-
Name
polymyxin B(1)
- EINECS
- CAS No. 4135-11-9
- Density 1.27g/cm3
- Solubility
- Melting Point
- Formula C56H98N16O13
- Boiling Point 1571.6°Cat760mmHg
- Molecular Weight 1203.49
- Flash Point 904.2°C
- Transport Information
- Appearance
- Safety Poison by subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms polymyxin B;Polymyxin B1;polymixin B1;
- PSA 490.66000
- LogP 2.12190
Polymyxin B1 Chemical Properties
Product Name: Polymyxin B1 (CAS NO.4135-11-9)
Molecular Formula: C56H98N16O13
Molecular Weight: 1203.70g/mol
Mol File: 4135-11-9.mol
Boiling point: 1571.6 °C at 760 mmHg
Flash Point: 904.2 °C
Density: 1.27 g/cm3
Surface Tension: 67.5 dyne/cm
Enthalpy of Vaporization: 256.27 kJ/mol
XLogP3-AA: -2.5
H-Bond Donor: 18
H-Bond Acceptor: 18
Structure Descriptors of Polymyxin B1 (CAS NO.4135-11-9):
Smiles: N(C(CCCC[C@@H](CC)C)=O)[C@H](C(N[C@H](C(=O)N[C@H](C(N[C@H]1CCNC([C@H]([C@H](O)C)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC1=O)CCN)=O)Cc1ccccc1)=O)=O)=O)=O)CCN)[C@@H](C)O)=O)CCN
Polymyxin B1 Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 19mg/kg (19mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 334, 1980. | |
| mouse | LD50 | intravenous | 1500ug/kg (1.5mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 334, 1980. | |
| mouse | LD50 | subcutaneous | 80mg/kg (80mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 334, 1980. |
Polymyxin B1 Safety Profile
Poison by subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Polymyxin B1 Specification
Polymyxin B1 ,its CAS NO. is 4135-11-9,the synonyms is BRN 0505906 ; UNII-B35S89JSRU .
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