Sulfamoyl chloride supplier

Name
Chlorosulfonamide
EINECS
CAS No. 7778-42-9
Article Data122
CAS DataBase
Density 1.788 g/cm³
Solubility
Melting Point 40-41 °C
Formula ClH₂NO₂S
Boiling Point 100-105 °C(Press: 4 Torr)
Molecular Weight 115.54
Flash Point
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Amidosulfonicacid chloride;Amidosulfonyl chloride;Aminosulfonyl chloride;Chloroimidosulfuric acid;NSC 158265;Sulfamyl chloride;
PSA 68.54000
LogP 1.20980

Synthetic route

: 1189-71-5
isocyanate de chlorosulfonyle

: 7778-42-9
sulphamoyl chloride

Conditions

Conditions	Yield
With formic acid at 0 - 20℃; for 1h;	100%
With formic acid In dichloromethane at 0 - 20℃; for 12h; Schlenk technique;	97%
With formic acid at 5 - 40℃; Inert atmosphere;	96%

: 64-18-6
formic acid

: 1189-71-5
isocyanate de chlorosulfonyle

: 7778-42-9
sulphamoyl chloride

Conditions

Conditions	Yield
In toluene at 23℃; for 10h; Inert atmosphere;	100%
In dichloromethane at 0 - 22℃; for 12h; Inert atmosphere; Schlenk technique;	97%
at 5 - 20℃;	92%

: 1189-71-5
isocyanate de chlorosulfonyle

: 7732-18-5
water

: 7778-42-9
sulphamoyl chloride

Conditions

Conditions	Yield
In tetrahydrofuran at -20 - 0℃;
In tetrahydrofuran at -20 - 0℃;

: 15790-84-8
sodium phenylsulfamate

: 7778-42-9
sulphamoyl chloride

Conditions

Conditions	Yield
With chlorosulfonic acid; triethanolamine; phosphorus pentachloride; aniline In NaOH; ethanol; chloroform; benzene

: 1093206-32-6
N-(1-(3-amino-2-cyanophenoxy)-2-methylpropan-2-yl)butyramide

: 7778-42-9
sulphamoyl chloride

: 1093206-31-5
N-(1-(3-sulfamoylamino-2-cyanophenoxy)-2-methylpropan-2-yl)butyramide

Conditions

Conditions	Yield
	100%

: 1093206-35-9
1-(1-(3-amino-2-cyanophenoxy)-2-methylpropan-2-yl)-3-ethylurea

: 7778-42-9
sulphamoyl chloride

: 1093206-34-8
1-(1-(3-sulfamoylamino-2-cyanophenoxy)-2-methylpropan-2-yl)-3-ethylurea

Conditions

Conditions	Yield
	100%

: 1093206-49-5
N-(4-(3-amino-2-cyanophenoxy)butyl)acetamide

: 7778-42-9
sulphamoyl chloride

: 1093206-48-4
N-(4-(2-cyano-3-(sulfamoylamino)phenoxy)butyl)acetamide

Conditions

Conditions	Yield
	100%

: 1093206-90-6
1-(3-(3-amino-2-cyanophenoxy)-2,2-dimethylpropyl)-3-(4-methoxybenzyl)urea

: 7778-42-9
sulphamoyl chloride

: 1093206-89-3
1-(3-(3-sulfamoylamino-2-cyanophenoxy)-2,2-dimethylpropyl)-3-(4-methoxybenzyl)urea

Conditions

Conditions	Yield
	100%

: 36016-38-3
tert-Butyl N-hydroxycarbamate

: 7778-42-9
sulphamoyl chloride

: 1310054-47-7
BocNHOSO2NH2

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 0 - 20℃; for 2h; Inert atmosphere;	100%

: 7664-39-3
hydrogen fluoride

: 7778-42-9
sulphamoyl chloride

: 7783-58-6
germanium tetrafluoride

: 2ClH2NO2S*2H(1+)*F6Ge(2-)

Conditions

Conditions	Yield
at -196 - -40℃; for 72h; Schlenk technique;	100%

...Expand

: 7664-39-3
hydrogen fluoride

: 7778-42-9
sulphamoyl chloride

: 7784-36-3
arsenic pentafluoride

: ClH2NO2S*H(1+)*AsF6(1-)

Conditions

Conditions	Yield
at -196 - -40℃; for 72h; Schlenk technique;	100%

...Expand

: N6-(prop-2"-ynyl)-2',3'-(O-isopropylidene)adenosine

: 7778-42-9
sulphamoyl chloride

: C16H20N6O6S

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 1h;	98%

: 1-sulfamoyloxymethyl-12-(3-ethyl-4-hydroxyphenyl)-12-dicarba-closo-dodecaborane

: 7778-42-9
sulphamoyl chloride

: 1-sulfamoyloxymethyl-12-(3-ethyl-4-sulfamoyloxyphenyl)-1,12-dicarba-closo-dodecaborane

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 20℃; for 7h;	97%

: 284045-28-9
17-(N-Butylcarbamoyl)-3-(hydroxy)estra-1,3,5(10),16-tetraene

: 7778-42-9
sulphamoyl chloride

: 284045-29-0
17-(N-Butylcarbamoyl)-estra-1,3,5(10),16-tetraene-3-yl sulfamate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide	96%

: 1002-28-4
3-hexyn-1-ol

: 7778-42-9
sulphamoyl chloride

: hex-3-yn-1-yl sulfamate

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; formic acid In N,N-dimethyl acetamide; acetonitrile at 0 - 25℃; for 3.5h; Inert atmosphere;	96%

: 1623785-56-7
(±)-2-(3-bromo-4,5-dimethoxybenzyl)-6-hydroxy-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline

: 7778-42-9
sulphamoyl chloride

: 1623785-62-5
(±)-2-(3′-bromo-4′,5′-dimethoxybenzyl)-7-methoxy-3-methyl-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
With N,N-dimethyl acetamide In toluene at 0 - 25℃; for 2h;	96%

: [4-[(1R)-7-chloroisochroman-1-yl]-5-methyl-2-thienyl]-[4-[[(1R,3R,4S)-3-(hydroxymethyl)-4-triisopropylsilyloxy-cyclopentyl]amino]pyrimidin-5-yl]methanone

: 7778-42-9
sulphamoyl chloride

: [(1R,2S,4R)-4-{[5-({4-[(1R)-7-chloro-3,4-dihydro-1H-isochromen-1-yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate

Conditions

Conditions	Yield
Stage #1: [4-[(1R)-7-chloroisochroman-1-yl]-5-methyl-2-thienyl]-[4-[[(1R,3R,4S)-3-(hydroxymethyl)-4-triisopropylsilyloxy-cyclopentyl]amino]pyrimidin-5-yl]methanone; sulphamoyl chloride With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 2h;	96%

: (R)-3-carbamoyl-2-phenyl propanol

: 7778-42-9
sulphamoyl chloride

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: (S)-3-carbamoyl-2-phenyl propanol sulfamate

Conditions

Conditions	Yield
In hexane; water; ethyl acetate; acetonitrile	93%
In hexane; water; ethyl acetate; acetonitrile	93%

...Expand

: 1193444-97-1
tert-butyl (2-hydroxyphenyl)(oxo)acetate

: 7778-42-9
sulphamoyl chloride

: C12H13NO5S

Conditions

Conditions	Yield
With formic acid In N,N-dimethyl acetamide; acetonitrile at 0 - 50℃; Schlenk technique; Inert atmosphere;	93%

: 7778-42-9
sulphamoyl chloride

: 53369-17-8
(1S,2S,5S)-(-)-myrtanol

: 1145767-51-6
[(1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-yl]methyl-sulfamate

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 0 - 20℃; for 3h;	92%

: 1082863-28-2
N6-cyclopropyl-2',3'-O-isopropylidene-2-phenyladenosine

: 7778-42-9
sulphamoyl chloride

: 1082863-30-6
N6-cyclopropyl-2',3'-O-isopropylidene-2-phenyl-5'-O-(sulfamoyl)adenosine

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 0℃; for 4h; Inert atmosphere;	92%

: [5-chloro-4-(methoxymethyl)-2-thienyl][4-({(1R,3R,4S)-3-(hydroxymethyl)-4-[(triisopropylsilyl)oxy]cyclopentyl}amino)pyrimidin-5-yl]methanone

: 7778-42-9
sulphamoyl chloride

: {(1R,2S,4R)-4-[(5-{[5-chloro-4-(methoxymethyl)-2-thienyl]carbonyl}pyrimidin-4-yl)amino]-2-hydroxycyclopentyl}methyl sulfamate

Conditions

Conditions	Yield
Stage #1: [5-chloro-4-(methoxymethyl)-2-thienyl][4-({(1R,3R,4S)-3-(hydroxymethyl)-4-[(triisopropylsilyl)oxy]cyclopentyl}amino)pyrimidin-5-yl]methanone; sulphamoyl chloride With triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: With hydrogenchloride In dichloromethane; water; N,N-dimethyl-formamide at 0 - 20℃; for 3h;	90%

: 1616-20-2
8-hydroxy-12a-methyl-3,4,4a,4b,5,6,10b,11,12,12a-decahydronaphtho[2,1-f]quinolin-2(1H)-one

: 7778-42-9
sulphamoyl chloride

: 205118-80-5
3-O-sulphamyl-13α-amino-13,17-seco-1,3,5(10)-estratrien-17-oic-13,17-lactam

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 23℃; for 18.5h; Inert atmosphere;	90%

: (E)-3-(4-hydroxyphenyl)-N-nonylacrylamide

: 7778-42-9
sulphamoyl chloride

: 501333-21-7
C18H28N2O4S

Conditions

Conditions	Yield
In ISOPROPYLAMIDE at 20℃; for 1h;	89%

: (S)-3-carbamoyl-2-phenyl propanol

: 7778-42-9
sulphamoyl chloride

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: (R)-3-Carbamoyl-2-phenyl propanol sulfamate

Conditions

Conditions	Yield
In hexane; water; ethyl acetate; acetonitrile	89%
In hexane; water; ethyl acetate; acetonitrile	89%

...Expand

: (S)-3-N-methylcarbamoyl-2-(m-chlorophenyl)propanol

: 7778-42-9
sulphamoyl chloride

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: (R)-3-N-methylcarbamoyl-2-(m-chlorophenyl)propanol sulfamate

Conditions

Conditions	Yield
In hexane; water; ethyl acetate; acetonitrile	89%

...Expand

: 3-N-methylcarbamoyl-2-(o-chlorophenyl)propanol

: 60-29-7
diethyl ether

: 7778-42-9
sulphamoyl chloride

: 3-N-methylcarbamoyl-2-(o-chlorophenyl)propanol sulfamate

Conditions

Conditions	Yield
With pyridine In water; ethyl acetate; acetonitrile	89%

...Expand

: 266689-70-7
2-((1S,2R)-6,6-dimethyl-norpinan-2-yl)-ethanol

: 7778-42-9
sulphamoyl chloride

: [(1S,2R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-yl]ethyl-sulfamate

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 0 - 20℃; for 3h;	89%

: 132203-71-5, 473-01-8, 514-99-8, 15358-91-5, 15358-92-6, 51152-12-6, 53369-17-8, 73136-30-8
6,6-dimethylbicyclo[3.1.1]heptane-2-methanol

: 7778-42-9
sulphamoyl chloride

: 1145767-53-8
[(1R,2R,5R)-6,6-dimethylbicyclo[3.1.1]hept-2-yl]methyl-sulfamate

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 0 - 20℃; for 3h;	89%

: 7778-42-9
sulphamoyl chloride

: 76911-01-8
5-hexynyl p-toluenesulfonate

: 8-(tosyloxy)oct-3-yn-1-sulfamate

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; formic acid In N,N-dimethyl acetamide; acetonitrile at 0 - 25℃; for 3.5h; Inert atmosphere;	89%

: tert-butyl 7-chloro-1-[5-[4-[[(1R,3R,4S)-3-(hydroxymethyl)-4-triisopropylsilyloxy-cyclopentyl]amino]pyrimidine-5-carbonyl]-2-methyl-3-thienyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate

: 7778-42-9
sulphamoyl chloride

: tert-butyl (1R)-7-chloro-1-[2-methyl-5-[4-[[(1R,3R,4S)-3-(sulfamoyloxymethyl)-4-triisopropylsilyloxy-cyclopentyl]amino]pyrimidine-5-carbonyl]-3-thienyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate

Conditions

Conditions	Yield
With triethylamine In 2-methyltetrahydrofuran; N,N-dimethyl-formamide at 0℃; for 0.166667h;	89%

Sulfamoyl chloride Specification

The Sulfamoyl chloride, with the CAS registry number 7778-42-9, is also known as Chlorosulfamic acid. It belongs to the product categories of Aliphatics; Amines; Sulfur & Selenium Compounds. This chemical's molecular formula is ClH₂NO₂S and molecular weight is 115.54. What's more, its systematic name is Sulfamyl chloride.

Physical properties of Sulfamoyl chloride are: (1)ACD/LogP: -0.641; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.66; (4)ACD/LogD (pH 7.4): -1.31; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)#H bond acceptors: 3; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 0; (10)Polar Surface Area: 68.54 Å²; (11)Index of Refraction: 1.509; (12)Molar Refractivity: 19.313 cm³; (13)Molar Volume: 64.63 cm³; (14)Polarizability: 7.656×10^-24cm³; (15)Surface Tension: 64.0 dyne/cm; (16)Density: 1.788 g/cm³.

You can still convert the following datas into molecular structure:
(1)SMILES: ClS(=O)(=O)N
(2)Std. InChI: InChI=1S/ClH2NO2S/c1-5(2,3)4/h(H2,2,3,4)
(3)Std. InChIKey: QAHVHSLSRLSVGS-UHFFFAOYSA-N

Product Name

Chlorosulfonamide

Synthetic route

Sulfamoyl chloride Specification

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