• Name

  RONIDAZOLE

• EINECS 231-675-1
• CAS No. 7681-76-7
• Article Data15
• CAS DataBase
• Density 1.65 g/cm³
• Solubility
• Melting Point 167-169°
• Formula C₆H₈N₄O₄
• Boiling Point 502.3 °C at 760 mmHg
• Molecular Weight 200.154
• Flash Point 257.6 °C
• Transport Information
• Appearance
• Safety 22-24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 1H-Imidazole-2-methanol,1-methyl-5-nitro-, carbamate (ester) (9CI);Imidazole-2-methanol,1-methyl-5-nitro-, carbamate (ester) (8CI);1-Methyl-2-carbamoyloxymethyl-5-nitroimidazole;Dugro;MCMN;Ridzol;Ridzol P;Ridzole;Ronida BT;
• PSA 115.96000
• LogP 1.14710

Synthetic route

263159-60-0

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl 4-nitrophenyl carbonate

7681-76-7

ronidazole

Conditions

Conditions	Yield
With ammonium hydroxide In dichloromethane at 0 - 10℃; for 3h; Inert atmosphere;

936-05-0

1-methyl-2-hydroxymethyl-5-nitroimidazole

7681-76-7

ronidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 2: ammonium hydroxide / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere View Scheme

nickel dibromide

7681-76-7

ronidazole

[Ni(ronidazole)Br2(H2O)2]

Conditions

Conditions	Yield
In ethanol; acetone for 2.5h; Reflux;	94%

nickel(II) chloride hexahydrate

7681-76-7

ronidazole

[Ni(ronidazole)Cl2(H2O)2]

Conditions

Conditions	Yield
In ethanol; acetone for 24h; Reflux;	89%

10025-99-7

potassium tetrachloroplatinate(II)

7681-76-7

ronidazole

84431-22-1

(NO2CCHNC(CH2OC(O)NH2)N(CH3))2PtCl2

Conditions

Conditions	Yield
In water solid ligand added to aq. soln. of K2(PtCl4), stirred at 50 °C for 1 h; ppt. filtered, washed with EtOH/Et2O, Et2O, dried in vac.; elem. anal.;	81%

7646-85-7

zinc(II) chloride

7681-76-7

ronidazole

[Zn(ronidazole)Cl2]

Conditions

Conditions	Yield
In ethanol; acetone for 2.5h; Reflux;	81%

zinc dibromide

7681-76-7

ronidazole

[Zn(ronidazole)2Br2]

Conditions

Conditions	Yield
In ethanol; acetone for 4h; Reflux;	78.86%

copper(II) choride dihydrate

7681-76-7

ronidazole

[Cu(ronidazole)2Cl2]*0.5AcOEt

Conditions

Conditions	Yield
In ethanol; acetone for 24h; Reflux;	78.67%

7646-85-7

zinc(II) chloride

7681-76-7

ronidazole

[Zn(ronidazole)2Cl2]

Conditions

Conditions	Yield
In ethanol; acetone for 4h; Reflux;	76.86%

cadmium chloride tetrahydrate

7681-76-7

ronidazole

[Cd(ronidazole)2Br2]

Conditions

Conditions	Yield
In ethanol; dichloromethane; acetone for 4h; Reflux;	74.96%

cobalt(II) chloride hexahydrate

7681-76-7

ronidazole

[Co(ronidazole)Cl2]*H2O

Conditions

Conditions	Yield
In ethanol; acetone for 2.5h; Reflux;	73%

cobalt(II) bromide

7681-76-7

ronidazole

[Co(ronidazole)Br2]*H2O

Conditions

Conditions	Yield
In ethanol; acetone for 2.5h; Reflux;	73%

cobalt(II) chloride hexahydrate

7681-76-7

ronidazole

[Co(ronidazole)2Cl2]

Conditions

Conditions	Yield
In ethanol; acetone for 24h; Reflux;	69%

mercury dichloride

7681-76-7

ronidazole

[Hg(ronidazole)2Cl2]

Conditions

Conditions	Yield
In ethanol; acetone for 4h; Reflux;	68.04%

copper nitrate hemi(pentahydrate)

7681-76-7

ronidazole

[Cu(ronidazole)2(H2O)2](NO3)2

Conditions

Conditions	Yield
In ethanol; acetone for 2.5h; Reflux;	62%

nickel(II) nitrate hexahydrate

7681-76-7

ronidazole

[Ni(ronidazole)2(H2O)2](NO3)2*3H2O

Conditions

Conditions	Yield
In ethanol; acetone for 2.5h; Reflux;	60%

7681-76-7

ronidazole

936-05-0

1-methyl-2-hydroxymethyl-5-nitroimidazole

Conditions

Conditions	Yield
With ammonia; potassium carbonate In methanol at 50℃; for 18h;	59%

cobalt(II) nitrate hexahydrate

7681-76-7

ronidazole

[Co(ronidazole)2(H2O)2](NO3)2*2H2O

Conditions

Conditions	Yield
In ethanol; acetone for 4h; Reflux;	58.71%

7789-45-9

copper(ll) bromide

7681-76-7

ronidazole

[Cu(ronidazole)2Br2]*0.5H2O

Conditions

Conditions	Yield
In ethanol; acetone for 2.5h; Reflux;	58%

52-90-4

L-Cysteine

7681-76-7

ronidazole

5-S-cysteinyl-1-methylimidazole-2-methanol carbamate

Conditions

Conditions	Yield
With sodium hydroxide; NaH2PO4 buffer at 37℃; for 120h;	36 % Chromat.

302-17-0

chloral hydrate

7681-76-7

ronidazole

C8H9Cl3N4O5

Conditions

Conditions	Yield
at 20 - 100℃; for 18h; Inert atmosphere;

7681-76-7

ronidazole

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl(1-(6-amino-2-chloro-9H-purin-9-yl)-N-2,2,2-trichloroethyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 18 h / 20 - 100 °C / Inert atmosphere 2: triethylamine; thionyl chloride / dichloromethane / 0 °C / Reflux; Inert atmosphere 3: dichloromethane; acetonitrile / 20 - 60 °C / Inert atmosphere View Scheme

7681-76-7

ronidazole

(1-methyl-5-nitro-1H-imidazol-2-yl)methyl(1-(6-amino-2-fluoro-9H-purin-9-yl)-N-2,2,2-trichloroethyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 18 h / 20 - 100 °C / Inert atmosphere 2: triethylamine; thionyl chloride / dichloromethane / 0 °C / Reflux; Inert atmosphere 3: dichloromethane; acetonitrile / 20 - 60 °C / Inert atmosphere View Scheme

7681-76-7

ronidazole

C8H8Cl4N4O4

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 18 h / 20 - 100 °C / Inert atmosphere 2: triethylamine; thionyl chloride / dichloromethane / 0 °C / Reflux; Inert atmosphere View Scheme

Ronidazole Chemical Properties

Molecular Formula: C₆H₈N₄O₄
Formula Weight: 200.15
storage temp. : -20 ^°C
Melting point: 168-169 ^°C
Appearance of Ronidazole (7681-76-7): milky white crystalline powder

Ronidazole Uses

Ronidazole Toxicity Data With Reference

Ronidazole Consensus Reports

Ronidazole Safety Profile