Product Name

  • Name

    Nicametate citrate

  • EINECS 216-694-5
  • CAS No. 1641-74-3
  • Density
  • Solubility
  • Melting Point 123 °C
  • Formula C12H18N2O2.C6H8O7
  • Boiling Point 311.9 °C at 760 mmHg
  • Molecular Weight 414.412
  • Flash Point 142.4 °C
  • Transport Information
  • Appearance White crystal power
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 1641-74-3 (Nicametate citrate)
  • Hazard Symbols
  • Synonyms 3-Pyridinecarboxylic acid,esters,2-(diethylamino)ethyl ester,2-hydroxy-1,2,3-propanetricarboxylate (1:1);Euclidan, citrate;Eucast;2-Diethylaminoethyl nicotinate citrate;Provasan;Soclidan;Nicotinic acid, 2-(diethylamino)ethyl ester, citrate (1:1);Euclidan;Manlate;3-Pyridinecarboxylic acid, 2- (diethylamino)ethyl ester, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Diethyl(2-(3-pyridiniocarbonyloxy)ethyl)ammonium hydrogen citrate;Nicotinic acid, 2- (diethylamino)ethyl ester, citrate (1:1);2-diethylaminoethyl pyridine-3-carboxylate; 2-hydroxypropane-1,2,3-tricarboxylic acid;53 IIC;3-Pyridinecarboxylic acid, 2-(diethylamino)ethyl ester, citrate (1:1);
  • PSA 174.56000
  • LogP 0.33170

Nicametate citrate Chemical Properties

Systematic Name: 2-(Diethylamino)ethyl pyridine-3-carboxylate 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
Synonyms of Eucast (CAS NO.1641-74-3): 2-Diethylaminoethyl nicotinate citrate ; 3-Pyridinecarboxylic acid, 2-(diethylamino)ethyl ester, citrate (1:1) ; Nicametate citrate ; Nicametate dihydrogen citrate ; Provasan ;Soclidan ; 3-Pyridinecarboxylic acid, 2-(diethylamino)ethyl ester, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (9CI) ; 3-Pyridinecarboxylic acid, 2-(diethylamino)ethyl ester, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (9CI) ; Nicotinic acid, 2-(diethylamino)ethyl ester, citrate (1:1)
CAS NO:1641-74-3
Molecular Formula:C18H26N2O9
Molecular Weight:414.407
Molecular Structure:
EINECS: 216-694-5
Flash Point: 142.4 °C
Enthalpy of Vaporization: 55.28 kJ/mol
Boiling Point: 311.9 °C at 760 mmHg
Vapour Pressure: 0.000548 mmHg at 25°C

Nicametate citrate Toxicity Data With Reference

pig LD50 intraperitoneal 920mg/kg (920mg/kg)   Therapie. Vol. 16, Pg. 265, 1961.
guinea pig LD50 intravenous 115mg/kg (115mg/kg)   Therapie. Vol. 16, Pg. 265, 1961.
guinea pig LD50 subcutaneous 1290mg/kg (1290mg/kg)   Therapie. Vol. 16, Pg. 265, 1961.
mouse LD50 intravenous 316mg/kg (316mg/kg)   Drugs in Japan Vol. 6, Pg. 542, 1982.
mouse LD50 oral 11900mg/kg (11900mg/kg)   Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.
mouse LD50 subcutaneous 2600mg/kg (2600mg/kg)   Drugs in Japan Vol. 6, Pg. 542, 1982.
rabbit LD50 intravenous 162mg/kg (162mg/kg)   Therapie. Vol. 16, Pg. 265, 1961.
rabbit LD50 subcutaneous 940mg/kg (940mg/kg)   Therapie. Vol. 16, Pg. 265, 1961.
rat LD50 intraperitoneal 1120mg/kg (1120mg/kg)   Therapie. Vol. 16, Pg. 265, 1961.
rat LD50 intravenous 327mg/kg (327mg/kg)   Drugs in Japan Vol. 6, Pg. 542, 1982.
rat LD50 oral 8400mg/kg (8400mg/kg)   Drugs in Japan Vol. 6, Pg. 542, 1982.
rat LD50 subcutaneous 1620mg/kg (1620mg/kg)   Therapie. Vol. 16, Pg. 265, 1961.

Nicametate citrate Safety Profile

Poison by intravenous route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion. When Eucast (CAS NO.1641-74-3) is heated to decomposition, it emits toxic fumes of NOx. See also ESTERS.

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