Product Name

  • Name

    Silicic acid

  • EINECS 231-716-3
  • CAS No. 7699-41-4
  • Article Data18
  • CAS DataBase
  • Density
  • Solubility Insoluble in water or acid, soluble in potassium hydroxide and sodium hydroxide solution
  • Melting Point 1704℃
  • Formula H2O3Si
  • Boiling Point
  • Molecular Weight 78.0996
  • Flash Point
  • Transport Information
  • Appearance White amorphous powder or bulk
  • Safety 22-26-36
  • Risk Codes 36/37
  • Molecular Structure Molecular Structure of 7699-41-4 (Silicic acid)
  • Hazard Symbols IrritantXi
  • Synonyms 7699-41-4
  • PSA 57.53000
  • LogP -1.61360

Synthetic route

sodium silicate

sodium silicate

sulfuric acid
7664-93-9

sulfuric acid

silicic acid
7699-41-4

silicic acid

Conditions
ConditionsYield
In water
sodium metasilicate nonahydrate

sodium metasilicate nonahydrate

nitric acid
7697-37-2

nitric acid

silicic acid
7699-41-4

silicic acid

Conditions
ConditionsYield
In water at 40℃; for 1h; pH=5;
hydrogenchloride
7647-01-0

hydrogenchloride

sodium silicate

sodium silicate

silicic acid
7699-41-4

silicic acid

Conditions
ConditionsYield
In water at 20℃; for 24h;
diethyl isopropylidenemalonate
6802-75-1

diethyl isopropylidenemalonate

1,14-dibromotetradecane
37688-96-3

1,14-dibromotetradecane

silicic acid
7699-41-4

silicic acid

tetraethyl 3,3,18,18-tetramethyleicosanetetraoate
103199-02-6

tetraethyl 3,3,18,18-tetramethyleicosanetetraoate

Conditions
ConditionsYield
copper(l) chloride In tetrahydrofuran; petrol ether; benzene86%
Ethyl 3-bromopropionate
539-74-2

Ethyl 3-bromopropionate

2-amino-3,5-dimethoxyacetophenone
23042-76-4

2-amino-3,5-dimethoxyacetophenone

silicic acid
7699-41-4

silicic acid

2'-(N-2-Carbethoxyethylamino)-3',5'-dimethoxyacetophenone
98300-29-9

2'-(N-2-Carbethoxyethylamino)-3',5'-dimethoxyacetophenone

Conditions
ConditionsYield
With sodium acetate; acetic acid In dichloromethane; water; ethyl acetate66.3%
With sodium acetate; acetic acid In chloroform-d1; dichloromethane; water; ethyl acetate
alumina hydrate

alumina hydrate

silicic acid
7699-41-4

silicic acid

Modified catalyst support EXAMPLE S3

Modified catalyst support EXAMPLE S3

Conditions
ConditionsYield
Stage #1: alumina hydrate; silicic acid In water at 100℃; for 16h;
Stage #2: at 725℃; for 4h;
silicic acid
7699-41-4

silicic acid

1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrole-2-carbonitrile
189268-26-6

1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrole-2-carbonitrile

1-(3-tert-butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-4-chloro-2-cyanopyrrole

1-(3-tert-butyldiphenylsilyloxymethyl-2,4-dichlorophenyl)-4-chloro-2-cyanopyrrole

Conditions
ConditionsYield
With tert-butylhypochlorite In tetrachloromethane
With tert-butylhypochlorite In tetrachloromethane
methyl cis-2-[(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)methyl]cyclopropanecarboxylate

methyl cis-2-[(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)methyl]cyclopropanecarboxylate

silicic acid
7699-41-4

silicic acid

trans-2-[(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)methyl]cyclopropanecarboxylic acid

trans-2-[(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)methyl]cyclopropanecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide; citric acid In tetrahydrofuran; methanol; hexane; ethyl acetate
5,12-epoxy-1,2,3,4,5,12-hexahydro-2-naphtacenyl methyl ketone
73862-81-4

5,12-epoxy-1,2,3,4,5,12-hexahydro-2-naphtacenyl methyl ketone

silicic acid
7699-41-4

silicic acid

2-acetyl-1,2,3,4-tetrahydro-5,12-naphtacenequinone
76811-54-6

2-acetyl-1,2,3,4-tetrahydro-5,12-naphtacenequinone

Conditions
ConditionsYield
With trifluoroacetic acid In diethyl ether; dichloromethane; chloroform
1-methoxy-6,6-dimethyl-6H-benzo[c]chromen-3-ol
55815-69-5

1-methoxy-6,6-dimethyl-6H-benzo[c]chromen-3-ol

1-(3-hydroxy-1-methoxy-6,6-dimethyl-6H-benzo[c]chromen-4-yl)-ethanone
55815-58-2

1-(3-hydroxy-1-methoxy-6,6-dimethyl-6H-benzo[c]chromen-4-yl)-ethanone

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

silicic acid
7699-41-4

silicic acid

ethanolamine salt of 2-carboxy-4-oxo-6,6-dimethyl-11-methoxy-4H,6H-[2]-benzopyrano-[3,4-f]-[1]-benzopyran
57394-20-4

ethanolamine salt of 2-carboxy-4-oxo-6,6-dimethyl-11-methoxy-4H,6H-[2]-benzopyrano-[3,4-f]-[1]-benzopyran

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; sodium; acetic acid In ethanol; water; benzene
(1,1-dimethyl-butyl)-urea
15363-96-9

(1,1-dimethyl-butyl)-urea

methyl 4-bromo-3-oxobutanoate
17790-81-7

methyl 4-bromo-3-oxobutanoate

silicic acid
7699-41-4

silicic acid

1-(1,1-dimethylbutyl)-3-(2,5-dihydro-5-oxo-furan-3-yl)urea

1-(1,1-dimethylbutyl)-3-(2,5-dihydro-5-oxo-furan-3-yl)urea

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol; ethyl acetate; benzene
With toluene-4-sulfonic acid In methanol; ethyl acetate; benzene
2,5-dimethylfuran
625-86-5

2,5-dimethylfuran

silicic acid
7699-41-4

silicic acid

A

bis (2,5-dimethyl-furan-3-yl)-disulfide
28588-73-0

bis (2,5-dimethyl-furan-3-yl)-disulfide

B

bis (2,5-dimethyl-furan-3-yl)-sulfide

bis (2,5-dimethyl-furan-3-yl)-sulfide

Conditions
ConditionsYield
With SCl2; sulphur dichloride; tin(IV) chloride In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; hexane
benzeneethyl acetate-methanol

benzeneethyl acetate-methanol

1,1-dimethylethylurea
1118-12-3

1,1-dimethylethylurea

4-methyl-1,1-dioxo-dihydro-1λ6-thiophen-3-one
39246-95-2

4-methyl-1,1-dioxo-dihydro-1λ6-thiophen-3-one

silicic acid
7699-41-4

silicic acid

1-tert-butyl-3-(4-methyl-4,5-dihydro-3-thienyl)urea S,S-dioxide
58254-33-4

1-tert-butyl-3-(4-methyl-4,5-dihydro-3-thienyl)urea S,S-dioxide

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene
dl-2β-formyl-3α-(dimethyl-t-butylsilyl)oxy-5-oxocyclopentane-1α-heptanoic acid
62413-89-2

dl-2β-formyl-3α-(dimethyl-t-butylsilyl)oxy-5-oxocyclopentane-1α-heptanoic acid

silicic acid
7699-41-4

silicic acid

3α-[(dimethyl-t-butylsilyl)oxy]-2β-(8-bromo-3-oxo-1-octenyl)-5-oxocyclopentane-1α-heptanoic acid
62344-09-6

3α-[(dimethyl-t-butylsilyl)oxy]-2β-(8-bromo-3-oxo-1-octenyl)-5-oxocyclopentane-1α-heptanoic acid

Conditions
ConditionsYield
In benzene
In benzene
methylene chloride-water

methylene chloride-water

methylene chloride (9.75 liters)-water

methylene chloride (9.75 liters)-water

2,2'-[(3-aminopropyl)imino]bis-ethanol
4985-85-7

2,2'-[(3-aminopropyl)imino]bis-ethanol

silicic acid
7699-41-4

silicic acid

1-Bromooctadecane
112-89-0

1-Bromooctadecane

N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)1,3-propanediamine
35607-20-6

N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)1,3-propanediamine

Conditions
ConditionsYield
With sodium hydroxide; succinic acid; potassium carbonate In dichloromethane; acetone
4(6-carbomethoxyhexyl)-5-(3-keto-1-trans-octenyl)-thiazole
58176-94-6

4(6-carbomethoxyhexyl)-5-(3-keto-1-trans-octenyl)-thiazole

silicic acid
7699-41-4

silicic acid

4-(6-carbomethoxyhexyl)-5-(3-hydroxy-1-trans-octenyl)-thiazole
58176-96-8

4-(6-carbomethoxyhexyl)-5-(3-hydroxy-1-trans-octenyl)-thiazole

Conditions
ConditionsYield
With sodium borohydrid In n-heptane; water; ethyl acetate; isopropyl alcohol
2-(7-hydroxyheptyl)-2-cyclopenten-1-one
33803-57-5

2-(7-hydroxyheptyl)-2-cyclopenten-1-one

silicic acid
7699-41-4

silicic acid

2-(7-chloroheptyl)-2-cyclopentenone
72489-60-2

2-(7-chloroheptyl)-2-cyclopentenone

Conditions
ConditionsYield
With triphenylphosphine In tetrachloromethane; dichloromethane; benzene
sodium dithionite

sodium dithionite

cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

silicic acid
7699-41-4

silicic acid

sodium hydroxide
1310-73-2

sodium hydroxide

[(Si7.93)(Co5.92)O20(OH)4]Na0.42

[(Si7.93)(Co5.92)O20(OH)4]Na0.42

Conditions
ConditionsYield
In neat (no solvent) mixing, according to: Mizutani T., et al., Clays Clay Miner. 1991, 39, 381, hydrothermal treatment (150°C, 50 h); washing floculent solids (distd. water), stirring (1 M NaCl, overnight),washing (distd. water), dialyzing (Spectra/por 3 membrane);
sodium dithionite

sodium dithionite

cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

silicic acid
7699-41-4

silicic acid

sodium hydroxide
1310-73-2

sodium hydroxide

[(Si8.05)(Co5.58)O20(OH)4]Na0.66

[(Si8.05)(Co5.58)O20(OH)4]Na0.66

Conditions
ConditionsYield
In neat (no solvent) mixing, according to: Mizutani T., et al., Clays Clay Miner. 1991, 39, 381, hydrothermal treatment (250°C, 15 h, 500 psi of Ar), according to: Bruce, L. A. et al., Clays Clay Miner 1986, 34, 25; washing floculent solids (distd. water), stirring (1 M NaCl, overnight),washing (distd. water), dialyzing (Spectra/por 3 membrane);
lithium nitrate

lithium nitrate

silver nitrate

silver nitrate

ferric nitrate
7782-61-8

ferric nitrate

silicic acid
7699-41-4

silicic acid

100Fe/2Li/1Ag/10SiO2

100Fe/2Li/1Ag/10SiO2

Conditions
ConditionsYield
Stage #1: ferric nitrate With water; ammonium carbonate pH=6;
Stage #2: lithium nitrate; silicic acid In water at 300℃; for 5h;
Stage #3: silver nitrate With hydrogen more than 3 stages;
lithium carbonate
554-13-2

lithium carbonate

silver nitrate

silver nitrate

ferric nitrate
7782-61-8

ferric nitrate

silicic acid
7699-41-4

silicic acid

calcium carbonate

calcium carbonate

100Fe/2Li/1Ag/1.5Ca/25SiO2

100Fe/2Li/1Ag/1.5Ca/25SiO2

Conditions
ConditionsYield
Stage #1: ferric nitrate With water; ammonium carbonate pH=6;
Stage #2: lithium carbonate; calcium carbonate In water
Stage #3: silica gel; silver nitrate; silicic acid With hydrogen more than 3 stages;
lithium carbonate
554-13-2

lithium carbonate

silver nitrate

silver nitrate

ferric nitrate
7782-61-8

ferric nitrate

silicic acid
7699-41-4

silicic acid

100Fe/2Li/1Ag/25SiO2

100Fe/2Li/1Ag/25SiO2

Conditions
ConditionsYield
Stage #1: ferric nitrate With water; ammonium carbonate pH=6;
Stage #2: lithium carbonate In water
Stage #3: silica gel; silver nitrate; silicic acid With hydrogen more than 3 stages;
lithium carbonate
554-13-2

lithium carbonate

potassium hydrogencarbonate
298-14-6

potassium hydrogencarbonate

silver nitrate

silver nitrate

ferric nitrate
7782-61-8

ferric nitrate

silicic acid
7699-41-4

silicic acid

100Fe/0.2K/4Li/1Ag/25SiO2

100Fe/0.2K/4Li/1Ag/25SiO2

Conditions
ConditionsYield
Stage #1: ferric nitrate With water; ammonium carbonate pH=6;
Stage #2: lithium carbonate; potassium hydrogencarbonate In water
Stage #3: silica gel; silver nitrate; silicic acid With hydrogen more than 3 stages;
lithium carbonate
554-13-2

lithium carbonate

silver nitrate

silver nitrate

ferric nitrate
7782-61-8

ferric nitrate

silicic acid
7699-41-4

silicic acid

100Fe/2Li/1Ag/10SiO2

100Fe/2Li/1Ag/10SiO2

Conditions
ConditionsYield
Stage #1: ferric nitrate With water; ammonium carbonate pH=6;
Stage #2: lithium carbonate; silicic acid In water at 300℃; for 5h;
Stage #3: silver nitrate With carbon monoxide more than 3 stages;
lithium carbonate
554-13-2

lithium carbonate

potassium hydrogencarbonate
298-14-6

potassium hydrogencarbonate

silver nitrate

silver nitrate

ferric nitrate
7782-61-8

ferric nitrate

silicic acid
7699-41-4

silicic acid

100Fe/3K/1.2Li/2Ag/25SiO2

100Fe/3K/1.2Li/2Ag/25SiO2

Conditions
ConditionsYield
Stage #1: ferric nitrate With water; ammonium carbonate pH=6;
Stage #2: lithium carbonate; potassium hydrogencarbonate; silicic acid In water at 300℃; for 5h;
Stage #3: silver nitrate With hydrogen more than 3 stages;
lithium hydroxide monohydrate
1310-66-3

lithium hydroxide monohydrate

silicic acid
7699-41-4

silicic acid

lithium metasilicate

lithium metasilicate

Conditions
ConditionsYield
In acetone Milling; Heating;

Silicic acid(H2SiO3) Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 341.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 42 ,1987,p. 39.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 42 ,1987,p. 39.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory.

Silicic acid(H2SiO3) Standards and Recommendations

OSHA PEL: TWA 6 mg/m3
ACGIH TLV: TWA (nuisance particulate) 10 mg/m3 of total dust (when toxic impurities are not present, e.g., quartz <1%)
DFG MAK: 0.3 mg/m3 as fine dust

Silicic acid(H2SiO3) Analytical Methods

For occupational chemical analysis use or NIOSH: 1994: silica, amorphous, 7501.

Silicic acid(H2SiO3) Specification

The IUPAC name of Silicic acid(H2SiO3) is dihydroxy(oxo)silane. With the CAS registry number 7699-41-4 and EINECS 231-716-3, it is also named as Acidum silicicum. The product's categories are Inorganics; Acids; Electronic Chemicals; Micro / Nanoelectronics; Adsorption / Partition; Protein Chromatography; Silica. It is white amorphous powder or bulk which is insoluble in water or acid, soluble in potassium hydroxide and sodium hydroxide solution. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)#H bond acceptors: 3; (2)#H bond donors: 2; (3)#Freely Rotating Bonds: 0; (4)Polar Surface Area: 35.53 Å2; (5)Exact Mass: 77.97732; (6)MonoIsotopic Mass: 77.97732; (7)Topological Polar Surface Area: 57.5; (8)Heavy Atom Count: 4; (9)Formal Charge: 0; (10)Complexity: 26.3; (11)Isotope Atom Count: 0; (12)Covalently-Bonded Unit Count: 1.

Preparation of Silicic acid(H2SiO3): Adding a certain amount of sodium silicate (SiO2 22.9% ~ 39%, Na2O 8.6% ~ 14.6%) to the reaction kettle. And then adding a small amount of sulfuric acid to fully dissolve while stirring. Adding a certain amount of aluminum sulfate (Si / Al molar ratio 2:5). Diluted with water to the content of SiO2 of 0.5% to 1.0%. Finally, after stirring, we can get the product by motionlessness and aging with 1.5h.

Uses of Silicic acid(H2SiO3): It is used as coagulant and analytical reagent. It is also used as basic raw materials of powder cosmetics and and toothpaste.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes and respiratory system, so people should not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
1. SMILES:O=[Si](O)O
2. InChI:InChI=1/H2O3Si/c1-4(2)3/h1-2H
3. InChIKey:IJKVHSBPTUYDLN-UHFFFAOYAA

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intravenous 234mg/kg (234mg/kg)   AMA Archives of Industrial Health. Vol. 17, Pg. 204, 1958.

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