N-Isopropylhydroxylamine supplier

Name
N-Isopropylhydroxylamine
EINECS 225-791-1
CAS No. 5080-22-8
Article Data29
CAS DataBase
Density 0.886 g/cm³
Solubility 199g/L at 25℃
Melting Point 159-160 °C (dec.)
Formula C₃H₉NO
Boiling Point 104.9 °C at 760 mmHg
Molecular Weight 75.1106
Flash Point 44.5 °C
Transport Information
Appearance
Safety 24/25
Risk Codes 21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Hydroxylamine,N-isopropyl- (6CI,7CI,8CI);Isopropylhydroxylamine;N-Hydroxy-2-propanamine;
PSA 32.26000
LogP 0.76450

Synthetic route

: 113768-49-3
2-Isopropyl-3-methyl-5-oxo-2,5-dihydro-isoxazole-4-carboxylic acid ethyl ester

: 5080-22-8
N-isopropylhydroxyamine

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water	96%

: 79-46-9
2-nitropropane

A: 75-31-0
isopropylamine

B: 5080-22-8
N-isopropylhydroxyamine

Conditions

Conditions	Yield
With hydrogen In para-xylene; isopropyl alcohol at 25℃; under 760.051 Torr; for 4h;	A 9% B 88%

: 79-46-9
2-nitropropane

: 5080-22-8
N-isopropylhydroxyamine

Conditions

Conditions	Yield
With ammonia borane; gold on titanium oxide In ethanol at 20℃; for 0.666667h; Inert atmosphere;	85%
elektrochemische Reduktion;
With ammonia; sodium at -33.5℃;

: 7647-01-0
hydrogenchloride

: 3-nitro-benzaldehyde-(N-isopropyl oxime )

A: 99-61-6
3-nitro-benzaldehyde

B: 5080-22-8
N-isopropylhydroxyamine

...Expand

m-nitro-N-isopropyl-isobenzaldoxime: m-nitro-N-isopropyl-isobenzaldoxime

A: 99-61-6
3-nitro-benzaldehyde

B: 5080-22-8
N-isopropylhydroxyamine

Conditions

Conditions	Yield
With hydrogenchloride

: 79-46-9
2-nitropropane

: 7664-41-7
ammonia

sodium: sodium

: 5080-22-8
N-isopropylhydroxyamine

...Expand

: 7647-01-0
hydrogenchloride

: 127-06-0
acetone oxime

platinum black: platinum black

A: 5765-61-7
N,N-diisopropylhydroxylamine

B: 5080-22-8
N-isopropylhydroxyamine

C N-isopropyl-hydroxylammonium chloride: N-isopropyl-hydroxylammonium chloride

D N.N-diisopropyl-hydroxylammonium chloride: N.N-diisopropyl-hydroxylammonium chloride

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 144-62-7
oxalic acid

: 127-06-0
acetone oxime

platinum black: platinum black

A: 5765-61-7
N,N-diisopropylhydroxylamine

B: 5080-22-8
N-isopropylhydroxyamine

C N-isopropyl-hydroxylammonium oxalate: N-isopropyl-hydroxylammonium oxalate

D N.N-diisopropyl-hydroxylammonium oxalate: N.N-diisopropyl-hydroxylammonium oxalate

Conditions

Conditions	Yield
Hydrogenation;

...Expand

: 127-06-0
acetone oxime

: 5080-22-8
N-isopropylhydroxyamine

Conditions

Conditions	Yield
Inert atmosphere;
Stage #1: acetone oxime With sodium cyanoborohydride In methanol at 20℃; for 4h; Stage #2: With hydrogenchloride In methanol

: 123-38-6
propionaldehyde

: 5080-22-8
N-isopropylhydroxyamine

: 107341-57-1, 118644-19-2, 118644-29-4
C6H13NO

Conditions

Conditions	Yield
In ethanol at 20℃; for 0.5h;	100%

: 5080-22-8
N-isopropylhydroxyamine

poly[1-(4-formylphenyl)ethylene], Mn: SEC (RI)= 5500, SEC (UV)= 5000, Mw: SEC (RI)= 5900, PD: SEC (RI)= 1.07, SEC (UV)= 1.15; monomer(s): 4-vinylbenzaldehyde: poly[1-(4-formylphenyl)ethylene], Mn: SEC (RI)= 5500, SEC (UV)= 5000, Mw: SEC (RI)= 5900, PD: SEC (RI)= 1.07, SEC (UV)= 1.15; monomer(s): 4-vinylbenzaldehyde

poly{1-[4-(N-isopropyl-N-oxo-iminomethyl)phenyl]ethylene}, Mn (SEC (RI)): 16300, PD (SEC (RI)): 9.24; monomer(s): 4-vinylbenzaldehyde; N-isopropylhydroxylamine: poly{1-[4-(N-isopropyl-N-oxo-iminomethyl)phenyl]ethylene}, Mn (SEC (RI)): 16300, PD (SEC (RI)): 9.24; monomer(s): 4-vinylbenzaldehyde; N-isopropylhydroxylamine

Conditions

Conditions	Yield
In chloroform at 25℃; for 24h;	100%

: 5080-22-8
N-isopropylhydroxyamine

poly[p-vinylbenzaldehyde-co-styrene], diblock copolymer (0.85:1), Mn: SEC (RI)= 15600, SEC (UV)= 14900, PD: SEC (RI)= 1.30, SEC (UV)= 1.68, Tg: 110 deg C; monomer(s): 4-vinylbenzaldehyde; styrene: poly[p-vinylbenzaldehyde-co-styrene], diblock copolymer (0.85:1), Mn: SEC (RI)= 15600, SEC (UV)= 14900, PD: SEC (RI)= 1.30, SEC (UV)= 1.68, Tg: 110 deg C; monomer(s): 4-vinylbenzaldehyde; styrene

poly[(4-vinylbenzaldehyde-N-isopropylnitron)-co-styrene], diblock copolymer (0.85:1), Mn: SEC (RI)= 18800, SEC (UV)= 16300, PD: SEC (RI)= 1.40, SEC (UV)= 1.54; monomer(s): 4-vinylbenzaldehyde; styrene; N-isopropylhydroxylamine: poly[(4-vinylbenzaldehyde-N-isopropylnitron)-co-styrene], diblock copolymer (0.85:1), Mn: SEC (RI)= 18800, SEC (UV)= 16300, PD: SEC (RI)= 1.40, SEC (UV)= 1.54; monomer(s): 4-vinylbenzaldehyde; styrene; N-isopropylhydroxylamine

Conditions

Conditions	Yield
In chloroform at 25℃; for 24h;	100%

: 5080-22-8
N-isopropylhydroxyamine

poly[1-(3-formylphenyl)ethylene], Mn: SEC (RI)= 12600, SEC (UV)= 11800, PD: SEC (RI)= 3.42, SEC (UV)= 3.45; monomer(s): 3-vinylbenzaldehyde: poly[1-(3-formylphenyl)ethylene], Mn: SEC (RI)= 12600, SEC (UV)= 11800, PD: SEC (RI)= 3.42, SEC (UV)= 3.45; monomer(s): 3-vinylbenzaldehyde

poly{1-[3-(N-isopropyl-N-oxo-iminomethyl)phenyl]ethylene}, Mn (SEC (RI)): 13400, PD (SEC (RI)): 3.53; monomer(s): 3-vinylbenzaldehyde; N-isopropylhydroxylamine: poly{1-[3-(N-isopropyl-N-oxo-iminomethyl)phenyl]ethylene}, Mn (SEC (RI)): 13400, PD (SEC (RI)): 3.53; monomer(s): 3-vinylbenzaldehyde; N-isopropylhydroxylamine

Conditions

Conditions	Yield
In chloroform at 25℃; for 24h;	100%

: 5080-22-8
N-isopropylhydroxyamine

poly[1-(4-formyl-3-hydroxyphenyl)ethylene], Mn: SEC (RI)= 8000, SEC (UV)= 8400, Mw: SEC (RI)= 34700, SEC (UV)= 33500, PD: SEC (RI)= 4.32, SEC (UV)= 4.00; monomer(s): 2-hydroxy-4-vinylbenzaldehyde: poly[1-(4-formyl-3-hydroxyphenyl)ethylene], Mn: SEC (RI)= 8000, SEC (UV)= 8400, Mw: SEC (RI)= 34700, SEC (UV)= 33500, PD: SEC (RI)= 4.32, SEC (UV)= 4.00; monomer(s): 2-hydroxy-4-vinylbenzaldehyde

poly{1-[3-hydroxy-4-(N-isopropyl-N-oxo-iminomethyl)phenyl]ethylene}, Mn (SEC (RI)): 12800, Mw (SEC (RI)): 29600, PD (SEC (RI)): 2.30; monomer(s): 2-hydroxy-4-vinylbenzaldehyde; N-isopropylhydroxylamine: poly{1-[3-hydroxy-4-(N-isopropyl-N-oxo-iminomethyl)phenyl]ethylene}, Mn (SEC (RI)): 12800, Mw (SEC (RI)): 29600, PD (SEC (RI)): 2.30; monomer(s): 2-hydroxy-4-vinylbenzaldehyde; N-isopropylhydroxylamine

Conditions

Conditions	Yield
In tetrahydrofuran at 25℃; for 24h;	100%

: 110-86-1
pyridine

: 16456-81-8, 170645-84-8
meso-tetraphenylporphyrin iron(III) chloride

: 5080-22-8
N-isopropylhydroxyamine

: 84027-23-6, 64479-14-7
iron(II)(tetraphenylporphyrin)(pyridine)(i-Pr-NO)

Conditions

Conditions	Yield
In chloroform 20°C, 15 h, under Ar; recrystn. from CHCl3, MeoH, pyridine; elem. anal.;	100%

...Expand

: 123-38-6
propionaldehyde

: 5080-22-8
N-isopropylhydroxyamine

: 107341-57-1, 118644-19-2, 118644-29-4
N-Isopropylpropylidenamin-N-oxid

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane for 15h; Ambient temperature;	98%

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 5080-22-8
N-isopropylhydroxyamine

: sodium (Z)-2-hydroxy-5-((isopropyloxidoimino)methyl)benzoate

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-5-formylbenzoic acid; N-isopropylhydroxyamine In methanol at 20℃; Stage #2: With sodium hydroxide In methanol; water at 20℃;	96%

: 16456-81-8, 170645-84-8
meso-tetraphenylporphyrin iron(III) chloride

: 5080-22-8
N-isopropylhydroxyamine

: 84040-45-9
[2-(hydroxyamino)propane](2-nitrosopropane)(meso-tetraphenylporphyrinato)iron(II)

Conditions

Conditions	Yield
In chloroform 6 h, under Ar; solvent was removed under vac., recrystn. from CHCl3, MeOH at -15° C; elem. anal.;	95%

: 7790-94-5
chlorosulfonic acid

: 5080-22-8
N-isopropylhydroxyamine

: 18247-17-1
N-isopropylhydroxylamine O-sulfonic acid

Conditions

Conditions	Yield
In dichloromethane at -78℃; for 2h;	94%

: 110-86-1
pyridine

: 19496-18-5
5,10,15,20-tetrakis(4-methylphenyl)porphyrinatoiron(III) chloride

: 5080-22-8
N-isopropylhydroxyamine

: 84027-28-1
(2-nitrosopropane)(pyridine)(meso-tetratolylporphyrinato)iron(II)

Conditions

Conditions	Yield
In chloroform 20°C, 4 h, under Ar; recrystn. from CHCl3, MeOH, pyridine;	93%

...Expand

: 5080-22-8
N-isopropylhydroxyamine

: 5222-73-1
3,4-dimethoxy-3-cyclobutene-1,2-dione

: 100749-01-7
3-(N-Hydroxy-isopropylamino)-4-methoxy-3-cyclobuten-1,2-dion

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 25℃; for 1h; retro-Cope elimination reaction;	92%

: 5080-22-8
N-isopropylhydroxyamine

: 473440-59-4
5-carbomethoxythiopentanoyl 2-(5,5-dimethyl-2-thiono-1,3,2-dioxaphosphorinanyl)sulfide

: N-(5-carbomethoxythiopentanoyl)-N-isoprpylhydroxylamine

Conditions

Conditions	Yield
With triethylamine	91%

: 110-86-1
pyridine

: 36965-70-5
5,10,15,20-tetrakis(p-chlorophenyl)porphyrin iron(III) chloride

: 5080-22-8
N-isopropylhydroxyamine

: 84027-27-0
(2-nitrosopropane)(pyridine)(meso-tetra(4-chlorophenyl)porphyrinato)iron(II)

Conditions

Conditions	Yield
In chloroform 20°C, 4 h, under Ar; recrystn. from CHCl3, MeOH, pyridine;	90%

...Expand

: 67-56-1
methanol

: 16456-81-8, 170645-84-8
meso-tetraphenylporphyrin iron(III) chloride

: 5080-22-8
N-isopropylhydroxyamine

: 84027-24-7
(methanol)(2-nitrosopropane)(meso-tetraphenylporphyrinato)iron(II)

Conditions

Conditions	Yield
In chloroform 20° C, 6 h, under Ar; recrystn. from CH2Cl2, MeOH; elem. anal.;	90%

...Expand

: {bis-(p-dimethylaminophenyl)allenylidene}(pentacarbonyl)chromium

: 5080-22-8
N-isopropylhydroxyamine

: pentacarbonyl[(N-isopropyl-3,3-bis-p-dimethylaminophenyl)isoxazolidinylidene]chromium * 0.25 pentane

Conditions

Conditions	Yield
In dichloromethane inert atmosphere; stirring Cr-complex with 1.27 equiv. of hydroxylamine derivative (room temp., 4 h); evapn. (vac.), chromy. (-20°C, SiO2, pentane/CH2Cl2/Et2O=8:1:1), evapn., crystn. (pentane/CH2Cl2=12:1); elem. anal.;	90%

: 16456-81-8, 170645-84-8
meso-tetraphenylporphyrin iron(III) chloride

: 75-31-0
isopropylamine

: 5080-22-8
N-isopropylhydroxyamine

: 73233-48-4
(2-aminopropane)(2-nitrosopropane)(meso-tetraphenylporphyrinato)iron(II)

Conditions

Conditions	Yield
In chloroform 20° C, 15 h, under Ar; recrystn. from CHCl3, MeOH, i-PrNH2 at -15° C; elem. anal.;	89%

...Expand

: 65961-86-6
(3,4-dimethoxy-phenyl)-glyoxylonitrile

: 5080-22-8
N-isopropylhydroxyamine

: 82461-66-3
C12H17NO4

Conditions

Conditions	Yield
	87%

: pentacarbonyl[3,3-bis(p-(dimethylamino)phenyl)-1,2-propadienylidene]tungsten

: 5080-22-8
N-isopropylhydroxyamine

: pentacarbonyl[(N-isopropyl-3,3-bis-p-dimethylaminophenyl)isoxazolidinylidene]tungsten * 0.25 pentane

Conditions

Conditions	Yield
In dichloromethane inert atmosphere; stirring W-complex with 1.3 equiv. of hydroxylamine derivative (room temp., 4 h); evapn. (vac.), chromy. (-20°C, SiO2, pentane/CH2Cl2/Et2O=7:2:1), evapn., crystn. (pentane/CH2Cl2=8:1); elem. anal.;	87%

: 5080-22-8
N-isopropylhydroxyamine

: 2243-42-7
2-phenoxybenzoic acid

: C16H17NO3

Conditions

Conditions	Yield
Stage #1: 2-phenoxybenzoic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide Stage #2: N-isopropylhydroxyamine With triethylamine In tetrahydrofuran; dichloromethane; water at 23℃;	87%

: 3282-30-2
pivaloyl chloride

: 5080-22-8
N-isopropylhydroxyamine

: 106129-12-8
N-Isopropylpivalohydroxamsaeure

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran	86%

: 5080-22-8
N-isopropylhydroxyamine

: 938-18-1
mesitylene-2-carboxylic acid chloride

: 1510834-18-0
N-isopropyl-2,4,6-trimethylbenzohydroxamic acid

Conditions

Conditions	Yield
at 20℃; for 2h; Inert atmosphere;	86%

: 5080-22-8
N-isopropylhydroxyamine

: 292638-85-8
acrylic acid methyl ester

: 95503-39-2
methyl 3-(N-hydroxy-N-isopropyl)aminopropanoate

Conditions

Conditions	Yield
In diethyl ether Ambient temperature;	84%

: 2233-18-3
4-hydroxy-3,5-dimethylbenzaldehyde

: 5080-22-8
N-isopropylhydroxyamine

: (Z)-N-(4-hydroxy-3, 5-dimethylbenzylidene)propan-2-amine oxide

Conditions

Conditions	Yield
In methanol; water at 20℃;	81%

: 5080-22-8
N-isopropylhydroxyamine

: 78-84-2
isobutyraldehyde

: 140116-61-6
(Z)-N-(2-methylpropylidene)propan-2-amine oxide

Conditions

Conditions	Yield
With magnesium sulfate In chloroform for 12h; Ambient temperature;	80%

: 5080-22-8
N-isopropylhydroxyamine

: 463962-41-6
thiobutyryl 2-(5,5-dimethyl-2-thiono-1,3,2-dioxaphosphorinanyl)sulfide

: N-isopropyl-N-thiobutyrylhydroxylamine

Conditions

Conditions	Yield
With triethylamine	80%

: 5080-22-8
N-isopropylhydroxyamine

: 143884-26-8
(5Z,7E,20R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-20-formylmethyl-9,10-seco-5,7,10(19)-pregnatriene

: 851228-80-3
C38H69NO3Si2

Conditions

Conditions	Yield
Stage #1: N-isopropylhydroxyamine; (5Z,7E,20R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-20-formylmethyl-9,10-seco-5,7,10(19)-pregnatriene With triethylamine In dichloromethane at 20℃; for 2h; Stage #2: With ammonium chloride In dichloromethane; water	80%

N-Isopropylhydroxylamine Chemical Properties

The molecular structure of 2-Propanamine,N-hydroxy- (CAS NO.5080-22-8) is

IUPAC Name: N-Propan-2-ylhydroxylamine
Canonical SMILES: CC(C)NO
Molecular Formula: C₃H₉ N O
Molecular Weight: 75.11
EINECS: 225-791-1
Density: 0.886g/cm³
Melting Point: 159-160 °C (dec.)
Boiling Point: 104.9°C at 760mmHg
Flash Point: 44.5°C
Freely Rotating Bonds: 2
Polar Surface Area: 12.47 Å²
Index of Refraction: 1.41
Molar Refractivity: 21.03 cm³
Molar Volume: 84.7 cm³
Polarizability: 8.33× 10^-24 cm³
Surface Tension: 27.2 dyne/cm
Enthalpy of Vaporization: 40.09 kJ/mol
Vapour Pressure: 16.5 mmHg at 25°C
The Cas Register Number of 2-Propanamine,N-hydroxy- is 5080-22-8. The chemical synonyms of 2-Propanamine,N-hydroxy- (CAS NO.5080-22-8) are N-hydroxy-2-propanamin ; N-hydroxy-2-Propaneamine ; N-isopropylhydroxylamineoxalate ; IPHA ; N-Isopropylhydroxylamine ; N-Isopropylhydroxylamine oxalate salt ; 2-Propanamine, N-hydroxy- ; 2-hydroxylaminopropane .

N-Isopropylhydroxylamine Uses

2-Propanamine,N-hydroxy- (CAS NO.5080-22-8) is used in organic synthesis.

N-Isopropylhydroxylamine Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 21/22
R21/22: Harmful in contact with skin and if swallowed.
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.

Product Name

N-Isopropylhydroxylamine

Synthetic route

N-Isopropylhydroxylamine Chemical Properties

N-Isopropylhydroxylamine Uses

N-Isopropylhydroxylamine Safety Profile

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