-
Name
Polymyxin B sulfate
- EINECS 215-774-7
- CAS No. 1405-20-5
- Density
- Solubility water: 50 mg/mL
- Melting Point 217-220°C (dec.)
- Formula C56H98N16O13.H2SO4
- Boiling Point 1651ºC at 760 mmHg
- Molecular Weight 1301.56
- Flash Point 952.3ºC
- Transport Information
- Appearance White crystalline powder
- Safety 22-24/25
- Risk Codes 22
-
Molecular Structure
-
Hazard Symbols
Xn
- Synonyms Campho-Phenique Antibiotic Plus Pain Relief Ointment;Ophthocort;Neosporin Plus;Dexacidin;Neobacimyx (Veterinary);Polymixin B sulfate (JP14);Aerosporin (TN);Poly-Pred;Drotic;Pediotic Suspension;Statrol;2-[(4-amino-2-formamido-butanoyl)amino]-N-[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]-4-hydroxy-butanamide; sulfuric acid;Neosporin;Aerosporin;Chloromyxin;Otocort;Mastimyxin;
- PSA 573.64000
- LogP 2.54990
Polymyxin B sulfate Chemical Properties
Molecular Formula: C56H100N16O17S
Molecular Weight: 1301.56
EINECS: 215-774-7
Flash Point: 952.3 °C
Enthalpy of Vaporization: 272.45 kJ/mol
Boiling Point: 1651 °C at 760 mmHg
Storage tempreture: 2-8 °C
Solubility: H2O: 50 mg/mL
Form: Powder
Structure of Polymyxin B sulfate (CAS NO.1405-20-5):
Product Category of Polymyxin B sulfate (CAS NO.1405-20-5): Interferes with Cell Membrane Permeability (Ionophores)Spectrum of Activity;PeptidesCell Signaling and Neuroscience;Antibiotics;Reagents and Supplements
Polymyxin B sulfate Uses
Polymyxin B sulfate (CAS NO.1405-20-5) is used for resistant gram negative infections as an antibiotic. In addition to its antibiotic function, it has been used to clear endotoxin contamination in reagents
Polymyxin B sulfate Toxicity Data With Reference
| 1. | dnd-esc 50 mg/L | MUREAV Mutation Research. 89 (1981),95. | ||
| 2. | orl-mus LD50:790 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794. | ||
| 3. | ipr-mus LD50:20,500 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794. | ||
| 4. | scu-mus LD50:59,500 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794. | ||
| 5. | ivn-mus LD50:5400 µg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),794. | ||
| 6. | ivn-dog LDLo:8 mg/kg | INURAQ Investigative Urology. 6 (1969),505. | ||
| 7. | ice-dog LDLo:320 µg/kg | BJPCAL British Journal of Pharmacology and Chemotherapy. 23 (1964),552. |
Polymyxin B sulfate Safety Profile
Poison by intravenous, subcutaneous, intraperitoneal and intracerebral routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also POLYMYXIN B.
Hazard Codes: 
Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 22-24/25
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
Polymyxin B sulfate Specification
Polymyxin B sulfate , its cas register number is 1405-20-5. It also can be called N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide sulfuric acid .
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