Product Name

  • Name

    Sodium methylparaben

  • EINECS 225-714-1
  • CAS No. 5026-62-0
  • Article Data5
  • CAS DataBase
  • Density 1.42 g/cm3 (20 °C)
  • Solubility 418g/L at 20℃
  • Melting Point >125 °C
  • Formula C8H7NaO3
  • Boiling Point 265.5 °C at 760 mmHg
  • Molecular Weight 174.132
  • Flash Point 116.4 °C
  • Transport Information
  • Appearance white powder
  • Safety 22-24/25
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 5026-62-0 (Sodium methylparaben)
  • Hazard Symbols HarmfulXn
  • Synonyms Benzoicacid, 4-hydroxy-, methyl ester, sodium salt (9CI);Sodium, (p-carboxyphenoxy)-, methyl ester(7CI);Bonomold OMNa;Methyl4-hydroxybenzoate sodium salt;Methylparaben sodium;Sodium 4-(methoxycarbonyl)phenoxide;Sodium methylp-hydroxybenzoate;Sodium methylparaben;Sodium p-methoxycarbonylphenoxide;
  • PSA 49.36000
  • LogP 1.61700

Synthetic route

methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

sodium methylparaben
5026-62-0

sodium methylparaben

Conditions
ConditionsYield
With sodium hydroxide In methanol Inert atmosphere;95%
In water
With sodium hydride In tetrahydrofuran; DMF (N,N-dimethyl-formamide) for 1.5h;
With sodium hydroxide In ethanol; water at 20℃; for 1.83333h;32.4 g
4-(N-phenyl-benzimidoyloxy)-benzoic acid methyl ester
73823-12-8

4-(N-phenyl-benzimidoyloxy)-benzoic acid methyl ester

sodium methylate
124-41-4

sodium methylate

A

E-[2-methoxy-1-phenyl-methylene]-phenylamine
6780-39-8

E-[2-methoxy-1-phenyl-methylene]-phenylamine

B

sodium methylparaben
5026-62-0

sodium methylparaben

Conditions
ConditionsYield
In methanol at 29.9℃; Mechanism; var. base concentrations;
...Expand
4-[4'-(1-methoxy carbonyl-1-methylethyl)-phenyl]-1,2-epoxybutane
141969-79-1

4-[4'-(1-methoxy carbonyl-1-methylethyl)-phenyl]-1,2-epoxybutane

sodium methylparaben
5026-62-0

sodium methylparaben

methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

4-{4-[4'-(methoxy carbonyl-1-methylethyl)phenyl]-2-hydroxybutoxy}-benzoic acid methyl ester

4-{4-[4'-(methoxy carbonyl-1-methylethyl)phenyl]-2-hydroxybutoxy}-benzoic acid methyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide98%
...Expand
sodium methylparaben
5026-62-0

sodium methylparaben

pyrrole-1-carboxylic acid anhydride
107962-24-3

pyrrole-1-carboxylic acid anhydride

Pyrrole-1-carboxylic acid 4-methoxycarbonyl-phenyl ester

Pyrrole-1-carboxylic acid 4-methoxycarbonyl-phenyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 25℃; for 0.25h;88%
sodium methylparaben
5026-62-0

sodium methylparaben

indole-1-carboxylic acid anhydride
109241-96-5

indole-1-carboxylic acid anhydride

Indole-1-carboxylic acid 4-methoxycarbonyl-phenyl ester
109242-03-7

Indole-1-carboxylic acid 4-methoxycarbonyl-phenyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 25℃; for 0.25h;78%
sodium methylparaben
5026-62-0

sodium methylparaben

prenyl bromide
870-63-3

prenyl bromide

A

methyl 4-((3-methylbut-2-en-1-yl)oxy)benzoate
34593-50-5

methyl 4-((3-methylbut-2-en-1-yl)oxy)benzoate

B

methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

Conditions
ConditionsYield
In Hexafluorobenzene at 20℃; for 24h; Solvent; Temperature;A 70%
B 26%
...Expand
2-(chloromethyl)thiirane
3221-15-6

2-(chloromethyl)thiirane

sodium methylparaben
5026-62-0

sodium methylparaben

methyl 4-(thietane-3-yloxy)benzoate

methyl 4-(thietane-3-yloxy)benzoate

Conditions
ConditionsYield
In methanol; water at 45 - 55℃; for 2h;68%
2-bromo-4-furan-2-yl-6-thiophen-2-yl-nicotinonitrile
956117-80-9

2-bromo-4-furan-2-yl-6-thiophen-2-yl-nicotinonitrile

sodium methylparaben
5026-62-0

sodium methylparaben

4-(3-cyano-4-furan-3-yl-6-thiophen-2-yl-pyridin-2-yloxy)-benzoic acid methyl ester

4-(3-cyano-4-furan-3-yl-6-thiophen-2-yl-pyridin-2-yloxy)-benzoic acid methyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 90℃; for 18h;68%
sodium methylparaben
5026-62-0

sodium methylparaben

3-chloroprop-1-ene
107-05-1

3-chloroprop-1-ene

2-allyloxybenzoic acid
59086-52-1

2-allyloxybenzoic acid

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide In methanol; water65%
sodium methylparaben
5026-62-0

sodium methylparaben

prenyl bromide
870-63-3

prenyl bromide

A

methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

B

methyl 4-hydroxy-3-(3'-methyl-2'-butenyl)-5-(3''-methyl-2''-butenyl)benzoate
98969-33-6

methyl 4-hydroxy-3-(3'-methyl-2'-butenyl)-5-(3''-methyl-2''-butenyl)benzoate

Conditions
ConditionsYield
at 80℃; for 24h;A 56%
B 39%
...Expand
sodium methylparaben
5026-62-0

sodium methylparaben

prenyl bromide
870-63-3

prenyl bromide

A

methyl 4-((3-methylbut-2-en-1-yl)oxy)benzoate
34593-50-5

methyl 4-((3-methylbut-2-en-1-yl)oxy)benzoate

B

methyl 3-(3-methylbut-2-en-1-yl)-4-((3-methylbut-2-en-1-yl)oxy)benzoate

methyl 3-(3-methylbut-2-en-1-yl)-4-((3-methylbut-2-en-1-yl)oxy)benzoate

C

methyl-4-methoxy-3-(3’-methyl-2’-butenyl)benzoate
101511-34-6

methyl-4-methoxy-3-(3’-methyl-2’-butenyl)benzoate

D

methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

Conditions
ConditionsYield
at 40℃; for 24h;A 18%
B 7%
C 51%
D 28%
...Expand
trans-geranyl bromide
6138-90-5

trans-geranyl bromide

sodium methylparaben
5026-62-0

sodium methylparaben

methyl (2'E,2''E)-4-hydroxy-3-(3',7'-dimethylocta-2',6'-dienyl)-5-(3'',7''-dimethylocta-2'',6''-dienyl)benzoate
641614-05-3

methyl (2'E,2''E)-4-hydroxy-3-(3',7'-dimethylocta-2',6'-dienyl)-5-(3'',7''-dimethylocta-2'',6''-dienyl)benzoate

Conditions
ConditionsYield
at 20℃; for 24h;45%
sodium methylparaben
5026-62-0

sodium methylparaben

prenyl bromide
870-63-3

prenyl bromide

A

methyl 4-((3-methylbut-2-en-1-yl)oxy)benzoate
34593-50-5

methyl 4-((3-methylbut-2-en-1-yl)oxy)benzoate

B

methyl 3,5-bis(3-methylbut-2-en-1-yl)-4-((3-methylbut-2-en-1-yl)oxy)benzoate

methyl 3,5-bis(3-methylbut-2-en-1-yl)-4-((3-methylbut-2-en-1-yl)oxy)benzoate

C

methyl-4-methoxy-3-(3’-methyl-2’-butenyl)benzoate
101511-34-6

methyl-4-methoxy-3-(3’-methyl-2’-butenyl)benzoate

D

methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

E

methyl 4-hydroxy-3-(3'-methyl-2'-butenyl)-5-(3''-methyl-2''-butenyl)benzoate
98969-33-6

methyl 4-hydroxy-3-(3'-methyl-2'-butenyl)-5-(3''-methyl-2''-butenyl)benzoate

Conditions
ConditionsYield
at 40℃; for 24h;A 9%
B 8%
C 29%
D 40%
E 11%
...Expand
sodium methylparaben
5026-62-0

sodium methylparaben

3,4-dihydroxybenzoic acid methyl ester
2150-43-8

3,4-dihydroxybenzoic acid methyl ester

Conditions
ConditionsYield
With α,α'-bisamino>m-xylene - Cu(MeCN)4ClO4 (1:2 complex); oxygen In acetonitrile37%
With N,N,N',N'-tetra-(2-(N-methylbenzimidazol-2-yl)ethyl)-m-xylylenediamine Cu(I)2; oxygen 1.) CH3CN; Yield given. Multistep reaction;
With α,α'-bisamino>-m-xylene - Cu(MeCN)4ClO4; oxygen In acetonitrile Mechanism; other phenol-deriv. sodium salts;
With oxygen; [Cu2(L-66)](2+) In acetone at -80 - -60℃; Oxidation;
With [((2-pyridyl)bis(3-tert-butylpyrazol-2-yl)methane)Cu2O2](SbF6)2 In dichloromethane at -78.16℃; Kinetics; Inert atmosphere;
sodium methylparaben
5026-62-0

sodium methylparaben

2-bromoethanol
540-51-2

2-bromoethanol

4-(2-hydroxyethoxy)benzoic acid methyl ester
3204-73-7

4-(2-hydroxyethoxy)benzoic acid methyl ester

Conditions
ConditionsYield
With sodium iodide In methanol at 60℃; for 18h;35%
2,2-dimethylpent-4-enoic acid
16386-93-9

2,2-dimethylpent-4-enoic acid

4-(2-aminoacetyl)phenyl ethylacetate hydrochloride

4-(2-aminoacetyl)phenyl ethylacetate hydrochloride

sodium methylparaben
5026-62-0

sodium methylparaben

C23H27NO6

C23H27NO6

Conditions
ConditionsYield
Stage #1: 2,2-dimethylpent-4-enoic acid With hydrogen bromide; dibenzoyl peroxide In toluene Cooling with ice;
Stage #2: With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h;
Stage #3: 4-(2-aminoacetyl)phenyl ethylacetate hydrochloride; sodium methylparaben Further stages;		13.9%
...Expand
carbon disulfide
75-15-0

carbon disulfide

sodium methylparaben
5026-62-0

sodium methylparaben

C17H14O6S
116858-42-5

C17H14O6S

Conditions
ConditionsYield
Yield given. Multistep reaction;
2-ethoxy-6-carbethoxytetrahydropyran
3612-48-4

2-ethoxy-6-carbethoxytetrahydropyran

sodium methylparaben
5026-62-0

sodium methylparaben

trans-2-(p-carbomethoxyphenoxy)-6-carbethoxytetrahydropyran
133754-29-7

trans-2-(p-carbomethoxyphenoxy)-6-carbethoxytetrahydropyran

Conditions
ConditionsYield
With hydrogenchloride 1.) diethyl ether, 30 min, 2.) DMF; Multistep reaction;
sodium methylparaben
5026-62-0

sodium methylparaben

2-chlorotetrahydro-2H-pyran
3136-02-5

2-chlorotetrahydro-2H-pyran

4-methoxycarbonylphenyl 2-tetrahydropyranyl ether
106342-09-0

4-methoxycarbonylphenyl 2-tetrahydropyranyl ether

Conditions
ConditionsYield
With hydrogenchloride 1.) diethyl ether, 30 min, 2.) DMF; Multistep reaction;
methyl 2,2-dichloropropionate
17640-02-7

methyl 2,2-dichloropropionate

sodium methylparaben
5026-62-0

sodium methylparaben

α-<4-Methoxycarbonyl-phenoxy>-acrylsaeure-methylester
16929-34-3

α-<4-Methoxycarbonyl-phenoxy>-acrylsaeure-methylester

Conditions
ConditionsYield
(i) cyclohexanone, (ii) TsOH; Multistep reaction;
sodium methylparaben
5026-62-0

sodium methylparaben

N,N-Dimethylthiocarbamoyl chloride
16420-13-6

N,N-Dimethylthiocarbamoyl chloride

O-(4-carbomethoxyphenyl) N,N-dimethylthiocarbamate
13492-59-6

O-(4-carbomethoxyphenyl) N,N-dimethylthiocarbamate

sodium methylparaben
5026-62-0

sodium methylparaben

4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

Conditions
ConditionsYield
With phosphate buffer; Sucrose at 60℃; pH=8.0; Kinetics; Further Variations:; Reagents;
sodium methylparaben
5026-62-0

sodium methylparaben

sodium salt of dimethyl methylmalonate

sodium salt of dimethyl methylmalonate

2-bromoallyl bromide
513-31-5

2-bromoallyl bromide

A

methyl 4-bromo-2-(methylcarboxy)-2-methylpent-4-enoate
199923-58-5

methyl 4-bromo-2-(methylcarboxy)-2-methylpent-4-enoate

B

2-[2-(4-methoxycarbonyl-phenoxy)-allyl]-2-methyl-malonic acid dimethyl ester

2-[2-(4-methoxycarbonyl-phenoxy)-allyl]-2-methyl-malonic acid dimethyl ester

C

2-[1-(4-methoxycarbonyl-phenoxymethyl)-vinyl]-2-methyl-malonic acid dimethyl ester

2-[1-(4-methoxycarbonyl-phenoxymethyl)-vinyl]-2-methyl-malonic acid dimethyl ester

D

C19H18O6

C19H18O6

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; for 5h; Further byproducts given. Title compound not separated from byproducts;
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; for 2h; Further byproducts given. Title compound not separated from byproducts;
...Expand
sodium methylparaben
5026-62-0

sodium methylparaben

4-(thietane-3-yloxy)benzoic acid

4-(thietane-3-yloxy)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 68 percent / methanol; H2O / 2 h / 45 - 55 °C
2: 93 percent / HCl / methanol; H2O
View Scheme
sodium methylparaben
5026-62-0

sodium methylparaben

4-[2-(tetrahydropyran-2-yloxy)ethoxy]benzoic acid methyl ester
182358-82-3

4-[2-(tetrahydropyran-2-yloxy)ethoxy]benzoic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 35 percent / NaI / methanol / 18 h / 60 °C
2: 90 percent / ISiMe3 / CH2Cl2 / 0.5 h / 25 °C
View Scheme
sodium methylparaben
5026-62-0

sodium methylparaben

4-<(dimethylcarbamoyl)thio>benzoic acid
13511-91-6

4-<(dimethylcarbamoyl)thio>benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
2: aq. HCl
3: tetrahydrothiophene 1,1-dioxide / 220 °C
View Scheme
sodium methylparaben
5026-62-0

sodium methylparaben

4--benzoesaeure
13522-57-1

4--benzoesaeure

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: aq. HCl
View Scheme
sodium methylparaben
5026-62-0

sodium methylparaben

α-(4-Carboxy-phenoxy)-acrylsaeure
16929-38-7

α-(4-Carboxy-phenoxy)-acrylsaeure

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) cyclohexanone, (ii) TsOH
2: aq. NaOH / Ambient temperature
View Scheme

Sodium methylparaben Chemical Properties

Molecular Formula: C8H7NaO3
Molecular Weight: 174.13 g/mol
EINECS: 225-714-1
Flash Point: 116.4 °C
Melting point: >125 °C
Solubility: Soluble in water
Appearance: White powder
Enthalpy of Vaporization: 52.38 kJ/mol
Boiling Point: 265.5 °C at 760 mmHg
Vapour Pressure: 0.00555 mmHg at 25 °C
Structure of Sodium methylparaben (CAS NO.5026-62-0):
               
IUPAC Name: Sodium 4-methoxycarbonylphenolate
Product Category of Sodium methylparaben (CAS NO.5026-62-0): Aromatic Esters;Benzoic acid Series

Sodium methylparaben Uses

 Sodium methylparaben (CAS NO.5026-62-0) has been used for water-soluble preservatives in dairy products, pickled products, beverages, fruit juice, jelly and cakes, etc..

Sodium methylparaben Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 760mg/kg (760mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA		 Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.
mouse LD50 intravenous 170mg/kg (170mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.
mouse LD50 oral 2gm/kg (2000mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.

 Sodium methylparaben (CAS NO.5026-62-0) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.

Sodium methylparaben Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 22
 R22:Harmful if swallowed.
Safety Statements: 22-24/25 
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes.

Sodium methylparaben Specification

 Sodium methylparaben , its cas register number is 5026-62-0. It also can be called p-Hydroxybenzoic acid methyl ester sodium salt ; Sodium (p-carboxyphenoxy)-methyl ester ; 4-Hydroxybenzoic acid methyl ester sodium salt ; Methyl 4-hydroxybenzoate sodium salt ; Methyl p-hydroxybenzoate sodium salt ; Methylparaben sodium ; Sodium 4-(methoxycarbonyl)phenoxide ; Sodium 4-carbomethoxyphenolate ; Sodium p-methoxycarbonylphenoxide ; and Sodium methyl p-hydroxybenzoate . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Sodium methylparaben (CAS NO.5026-62-0) absorbs moisture or water from the air. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials, dust generation. It should be exposured to moist air or water. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide.

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