IUPAC Name: N,N-Dimethyl-3-phenothiazin-10-ylpropan-1-amine
The MF of Promazine (CAS NO.58-40-2) is C17H20N2S.
The MW of Promazine (CAS NO.58-40-2) is 284.4191.
Synonyms of Promazine (CAS NO.58-40-2): 10-(3-Dimethylaminopropyl)phenothiazine ; 10H-Phenothiazine-10-propanamine, N,N-dimethyl- ; Phenothiazine, 10-[3- (dimethylamino)propyl]-
Index of Refraction: 1.617
EINECS: 200-382-0
Density: 1.133 g/ml
Flash Point: 203.4 °C
Boiling Point: 412.7 °C
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 140mg/kg (140mg/kg) | AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 69, 1965. |
mouse | LD50 | intravenous | 45mg/kg (45mg/kg) | BEHAVIORAL: SLEEP | Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 87, 1962. |
mouse | LD50 | oral | 401mg/kg (401mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 489, 1958. |
mouse | LD50 | subcutaneous | 110mg/kg (110mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974. |
rabbit | LD50 | intravenous | 21mg/kg (21mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959. | |
rat | LD50 | intravenous | 14500ug/kg (14.5mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGES IN CIRCULATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 119, Pg. 311, 1959. |
rat | LD50 | oral | 350mg/kg (350mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 507, 1958. | |
rat | LD50 | subcutaneous | 192mg/kg (192mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR | Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974. |
rat | LDLo | intraperitoneal | 210mg/kg (210mg/kg) | Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959. |
EPA Genetic Toxicology Program.
Human poison by unspecified route. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx.
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