N-Methyl-D-Glucamine supplier

Name
Meglumine
EINECS 228-506-9
CAS No. 6284-40-8
Article Data34
CAS DataBase
Density 1.375 g/cm³
Solubility 100 g/100 mL (25 ºC)
Melting Point 129-131.5 °C(lit.)
Formula C₇H₁₇NO₅
Boiling Point 490.4 °C at 760 mmHg
Molecular Weight 195.216
Flash Point 251.6 °C
Transport Information
Appearance white to almost white crystalline powder
Safety 24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Glucitol,1-deoxy-1-(methylamino)-, D- (8CI);Sorbitol, 1-deoxy-1-methylamino- (6CI);1-Deoxy-1-(methylamino)-D-glucitol;D-(-)-N-Methylglucamine;Meglumin;Meglumine;Methylglucamin;Methylglucamine;N-Methyl-D(-)-glucamine;N-Methylglucamine;N-Methylsorbitylamine;NSC 52907;NSC 7391;
PSA 113.18000
LogP -2.96740

Synthetic route

: 24758-59-6
N-methyl-D-gluconamide

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

Conditions

Conditions	Yield
With ammonia borane; palladium/alumina at 78℃; under 975.098 - 48004.8 Torr; for 2h; Temperature; Pressure; Reagent/catalyst; Inert atmosphere; Large scale;	69.3%

: 50-99-7
D-glucose

: 74-89-5
methylamine

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

Conditions

Conditions	Yield
With hydrogen In water at 10 - 100℃; under 5171.62 - 25858.1 Torr; for 21.5h;	62.5%
With nickel kieselguhr; water at 95 - 120℃; under 36775.4 - 102971 Torr; Hydrogenation;
With ethanol Hydrierung des Reaktionsprodukts an Palladium-Kohle in Methanol bei 60grad/20-25at;

: 50-99-7
D-glucose

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

Conditions

Conditions	Yield
With methylamine

: 50-99-7
D-glucose

: 3400-38-2
methylaminomethanol

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 557-04-0
magnesium stearate

A poloxamer: poloxamer

B: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 50-99-7
D-glucose

: 74-89-5
methylamine

A: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

B: 110-70-3
N,N`-dimethylethylenediamine

Conditions

Conditions	Yield
With 5 wt% ruthenium/carbon; hydrogen In water at 124.84℃; under 56255.6 Torr; for 1h;

...Expand

: 5-({4-[(4-butylphenyl)ethynyl]benzyl}{[2-(ethoxycarbonyl)cyclopropyl]methyl}amino)-2-fluorobenzoic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 5-({4-[(4-butylphenyl)ethynyl]benzyl}{[2-(ethoxycarbonyl)cyclopropyl]methyl}amino)-2-fluorobenzoic acid N-methyl-D-glucamine salt

Conditions

Conditions	Yield
In methanol; water	100%

: gadolinium(III) oxide

: 124628-06-4
2-[1,4,7,10-tetraaza-4,7-di(1-carboxy-2-benzyloxy-ethyl)-10-carboxymethyl-cyclododecane-1-yl]-3-benzyloxypropionic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: {gadolinium(C8H17N4(CH2COO)(CH(COO)CH2OCH2C6H5)3)(D(-)-N-methylglucamine)}

Conditions

Conditions	Yield
In water heating to 70°C until a clear soln. was obtained; evapn. (vac.) and isolation after drying to const. weight; elem. anal.;	100%

...Expand

: gadolinium(III) oxide

: 124628-02-0
2-[1,4,7,10-tetraaza-4-(1-carboxy-2-benzyloxy-ethyl)-7,10-di(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: {gadolinium(C8H17N4(CH2COO)2(CH(COO)CH2OCH2C6H5)2)(D(-)-N-methylglucamine)}

Conditions

Conditions	Yield
In water heating to 70°C until a clear soln. was obtained; evapn. (vac.) and isolation after drying to const. weight; elem. anal.;	100%

...Expand

: gadolinium(III) oxide

: 124628-08-6
2-[1,4,7,10-tetraaza-4,7,10-tri(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: {gadolinium(C8H17N4(CH2COO)3CH(COO)CH2OCH2C6H5)(D(-)-N-methylglucamine)}

Conditions

Conditions	Yield
In water heating to 70°C until a clear soln. was obtained; evapn. (vac.) and isolation after drying to const. weight; elem. anal.;	100%

...Expand

: gadolinium(III) oxide

: 124628-04-2
2-[1,4,7,10-tetraaza-7-(1-carboxy-2-benzyloxy-ethyl)-4,10-di(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: {gadolinium(C8H17N4(CH2COO)2(CH(COO)CH2OCH2C6H5)2)(D(-)-N-methylglucamine)}

Conditions

Conditions	Yield
In water heating to 70°C until a clear soln. was obtained; evapn. (vac.) and isolation after drying to const. weight; elem. anal.;	100%

...Expand

: 186087-26-3
D-isoglutamyl-D-tryptophan

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 1034125-74-0
D-isoglutamyl-D-tryptophan mono-N-methyl-D-glucamine salt

Conditions

Conditions	Yield
In water at 20℃; pH=~ 7;	100%
In water at 20℃; for 168h; pH=Ca. 7;	100%

: 1190221-43-2
5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoehtoxy)acetyl]amino)benzoic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 1190221-63-6
5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoethoxy)acethyl]amino)benzoic acid N-methyl-D-glucaminesalt

Conditions

Conditions	Yield
In methanol for 0.5h;	100%

: (S)-2-((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenamido)-4-methylpentanoic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: C7H17NO5*C26H41NO3

Conditions

Conditions	Yield
In methanol at 20℃; for 2h;	100%

: O-[1-(propofol-O-yl)]cyclobut-1-yl-monoester phosphoric acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: O-[1-(propofol-O-yl)]cyclobut-1-yl-monoester dimeglumine phosphate

Conditions

Conditions	Yield
In water at 20℃; for 1h;	100%

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 106-89-8
epichlorohydrin

: C10H22ClNO6

Conditions

Conditions	Yield
In methanol at 20℃; for 72h;	100%

: 2-(5-nitrothiazol-2-yl-carbamoyl)phenyl dihydrogen phosphate

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 2-(5-nitrothiazol-2-ylcarbamoyl)phenyl dihydrogen phosphate methylglucamine salt

Conditions

Conditions	Yield
In methanol at 20℃; for 0.333333h;	100%

: (4S)-4-[5-(2,5-dichloro-4-[[(4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidin-3-yl]methyl]phenyl)pentanamido]-5-methoxy-5-oxopentanoic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: methyl (2S)-2-[5-(2,5-dichloro-4-[[(4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidin-3-yl]methyl]phenyl)pentanamido]-4-[methyl[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamoyl]butanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	100%

: 3,8-bis(1-methoxyethyl)deuteroporphyrin IX

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 3,8-bis(1-methoxyethyl)porphyrin IX dimeglumine salt

Conditions

Conditions	Yield
In ethanol for 1h; Reflux;	100%

: (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: tedizolid phosphate dimeglumine

Conditions

Conditions	Yield
In water at 20℃; Concentration;	99.5%

: gadolinium(III) oxide

: 174267-98-2
(3β,5β,7α,12α)-3-[[[[[bis[2-[bis(carboxymethyl)amino]ethyl]amino]-acetyl]amino]-acetyl]amino]-7,12-dihydroxycholan-24-oic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: gadolinium complex of (3β,5β,7α, 12α)-3-[[[[[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetyl]amino]acetyl]amino]-7,12-dihydroxycholan-24-oic acid salified with 1-deoxy-1-(methylamino)-D-glucitol (1:2)

Conditions

Conditions	Yield
In water at 50℃; for 25h; pH=5.0 - 6.8;	99%

...Expand

: 80003-64-1
2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylic acid, bis-((2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol) salt

Conditions

Conditions	Yield
In water at 20℃; for 0.166667h;	99%

: 1256465-11-8
26-succinate-22-deacetyl-neoboutomellerone

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 1256465-12-9
26-succinate-22-deacetyl-neoboutomellerone N-methyl-D-glucamine salt

Conditions

Conditions	Yield
In ethanol; water for 0.166667h;	99%
In ethanol; water for 0.166667h;	99%

: 132178-37-1
2,5-dioxopyrrolidin-1-yl pent-4-ynoate

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 1448147-88-3
N-methyl-N-(4-pentynoyl)-D-glucamine

Conditions

Conditions	Yield
With triethylamine In pyridine; N,N-dimethyl-formamide at 20℃; for 1h;	99%

: 760-93-0
methacryloyl anhydride

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: N-methacryloyl-N-methyl-1-amino-1-deoxy-D-glucitol

Conditions

Conditions	Yield
In methanol at 15 - 25℃; for 2h; Solvent;	99%

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 24801-88-5
3-(triethoxypropyl) isocyanate

: N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)-N'-(3-triethoxysilylpropyl)urea

Conditions

Conditions	Yield
In tetrahydrofuran at 80 - 90℃; for 2.5h;	99%

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: tris(4-hydroxyphenyl)methane triglycidyl ether

: 4,4',4''-tris{2-hydroxy-3-[N-methyl-(2',3',4',5',6'-pentahydroxy-D-gluco-hexyl)amino]propoxy}triphenylmethane

Conditions

Conditions	Yield
In ethanol for 7h; Reflux;	99%

: (R)-3-methyl-6-(2-((5-methyl-2-(6-(trifluoromethyl)pyridin-3-yl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: C24H26F3N3O3*C7H17NO5

Conditions

Conditions	Yield
In tetrahydrofuran; water at 20℃; for 16h; Solvent; Temperature;	98.95%
In isopropyl alcohol at 25 - 50℃; for 1.33333h; Solvent; Sealed tube;
In isopropyl alcohol at 25 - 50℃; for 1.33333h; Solvent; Sealed tube; Sonication;

: (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: tedizolid phosphate monomeglumine

Conditions

Conditions	Yield
In water at 20℃; Concentration;	98.9%

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 19545-26-7
wortmannin

: WmC20-N-methyl-glucamine

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 0.5h;	98.7%

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 4748-78-1
4-ethylbenzylaldehyde

: 1042065-80-4
(2R,5S)-2-(4-ethylphenyl)-3-methyl-5-(D-arabino-1,2,3,4-tetrahydroxybutyl)oxazolidine

Conditions

Conditions	Yield
In benzene Heating;	98%

: 4538-39-0
1,10-diisocyanatodecane

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 1056030-07-9
N,N'-decamethylenebis[N''-(1-deoxy-D-glucitol-1-yl)-N''-methylurea]

Conditions

Conditions	Yield
In 1,4-dioxane; water at 20℃; for 2h;	98%

: 1380445-03-3
4-(((1S,2S)-2,3-dihydro-1-hydroxy-2-(1H-inden-2-yl)-1H-inden-2-yl)methyl)benzoic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 1380445-04-4
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentanol 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2-biinden]-2-yl)methyl)benzoic acid

Conditions

Conditions	Yield
In methanol at 55℃;	98%
In water

: gadolinium(III) oxide

: 67-43-6
diethylenetriaminopentaacetic acid

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: gadopentate dimeglumine

Conditions

Conditions	Yield
Stage #1: diethylenetriaminopentaacetic acid; 1-deoxy-1-(methylamino)-D-glucitol In water for 0.0333333h; Sonication; Green chemistry; Stage #2: gadolinium(III) oxide In water for 0.3h; Sonication; Green chemistry;	98%

...Expand

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: 170729-80-3
aprepitant

: Fosaprepitant dimeglumine

Conditions

Conditions	Yield
Stage #1: aprepitant With dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate; sodium hexamethyldisilazane In tetrahydrofuran at -3℃; for 2h; Stage #2: 1-deoxy-1-(methylamino)-D-glucitol With palladium 10% on activated carbon; hydrogen In methanol; water for 4h;	98%

: 6284-40-8
1-deoxy-1-(methylamino)-D-glucitol

: fosaprepitant

: fosaprepitant dimeglumine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol; water for 4h;	98%

N-Methyl-D-Glucamine Specification

N-Methyl-D-Glucamine , with the CAS register number 6284-40-8, is also known as 1-deoxy-1-(methylamino)-d-glucito;1-deoxy-1-(methylamino)hexitol ; glucitol, 1-deoxy-1-(methylamino)-, d- ; meglumin ; methylglucamin ; methylglucamine ; d-glucitol, 1-deoxy-1-(methylamino)- ; d(-)-n-methylglucamine .

The characteristics of this kind of chemical are as below: (1)#H bond acceptors: 6 ; (2)#H bond donors: 6 ; (3)#Freely Rotating Bonds: 11 ; (4)Polar Surface Area: 49.39 ; (5)Index of Refraction: 1.555 ; (6)Molar Refractivity: 45.58 cm³ ; (7)Molar Volume: 141.9 cm³ ; (8)Polarizability: 18.07 ×10-24cm³ ; (9)Surface Tension: 70.8 dyne/cm ; (10)Density: 1.375 g/cm³ ; (11)Flash Point: 251.6 °C ; (12)Enthalpy of Vaporization: 87.2 kJ/mol ; (13)Boiling Point: 490.4 °C at 760 mmHg ; (14)Vapour Pressure: 1.12E-11 mmHg at 25°C .

It is white to almost white crystalline powder. It is soluble in the H2O: 0.1 g/mL(clear, colorless liquid) while in the water 100 g/100 mL (25 ºC). The raw materials are acetaldehyde ammonia and 1-glucose-methylamine schiffbase . Beside, it is sensitive to air and hygroscopic.

Being a kind of irritant chemical, it is harmful to eyes, respiratory system and skin. And while using this chemical, remember to avoid contacting with skin and eyes. If you need more safety information, you could refer to the WGK Germany 3. When it comes to storing method, it should be kept under argon and in a dry place.

N-Methyl-D-Glucamine's product categories are in the below listing of anilines, aromatic amines and nitro compounds, aminosugars, biochemistry, and sugars. As for its uage, it is usualy used as the cosolvent and the surface active agent for contrast agent. We could make it as the following steps:
condense glucose and Monomethylamine and then have the catalytic hydrogenation, finally, you could get this chemical.

In addition, you could obtain the molecular structure by converting the following data information:
SMILES:O[C@H]([C@@H](O)CNC)[C@H](O)[C@H](O)CO
InChI:InChI=1/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1
InChIKey:MBBZMMPHUWSWHV-BDVNFPICBL

Product Name

Meglumine

Synthetic route

N-Methyl-D-Glucamine Specification

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