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Chemsigma International Co.,Ltd.

bulk production ProName: 4-Chloro-4'-fluorobutyrophenone CasNo: 3874-54-2 Molecular Formula: C10H10ClFO Appearance: white powder Application: Chemical,Pharmacetical,OLED intermedia... DeliveryTime: in stock, deliver aga

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Gram

FOB Price: $3.0 / 4.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Chloro-4'-Fluorobutyrophenone supplier in China

Cas:3874-54-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for t

High purity 4-Chloro-4'-fluorobutyrophenone 98% TOP1 supplier in China

Cas:3874-54-2

Min.Order:100 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 4-Chloro-4'-fluorobutyrophenone CAS No. 3874-54-2

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Metric Ton

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can

4-Chloro-4'-fluorobutyrophenone CAS:3874-54-2

Cas:3874-54-2

Min.Order:1 Metric Ton

FOB Price: $520.0 / 888.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 3874-54-2 with best quality

Cas:3874-54-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Butanone,4-chloro-1-(4-fluorophenyl)- 3874-54-2

Cas:3874-54-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

4-Chloro-4'-fluorobutyrophenone CAS:3874-54-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

4-Chloro-4'-fluorobutyrophenone CAS:3874-54-2

Cas:3874-54-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Butanone,4-chloro-1-(4-fluorophenyl)-

Cas:3874-54-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

1-Butanone,4-chloro-1-(4-fluorophenyl)-/ LIDE PHARMA- Factory supply / Best price

Cas:3874-54-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big cust

4-Chloro-4'-Fluorobutyrophenone CAS 3874-54-2

Cas:3874-54-2

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Butanone,4-chloro-1-(4-fluorophenyl)-

Cas:3874-54-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Chloro-4'-Fluorobutyrophenone

Cas:3874-54-2

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance: light yellow liquid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Ai

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-CHLORO-4'-FLUOROBUTYROPHENONE

Cas:3874-54-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi New nine Material Technology Co., Ltd.

Our Advantage: 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good quali

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4-Chloro-4'-Fluorobutyrophenone

Cas:3874-54-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Established in 2010, located in Hangzhou Qinglan science park, lingruichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. In our R&D centre, we have a staff of skilled and experie

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:colourless or light yellow liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum, or as per your request. Application:Used for APIs Tra

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 4-Chloro-4’-Fluoro Butyrophenone CAS No.:3874-54-2 Molecule Formula:C10H10ClFO Molecule Weight:200.63 Purity: 99% Package: 25kg/drum Description:Yellow or light yellow liquid Manufacture Standards:Enterprise Standard

High Quality 4-Chloro-4’-Fluoro Butyrophenone in stock

Cas:3874-54-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM 4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Synonyms: GAMMA-CHLORO-4-FLUOROBUTYROPHENONE;GAMMA-CHLORO-P-FLUOROBUTYROPHENONE;G-CHLORO-P-FLUOROBUTYROPHENONE;AKOS BBS-00006481;4-CHLORO-1-(4-FLUOROPHENYL)-1-BUTANONE;4-CHLORO-1-(4-FLUOROPHENYL)-1-OXOBUTANE;4-CHLORO-4'-FLUOROBUTYROPHENONE;4-CH

4-Chloro-4’-fluorobutyrophenone 3874-54-2 Large in promotion

Cas:3874-54-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Melting point 5-6 ° C Boiling point: 130-132 ° C (0.97513 mmHg) Density: 1.22 g / ml at 25 ° C (lit.) Refractive index n 20 / D 1.5255 (lit.) Flash point > 230 ° F Appearance:Slightly yellow-greenish clear oil Storage:Sealed in

4-Chloro-4'-fluorobutyrophenone China manufacture

Cas:3874-54-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

Zhejiang Jiuzhou Chem Co., Ltd is a national high-and new-tech enterprise specialized in the research, manufacturing of APIs and intermediates. Our company has passed the ISO9001 quality system and established an image as a provider of high qua

3874-54-2 4-Chloro-4'-fluorobutyrophenone

Cas:3874-54-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Synthetic route

fluorobenzene
462-06-6

fluorobenzene

4-Chlorobutanoyl chloride
4635-59-0

4-Chlorobutanoyl chloride

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 20℃; for 4h; Time;90%
With aluminium trichloride In carbon disulfide at 20℃; for 2h;73.2%
With aluminium trichloride
4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane
3308-94-9

4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
In(OSO2CF3)3 In acetone at 100℃; for 0.0833333h; microwave irradiation;89%
4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

4-Chlorobutanoyl chloride
4635-59-0

4-Chlorobutanoyl chloride

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
Stage #1: 4-Chlorobutanoyl chloride With 1-methyl-pyrrolidin-2-one In toluene at 0℃; for 0.5h;
Stage #2: 4-flourophenylmagnesium bromide In tetrahydrofuran; toluene at -10 - 0℃; for 4.25h; chemoselective reaction;
88%
1-(4-chlorobut-1-yn-1-yl)-4-fluorobenzene
1183278-95-6

1-(4-chlorobut-1-yn-1-yl)-4-fluorobenzene

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
With iron(III) chloride; water; silver(I) triflimide In 1,4-dioxane for 18h; regioselective reaction;85%
With water; bis(trifluoromethanesulfonyl)amide In 1,4-dioxane at 100℃;85%
With water In 1,4-dioxane at 80 - 120℃; regioselective reaction;85%
1-(4-fluorophenyl)cyclobutan-1-ol
339365-53-6

1-(4-fluorophenyl)cyclobutan-1-ol

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
With manganese(II) triflate; tetrabutylammonium acetate; acetic acid; magnesium chloride In acetonitrile at 25℃; for 3.5h; Inert atmosphere; Electrochemical reaction; Sealed tube;84%
With 1,10-Phenanthroline; tert-butylhypochlorite; silver trifluoromethanesulfonate In acetonitrile at 20℃; for 6h; Inert atmosphere; Schlenk technique; regioselective reaction;81%
4-chlorobutyraldehyde
6139-84-0

4-chlorobutyraldehyde

1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
With Quinuclidine; 4,4'-di-tert-butyl-2,2'-bipyridine nickel(II) bromide; [Ir(C6H2F2-C5H3NCF3)2(4,4′-di-tert-butyl-2,2′-dipyridyl)]; potassium carbonate In 1,4-dioxane at 20℃; for 20h; Inert atmosphere; Sealed tube; Irradiation;77%
With palladium diacetate; 9,10-phenanthrenequinone; potassium hydrogencarbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In acetone at 20℃; for 24h; Reagent/catalyst; Irradiation;71%
1-iodo-3-chloro-propane
6940-76-7

1-iodo-3-chloro-propane

4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

molybdenum hexacarbonyl
13939-06-5, 199620-15-0

molybdenum hexacarbonyl

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
Stage #1: 1-iodo-3-chloro-propane; 4-fluoroboronic acid With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; benzene at 20℃; for 24h; Suzuki-Miyaura Coupling; Inert atmosphere; Irradiation;
Stage #2: molybdenum hexacarbonyl With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 70℃; Suzuki-Miyaura Coupling; Inert atmosphere;
68%
1-ethynyl-4-fluorobenzene
766-98-3

1-ethynyl-4-fluorobenzene

3-chloropropionyl peroxide
19263-25-3

3-chloropropionyl peroxide

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
With iron(III) trifluoromethanesulfonate; trifluorormethanesulfonic acid In tetrahydrofuran at 70 - 80℃; for 12.25h; Inert atmosphere; Schlenk technique;60%
3-chloro-4'-fluoropropiophenone
347-93-3

3-chloro-4'-fluoropropiophenone

diethyl 4-chloromethyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
3613-34-1

diethyl 4-chloromethyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
With manganese; di-tert-butyl peroxide; α,α,α-trifluorotoluene at 100℃; for 48h; Inert atmosphere;51%
1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux; Sealed tube
1.2: 0 - 20 °C / Inert atmosphere; Sealed tube
2.1: acetic acid; manganese(II) triflate; magnesium chloride; tetrabutylammonium acetate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere; Electrochemical reaction; Sealed tube
View Scheme
para-thiocresol
106-45-6

para-thiocresol

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

1-(4-fluorophenyl)-4-(p-tolylthio)butan-1-one
132427-90-8

1-(4-fluorophenyl)-4-(p-tolylthio)butan-1-one

Conditions
ConditionsYield
100%
With triethylamine In tetrahydrofuran for 16h; Ambient temperature;99%
N-methoxylamine hydrochloride
593-56-6

N-methoxylamine hydrochloride

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

4-chloro-1-(4-fluorophenyl)butan-1-one O-methyl oxime
1352950-38-9

4-chloro-1-(4-fluorophenyl)butan-1-one O-methyl oxime

Conditions
ConditionsYield
With pyridine at 20℃;100%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

cyclopropyl(4-fluorophenyl)methanone
772-31-6

cyclopropyl(4-fluorophenyl)methanone

Conditions
ConditionsYield
With sodium hydroxide In water at 60℃; for 5h;100%
toluene-3-thiol
108-40-7

toluene-3-thiol

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

1-(Fluorophenyl)-4-(3-methylphenylthio)-1-butanone

1-(Fluorophenyl)-4-(3-methylphenylthio)-1-butanone

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran99%
With triethylamine In tetrahydrofuran99%
toluene-3-thiol
108-40-7

toluene-3-thiol

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

1-(4-Fluorophenyl)-4-(3-methylphenylthio)-1-butanone

1-(4-Fluorophenyl)-4-(3-methylphenylthio)-1-butanone

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran99%
ethylene glycol
107-21-1

ethylene glycol

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane
3308-94-9

4-chloro-1-(4-fluorophenyl)-1,1-(ethylenedioxy)butane

Conditions
ConditionsYield
With toluene-4-sulfonic acid In water; toluene for 16h; Inert atmosphere; Reflux;98%
With toluene-4-sulfonic acid In benzene for 18h; Heating;93%
With toluene-4-sulfonic acid In benzene for 15h; Heating;90%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

1-(2,5-dimethylphenyl)piperazine
1013-25-8

1-(2,5-dimethylphenyl)piperazine

4-[4-(2,5-dimethylphenyl)piperazin-1-yl]-1-(4-fluorophenyl)butan-1-one

4-[4-(2,5-dimethylphenyl)piperazin-1-yl]-1-(4-fluorophenyl)butan-1-one

Conditions
ConditionsYield
With sodium hydrogencarbonate; sodium iodide In acetonitrile for 22h; Reflux;96%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

(+/-)-4-chloro-1-(4-fluorophenyl)butan-1-ol
51787-87-2

(+/-)-4-chloro-1-(4-fluorophenyl)butan-1-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 0℃; for 7h;95%
With sodium tetrahydroborate In ethanol at 0 - 20℃; for 3h;94%
With sodium tetrahydroborate In ethanol at 0 - 20℃; for 12h;93%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

1-iodo-3-(p-fluorophenylcarbonyl)propane
40862-32-6

1-iodo-3-(p-fluorophenylcarbonyl)propane

Conditions
ConditionsYield
With sodium iodide In butanone for 3h; Heating;95%
With sodium iodide In acetone for 24h; Reflux;92%
With sodium iodide In acetone for 16h; Reflux;77%
In sodium iodide; butanone
With sodium iodide In [(2)H6]acetone for 8h; Reflux;
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

4-(n-butyl)fluorobenzene
20651-65-4

4-(n-butyl)fluorobenzene

Conditions
ConditionsYield
With nickel In tetrahydrofuran for 15h; Heating;95%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

C10H10FN3O
154440-76-3

C10H10FN3O

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide95%
With sodium azide; potassium iodide In N,N-dimethyl-formamide at 90℃;
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

(S)-2-methylpropane-2-sulfinamide
343338-28-3

(S)-2-methylpropane-2-sulfinamide

(S,E)-N-(4-chloro-1-(4-fluorophenyl)butylidene)-2-methylpropane-2-sulfinamide
1218989-31-1

(S,E)-N-(4-chloro-1-(4-fluorophenyl)butylidene)-2-methylpropane-2-sulfinamide

Conditions
ConditionsYield
With titanium (IV) ethoxide In tetrahydrofuran at 65℃; for 48h; Inert atmosphere;94%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

C10H11FO

C10H11FO

Conditions
ConditionsYield
Stage #1: 4-(4-fluorophenyl)-4-oxo-n-butyl chloride With C32H33FeN3O2Si; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at -40 - 20℃; for 2h; Schlenk technique; Glovebox;
Stage #2: With potassium carbonate In methanol; toluene at 20℃; for 12h; Schlenk technique; Glovebox; enantioselective reaction;
94%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
1021-25-6

1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

spiperone
749-02-0

spiperone

Conditions
ConditionsYield
With diisopropylamine In N,N-dimethyl-formamide at 80℃; for 17h; Inert atmosphere;93%
With triethylamine; potassium iodide In acetonitrile for 20h; Heating;74%
With triethylamine; potassium iodide In acetonitrile for 20h; Inert atmosphere; Reflux;63%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

potassium thioacetate
10387-40-3

potassium thioacetate

S-(4-(4-fluorophenyl)-4-oxobutyl) ethanethioate

S-(4-(4-fluorophenyl)-4-oxobutyl) ethanethioate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 0 - 20℃; for 10h; Inert atmosphere;92%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

(1R)-(+)-4-chloro-1-(4-fluorophenyl)butan-1-ol
126640-11-7

(1R)-(+)-4-chloro-1-(4-fluorophenyl)butan-1-ol

Conditions
ConditionsYield
With B-chlorodiisopinocampheylborane In diethyl ether at -25℃; for 16h;90%
With C22H27Cl2CoN3O; sodium triethylborohydride; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; enantioselective reaction;87%
Stage #1: 4-(4-fluorophenyl)-4-oxo-n-butyl chloride With Triethoxysilane; (S,E)-(+)-2,6-diisopropyl-N-(2-((2-(4-phenyl-4,5-dihydrooxazol-2-yl)phenyl)amino)benzylidene)aniline; sodium triethylborohydride; cobalt(II) chloride In tetrahydrofuran; dichloromethane at 20℃; for 15h; Schlenk technique; Inert atmosphere;
Stage #2: With potassium carbonate In tetrahydrofuran; methanol; dichloromethane at 20℃; for 2h; Schlenk technique; Inert atmosphere; enantioselective reaction;
75%
Multi-step reaction with 2 steps
1: 81 percent / NaBH4 / methanol / 4 °C
View Scheme
With B-chlorodiisopinocampheylborane In tetrahydrofuran; diethyl ether; 2,2'-iminobis[ethanol] at 25℃;
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

(1S)-(-)-4-chloro-1-(4-fluorophenyl)butan-1-ol
126640-10-6

(1S)-(-)-4-chloro-1-(4-fluorophenyl)butan-1-ol

Conditions
ConditionsYield
With (-)-diisopinocamphenylborane chloride In diethyl ether at -25℃; for 16h;90%
Multi-step reaction with 2 steps
1: 81 percent / NaBH4 / methanol / 4 °C
View Scheme
With (-)-diisopinocamphenylborane chloride In tetrahydrofuran; diethyl ether; 2,2'-iminobis[ethanol] at 25℃;
4-fluorobenzylic alcohol
459-56-3

4-fluorobenzylic alcohol

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

cyclopropyl-[4-(4-fluoro-benzyloxy)-phenyl]-methanone
868699-44-9

cyclopropyl-[4-(4-fluoro-benzyloxy)-phenyl]-methanone

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium hydride In tetrahydrofuran at 30℃; for 18h;90%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

(-)-4-chloro-1-(4-fluorophenyl)butan-1-ol

(-)-4-chloro-1-(4-fluorophenyl)butan-1-ol

Conditions
ConditionsYield
Stage #1: 4-(4-fluorophenyl)-4-oxo-n-butyl chloride With (S)-2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine; phenylsilane; copper(II) acetate monohydrate In toluene at -20 - 20℃; for 48h;
Stage #2: With hydrogenchloride In water; toluene Reagent/catalyst; enantioselective reaction;
90%
fluoroiodomethane
373-53-5

fluoroiodomethane

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

5-chloro-1-fluoro-2-(4-fluorophenyl)pentan-2-ol

5-chloro-1-fluoro-2-(4-fluorophenyl)pentan-2-ol

Conditions
ConditionsYield
With methyllithium lithium bromide In tetrahydrofuran; diethyl ether at -78℃; for 0.0833333h; Inert atmosphere;90%
1-phenylmethylpiperazine
2759-28-6

1-phenylmethylpiperazine

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

cyclopropyl-{4-(4-benzylpiperazin-1-yl)phenyl}methanone

cyclopropyl-{4-(4-benzylpiperazin-1-yl)phenyl}methanone

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 140℃;90%
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

1-(4-chlorobutyl)-4-fluorobenzene
54540-58-8

1-(4-chlorobutyl)-4-fluorobenzene

Conditions
ConditionsYield
With triethylsilane; trifluoroacetic acid at 0℃; for 2h;89%
With hydrogen; palladium on activated charcoal In ethanol
With hydrogenchloride; mercury dichloride; zinc In toluene for 5h; Reflux;
With triethylsilane In trifluoroacetic acid
4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

δ-Hydroxy-δ-bis(p-fluorophenyl)butyl chloride
51787-80-5

δ-Hydroxy-δ-bis(p-fluorophenyl)butyl chloride

Conditions
ConditionsYield
In diethyl ether Heating;88.4%
4-hydroxy-4-phenylpiperidin
40807-61-2

4-hydroxy-4-phenylpiperidin

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

1-(4-fluorophenyl)-4-(4-hydroxy-4-phenylpiperidin-1-yl)butan-1-one
3109-12-4

1-(4-fluorophenyl)-4-(4-hydroxy-4-phenylpiperidin-1-yl)butan-1-one

Conditions
ConditionsYield
With sodium hydrogencarbonate; potassium iodide In toluene for 24h; Reflux;88%
With potassium iodate; potassium carbonate In toluene Inert atmosphere;27%
With toluene; potassium iodide
4-(4-chlorophenyl)-4-hydroxypiperidine
39512-49-7

4-(4-chlorophenyl)-4-hydroxypiperidine

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

haloperidol
52-86-8

haloperidol

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 75℃; for 24h; Temperature;88%
With potassium iodide In toluene for 45h; Reflux;85%
With potassium iodide In toluene at 130℃; for 45h; Sealed tube;79%
1-(4-chlorophenyl)-1,4-diazepane
41885-98-7

1-(4-chlorophenyl)-1,4-diazepane

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one

4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In 1,2-dimethoxyethane for 18h; Heating;87%
[bis(acetoxy)iodo]benzene
3240-34-4

[bis(acetoxy)iodo]benzene

4-(4-fluorophenyl)-4-oxo-n-butyl chloride
3874-54-2

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

C12H12ClFO3
1394244-16-6

C12H12ClFO3

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium hydroxide In 1,4-dioxane at 20℃; for 1h;87%
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