N-phenylglycine supplier | CasNO.103-01-5

Name
Anilinoacetic acid
EINECS 203-070-2
CAS No. 103-01-5
Article Data101
CAS DataBase
Density 1.259 g/cm³
Solubility moderately soluble in water
Melting Point 121-127 °C
Formula C₈H₉NO₂
Boiling Point 359 °C at 760 mmHg
Molecular Weight 151.165
Flash Point 170.9 °C
Transport Information
Appearance ochre to yellow-brown fine powder
Safety 22-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms H-DL-Phg-OH;TR-NPG;(Phenylamino)aceticacid;Acetic acid, (phenylamino)-;Anilinoacetic acid;N-(Phenylamino)aceticacid;N-Phenylglycine;NSC 83567;
PSA 49.33000
LogP 1.25610

Synthetic route

: 105-36-2
ethyl bromoacetate

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
Stage #1: ethyl bromoacetate; aniline With silica gel at 20℃; for 0.116667h; microwave irradiation; Stage #2: With sodium hydroxide In ethanol for 0.166667h; Heating;	93%
Stage #1: ethyl bromoacetate; aniline With potassium carbonate for 1.5h; Milling; Stage #2: With potassium hydroxide for 1.5h; Milling;	91%
Stage #1: ethyl bromoacetate; aniline Stage #2: With sodium hydroxide

: 21969-70-0
2-anilinoacetamide

: 71-36-3
butan-1-ol

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
	90%

: 65171-67-7
tert-butyl 2-(phenylamino)acetate

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 3h;	90%
In water; isopropyl alcohol at 200℃; for 0.25h; Solvent; Temperature; Flow reactor;	77%

: 591-50-4
iodobenzene

: 56-40-6
glycine

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; 2-(N,N-dimethylamino)ethanol In water at 75 - 80℃; for 72h;	87%
With copper(l) iodide; 2-(2-methyl-1-oxopropyl)cyclohexanone; caesium carbonate In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere;	82%
With copper(I) oxide; caesium carbonate at 100℃; for 0.666667h; Sealed tube; Microwave irradiation;	10%

: 108-86-1
bromobenzene

: 56-40-6
glycine

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With copper(l) iodide; 2-(2-methyl-1-oxopropyl)cyclohexanone; potassium carbonate In water at 90℃; for 0.833333h; Microwave irradiation; Green chemistry;	81%
With pectin-stabilized copper nanoparticles In dimethyl sulfoxide at 110℃; for 2h;	71%
With potassium phosphate; copper(l) iodide; 2-(N,N-dimethylamino)ethanol In water at 90℃;	62%
With copper(l) iodide; potassium carbonate In N,N-dimethyl acetamide at 90℃;

: 2216-92-4
N-phenylglycine ethyl ester

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With sodium hydroxide In water for 0.5h; Heating;	73%
With sodium hydroxide for 0.5h; Heating;	70%
Stage #1: N-phenylglycine ethyl ester With sodium hydroxide In water for 0.5h; Reflux; Stage #2: With hydrogenchloride In water pH=2;

: 178695-68-6, 181121-53-9
1-phenyl-4-oximinoimidazolidine

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With hydrogenchloride Hydrolysis;	60%

: 591-50-4
iodobenzene

: 556-50-3
glycylglycine

A: 852380-00-8
N-(N-phenyl-glycyl)-glycine

B: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; 2-(N,N-dimethylamino)ethanol In water at 70℃; for 16h;	A 40% B 27%

...Expand

: 1457-85-8
Ethyl oxanilate

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With sulfuric acid Electrolysis.elektrolytische Reduktion;

: 622-14-0
N,N'-diphenylmethylenediamine

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With potassium cyanide; ethanol

: 3009-97-0
N-phenylglycinonitrile

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With hydrogenchloride
With calcium hydroxide; alkali carbonate; water
With water In aq. phosphate buffer at 37℃; pH=7; Green chemistry; Enzymatic reaction;

: 500-72-1
oxanilic acid

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With water; zinc
With sulfuric acid Electrolysis.elektrolytische Reduktion;

: 2567-62-6
N-phenylglycine anilide

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With alkali

: 39126-37-9
anilino-malonic acid

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With water

: 861321-16-6
N-anilinomethyl formanilide

: 151-50-8
potassium cyanide

: 103-01-5
N-Phenylglycine

: 861321-16-6
N-anilinomethyl formanilide

: 151-50-8
potassium cyanide

A: 21969-70-0
2-anilinoacetamide

B: N-carbamoylmethyl-N-phenyl-glycine

C: 103-01-5
N-Phenylglycine

D: 62-53-3
aniline

...Expand

: 79-08-3
bromoacetic acid

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With diethyl ether

: 105-39-5
chloroacetic acid ethyl ester

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
man verseift den entstehenden Anilinoessigsaeure-aethylester durch Kochen mit alkoh.Kalilauge;
With water bei Gegenwart eines salzsaeurebindenen Mittels (anorganischer Basen oder basich wirkender Salze); man verseift den entstandenen Anilinoessigsaeure-aethylester durch Kochen mit alkoh.Kalilauge;
Anilinoessigsaeure-aethylester entsteht;
With water bei Gegenwart eines salzsaeurebindenen Mittels (anorganischer Basen oder basich wirkender Salze); Anilinoessigsaeure-aethylester entsteht;

: 98-95-3
nitrobenzene

: 79-11-8
chloroacetic acid

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With iron

: 79-11-8
chloroacetic acid

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With water; sodium acetate
With iron(II) oxide; sodium chloride
With sodium chloride bei Gegenwart von Carbonaten der Schwermetalle;

: 79-11-8
chloroacetic acid

: 62-53-3
aniline

A: 1137-73-1
N,N-bis(carboxymethyl)aniline

B: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With water; sodium acetate ueber mehrere Stufen;

...Expand

: 79-11-8
chloroacetic acid

: 62-53-3
aniline

A: phenylimino-di-acetic acid ; compound with aniline

B: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With water man trennt die Reaktionsprodukte durch wiederholte fraktionierte Krystallisation aus Wasser, wobei sich das Anilinsalz der Anilin-N.N-diessigsaeure zuletzt abscheidet;

...Expand

: 50-00-0
formaldehyd

: 151-50-8
potassium cyanide

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With potassium hydroxide; N-phenylglycine potassium salt

...Expand

: 50-00-0
formaldehyd

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With alkali cyanide

: 79-01-6
Trichloroethylene

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
With calcium hydroxide; water at 180℃;

: 5326-92-1
3-methylbutyl chloroacetate

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
man verseift den entstandenen Anilinoessigsaeure-isoamylester mit konz.waessr.Natronlauge;

: 3926-62-3
sodium monochloroacetic acid

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
In water for 0.5h;

: 1068-52-6
sodium 2-bromoacetate

: 62-53-3
aniline

: 103-01-5
N-Phenylglycine

Conditions

Conditions	Yield
Alkylation;

: 20635-51-2
1,4-diphenylpiperazine-2,5-dione

alcoholic KOH-solution: alcoholic KOH-solution

: 103-01-5
N-Phenylglycine

: 50-00-0
formaldehyd

: 103-01-5
N-Phenylglycine

: 115011-74-0
N-phenyloxazolidin-5-one

Conditions

Conditions	Yield
In toluene for 0.5h; Heating;	100%
In benzene at 80℃; for 1h;	96%
In toluene Heating;	96%

: 24424-99-5
di-tert-butyl dicarbonate

: 103-01-5
N-Phenylglycine

: 150806-61-4
N-t-butoxycarbonyl L-phenylglycine

Conditions

Conditions	Yield
With triethylamine In dichloromethane; water	100%
With triethylamine In water; acetone at 20℃; for 19h;	75%
With sodium hydroxide In 1,4-dioxane-water; citric acid
With triethylamine In water; acetone at 20℃;

: 103-01-5
N-Phenylglycine

: 78733-46-7
methyl (+/-)-phenylglycinate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In methanol	100%

: 883-99-8
3-hydroxy-2-naphthoic acid methyl ester

: 103-01-5
N-Phenylglycine

: C19H19NO3

Conditions

Conditions	Yield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 24h; Sealed tube; Irradiation; Inert atmosphere;	99%

: C16H15N3O2

: 103-01-5
N-Phenylglycine

: C23H24N4O2

Conditions

Conditions	Yield
With disodium hydrogenphosphate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile In acetonitrile at 20℃; for 5h; Catalytic behavior; Reagent/catalyst; Solvent; Sealed tube; Irradiation; Inert atmosphere; diastereoselective reaction;	99%

: 3317-61-1
5,5-Dimethyl-1-pyrroline N-oxide

: 103-01-5
N-Phenylglycine

: 2,2-dimethyl-5-((phenylamino)methyl)pyrrolidin-1-ol

Conditions

Conditions	Yield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; lithium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation;	99%

: 67-56-1
methanol

: 103-01-5
N-Phenylglycine

: 23284-84-6
N-phenylglycine methyl ester

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 20℃;	98%
With sulfuric acid for 1h; Heating;	85%
With hydrogenchloride

: 103-01-5
N-Phenylglycine

: 4748-78-1
4-ethylbenzylaldehyde

: 1-(4-ethylphenyl)-2-(phenylamino)ethan-1-ol

Conditions

Conditions	Yield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In water at 20℃; for 3h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;	98%

: 459-57-4
4-fluorobenzaldehyde

: 103-01-5
N-Phenylglycine

: 1181454-77-2
1-(4-fluorophenyl)-2-(phenylamino)ethan-1-ol

Conditions

Conditions	Yield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In water at 20℃; for 3h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;	98%

: C17H17N3O2

: 103-01-5
N-Phenylglycine

: C19H18N2O2

Conditions

Conditions	Yield
Stage #1: C17H17N3O2; N-Phenylglycine With disodium hydrogenphosphate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile In acetonitrile at 20℃; for 15h; Sealed tube; Irradiation; Inert atmosphere; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 0.0833333h; Sealed tube; Inert atmosphere;	98%

: 29540-83-8
p-tolyl triflate

: 103-01-5
N-Phenylglycine

: 15818-64-1
N-(4-methylbenzyl)aniline

Conditions

Conditions	Yield
With nickel(II) triflate; P(p-CH3OC6H4)3; Ir(dFCF3(ppy))2(4,4’-ditert-butyl-2,2’-bipyrididyl)PF6; caesium carbonate In acetonitrile at 20℃; for 24h; Sealed tube; Irradiation; Inert atmosphere;	97%

: 1616784-38-3
2-(1-([1,1'-biphenyl]-4-yl)vinyl)pyridine

: 103-01-5
N-Phenylglycine

: C26H24N2

Conditions

Conditions	Yield
With lithium hexafluorophosphate; 5,6-bis(5-methoxythiophen-2-yl)pyrazine-2,3-dicarbonitrile; C31H21F6O4P In tetrahydrofuran at -35℃; Inert atmosphere; Irradiation; enantioselective reaction;	97%

: C17H17N3O3

: 103-01-5
N-Phenylglycine

: C24H26N4O3

Conditions

Conditions	Yield
With disodium hydrogenphosphate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile In acetonitrile at 20℃; for 5h; Sealed tube; Irradiation; Inert atmosphere; diastereoselective reaction;	97%

: 24423-88-9
1-pyrroline N-oxide

: 103-01-5
N-Phenylglycine

: 2-((phenylamino)methyl)pyrrolidin-1-ol

Conditions

Conditions	Yield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; lithium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation;	97%

: 103-01-5
N-Phenylglycine

: D(-)-phenylglycine butyl ester hydrochloride

Conditions

Conditions	Yield
With sodium In butan-1-ol	96.3%

: 100-52-7
benzaldehyde

: 103-01-5
N-Phenylglycine

: 99342-73-1, 31121-09-2
1-phenyl-2-phenylaminoethanol

Conditions

Conditions	Yield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In water at 20℃; for 3h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;	96%
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In water for 4h; Catalytic behavior; Solvent; Schlenk technique; Sealed tube; Irradiation;	96.2%

: 939-97-9
4-tert-Butylbenzaldehyde

: 103-01-5
N-Phenylglycine

: 1-(4-(tert-butyl)phenyl)-2-(phenylamino)ethan-1-ol

Conditions

Conditions	Yield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In water at 20℃; for 3h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;	96%

: C16H13F2N3O2

: 103-01-5
N-Phenylglycine

: C23H22F2N4O2

Conditions

Conditions	Yield
With disodium hydrogenphosphate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile In acetonitrile at 20℃; for 9h; Sealed tube; Irradiation; Inert atmosphere; diastereoselective reaction;	96%

: C16H14BrN3O2

: 103-01-5
N-Phenylglycine

: C23H23BrN4O2

Conditions

Conditions	Yield
With disodium hydrogenphosphate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile In acetonitrile at 20℃; for 5h; Sealed tube; Irradiation; Inert atmosphere; diastereoselective reaction;	96%

: C17H17N3O3

: 103-01-5
N-Phenylglycine

: C24H26N4O3

Conditions

Conditions	Yield
With disodium hydrogenphosphate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile In acetonitrile at 20℃; for 8h; Sealed tube; Irradiation; Inert atmosphere; diastereoselective reaction;	96%

: 103-01-5
N-Phenylglycine

: 508191-77-3
3-phenylsydnone

Conditions

Conditions	Yield
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide; acetic anhydride; sodium nitrite In dichloromethane at 0 - 5℃; for 5h;	95%
Stage #1: N-Phenylglycine With sodium nitrite Milling; Stage #2: With trifluoroacetic anhydride Milling;	95%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic anhydride; sodium nitrite In dichloromethane at 0 - 5℃; for 10h;	94%

: 2-acetylthiomethyl-3-phenylpropanoyl acid chloride

: 103-01-5
N-Phenylglycine

: N-[S-Acetyl-2'-benzyl-3'-mercaptopropionyl]-D-phenylglycine

Conditions

Conditions	Yield
With chloro-trimethyl-silane; triethylamine In methanol; dichloromethane; chloroform; acetonitrile	95%

: (E)-N-butyl-N-(3-formyl-2-oxo-2H-chromen-4-yl)-2-phenylethenesulfonamide

: 103-01-5
N-Phenylglycine

: 10-butyl-1,3-diphenyl-1,2,3,3a,10,11a-hexahydro-4H-chromeno[4,3-c]pyrrolo[2,3-e][1,2]thiazin-4-one 11,11-dioxide

Conditions

Conditions	Yield
In acetonitrile for 5h; Reflux; Molecular sieve;	95%

: 32578-31-7
3-tolyl triflate

: 103-01-5
N-Phenylglycine

: 75366-13-1
N-(3-methylbenzyl)aniline

Conditions

Conditions	Yield
With nickel(II) triflate; P(p-CH3OC6H4)3; Ir(dFCF3(ppy))2(4,4’-ditert-butyl-2,2’-bipyrididyl)PF6; caesium carbonate In acetonitrile at 20℃; for 24h; Sealed tube; Irradiation; Inert atmosphere;	95%

: 66107-32-2
4-cyanophenyl trifluoromethanesulfonate

: 103-01-5
N-Phenylglycine

: 37812-49-0
4-phenylaminomethyl-benzonitrile

Conditions

Conditions	Yield
With nickel(II) triflate; P(p-CH3OC6H4)3; Ir(dFCF3(ppy))2(4,4’-ditert-butyl-2,2’-bipyrididyl)PF6; caesium carbonate In acetonitrile at 20℃; for 24h; Sealed tube; Irradiation; Inert atmosphere;	95%

: 17763-71-2
4-carbomethoxyphenyl triflate

: 103-01-5
N-Phenylglycine

: 39126-16-4
N-[4-(methyloxycarbonyl)benzyl]aniline

Conditions

Conditions	Yield
With nickel(II) triflate; P(p-CH3OC6H4)3; Ir(dFCF3(ppy))2(4,4’-ditert-butyl-2,2’-bipyrididyl)PF6; caesium carbonate In acetonitrile at 20℃; for 24h; Sealed tube; Irradiation; Inert atmosphere;	95%

: 1581709-76-3
4-methyl-2-(1-phenylvinyl)pyridine

: 103-01-5
N-Phenylglycine

: C21H22N2

Conditions

Conditions	Yield
With lithium hexafluorophosphate; 5,6-bis(5-methoxythiophen-2-yl)pyrazine-2,3-dicarbonitrile; C31H21F6O4P In tetrahydrofuran at -35℃; Inert atmosphere; Irradiation; enantioselective reaction;	95%

: 446-52-6
2-Fluorobenzaldehyde

: 103-01-5
N-Phenylglycine

: 1-(2-fluorophenyl)-2-(phenylamino)ethan-1-ol

Conditions

Conditions	Yield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In water at 20℃; for 3h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;	95%

2N-NaOH: 2N-NaOH

: 103-01-5
N-Phenylglycine

: 7148-74-5
2-Bromopropionyl chloride

A: N-(2-bromopropionylphenyl)glycine

B: 861570-46-9
N-(2-bromo-propionyl)-N-phenyl-glycine

Conditions

Conditions	Yield
	A 94.8% B n/a

...Expand

: 909114-66-5
9-fluorenylmethyl 4,6-dimethoxy-1,3,5-triazinyl carbonate

: 103-01-5
N-Phenylglycine

: 909114-68-7
N-{[(9H-fluoren-9-yl)meth-1-yl-oxy]carbonyl}-N-phenylglycine

Conditions

Conditions	Yield
With sodium carbonate In acetonitrile at 20℃; for 1.08333h;	94%

N-phenylglycine Chemical Properties

The molecular formula of N-phenylglycine(103-01-5) is C₈H₉NO₂ and its formula weight is 151.16.
N-phenylglycine(103-01-5) has a melting point of 121-123 °C(lit.).
The chemical synonyms of N-phenylglycine(103-01-5) are AURORA KA-3653;ANILINOACETIC ACID;H-PHENYLGLY-OH;AKOS B003332;RARECHEM AL BO 1139;N-PHENYLGLYCIN;N-PHENYLGLYCINE;N-PHENYL-GLY-OH
The molecular structure of N-phenylglycine(103-01-5):

N-phenylglycine Toxicity Data With Reference

RTECS#: CAS# 103-01-5: None listed
LD50/LC50: RTECS: Not available.
Carcinogenicity: N-PHENYLGLYCINE, 93%(TLC) - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: The toxicological properties have not been fully investigated.

N-phenylglycine Safety Profile

Safety Statements 22-24/25
WGK Germany 3
HS Code 29224995

N-phenylglycine Specification

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials Strong oxidizing agents.
Hazardous Decomposition Products Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization Has not been reported.

Product Name

Anilinoacetic acid

Synthetic route

N-phenylglycine Chemical Properties

N-phenylglycine Toxicity Data With Reference

N-phenylglycine Safety Profile

N-phenylglycine Specification

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