinolin-4-yloxy)-pyrrolidine-2S-carboxylic acid methyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h;	100%

: 4R-(5-chloropyridin-2-yloxy)-pyrrolidine-2S-carboxylic acid methyl ester hydrochloride salt

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 1-(2S-tert-butoxycarbonylamino-3,3-dimethylbutyryl)-4R-(5-chloropyridin-2-yloxy)-pyrrolidine-2S-carboxylic acid methyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h;	100%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 74-88-4
methyl iodide

: 287210-99-5
methyl (2S)-3,3-Dimethyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]butanoate

Conditions

Conditions	Yield
With silver(l) oxide In N,N-dimethyl-formamide at 45℃; Inert atmosphere;	100%
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 8h;	89%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 506-59-2
N,N-dimethylammonium chloride

: 340161-34-4
(S)-tert-butyl 1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Conditions

Conditions	Yield
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With HBTU In dichloromethane for 0.0333333h; Inert atmosphere; Stage #2: N,N-dimethylammonium chloride With N-ethyl-N,N-diisopropylamine In dichloromethane for 1.5h; Inert atmosphere;	100%
With triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 12h; Cooling with ice;	91%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3h;

: 66854-34-0
(R)-3-[(2S,3S)-2-amino-3-phenylbutyrylamino]-3-(thiazol-2-yl)propanoic acid methyl ester

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 1138161-59-7
N-{N'-tert-butoxycarbonyl-L-tert-leucyl-[(3S)-3-methyl-L-phenylalanyl]}-3-amino-3-(thiazol-2-yl)propanoic acid methyl ester

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;	100%
With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate In dichloromethane; N,N-dimethyl-formamide	100%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 95-54-5
1,2-diamino-benzene

: 1138161-53-1
N-tert-butoxycarbonyl-L-tert-leucine 2-aminoanilide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	100%

: 4-nitro-benzoic acid 5-(1-methoxycarbonyl-2-vinylcyclopropylcarbamoyl)pyrrolidin-3-yl ester hydrochloride

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 1219511-19-9
C30H40N4O10

Conditions

Conditions	Yield
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 0.166667h; Stage #2: 4-nitro-benzoic acid 5-(1-methoxycarbonyl-2-vinylcyclopropylcarbamoyl)pyrrolidin-3-yl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane for 15h; Stage #3: N-tert-butyloxycarbonyl-L-tert-leucine With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane for 5h;	100%

Yield

Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 0.166667h;
Stage #2: 4-nitro-benzoic acid 5-(1-methoxycarbonyl-2-vinylcyclopropylcarbamoyl)pyrrolidin-3-yl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane for 15h;
Stage #3: N-tert-butyloxycarbonyl-L-tert-leucine With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane for 5h;

100%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: (S)-methyl 3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

: (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate

Conditions

Conditions	Yield
With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 99-73-0
para-bromophenacyl bromide

: (S)-2-(4-bromophenyl)-2-oxoethyl 2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 2h; Cooling with ice;	100%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 100-51-6
benzyl alcohol

: 154092-61-2
(S)-benzyl 2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;	99%
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile; triethylamine In 1,4-dioxane Stage #2: benzyl alcohol With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 0℃;
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0℃;

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 74-89-5
methylamine

: 200865-04-9
(S)-(2,2-dimethyl-1-methylcarbamoylpropyl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 4h;	99%
Stage #1: methylamine With 1-hydroxy-pyrrolidine-2,5-dione In methanol; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: N-tert-butyloxycarbonyl-L-tert-leucine With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In methanol; N,N-dimethyl-formamide at 0 - 20℃; for 3h;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 23℃; for 18h; Inert atmosphere;
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere;

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 100-46-9
benzylamine

: 207121-91-3
(S)-2-amino-N-benzyl-3,3-dimethylbutanamide

Conditions

Conditions	Yield
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine; benzylamine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 1.5h; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 1h; Further stages.;	99%
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine; benzylamine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 23℃; for 2h; Stage #2: With trifluoroacetic acid In dichloromethane at 23℃; for 1h; Further stages.;	98%
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.0333333h; Sealed tube; Stage #2: benzylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; Sealed tube; Stage #3: With trifluoroacetic acid In dichloromethane at 20℃; for 1h; Sealed tube;

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 1499-56-5
(R)-4-hydroxy-L-proline ethyl ester

: 630421-45-3
(2S,4R)-methyl 1-{(S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutanoyl}-4-hydroxypyrrolidine-2-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 12h;	99%
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0 - 20℃; for 12h;	99%
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tert-butyl alcohol In dichloromethane at 20℃;	60%
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 18h;
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With HATU In dichloromethane at 20℃; for 0.25h; Stage #2: (R)-4-hydroxy-L-proline ethyl ester With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 15h;

: 630424-24-7
2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(2-isopropylamino-thiazol-4-yl)-7-methoxy-quinolin-4-yloxy]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 630424-25-8
BocNH-(L-t-BuGly)-[(4R)-[2-(2-isopropylaminothiazol-4-yl)-7-methoxyquinoline-4-oxo]-S-proline]-(1R,2S-vinyl acca)-COOEt

Conditions

Conditions	Yield
Stage #1: 2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(2-isopropylamino-thiazol-4-yl)-7-methoxy-quinolin-4-yloxy]-pyrrolidine-1-carboxylic acid tert-butyl ester With hydrogenchloride In 1,4-dioxane for 2.5h; Stage #2: N-tert-butyloxycarbonyl-L-tert-leucine With 4-methyl-morpholine; HATU In DMF (N,N-dimethyl-formamide)	99%
Stage #1: 2-(1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(2-isopropylamino-thiazol-4-yl)-7-methoxy-quinolin-4-yloxy]-pyrrolidine-1-carboxylic acid tert-butyl ester With hydrogenchloride In 1,4-dioxane for 2.5h; Stage #2: N-tert-butyloxycarbonyl-L-tert-leucine With 4-methyl-morpholine; HATU In N,N-dimethyl-formamide	99%

: (2S,4R)-N-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)pyrrolidine-2-carboxamide dihydrochloride

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 445304-34-7
tert-butyl ((S)-1-((2S,4R)-2-(((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; Product distribution / selectivity;	99%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 14683-47-7
N-(diphenylmethyl)methylamine

: 1200405-67-9
tert-butyl (S)-{1-[benzhydryl(methyl)amino]-3,3-dimethyl-1-oxobutan-2-yl}carbamate

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 72h; Inert atmosphere;	99%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 72h;	91%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere;

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 1448189-90-9
(2S,4R)-4-hydroxy-N-{ [4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide hydrochloride

: 1448189-98-7
tert‐butyl N‐[(2S)‐1‐[(2S,4R)‐4‐hydroxy‐2‐({[4‐(4‐methyl‐1,3‐thiazol‐5‐yl)phenyl]methyl}carbamoyl)pyrrolidin‐1‐yl]‐3,3‐dimethyl‐1‐oxobutan‐2‐yl]carbamate

Conditions

Conditions	Yield
With triethylamine; HATU In N,N-dimethyl-formamide at 20℃; for 2h;	99%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 16h;	84.46%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;	70%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: [(3R,5S)-5-[[4-[4-[[2-[2-(cyclopropylmethylamino)-4-pyridyl]oxazole-4-carbonyl]amino]-3-(difluoromethyl)pyrazol-1-yl]phenyl]methylcarbamoyl]pyrrolidin-3-yl]acetate

: [(3R,5S)-1-[(2S)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoyl]-5-[[4-[4-[[2-[2-(cyclopropylmethylamino)-4-pyridyl]oxazole-4-carbonyl] amino]-3-(difluoromethyl)pyrazol-1-yl]phenyl]methylcarbamoyl]pyrrolidin-3-yl]acetate

Conditions

Conditions	Yield
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine; [(3R,5S)-5-[[4-[4-[[2-[2-(cyclopropylmethylamino)-4-pyridyl]oxazole-4-carbonyl]amino]-3-(difluoromethyl)pyrazol-1-yl]phenyl]methylcarbamoyl]pyrrolidin-3-yl]acetate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;	99%

Yield

Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine; [(3R,5S)-5-[[4-[4-[[2-[2-(cyclopropylmethylamino)-4-pyridyl]oxazole-4-carbonyl]amino]-3-(difluoromethyl)pyrazol-1-yl]phenyl]methylcarbamoyl]pyrrolidin-3-yl]acetate With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;

99%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 103-67-3
benzyl-methyl-amine

: 1032509-62-8
tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 23℃; for 18h; Inert atmosphere;	98%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In chloroform at 23℃; for 18h; Inert atmosphere;	98%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	97%

: 630422-57-0
C2HF3O2*C14H21N3O5S

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 630419-17-9
BOC-NH-(L-tert-BuGly)-[(4R)-hydroxy-S-proline]-(1R,2S-vinyl acca)-CONHSO2-cyclopropane

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 48h;	98%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: (2S,4R)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide trifluoroacetic acid

: 1448189-98-7
tert‐butyl N‐[(2S)‐1‐[(2S,4R)‐4‐hydroxy‐2‐({[4‐(4‐methyl‐1,3‐thiazol‐5‐yl)phenyl]methyl}carbamoyl)pyrrolidin‐1‐yl]‐3,3‐dimethyl‐1‐oxobutan‐2‐yl]carbamate

Conditions

Conditions	Yield
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine; (2S,4R)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide trifluoroacetic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;	98%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;	98%

Yield

Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine; (2S,4R)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide trifluoroacetic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;

98%

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;

98%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: (S)-7-nitro-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

: tert-butyl ((S)-3,3-dimethyl-1-((S)-7-nitro-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-1-oxobutan-2-yl)carbamate

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	98%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 450-91-9
4-fluoro-2-methoxyaniline

: tert-butyl (S)-(1-((4-fluoro-2-methoxyphenyl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Conditions

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;	98%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 543-27-1
isobutyl chloroformate

: 372199-21-8
(S)-tert-butyl (1-amino-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Conditions

Conditions	Yield
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine; isobutyl chloroformate at 0℃; for 0.5h; Stage #2: With ammonium hydroxide In water at 20℃; for 1.5h;	98%

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 20859-02-3
L-tert-Leucine

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane	97%
Stage #1: N-tert-butyloxycarbonyl-L-tert-leucine With methanesulfonic acid In dichloromethane at 25℃; for 3h; Stage #2: With triethylamine In dichloromethane at 25℃; for 1h;	75%
With hydrogenchloride In water; toluene at 60℃; for 3h;

N-Boc-L-tert-Leucine Chemical Properties

Molecular structure of N-Boc-L-tert-Leucine (CAS NO.62965-35-9) is:

Product Name: N-Boc-L-tert-Leucine
CAS Registry Number: 62965-35-9
Empirical Formula: C₁₁H₂₁NO₄
Molecular Weight: 231.2887
Melting Point: 118-121 °C
Surface Tension: 35.7 dyne/cm
Density: 1.063 g/cm³
Flash Point: 165.5 °C
Enthalpy of Vaporization: 65.33 kJ/mol
Boiling Point: 350 °C at 760 mmHg
Vapour Pressure: 7.8E-06 mmHg at 25°C
Product Categories: Amino Acids;Leucine [Leu, L];Amino Acids & Deriv.;Chiral Chemicals;Peptide

N-Boc-L-tert-Leucine Safety Profile

Safety Statements: 24/25
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
HazardClass: IRRITANT

N-Boc-L-tert-Leucine Specification

N-Boc-L-tert-Leucine , its cas register number is 62965-35-9. It also can be called N-(tert-Butoxycarbonyl)-L-tert-leucine ; (S)-N-Boc-2-Amino-3,3-dimethylbutyric acid .It is a white crystalline powder.

Product Name

N-Boc-L-tert-Leucine

Synthetic route

N-Boc-L-tert-Leucine Chemical Properties

N-Boc-L-tert-Leucine Safety Profile

N-Boc-L-tert-Leucine Specification

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