N-Phenylpiperidin-4-amine supplier

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Name
N-phenylpiperidin-4-amine
EINECS
CAS No. 23056-29-3
Article Data10
CAS DataBase
Density 1.052g/cm³
Solubility
Melting Point
Formula C11H16 N2
Boiling Point 312°Cat760mmHg
Molecular Weight 176.261
Flash Point 185.3°C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Piperidine,4-anilino- (8CI); 4-Anilinopiperidine; N-(Piperidin-4-yl)aniline;N-Phenylpiperidin-4-amine; NSC 80678
PSA 24.06000
LogP 2.25230

Synthetic route

: 125541-22-2
1-(tert-butoxycarbonyl)-4-phenylaminopiperidine

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃; for 1h;	100%
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 3h;	86%
With trifluoroacetic acid In dichloromethane

: 116512-92-6
N-(1-ethoxycarbonyl-4-piperidinyl)aniline

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
With hydrogenchloride In water for 16h; Heating;	92%

: 13035-19-3
4-aminopiperidine

: 108-90-7
chlorobenzene

A: 63921-23-3
1-phenylpiperidin-4-ylamine

B: 1-phenyl-4-(phenylamino)piperidine

C: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
With sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium(0) In xylene at 130℃; for 24h;	A 60% B 7% C n/a

...Expand

: 13035-19-3
4-aminopiperidine

: 108-86-1
bromobenzene

A: 63921-23-3
1-phenylpiperidin-4-ylamine

B: 1-phenyl-4-(phenylamino)piperidine

C: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
With chiral ferrocene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) In xylene at 130℃; for 24h; Product distribution; Further Variations:; Reagents;	A 18% B 8% C 15%

...Expand

: 62-53-3
aniline

ethane-α.β-bis-sulfonic acid chloride: ethane-α.β-bis-sulfonic acid chloride

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) molecular sieves; 2) NaBH4 / 1) benzene, reflux, 20 h; 2) EtOH, room temp., 5 h 2: 92 percent / 6 N aq. HCl / H2O / 16 h / Heating View Scheme

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) molecular sieves; 2) NaBH4 / 1) benzene, reflux, 20 h; 2) EtOH, room temp., 5 h 2: 92 percent / 6 N aq. HCl / H2O / 16 h / Heating View Scheme

: 41979-39-9
4-piperidone hydrochloride

: 62-53-3
aniline

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Stage #1: 4-piperidone hydrochloride; aniline With acetic acid; zinc at 20 - 70℃; for 24h; Stage #2: With sodium hydroxide In water Product distribution / selectivity; Cooling with ice;

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme

: 62-53-3
aniline

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme

: 41979-39-9
4-piperidone hydrochloride

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 24 h / 20 °C 2: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C 3: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme

: 96-09-3
styrene oxide

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 1269606-71-4
1-phenyl-2-(4-phenylamino-piperidin-1-yl)-ethanol

Conditions

Conditions	Yield
	85%

: 1716-42-3
1-(3-chloropropoxy)-4-fluorobenzene

: 23056-29-3
phenyl-piperidin-4-yl-amine

: {1-[3-(4-Fluoro-phenoxy)-propyl]-piperidin-4-yl}-phenyl-amine

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In 1,4-dioxane for 16h; Heating;	60%

: 1198-30-7
1-isoquinolinecarbonitrile

: 23056-29-3
phenyl-piperidin-4-yl-amine

: N-phenyl-N-(piperidin-4-yl)isoquinoline-1-amine

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; 1,3-dicyano-5-fluoro-2,4,6-tris(diphenylamino)benzene In acetonitrile at 20℃; for 12h; Inert atmosphere; Irradiation;	60%

: C14H17Cl3N2O

: 23056-29-3
phenyl-piperidin-4-yl-amine

A: C25H32Cl2N4O

B: C39H48Cl4N6O2

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 25℃; for 18h;	A 55% B n/a

...Expand

: 4-chloro-1-(4-phenylpiperazin-1-yl)butan-1-one

: 23056-29-3
phenyl-piperidin-4-yl-amine

A: C25H34N4O

B: C39H52N6O2

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 25℃; for 18h;	A 49% B n/a

...Expand

: C15H21ClN2O2

: 23056-29-3
phenyl-piperidin-4-yl-amine

A: C26H36N4O2

B: C41H56N6O4

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 25℃; for 18h;	A 45% B n/a

...Expand

: 1-(6-morpholinopyrimidin-4-yl)piperidine-4-carboxylic acid

: 23056-29-3
phenyl-piperidin-4-yl-amine

: (1-(6-morpholinopyrimidin-4-yl)piperidin-4-yl)(4-(phenylamino)piperidin-1-yl)methanone

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	41%

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 3874-54-2
4-(4-fluorophenyl)-4-oxo-n-butyl chloride

: 1-(4-Fluoro-phenyl)-4-(4-phenylamino-piperidin-1-yl)-butan-1-one

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In 1,4-dioxane for 16h; Heating;	35%

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 166964-34-7
5-({[1-(4-Chloro-phenyl)-methanoyl]-amino}-methyl)-thiophene-2-sulfonyl chloride

: N-({5-[(4-anilinopiperidin-1-yl)sulfonyl]thien-2-yl}methyl)-4-chlorobenzamide

Conditions

Conditions	Yield
Stage #1: phenyl-piperidin-4-yl-amine With polymer-bound morpholine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: 5-({[1-(4-Chloro-phenyl)-methanoyl]-amino}-methyl)-thiophene-2-sulfonyl chloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 15h; Stage #3: With polymer-bound aminobenzene; polymer-bound isocyanate In dichloromethane; N,N-dimethyl-formamide at 20℃; for 5h;

Yield

Stage #1: phenyl-piperidin-4-yl-amine With polymer-bound morpholine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 5-({[1-(4-Chloro-phenyl)-methanoyl]-amino}-methyl)-thiophene-2-sulfonyl chloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 15h;
Stage #3: With polymer-bound aminobenzene; polymer-bound isocyanate In dichloromethane; N,N-dimethyl-formamide at 20℃; for 5h;

: 7516-60-1
4-chlorosulfonylbenzoyl chloride

: 23056-29-3
phenyl-piperidin-4-yl-amine

4-Br-2-[C(O)O-Wang resin]-aniline: 4-Br-2-[C(O)O-Wang resin]-aniline

: 5-bromo-2-[4-(4-phenylamino-piperidine-1-sulfonyl)-benzoylamino]-benzoic acid

Conditions

Conditions	Yield
Stage #1: 4-chlorosulfonylbenzoyl chloride; 4-Br-2-[C(O)O-Wang resin]-aniline With pyridine In dichloromethane at 20℃; for 4h; Stage #2: phenyl-piperidin-4-yl-amine With triethylamine In dichloromethane at 20℃; for 15h; Stage #3: With trifluoroacetic acid In dichloromethane at 20℃; for 1h;

...Expand

: 40047-23-2
6-hydroxy-1H-indole-2-carboxylic acid

: 23056-29-3
phenyl-piperidin-4-yl-amine

: C20H21N3O2

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide for 16h;

: 23056-29-3
phenyl-piperidin-4-yl-amine

: {1-[3-(4-Fluoro-phenoxy)-propyl]-piperidin-4-yl}-methyl-phenyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 60 percent / K2CO3, NaI / dioxane / 16 h / Heating 2: H2 / 10percent Pd/C / aq. ethanol / 16 h View Scheme

: C21H18Cl3F6NO2

: 23056-29-3
phenyl-piperidin-4-yl-amine

: C32H33Cl2F6N3O2

Conditions

Conditions	Yield
With 3 A molecular sieve; sodium cyanoborohydride In CF3CH2OH at 23℃; for 4h;

: 1094173-12-2
C20H24N2O2

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 1094173-07-5
C31H38N4O

Conditions

Conditions	Yield
With polymer-supported carbodiimide; benzotriazol-1-ol In N,N-dimethyl-formamide at 50℃;

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 103-63-9
1-phenyl-2-bromoethane

: 21409-26-7
(1-Phenethyl-piperidin-4-yl)-phenyl-amine

Conditions

Conditions	Yield
With sodium hydroxide at 120℃; Product distribution / selectivity;

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 120-92-3
cyclopentanone

: (1-cyclopentyl-piperidin-4-yl)-phenyl-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In dichloromethane

: 34330-08-0
C14H16N2O3S

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 1135023-95-8
C25H30N4O2S

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 103-72-0
phenyl isothiocyanate

: 1620774-22-2
C18H21N3S

Conditions

Conditions	Yield
In toluene at 20℃; for 2h;

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 1-(2-(methylamino)ethyl)-N-phenylpiperidin-4-amine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C 2: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C View Scheme

: 23056-29-3
phenyl-piperidin-4-yl-amine

: 123387-72-4
O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate

: C19H31N3O2

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 16h;

N-Phenylpiperidin-4-amine Chemical Properties

Molecular Structure of N-Phenyl-4-piperidinamine (CAS NO.23056-29-3):

IUPAC Name: N-phenylpiperidin-4-amine
Empirical Formula: C₁₁H₁₆N₂
Molecular Weight: 176.2581
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 24.06 Å²
Index of Refraction: 1.579
Molar Refractivity: 55.634 cm³
Molar Volume: 167.427 cm³
Surface Tension: 42.068 dyne/cm
Density: 1.053 g/cm³
Flash Point: 185.298 °C
Enthalpy of Vaporization: 55.297 kJ/mol
Boiling Point: 312.012 °C at 760 mmHg
Vapour Pressure: 0.001 mmHg at 25°C
InChI
InChI=1/C11H16N2/c1-2-4-10(5-3-1)13-11-6-8-12-9-7-11/h1-5,11-13H,6-9H2
Smiles
N1CCC(Nc2ccccc2)CC1

N-Phenylpiperidin-4-amine Safety Profile

HazardClass: Irritant

N-Phenylpiperidin-4-amine Specification

N-Phenyl-4-piperidinamine , with CAS number of 23056-29-3, can be called 4-piperidinamine, N-phenyl- ; N-phenylpiperidin-4-amine .

Product Name

N-phenylpiperidin-4-amine

Synthetic route

N-Phenylpiperidin-4-amine Chemical Properties

N-Phenylpiperidin-4-amine Safety Profile

N-Phenylpiperidin-4-amine Specification

Related Products

Hot Products