Sulfaquinoxaline

Reported in EPA TSCA Inventory.

The IUPAC name of Sulfaquinoxaline is 4-amino-N-quinoxalin-2-ylbenzenesulfonamide. With the CAS registry number 59-40-5, it is also named as 2-(p-Sulfanilamido)quinoxaline. The product's categories are Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds. It is light yellow crystalline powder which is insoluble in water, ethanol and acetone, soluble in alkaline solution. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. Additioanlly, this chemical should be sealed in the container.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.63; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.57; (4)ACD/LogD (pH 7.4): -0.48; (5)ACD/BCF (pH 5.5): 1.52; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 45.01; (8)ACD/KOC (pH 7.4): 4.07; (9)#H bond acceptors: 6; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.733; (13)Molar Refractivity: 80.7 cm³; (14)Molar Volume: 201.3 cm³; (15)Polarizability: 31.99×10^-24 cm³; (16)Surface Tension: 83.7 dyne/cm; (17)Enthalpy of Vaporization: 83.13 kJ/mol; (18)Vapour Pressure: 3.42E-12 mmHg at 25°C; (19)Rotatable Bond Count: 3; (20)Tautomer Count: 2; (21)Exact Mass: 300.068096; (22)MonoIsotopic Mass: 300.068096; (23)Topological Polar Surface Area: 106; (24)Heavy Atom Count: 21; (25)Complexity: 442.

Preparation of Sulfaquinoxaline: Using o-phenylenediamine as raw material. Firstly, o-phenylenediamine reacts with sodium cyanide, formaldehyde in acidic media to obtain N-cyanomethyl-o-phenylenediamine. Secondly, the cyclization of N-cyanomethyl-o-phenylenediamine and potassium hydroxide to generate 2-amino-3,4-dihydro-yl. Thirdly, using hydrogen peroxide to dehydrogenize in the presence of ferrous chloride to get 2-amino-quinoxaline. Finally, after condensation and hydrolysis with acetylsulfanilyl chloride
sulfonamides, we can get the product.

Uses of Sulfaquinoxaline: It is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis. It is also used as an animal-specific broad-spectrum antimicrobial agent, which is more toxic to mammals.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. And it also may cause sensitization by inhalation and skin contact, so people should not breathe dust. If you want to contact this product, you must wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
1. SMILES:O=S(=O)(c1ccc(N)cc1)Nc2nc3ccccc3nc2
2. InChI:InChI=1/C14H12N4O2S/c15-10-5-7-11(8-6-10)21(19,20)18-14-9-16-12-3-1-2-4-13(12)17-14/h1-9H,15H2,(H,17,18) 
3. InChIKey:NHZLNPMOSADWGC-UHFFFAOYAA

The following are the toxicity data which has been tested.