Prednisone supplier | CasNO.53-03-2

Name
Prednisone
EINECS 200-160-3
CAS No. 53-03-2
Article Data51
CAS DataBase
Density 1.3 g/cm³
Solubility 115mg/L(25 oC)
Melting Point 236-238 °C(lit.)
Formula C₂₁H₂₆O₅
Boiling Point 573.7 °C at 760 mmHg
Molecular Weight 358.434
Flash Point 314.8 °C
Transport Information
Appearance white crystalline powder
Safety 36/37/39-45-26-16
Risk Codes 63-34-11
Molecular Structure
Hazard Symbols Xn,C,F
Synonyms 1,2-Dehydrocortisone;1,4-Pregnadiene-17a,21-diol-3,11,20-trione;1-Dehydrocortisone;17,21-Dihydroxypregn-1,4-diene-3,11,20-trione;17a,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione;Apo-Prednisone;Bicortone;Cartancyl;Colisone;Cortidelt;Dacorten;Decortancyl;Decortin;Dellacort A;Delta-Cortelan;Delta-Dome;Deltacortisone;Deltasone;Deltison;Deltisone;Deltra;Di-Adreson;Pregna-1,4-diene-3,11,20-trione,17,21-dihydroxy-;
PSA 91.67000
LogP 1.76580

Synthetic route

: 53-06-5
Cortisone

: 53-03-2
Prednison

Conditions

Conditions	Yield
With Rhodococcus coprophilus DSM 43347 In dimethyl sulfoxide at 30℃; for 24h; Reagent/catalyst; Green chemistry; regiospecific reaction;	94%
With selenium(IV) oxide
mit Hilfe von Didymella lycopersici;
mit Hilfe von Corynebacterium simplex;
mit Hilfe von Corynebacterium simplex;

: 125-10-0
prednisone acetate

: 53-03-2
Prednison

Conditions

Conditions	Yield
With di(n-butyl)tin oxide In methanol for 4h; Heating;	89%
Stage #1: prednisone acetate With potassium carbonate In ethanol; water at 15℃; Stage #2: With acetic acid In ethanol; water Solvent; Reagent/catalyst; Temperature;	68.5%
With potassium hydrogencarbonate
With potassium hydroxide
With sodium methylate

: 53-06-5
Cortisone

A: 53-03-2
Prednison

B: 17α,20β,21-trihydroxy-1,4-pregnadiene-3,11-dione

Conditions

Conditions	Yield
With Rhodococcus baikonurensis DSM 44587 In dimethyl sulfoxide at 30℃; for 72h; Reagent/catalyst; Green chemistry; regiospecific reaction;	A 27% B 68%

: 53-06-5
Cortisone

A: 53-03-2
Prednison

B: 600-92-0
17α,20β,21-trihydroxy-1,4-pregnadiene-3,11-dione

Conditions

Conditions	Yield
With Rhodococcus rhodnii DSM 43960 In dimethyl sulfoxide for 24h; Green chemistry; Enzymatic reaction;	A 30% B 10%

: 50-24-8
prednisolon

A: 898-84-0
(8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-6H-cyclopenta[a]phenanthrene-3,17-dione

B: 53-03-2
Prednison

Conditions

Conditions	Yield
Product distribution; Rate constant; Irradiation; radiolytic degradation;

: 51192-49-5
Prednisone pivalate

: 53-03-2
Prednison

Conditions

Conditions	Yield
With Curvularia tuberculata In water at 30℃; for 72h; Yield given;

: 50-04-4
Cortisone acetate

: 53-03-2
Prednison

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SeO2 2: methanol.KOH View Scheme

: 52-21-1
prednisolone 21-acetate

: 53-03-2
Prednison

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-bromo-acetamide 2: aqueous methanol.KHCO3 View Scheme

: 28449-43-6
21-acetoxy-11β-hydroxy-pregna-1,4,17(20)c-trien-3-one

: 53-03-2
Prednison

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: diacetoxyiodanyl-benzene 2: N-bromo-acetamide 3: aqueous methanol.KHCO3 View Scheme

: 50-24-8
prednisolon

: 53-03-2
Prednison

Conditions

Conditions	Yield
With oxygen In water; acetonitrile at 24.84℃; Kinetics; Quantum yield; Reagent/catalyst; Photolysis;

: 50-03-3
hydrocortisone acetate

: 53-03-2
Prednison

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetic acid; manganese(ll) chloride; chromium(VI) oxide / water; chloroform / 30 °C 2: Arthrobacter simplex By-2-13 3: potassium carbonate / water; ethanol / 15 °C View Scheme

: 53-03-2
Prednison

: 108-24-7
acetic anhydride

: 6677-19-6
17α,21-diacetoxypregna-1,4-diene-3,11,20-trione

Conditions

Conditions	Yield
With pyridine at 85 - 90℃; for 2.5h; Reagent/catalyst; Temperature;	98.4%

: 53-03-2
Prednison

: 53-06-5
Cortisone

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrazine hydrate In methanol at 62 - 64℃; for 8h;	98%

: 53-03-2
Prednison

: 7693-46-1
4-Nitrophenyl chloroformate

: 1092578-27-2
prednisone

Conditions

Conditions	Yield
With dmap In dichloromethane at 0℃;	95%
Stage #1: Prednison; 4-Nitrophenyl chloroformate In chloroform at 0℃; for 1.25h; Stage #2: With pyridine In chloroform

: 53-03-2
Prednison

: 7738-93-4
androsta-1,4-diene-3,11,17-trione

Conditions

Conditions	Yield
In water; acetonitrile at 20℃; Electrochemical reaction;	89%
With manganese(IV) oxide In chloroform for 4h; Heating;	55.3%
Product distribution; Rate constant; Irradiation; radiolytic degradation;
Multi-step reaction with 2 steps 1: borane-THF / tetrahydrofuran / 1.17 h / 0 °C / Inert atmosphere 2: sodium periodate / tetrahydrofuran; water; acetone / 3.08 h / 0 - 23 °C / Inert atmosphere View Scheme

: 53-03-2
Prednison

: ((8S,9S,10R,13S,14S,17R)-17-Hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-oxo-acetaldehyde

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide for 24h; Ambient temperature;	86%

: 53-03-2
Prednison

: 124-63-0
methanesulfonyl chloride

: 76676-23-8
17-hydroxy-21-methanesulfonyloxy-pregna-1,4-diene-3,11,20-trione

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;	86%

: 53-03-2
Prednison

2-phenethyl-1,1,3,3-tetramethylisothiouronium salt: 2-phenethyl-1,1,3,3-tetramethylisothiouronium salt

: C29H34O4S

Conditions

Conditions	Yield
With N,N,N′,N′-tetramethyl-N″-tert-butylguanidine In chloroform at 20℃; for 2h;	86%

: 53-03-2
Prednison

: 78261-67-3
17α-hydroxy-11-oxoandrosta-1,4-dien-3-one-17β-carboxylic acid

Conditions

Conditions	Yield
With sodium periodate In tetrahydrofuran; methanol at 20℃; for 2h;	84%

: 53-03-2
Prednison

: 107-15-3
ethylenediamine

: 1522230-44-9
C27H44N6O2

Conditions

Conditions	Yield
With boric acid In ethanol at 20℃; for 72h;	80%

: 50-00-0
formaldehyd

: 53-03-2
Prednison

: 26341-55-9
prednisone-BMD

Conditions

Conditions	Yield
With hydrogenchloride In chloroform for 16h; Ambient temperature;	77%

: 53-03-2
Prednison

: 1242-49-5
17-hydroxypregna-1,4-diene-3,11,20-trione

Conditions

Conditions	Yield
With pyridine; iodine; triphenylphosphine In toluene for 6h; Inert atmosphere; Reflux; chemoselective reaction;	76%

: 50-00-0
formaldehyd

: 53-03-2
Prednison

: 67254-01-7
(20R)-17,20:20,21-bis[methylenebis(oxy)]pregna-1,4-diene-3,11-dione

Conditions

Conditions	Yield
With hydrogenchloride In chloroform; water	73.3%

: 20060-41-7
oleyl hemisuccinate

: 53-03-2
Prednison

: oleyl 2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethylsuccinate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 14h; Inert atmosphere;	71%

: 53-03-2
Prednison

: 57099-40-8
17-hydroxy-21-phosphonooxy-pregna-1,4-diene-3,11,20-trione

Conditions

Conditions	Yield
With pyridine; 2-cyanoethyl phosphate; dicyclohexyl-carbodiimide	70%

: 53-03-2
Prednison

: 117835-14-0
bicyclo[2.2.1]hept-5-ene-2-carbonyl chloride

: 1119900-18-3
C29H34O6

Conditions

Conditions	Yield
With pyridine at 20℃; for 0.5h; Molecular sieve; Inert atmosphere;	60%

: 53-03-2
Prednison

: 67067-81-6
21-hydroxy-1,4-pregnadiene-3,11,20-trione

Conditions

Conditions	Yield
With trimethylsilyl iodide In acetonitrile for 4h; Ambient temperature;	54%
With trimethylsilyl iodide; sodium sulfite In hexane; chloroform; ethyl acetate; acetonitrile

: 53-03-2
Prednison

A: 118724-36-0
20-hydroxy-3,11-dioxo-1,4,trans-17(20)-pregnatrien-21-al

B: 118724-35-9
20-hydroxy-3,11-dioxo-1,4,cis-17(20)-pregnatrien-21-al

Conditions

Conditions	Yield
With zinc diacetate; acetic acid Heating;	A 5.1% B 42.2%

: 53-03-2
Prednison

: sodium 2-(4-methylpiperazin-1-yl)acetate

: C28H38N2O6

Conditions

Conditions	Yield
With 2-chloro-1-methyl-pyridinium iodide In acetonitrile at 20℃; for 18h;	38%

: 53-03-2
Prednison

: sodium 4-(4-methylpiperazin-1-yl)butanoate

: C30H42N2O6

Conditions

Conditions	Yield
With 2-chloro-1-methyl-pyridinium iodide In acetonitrile at 20℃; for 18h;	36%

: 53-03-2
Prednison

: 225242-73-9
phenyl(2-trifluoracetamido-2-deoxy-3,4,6-tri-O-acetyl-1-thio-D-glucopyranoside)

: 1092578-16-9
17α-hydroxy-3,11,20-trioxo-pregnadien-(1,4)-yl-(21)-2-trifluoracetamido-2-deoxy-3,4,6-tri-O-acetyl-D-glucopyranoside

Conditions

Conditions	Yield
With N-iodo-succinimide; trimethylsilyl trifluoromethanesulfonate In chloroform at 0℃; Molecular sieve;	26%

: 1092578-22-7
phenyl-4-O-(2-trifluoracetamido-2-deoxy-3,4,6-tri-O-acetyl-D-glucopyranosyl)-2-trifluoracetamido-2-deoxy-3,6-di-O-acetyl-1-thio-D-glucopyranoside

: 53-03-2
Prednison

: 1092578-23-8
17α-hydroxy-3,11,20-trioxo-pregnadien-(1,4)-yl-(21)-4-O-(2-trifluoracetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl)-2-trifluoracetamido-2-deoxy-3,6-di-O-acetyl-β-D-glucopyranose

Conditions

Conditions	Yield
With N-iodo-succinimide; trimethylsilyl trifluoromethanesulfonate In chloroform at 0℃; Molecular sieve;	26%

: 53-03-2
Prednison

: 563-41-7
semicarbazide hydrochloride

: 113927-06-3
17,21-dihydroxy-pregna-1,4-diene-3,11,20-trione-3,20-disemicarbazone

: 53-03-2
Prednison

: 600-93-1
20β-dihydroprednisone

Conditions

Conditions	Yield
With Rhodotorula longissima

: 53-03-2
Prednison

: 600-92-0
17α,20β,21-trihydroxy-1,4-pregnadiene-3,11-dione

Conditions

Conditions	Yield
With sodium tetrahydroborate
With calonectria decora
With streptomyces griseus
With streptomyces hydrogenating agents

: 53-03-2
Prednison

: 3282-30-2
pivaloyl chloride

: 51192-49-5
Prednisone pivalate

Conditions

Conditions	Yield
With pyridine; chloroform

: 53-03-2
Prednison

: 123-62-6
propionic acid anhydride

: 115322-27-5
17-hydroxy-21-propionyloxy-pregna-1,4-diene-3,11,20-trione

Conditions

Conditions	Yield
With pyridine

Prednisone Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 326.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 293.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 293.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); No Evidence: mouse CANCAR Cancer. 40 (1977),1935. ; (ipr); Equivocal Evidence: rat CANCAR Cancer. 40 (1977),1935. . Reported in EPA TSCA Inventory.

Prednisone Specification

1. Introduction of Prednisone
Prednisone is a white crystalline powder and an organic compound. The systematic name of this chemical is 17,21-dihydroxypregna-1,4-diene-3,11,20-trione. The product's categories are Antitumors for Research and Experimental Use; Biochemistry; Hydroxyketosteroids; Steroids; Intermediates & Fine Chemicals; Pharmaceuticals; Steroid and Hormone. It is also named as 1,4-Pregnadiene-17a,21-diol-3,11,20-trione. In addition, the Classification Code of Prednisone is Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antineoplastic Agents; Antineoplastic agents, hormonal; Drug / Therapeutic Agent; Glucocorticoid; Glucocorticoids; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Human Data; Mutation data; Reproductive Effect; Tumor data. Prednisone is practically insoluble in water.

2. Properties of Prednisone
Physical properties about Prednisone are:
(1)ACD/LogP: 1.57; (2)ACD/LogD (pH 5.5): 1.57; (3)ACD/LogD (pH 7.4): 1.57; (4)ACD/BCF (pH 5.5): 9.16; (5)ACD/BCF (pH 7.4): 9.16; (6)ACD/KOC (pH 5.5): 169.92; (7)ACD/KOC (pH 7.4): 169.92; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 4; (11)Polar Surface Area: 69.67 Å²; (12)Index of Refraction: 1.603; (13)Molar Refractivity: 94.08 cm³; (14)Molar Volume: 273.6 cm³; (15)Polarizability: 37.29×10^-24cm³; (16)Surface Tension: 58.5 dyne/cm; (17)Density: 1.3 g/cm³; (18)Flash Point: 314.8 °C; (19)Enthalpy of Vaporization: 98.73 kJ/mol; (20)Boiling Point: 573.7 °C at 760 mmHg; (21)Vapour Pressure: 1.51E-15 mmHg at 25°C.

3. Structure Descriptors of Prednisone
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(CO)[C@@]3(O)CC[C@H]2[C@@H]4CC\C1=C\C(=O)\C=C/[C@]1(C)[C@H]4C(=O)C[C@@]23C
(2)InChI: InChI=1/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
(3)InChIKey: XOFYZVNMUHMLCC-ZPOLXVRWBN
(4)Std. InChI: InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
(5)Std. InChIKey: XOFYZVNMUHMLCC-ZPOLXVRWSA-N

4. Safety information of Prednisone
The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	LDLo	oral	400ug/kg (0.4mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Irish Journal of Medical Science. Vol. 155, Pg. 234, 1986.
man	TDLo	oral	857ug/kg (0.857mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE	Neurology. Vol. 36, Pg. 729, 1986.
mouse	LD50	intramuscular	600mg/kg (600mg/kg)		Cancer Research. Vol. 42, Pg. 122, 1982.
mouse	LD50	intraperitoneal	135mg/kg (135mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	subcutaneous	101mg/kg (101mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
women	TDLo	oral	2400ug/kg/2D- (2.4mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE	Neurology. Vol. 36, Pg. 729, 1986.
women	TDLo	unreported	113mg/kg (113mg/kg)	BLOOD: HEMORRHAGE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1260, 1980.

5. Safety information of Prednisone
Hazard Codes: Xn,C,F
Risk Statements: 63-34-11
63: Possible risk of harm to the unborn child.
34: Causes burns.
11: Highly Flammable.
Safety Statements: 36/37/39-45-26-16
36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
16: Keep away from sources of ignition - No smoking.
WGK Germany: 3
RTECS: TU4154100
HazardClass: IRRITANT

When you are using this chemical, please be cautious about it as the following:
It is highly flammable and can cause burns. Please keep away from sources of ignition - No smoking. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is possible risk of harm to the unborn child. When you are using it, wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).

6. Uses of Prednisone
Prednisone can be used to produce androsta-1,4-diene-3,11,17-trione by heating. It will need reagent MnO₂ and solvent CHCl₃ with reaction time of 4 hours. The yield is about 55.3%.

Besides, it is a white crystalline powder, which should be used in biochemical research. Adrenal cortex hormones drugs, it's anti-inflammatory, anti-allergy and commonly used in chemotherapy, you can improve patient general, and it can be used in acute leukemia and other tumors.

7. Production of Prednisone
Prednisone can be got from CORTISONE.

Product Name

Prednisone

Synthetic route

Prednisone Consensus Reports

Prednisone Specification

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