• Name

  TRIS(2,2,2-TRIFLUOROETHYL)ORTHOFORMATE

• EINECS
• CAS No. 58244-27-2
• Article Data3
• CAS DataBase
• Density 1.457g/cm³
• Solubility
• Melting Point
• Formula C₇H₇F₉O₃
• Boiling Point 164.7°Cat760mmHg
• Molecular Weight 310.116
• Flash Point 59.5°C
• Transport Information
• Appearance
• Safety

  Hazard Codes

  Xi

• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms TRIS[(TRIFLUOROETHOXY)METHANE];TRIS(2,2,2-TRIFLUOROETHYL)ORTHOFORMATE;Tris(2,2,2-trifluoroethyl)orthoformate 97%;Tris(2,2,2-trifluoroethyl)orthoformate97%
• PSA 27.69000
• LogP 3.00670

Synthetic route

67-66-3

chloroform

75-89-8

2,2,2-trifluoroethanol

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

Conditions

Conditions	Yield
With iron(III) chloride

75-89-8

2,2,2-trifluoroethanol

154914-84-8

trifluoroethoxyfluorodiazirine

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

Conditions

Conditions	Yield
Irradiation;

75-89-8

2,2,2-trifluoroethanol

154914-85-9

bis-trifluoroethoxydiazirine

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

Conditions

Conditions	Yield
Ambient temperature; Yield given;

126814-93-5

3-[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)oxy]-1,2-propanediol

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

4-(((3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)oxy)methyl)-2-(2,2,2-trifluoroethoxy)-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In cyclohexane for 3h; Dean-Stark; Reflux;	74%

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

147274-18-8

5,5,6,6,7,7,8,8,9,9,10,10,10-Tridecafluorodecane-1,2-diol

4-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-2-(2,2,2-trifluoroethoxy)-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In cyclohexane for 1h; Dean-Stark; Reflux;	44%

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

125070-38-4

1H,1H,2H,3H,3H-perfluoroheptane-1,2-diol

4-(2,2,3,3,4,4,5,5,5-nonafluoropentyl)-2-(2,2,2-trifluoroethoxy)-1,3-dioxolane

Conditions

Conditions	Yield
With Amberlyst 15 (H form, Aldrich) In cyclohexane for 4h; Dean-Stark; Reflux;	39%

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

269394-13-0

5,5,6,6,7,7,8,8,8-Nonafluorooctane-1,2-diol

4-(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-2-(2,2,2-trifluoroethoxy)-1,3-dioxolane

Conditions

Conditions	Yield
With Amberlyst 15 (H form, Aldrich) In cyclohexane Dean-Stark; Reflux;	20%

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

100-19-6

(4-nitrophenyl)ethanone

64600-24-4

1-[1,1-Bis-(2,2,2-trifluoro-ethoxy)-ethyl]-4-nitro-benzene

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

445312-74-3

(R)-2-tert-butyl 8a-methyl 6-oxo-3,4,6,7,8, 8a-hexahydroisoquinoline-2,8a(1H)-dicarboxylate

864973-65-9

(R,Z)-2-tert-butyl 8a-methyl 7-(hydroxymethylene)-6-oxo-3,4,6,7,8,8a-hexahydroisoquinoline-2,8a(1H)-dicarboxylate

Conditions

Conditions	Yield
Stage #1: (R)-2-tert-butyl 8a-methyl 6-oxo-3,4,6,7,8, 8a-hexahydroisoquinoline-2,8a(1H)-dicarboxylate With n-butyllithium; diisopropylamine In diethyl ether at -78℃; for 0.333333h; Stage #2: tris(2,2,2-trifluoroethyl)orthoformate In diethyl ether for 1.5h;

864973-62-6

(S)-8a-methyl-6-oxo-3,4,6,7,8,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

58244-27-2

tris(2,2,2-trifluoroethyl)orthoformate

864973-64-8

(S)-7-[1-hydroxy-meth-(Z)-ylidene]-8a-methyl-6-oxo-3,4,6,7,8,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: (S)-8a-methyl-6-oxo-3,4,6,7,8,8a-hexahydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester With n-butyllithium; diisopropylamine In diethyl ether at -78℃; for 0.333333h; Stage #2: tris(2,2,2-trifluoroethyl)orthoformate In diethyl ether for 1.5h;