Product Name

  • Name

    co-trifamole

  • EINECS
  • CAS No. 57197-43-0
  • Density g/cm3
  • Solubility
  • Melting Point
  • Formula C14H18N4O3•C11H13N3O3S
  • Boiling Point 526°Cat760mmHg
  • Molecular Weight 557.69
  • Flash Point 271.9°C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx. See also AROMATIC AMINES and AMIDES.
  • Risk Codes
  • Molecular Structure Molecular Structure of 57197-43-0 (co-trifamole)
  • Hazard Symbols
  • Synonyms co-trifamole
  • PSA 213.57000
  • LogP 4.52720

Sulfamoxole-trimethoprim mixture Chemical Properties

IUPAC Name: 4-Amino-N-(4,5-dimethyl-1,3-oxazol-2-yl)benzenesulfonamide ; 5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Synonyms: Benzenesulfonamide, 4-amino-N-(4,5-dimethyl-2-oxazolyl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine ; Co-trifamole ;Nevin (mixture) ; Sulfamoxazole + trimethoprim ;Sulfamoxole and trimethoprim
CAS NO: 57197-43-0
Molecular Formula of Sulfamoxole-trimethoprim mixture (CAS NO.57197-43-0) : C25H31N7O6S
Molecular Weight of Sulfamoxole-trimethoprim mixture (CAS NO.57197-43-0) : 557.6219
Molecular Structure of Sulfamoxole-trimethoprim mixture (CAS NO.57197-43-0) :
Flash Point: 271.9 °C
Enthalpy of Vaporization: 80.02 kJ/mol
Boiling Point: 526 °C at 760 mmHg
Vapour Pressure: 3.74E-11 mmHg at 25°C
 

Sulfamoxole-trimethoprim mixture Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
mouse LD50 intraperitoneal 1870mg/kg (1870mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
mouse LD50 oral > 12gm/kg (12000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
rat LD50 intraperitoneal 2gm/kg (2000mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.
rat LD50 oral 14gm/kg (14000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 634, 1976.

 

Sulfamoxole-trimethoprim mixture Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx. See also AROMATIC AMINES and AMIDES.

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