Pyriproxyfen supplier | CasNO.95737-68-1

Name
Pyriproxyfen
EINECS 429-800-1
CAS No. 95737-68-1
Article Data5
CAS DataBase
Density 1.151 g/cm³
Solubility 0.4 mg l-1 (25 °C)
Melting Point 45-47 °C
Formula C₂₀H₁₉NO₃
Boiling Point 462 °C at 760 mmHg
Molecular Weight 321.376
Flash Point 165.4 °C
Transport Information UN 3077 9/PG 3
Appearance White to pale yellow crystalline powder
Safety 60-61
Risk Codes 50/53
Molecular Structure
Hazard Symbols N
Synonyms Pyriproxyfen [ISO:BSI];S 9138;Pyridine, 2-(1-methyl-2-(4-phenoxyphenoxy)ethoxy)- .;2-(1-Methyl-2-(4-phenoxyphenoxy)ethoxy)pyridine;4-Phenoxyphenyl (RS)-2-(2-pyridyloxy)propyl ether;HSDB 7053;OMS 3019;SK 591;
PSA 40.58000
LogP 4.72020

Synthetic route

: 109-09-1
2-chloropyridine

: 57650-78-9
(R,S)-2-hydroxypropyl 4-phenoxyphenyl ether

: 95737-68-1
pyriproxyfen

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 50 - 110℃; Solvent; Temperature; Reagent/catalyst;	93.9%

: 67969-82-8
tetrafluoroboric acid diethyl ether

: 13755-29-8
sodium tetrafluoroborate

: 2362-50-7
thianthrene-5-oxide

: 95737-68-1
pyriproxyfen

: C32H26NO3S2(1+)*BF4(1-)

Conditions

Conditions	Yield
Stage #1: tetrafluoroboric acid diethyl ether; thianthrene-5-oxide; pyriproxyfen With trifluoroacetic anhydride In acetonitrile at 0 - 25℃; for 3h; Sealed tube; Stage #2: sodium tetrafluoroborate In dichloromethane; water	95%

...Expand

: 67969-82-8
tetrafluoroboric acid diethyl ether

: 2,3,7,8-tetrafluorothianthrene-S-oxide

: 95737-68-1
pyriproxyfen

: C32H22F4NO3S2(1+)*BF4(1-)

Conditions

Conditions	Yield
With 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride In acetonitrile at 0 - 25℃; regioselective reaction;	92%

...Expand

: 67969-82-8
tetrafluoroboric acid diethyl ether

: 13755-29-8
sodium tetrafluoroborate

: 2,3,7,8-tetrafluorothianthrene-S-oxide

: 95737-68-1
pyriproxyfen

: C32H22F4NO3S2(1+)*BF4(1-)

Conditions

Conditions	Yield
Stage #1: tetrafluoroboric acid diethyl ether; 2,3,7,8-tetrafluorothianthrene-S-oxide; pyriproxyfen With trifluoroacetic anhydride In acetonitrile at 0 - 25℃; for 3h; Sealed tube; Stage #2: sodium tetrafluoroborate In dichloromethane; water	92%

...Expand

: 358-23-6
trifluoromethylsulfonic anhydride

: 603-35-0
triphenylphosphine

: 95737-68-1
pyriproxyfen

: (2-((1-(4-phenoxyphenoxy)propan-2-yl)oxy)pyridin-4-yl)triphenylphosphonium trifluoromethanesulfonate

Conditions

Conditions	Yield
at -78 - 20℃; Alkaline conditions;	89%
Stage #1: trifluoromethylsulfonic anhydride; pyriproxyfen In dichloromethane at -78℃; for 0.5h; Inert atmosphere; Stage #2: triphenylphosphine In dichloromethane at -78℃; for 0.5h; Inert atmosphere; Stage #3: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at -78 - 20℃; Inert atmosphere; regioselective reaction;	61%

...Expand

: 98-86-2
acetophenone

: 95737-68-1
pyriproxyfen

: 1-phenyl-2-(4-(4-(2-(pyridin-2-yloxy)propoxy)phenoxy)phenyl)ethan-1-one

Conditions

Conditions	Yield
Stage #1: pyriproxyfen With thianthrene-5-oxide; trifluoromethylsulfonic anhydride In acetonitrile at -20 - 20℃; for 0.666667h; Inert atmosphere; Schlenk technique; Stage #2: acetophenone With palladium diacetate; cesium fluoride; XPhos In N,N-dimethyl-formamide; acetonitrile at 80℃; for 11h; Inert atmosphere; Schlenk technique; regioselective reaction;	84%

: 358-23-6
trifluoromethylsulfonic anhydride

: 2,8-dimethoxydibenzothiophene S-oxide

: 95737-68-1
pyriproxyfen

: C34H30NO5S(1+)*CF3O3S(1-)

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at -40 - 25℃; for 2h; Schlenk technique; Glovebox; Inert atmosphere;	45%

...Expand

: 5720-05-8
4-methylphenylboronic acid

: 95737-68-1
pyriproxyfen

: C26H23FNO3(1+)*CF3O3S(1-)

Conditions

Conditions	Yield
Stage #1: 4-methylphenylboronic acid With copper(II) bis(trifluoromethanesulfonate) In toluene for 1h; Inert atmosphere; Glovebox; Stage #2: pyriproxyfen In toluene at 90℃; for 16h; Inert atmosphere; Sealed tube;	6%

: 95737-68-1
pyriproxyfen

: 7585-39-9
β‐cyclodextrin

: 1.3C36H60O30*C20H19NO3

Conditions

Conditions	Yield
In water at 20 - 50℃; for 26h;

: 95737-68-1
pyriproxyfen

: 4-phenoxyphenyl 2-(2-pyridyloxy)propyl ether

: 4-phenoxyphenyl 2-(2-pyridyloxy)propyl ether

Conditions

Conditions	Yield
With Chiralpak IC In water; acetonitrile at 15℃; Solvent; Reagent/catalyst; Resolution of racemate;

: 95737-68-1
pyriproxyfen

: 2-((1-(4-phenoxyphenoxy)propan-2-yl)oxy)pyridine-4-d

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: dichloromethane / 0.5 h / -78 °C / Inert atmosphere 1.2: 0.5 h / -78 °C / Inert atmosphere 1.3: -78 - 20 °C / Inert atmosphere 2.1: d(4)-methanol; water-d2; potassium carbonate / 2 h / 20 °C / Inert atmosphere View Scheme

: 95737-68-1
pyriproxyfen

: cyclopropylpyriproxyfen

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / tetrahydrofuran / 50 °C View Scheme

: 95737-68-1
pyriproxyfen

: methylpyriproxyfen

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / tetrahydrofuran / 50 °C View Scheme

: 95737-68-1
pyriproxyfen

: hexynylpyriproxyfen

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 4-methyl-morpholine / 1,4-dioxane / 40 °C View Scheme

: 95737-68-1
pyriproxyfen

: C28H31NO3

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol / 50 °C View Scheme

: 95737-68-1
pyriproxyfen

: carboxyethylpyriproxyfen

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 4-methyl-morpholine / 1,4-dioxane / 50 °C / 750.08 Torr View Scheme

: 95737-68-1
pyriproxyfen

: 2-((1-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)phenoxy)propan-2-yl)oxy)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; pyridine / acetonitrile / 22 °C / Irradiation View Scheme
Multi-step reaction with 2 steps 1: dichloromethane / 1 h / -40 - 20 °C 2: dmap; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile / acetonitrile / 8 h / 20 °C / Irradiation; Inert atmosphere View Scheme
Multi-step reaction with 2 steps 1: dichloromethane / 1.5 h / -40 - 20 °C / Schlenk technique; Inert atmosphere 2: palladium diacetate; XPhos; sodium pivalate / acetone; dichloromethane / 12 h / 20 °C / Inert atmosphere View Scheme

: 95737-68-1
pyriproxyfen

: C32H28NO6P

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; pyridine; sodium iodide / acetonitrile / 22 °C / Irradiation View Scheme

: 95737-68-1
pyriproxyfen

: cyanopyriproxyfen

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; tetrakis(acetonitrile)copper(I)tetrafluoroborate / acetonitrile / 22 °C / Irradiation View Scheme

: 95737-68-1
pyriproxyfen

: 2-((1-(4-(4-((trifluoromethyl)thio)phenoxy)phenoxy)propan-2-yl)oxy)pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; tetrakis(acetonitrile)copper(I)tetrafluoroborate / acetonitrile / 22 °C / Irradiation View Scheme

: 95737-68-1
pyriproxyfen

: chloropyriproxyfen

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; copper(l) chloride; tetrabutyl-ammonium chloride / acetonitrile / 22 °C / Irradiation View Scheme

: 95737-68-1
pyriproxyfen

: iodopyriproxyfen

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; tetrakis(acetonitrile)copper(I)tetrafluoroborate; lithium iodide / acetonitrile; dimethyl sulfoxide / 22 °C / Irradiation View Scheme

: 95737-68-1
pyriproxyfen

: styrenylpyriproxyfen

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,3,7,8-tetrafluorothianthrene; trifluoroacetic anhydride / acetonitrile / 0 - 25 °C 2: palladium diacetate; triphenylphosphine; triethylamine / N,N-dimethyl-formamide / 100 °C View Scheme

: 95737-68-1
pyriproxyfen

: C24H27NO3

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: -78 - 20 °C / Alkaline conditions 2: cobalt(III) acetylacetonate; C22H28N2O2; 1-methyl-1H-imidazole / tetrahydrofuran / 12 h / 23 °C View Scheme

: 2362-50-7
thianthrene-5-oxide

: 358-23-6
trifluoromethylsulfonic anhydride

: 95737-68-1
pyriproxyfen

: C32H26NO3S2(1+)*CF3O3S(1-)

Conditions

Conditions	Yield
In dichloromethane at -40 - 20℃; for 1h;
In dichloromethane at -40 - 20℃; Inert atmosphere; Schlenk technique;
In dichloromethane at -40 - 20℃; for 1.5h; Schlenk technique; Inert atmosphere;
In dichloromethane at -40 - 20℃; for 0.333333h; Schlenk technique; Inert atmosphere; regioselective reaction;

...Expand

: 95737-68-1
pyriproxyfen

: C20H19NO4

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 18h;

: 95737-68-1
pyriproxyfen

: C28H25NO5

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dichloromethane / -40 - 20 °C / Inert atmosphere; Schlenk technique 2: sodium hydrogencarbonate; bis(tri-t-butylphosphine)palladium(0) / dichloromethane; acetone / 12 h / 50 °C / Inert atmosphere; Schlenk technique; Sealed tube View Scheme

: ethyl 2-((trifluoromethyl)sulfinyl)acetate

: 95737-68-1
pyriproxyfen

: C25H25F3NO5S(1+)

Conditions

Conditions	Yield
With trifluoromethylsulfonic anhydride In nitromethane at -25 - 20℃; for 3.16667h; Inert atmosphere;

Pyriproxyfen Chemical Properties

Molecular structure of Pyriproxyfen (CAS NO.95737-68-1) is:

Product Name: Pyriproxyfen
CAS Registry Number: 95737-68-1
IUPAC Name: 2-[1-(4-Phenoxyphenoxy)propan-2-yloxy]pyridine
Molecular Weight: 321.36976 [g/mol]
Molecular Formula: C₂₀H₁₉NO₃
XLogP3-AA: 4.8
H-Bond Donor: 0
H-Bond Acceptor: 4
EINECS: 429-800-1
Melting Point: 45-47 °C
Storage temp.: 0-6°C
Surface Tension: 43.8 dyne/cm
Density: 1.151 g/cm³
Flash Point: 165.4 °C
Enthalpy of Vaporization: 69.52 kJ/mol
Boiling Point: 462 °C at 760 mmHg
Vapour Pressure: 2.83E-08 mmHg at 25°C
Product Categories: Pesticide & intermediate; Insect hormone

Pyriproxyfen Uses

Pyriproxyfen (CAS NO.95737-68-1) can be used to protect other crops and also be used as a treatment for cat fleas. It is a juvenile hormone analogue, preventing larvae from developing into adulthood and thus rendering them unable to reproduce.

Pyriproxyfen Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Pesticide Manual. Vol. 9, Pg. 745, 1991.
rat	LD50	skin	> 2gm/kg (2000mg/kg)		Pesticide Manual. Vol. 9, Pg. 745, 1991.

Pyriproxyfen Safety Profile

Safty information about Pyriproxyfen (CAS NO.95737-68-1) is:
Hazard Codes: Dangerous N
Risk Statements: 50/53
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 60-61
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN3077 9/PG 3
RTECS: UT5804000

Pyriproxyfen Specification

Pyriproxyfen , its cas register number is 95737-68-1. It also can be called Pyriproxyfen [ISO:BSI] ; S 31183 ; 2-(1-Methyl-2-(4-phenoxyphenoxy)ethoxy)pyridine ; 4-Phenoxyphenyl (RS)-2-(2-pyridyloxy)propyl ether ; HSDB 7053 ; OMS 3019 ; S 9138 ; SK 591 ; Pyridine, 2-(1-methyl-2-(4-phenoxyphenoxy)ethoxy)- . It is a colorless crystals. It is a pyridine based pesticide which is found to be effective against a variety of arthropoda.

Product Name

Pyriproxyfen

Synthetic route

Pyriproxyfen Chemical Properties

Pyriproxyfen Uses

Pyriproxyfen Toxicity Data With Reference

Pyriproxyfen Safety Profile

Pyriproxyfen Specification

Related Products

Hot Products