• Name

  Sodium ascorbate

• EINECS 205-126-1
• CAS No. 134-03-2
• Article Data10
• CAS DataBase
• Density 1.799 g/cm3
• Solubility 620 g/L (20 °C) in water
• Melting Point 220 °C (dec.)(lit.)
• Formula C₆H₇NaO₆
• Boiling Point 552.7 °C at 760 mmHg
• Molecular Weight 198.108
• Flash Point 238.2 °C
• Transport Information
• Appearance white to off-white solid
• Safety 24/25
• Risk Codes 68
• Molecular Structure
• Hazard Symbols
• Synonyms L-Ascorbic acid,compounds,monosodium salt;3-Oxo-L-gulofuranolactone sodium;L-Ascorbic acid sodium salt;Ascorbate de sodium;Ascorbato sodico;Ascorbic acid sodium derivative;Ascorbic acid sodium salt;Monosodium L-ascorbate;l-Ascorbate, sodium;Vitamin C Sodium;Vitamin c Na;
• PSA 110.05000
• LogP -1.53490

Synthetic route

134-03-2

sodium ascorbate

866-55-7

dichlorodiethylstannane

Sn(4+)*2C2H5(1-)*C6H6O6(2-)*H2O=Sn(C2H5)2(C6H6O6)*H2O

Conditions

Conditions	Yield
In methanol (N2); dropwise addn. of the Sn-compound in MeOH to a suspension of ascorbate in MeOH with stirring at 0°C; after allowing to warm up to room temp. the mixt. is heated under reflux for 3 h; volatiles are removed in vac. and the solid is successively washed with CH2Cl2 and THF and water, recrystn. from MeOH; elem. anal.;	85%

753-73-1

dimethyltin dichloride

134-03-2

sodium ascorbate

Sn(CH3)2(C6H6O6)*H2O

Conditions

Conditions	Yield
In methanol (N2;) dropwise addn. of Sn compound in MeOH to a suspension of ascorbate in MeOH with stirring at 0°C; after allowing to warm up to room temp. the mixt. is heated under reflux for 3.5 h; volatiles are removed in vac. and the solid is successively washed with CH2Cl2 and THF, recrystn. from MeOH; elem. anal.;	73%

134-03-2

sodium ascorbate

1135-99-5

diphenyltin(IV) dichloride

[Ph2Sn(L-ascorbic acid(-2H))]

Conditions

Conditions	Yield
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (2 equiv.) in methanol at 0°C; soln. was warmed to room temp.; refluxed for 3 h; filtered; concd. (vac.); washed (CH2Cl2); recrystd. (methanol); elem. anal.;	50%

134-03-2

sodium ascorbate

639-58-7

triphenyltin chloride

[Ph3Sn(L-ascorbate)]

Conditions

Conditions	Yield
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (1 equiv.) in methanol; soln. was stirred at room temp. for 10 min; refluxed for 6 h; filtered; volatiles removed (vac.); washed (CH2Cl2); dried (vac.); recrystd. (methanol); elem. anal.;	47%

1271-19-8

bis(cyclopentadienyl)titanium dichloride

134-03-2

sodium ascorbate

{(C5H5)2Ti(C6H7O6)2}

Conditions

Conditions	Yield
In water (N2); dropwise addn. of a soln. of ascorbate in water to a soln. of the Ti-compd. in water with stirring at 10°C, stirring of the mixt. for 2 h; allowing to warm slowly up to room temp.;; ppt. is collected by filtn., washed with cooled water and redissolved in THF, pptn. by addn. of hexane; elem. anal.;	45%

1461-22-9

tributyltin chloride

134-03-2

sodium ascorbate

[(n-Bu)3Sn(L-ascorbate)]

Conditions

Conditions	Yield
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (1 equiv.) in methanol; soln. was stirred at room temp. for 10 min; refluxed for 6 h; filtered; volatiles removed (vac.); washed (CH2Cl2); dried (vac.); recrystd. (methanol); elem. anal.;	23%

1066-45-1

trimethyltin(IV)chloride

134-03-2

sodium ascorbate

[Me3Sn(L-ascorbate)]

Conditions

Conditions	Yield
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (1 equiv.) in methanol; soln. was stirred at room temp. for 10 min; refluxed for 6 h; filtered; volatiles removed (vac.); washed (CH2Cl2); dried (vac.); recrystd. (methanol); elem. anal.;	20%

683-18-1

dibutyltin chloride

134-03-2

sodium ascorbate

[(n-Bu)2Sn(L-ascorbic acid(-2H))]

Conditions

Conditions	Yield
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (2 equiv.) in methanol at 0°C; soln. was warmed to room temp.; refluxed for 3 h; filtered; concd. (vac.); washed (CH2Cl2); recrystd. (methanol); elem. anal.;	20%

134-03-2

sodium ascorbate

2279-76-7

tripropyltin chloride

[(n-Pr)3Sn(L-ascorbate)]

Conditions

Conditions	Yield
In methanol byproducts: NaCl; (N2); soln. of Sn compd. (1 equiv.) in methanol was added dropwise with stirring to suspn. of ascorbate (1 equiv.) in methanol; soln. was stirred at room temp. for 10 min; refluxed for 6 h; filtered; volatiles removed (vac.); washed (CH2Cl2); dried (vac.); recrystd. (methanol); elem. anal.;	20%

134-03-2

sodium ascorbate

129499-78-1

2-O-α-D-glucopyranosyl L-ascorbate

Conditions

Conditions	Yield
rat intestinal (or rice seed) α-glucosidase, maltose, thiourea, 0.1 M acetate buffer, 3 h, 50 deg C, in the dark;	14%

134-03-2

sodium ascorbate

10016-20-3

alpha cyclodextrin

129499-78-1

2-O-α-D-glucopyranosyl L-ascorbate

Conditions

Conditions	Yield
Stage #1: sodium ascorbate; alpha cyclodextrin With cyclodextrin glucanotransferase from Thermoanaerobacter sp. In aq. acetate buffer at 40℃; for 24h; pH=4.0; Enzymatic reaction; Stage #2: With amyloglucosidase from Aspergillus niger In aq. acetate buffer at 60℃; for 2h; Enzymatic reaction; regioselective reaction;	0.27%

134-03-2

sodium ascorbate

7585-39-9

β‐cyclodextrin

129499-78-1

2-O-α-D-glucopyranosyl L-ascorbate

Conditions

Conditions	Yield
Stage #1: sodium ascorbate; β‐cyclodextrin With cyclodextrin glucanotransferase from Thermoanaerobacter sp. In aq. acetate buffer at 40℃; for 24h; pH=4.0; Enzymatic reaction; Stage #2: With amyloglucosidase from Aspergillus niger In aq. acetate buffer at 60℃; for 2h; Enzymatic reaction; regioselective reaction;	0.24%

134-03-2

sodium ascorbate

17465-86-0

cyclomaltooctaose

129499-78-1

2-O-α-D-glucopyranosyl L-ascorbate

Conditions

Conditions	Yield
Stage #1: sodium ascorbate; cyclomaltooctaose With cyclodextrin glucanotransferase from Thermoanaerobacter sp. In aq. acetate buffer at 40℃; for 24h; pH=4.0; Enzymatic reaction; Stage #2: With amyloglucosidase from Aspergillus niger In aq. acetate buffer at 60℃; for 2h; Enzymatic reaction; regioselective reaction;	0.21%

133-99-3, 490-37-9, 2152-98-9, 4482-75-1, 5965-66-2, 13299-27-9, 13360-52-6, 14641-93-1, 15548-43-3, 16462-44-5, 16984-36-4, 16984-38-6, 20869-27-6, 22688-72-8, 27452-49-9, 29276-55-9, 30608-12-9, 34481-13-5, 37169-60-1, 37169-64-5, 64234-01-1, 64234-02-2, 75281-88-8, 80446-85-1, 84413-57-0, 92344-56-4, 93221-87-5, 93301-77-0, 94799-29-8, 100427-98-3, 100428-00-0, 101312-82-7, 102046-24-2, 102046-25-3, 109432-00-0, 109432-02-2, 109432-04-4, 109432-08-8, 135268-49-4, 138231-26-2, 140461-59-2, 145414-22-8, 145414-26-2, 146339-75-5, 146339-76-6, 149116-55-2, 6363-53-7

Maltose

134-03-2

sodium ascorbate

129499-78-1

2-O-α-D-glucopyranosyl L-ascorbate

Conditions

Conditions	Yield
With acetate buffer; rice seed α-glucosidase; thiourea at 50℃; for 5h;

7732-18-5

water

134-03-2

sodium ascorbate

oxygen

oxygen

alkaline solution

alkaline solution

A

144-62-7

oxalic acid

B

21730-93-8

L-threonic acid-4-lactone

Conditions

Conditions	Yield
Behandeln des Natrium-Salzes oder anderer Alkalisalze;

...Expand

7775-19-1

sodium metaborate

134-03-2

sodium ascorbate

3Na(1+)*{B(C6H5O6)2}(3-)*3H2O=Na3{B(C6H5O6)2}*3H2O

Conditions

Conditions	Yield
In not given pptg. with methanol;
In not given pptg. with methanol;

134-03-2

sodium ascorbate

50-81-7

ascorbic acid

1333-74-0

hydrogen

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride; C18H23N3NiS3(2+)*2ClO4(1-) In N,N-dimethyl acetamide; water pH=4; Catalytic behavior; Irradiation;

Sodium ascorbate Consensus Reports

Sodium ascorbate Specification