• Name

  Nepafenac

• EINECS
• CAS No. 78281-72-8
• Article Data8
• CAS DataBase
• Density 1.249 g/cm³
• Solubility 0.014 mg/mL in water
• Melting Point 177-181oC
• Formula C₁₅H₁₄N₂O₂
• Boiling Point 562.5 °C at 760 mmHg
• Molecular Weight 254.288
• Flash Point 294 °C
• Transport Information
• Appearance
• Safety 60-61
• Risk Codes 50/53
• Molecular Structure
• Hazard Symbols N
• Synonyms Benzoic acid,3-fluoro-2-iodo-;AHR 9434;AL 6515;Nevanac;
• PSA 86.18000
• LogP 2.80910

Synthetic route

78281-61-5

2-amino-3-benzoyl-α-(methylthio)benzeneacetamide

78281-72-8

nepafenac

Conditions

Conditions	Yield
nickel In tetrahydrofuran; water at 20℃; for 0.166667h; Product distribution / selectivity;	86%
With Raney nickel In tetrahydrofuran at -5 - 5℃; for 0.5h;	78.8%
With nickel In tetrahydrofuran for 0.25h;	73%

2835-77-0

(2-aminophenyl)(phenyl)methanone

78281-72-8

nepafenac

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) tert-butyl hypochlorite, 2.) triethylamine / 1.) CH2Cl2, THF, -60 deg C, 1 h, 2.) CH2Cl2, 5 min 2: 73 percent / Raney nickel / tetrahydrofuran / 0.25 h View Scheme

173262-94-7

2-amino-3-benzoyl-α-(1-propylthio)-benzeneacetamide

78281-72-8

nepafenac

78281-72-8

nepafenac

51135-38-7

7-benzoyl-1,3-dihydroindol-2-one

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 30℃; for 3h; Temperature; Reagent/catalyst; Solvent;	92.1%
With hydrogenchloride In ethanol Heating;

78281-72-8

nepafenac

1246956-18-2

2-{2-amino-3-[hydroxy(phenyl)methyl]phenyl}acetamide

Conditions

Conditions	Yield
With sodium tetrahydroborate; ethanol for 2h; Reflux;	75%

50-00-0

formaldehyd

78281-72-8

nepafenac

3-Benzoyl-2-(N,N-dimethylamino)-phenylacetamide

Conditions

Conditions	Yield
With sodium cyanoborohydride In acetic acid; acetonitrile

Nepafenac Chemical Properties

Nepafenac Specification