Pramoxine hydrochloride supplier

Name
Pramoxine hydrochloride
EINECS 211-293-1
CAS No. 637-58-1
Article Data1
CAS DataBase
Density
Solubility
Melting Point 181-183oC
Formula C₁₇H₂₈ClNO₃
Boiling Point 427 °C at 760 mmHg
Molecular Weight 329.867
Flash Point 123.5 °C
Transport Information
Appearance White or off white crystalline powder
Safety 26-36
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xi, Xn
Synonyms Morpholine,4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (9CI);Morpholine, 4-[3-(p-butoxyphenoxy)propyl]-,hydrochloride (7CI,8CI);Pramoxine hydrochloride (6CI);4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride;Pramocainehydrochloride;Proctofoam;Tronolaine;Tronothan;Tronothane;Tronothanehydrochloride;
PSA 30.93000
LogP 3.70650

Synthetic route

: 4441-30-9
3-morpholin-4-ylpropan-1-ol

: 39969-57-8
1-bromo-4-butoxybenzene

: 637-58-1
pramoxine hydrochloride

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 20℃; for 5h; Reflux;	82.61%

Pramoxine hydrochloride Specification

The Pramoxine hydrochloride, with the CAS registry number 637-58-1,is also known as 4-n-Butoxyphenyl gamma-morpholinopropyl ether hydrochloride. It belongs to the product categories of Organic matters.Its EINECS number is 211-293-1. This chemical's molecular formula is C₁₇H₂₇NO₃^.HCl and molecular weight is 329.87. What's more,Its systematic name is Pramocaine hydrochloride.The Pramoxine hydrochloride is harmful if swallowed and irritating to eyes, respiratory system and skin.When you use it ,wear suitable protective clothing .In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Physical properties about Pramoxine hydrochloride are:
(1)ACD/LogP: 3.477; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.52; (4)ACD/LogD (pH 7.4): 3.13; (5)ACD/BCF (pH 5.5): 2.85; (6)ACD/BCF (pH 7.4): 116.77; (7)ACD/KOC (pH 5.5): 20.48; (8)ACD/KOC (pH 7.4): 838.17; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 9; (12)Flash Point: 123.5 °C; (13)Enthalpy of Vaporization: 68.19 kJ/mol ; (14)Boiling Point: 427 °C at 760 mmHg; (15)Vapour Pressure: 1.7E-07 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:Cl.O(c2ccc(OCCCN1CCOCC1)cc2)CCCC;
(2)Std. InChI:InChI=1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H;
(3)Std. InChIKey:SYCBXBCPLUFJID-UHFFFAOYSA-N.

The toxicity data of Pramoxine hydrochloride are as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intravenous	109mg/kg (109mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CARDIAC OUTPUT LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.
mouse	LD50	intraperitoneal	460mg/kg (460mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.
mouse	LD50	intravenous	79500ug/kg (79.5mg/kg)		Toxicology and Applied Pharmacology. Vol. 1, Pg. 454, 1959.
mouse	LD50	oral	1050mg/kg (1050mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.
mouse	LD50	subcutaneous	1470mg/kg (1470mg/kg)	CARDIAC: CARDIAC OUTPUT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.
rabbit	LD50	intravenous	39mg/kg (39mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.

Product Name

Pramoxine hydrochloride

Synthetic route

Pramoxine hydrochloride Specification

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