pyridine
Hexafluorobenzene
ethanol
A
2,3,4,5,6-pentafluorophenol
B
ethoxy pentafluorobenzene
C
3,4,5,6-tetrafluorobenzene-1,2-diol
D
1,4,5,6-Tetrafluor-2,3-diethoxy-benzol
tetrahydrofuran
tetrafluoro-1,2-benzoquinone
A
2,3,4,5-tetrafluoro-6-((tetrahydrofuran-2-yl)oxy)phenol
B
3,4,5,6-tetrafluorobenzene-1,2-diol
Conditions | Yield |
---|---|
for 0.5h; Irradiation; |
diethyl ether
tetrafluoro-1,2-benzoquinone
A
2-(1-ethoxyethoxy)-3,4,5,6-tetrafluorophenol
B
3,4,5,6-tetrafluorobenzene-1,2-diol
Conditions | Yield |
---|---|
for 0.5h; Irradiation; |
3,4,5,6-tetrafluorobenzene-1,2-diol
pentafluorophenylboronic acid
2-(pentafluorophenyl)-tetrafluoro-1,3,2-benzodioxaborole
Conditions | Yield |
---|---|
In toluene byproducts: water; mixt. heated to reflux; water removed by azeotropic distillation; after 4 h solvent evapd. under reduced pressure; residue sublimed at 110°C/0.1 mm Hg; | 87% |
In toluene under N2; C6F4(OH)2 and C6F5B(OH)2 in toluene heated to reflux for 12 h using Dean-Stark apparatus; volatiles removed under reduced pressure; sublimed at 80°C; takenup in pentane; filtered; cryst. at -35°C; elem. anal.; | 42% |
In toluene byproducts: H2O; (Ar or under vac.); mixed in toluene; heated to reflux; water removed byazeotropic distillation; after 4 h, solvent evapd. under reduced pressu re; sublimed at 110°C; |
Conditions | Yield |
---|---|
In tetrahydrofuran at 22℃; for 0.5h; Inert atmosphere; | 80% |
Conditions | Yield |
---|---|
In tetrahydrofuran byproducts: NaOCOCH3, NaCl, H2O; (N2); stirring a suspn. of ruthenium complex, ligand, NaOH in THF for 1 d at room temp.; drying in vac., extn. with THF, slow diffusion of hexane; elem. anal.; | 72% |
tripropyl arsenite
3,4,5,6-tetrafluorobenzene-1,2-diol
Conditions | Yield |
---|---|
at 150 - 160℃; for 2h; | 64.8% |
Conditions | Yield |
---|---|
In methanol for 12h; Inert atmosphere; Schlenk technique; | 60% |
Conditions | Yield |
---|---|
With arsenic trichloride In diethyl ether for 2h; Ambient temperature; | 59% |
tetrachlorosilane
3,4,5,6-tetrafluorobenzene-1,2-diol
Conditions | Yield |
---|---|
In acetonitrile at 0 - 25℃; for 20h; | 53% |
Conditions | Yield |
---|---|
In acetonitrile (Ar); heating (50°C); crystn. (5°C, 3 d), recrystn. (benzene/MeCN), washing (benzene); | 30.8% |
3,4,5,6-tetrafluorobenzene-1,2-diol
2,4-difluorophenylboronic acid
2-(2,4-difluorophenyl)-tetrafluoro-1,3,2-benzodioxaborole
Conditions | Yield |
---|---|
In toluene byproducts: H2O; (Ar or under vac.); mixed in toluene; heated to reflux; water removed byazeotropic distillation; after 4 h, solvent evapd. under reduced pressu re; sublimed at 125°C; |
3,4,5,6-tetrafluorobenzene-1,2-diol
2-(trifluoromethyl)phenylboronic acid
2-(2-trifluoromethyl phenyl)-tetrafluoro-1,3,2-benzodioxaborole
Conditions | Yield |
---|---|
In toluene byproducts: H2O; (Ar or under vac.); mixed in toluene; heated to reflux; water removed byazeotropic distillation; after 4 h, solvent evapd. under reduced pressu re; sublimed at 110°C; |
(2,5-di(trifluoromethyl)phenyl)boronic acid
3,4,5,6-tetrafluorobenzene-1,2-diol
2,5-bis(trifluoromethyl)phenyl-tetrafluoro-1,3,2-benzodioxaborole
Conditions | Yield |
---|---|
In toluene byproducts: H2O; (Ar or under vac.); mixed in toluene; heated to reflux; water removed byazeotropic distillation; after 4 h, solvent evapd. under reduced pressu re; sublimed at 105-110°C; |
3,4,5,6-tetrafluorobenzene-1,2-diol
4-fluoroboronic acid
2-(4-fluorophenyl)-tetrafluoro-1,3,2-benzodioxaborole
Conditions | Yield |
---|---|
In toluene byproducts: H2O; (Ar or under vac.); mixed in toluene; heated to reflux; water removed byazeotropic distillation; after 4 h, solvent evapd. under reduced pressu re; sublimed at 135°C; |
3,4,5,6-tetrafluorobenzene-1,2-diol
ethyl 4,5,6,7-tetrafluorobenzo[d]-1,3-dioxole-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid / nitromethane / -30 °C 2: benzene / 8 h / Reflux View Scheme |
3,4,5,6-tetrafluorobenzene-1,2-diol
2,3,4,5-tetrafluoro-6-(1-hexyl-1H-indol-3-yl)-6-hydroxycyclohexa-2,4-dienone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid / nitromethane / -30 °C 2: benzene / 0.17 h / 20 °C View Scheme |
3,4,5,6-tetrafluorobenzene-1,2-diol
2,3,4,5-tetrafluoro-6-hydroxy-6-(1-methyl-1H-pyrrol-2-yl)-cyclohexa-2,4-dienone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid / nitromethane / -30 °C 2: chloroform-d1 / 0.03 h / 20 °C View Scheme |
3,4,5,6-tetrafluorobenzene-1,2-diol
C7H4F4O3
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid / nitromethane / -30 °C 2: chloroform-d1 / 0 °C View Scheme |
3,4,5,6-tetrafluorobenzene-1,2-diol
C8H7F3O4
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: nitric acid / nitromethane / -30 °C 2: chloroform-d1 / 0 °C 3: chloroform-d1 / 0 - 20 °C View Scheme |
3,4,5,6-tetrafluorobenzene-1,2-diol
C6F4O2*C12H18
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid / nitromethane / -30 °C 2: chloroform / 1 h View Scheme |
Conditions | Yield |
---|---|
With nitric acid In nitromethane at -30℃; |
Conditions | Yield |
---|---|
With potassium carbonate In water; acetone for 3h; Solvent; Time; Reflux; Inert atmosphere; | 1.36 g |
Conditions | Yield |
---|---|
With caesium carbonate In water; acetone for 40h; Reflux; | 0.181 g |
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 20℃; for 1h; Inert atmosphere; |
Conditions | Yield |
---|---|
With caesium carbonate In acetone at 30℃; for 8h; Inert atmosphere; |
2-dimethylamino-4,6-dichloro-1,3,5-triazine
3,4,5,6-tetrafluorobenzene-1,2-diol
C22H12F8N8O4
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: caesium carbonate / acetone / 8 h / 30 °C / Inert atmosphere 2: caesium carbonate / acetone; water / 40 h / Reflux View Scheme |
Conditions | Yield |
---|---|
In dichloromethane for 0.5h; Inert atmosphere; |
The Tetrafluorobenzene-1,2-diol, with the CAS registry number 1996-23-2, is also known as Perfluorobenzene-1,2-diol. This chemical's molecular formula is C6H2F4O2 and molecular weight is 182.07. What's more, both its IUPAC name and systematic name are the same which is called 3,4,5,6-Tetrafluorobenzene-1,2-diol.
Physical properties about Tetrafluorobenzene-1,2-diol are: (1) ACD/LogP: 3.37; (2) # of Rule of 5 Violations: 0; (3) ACD/LogD (pH 5.5): 3.3; (4) ACD/LogD (pH 7.4): 2.23; (5) ACD/BCF (pH 5.5): 184.43; (6) ACD/BCF (pH 7.4): 15.42; (7) ACD/KOC (pH 5.5): 1395.87; (8) ACD/KOC (pH 7.4): 116.73; (9) #H bond acceptors: 2; (10) #H bond donors: 2; (11) #Freely Rotating Bonds: 2; (12) Polar Surface Area: 18.46 Å2; (13) Index of Refraction: 1.493; (14) Molar Refractivity: 29.99 cm3; (15) Molar Volume: 103.1 cm3; (16) Surface Tension: 44.1 dyne/cm; (17) Density: 1.765 g/cm3; (18) Flash Point: 101.1 °C; (19) Enthalpy of Vaporization: 50.01 kJ/mol; (20) Boiling Point: 243.6 °C at 760 mmHg; (21) Vapour Pressure: 0.0204 mmHg at 25 °C; (22) Melting Point: 68-69 °C.
Uses of Tetrafluorobenzene-1,2-diol: it is used to produce other chemicals. For example, it is used to produce 2-Oxabis(4,5,6,7-tetrafluorobenzo-1,3,2-dioxaarsole). This reaction will occur at temperature of 150-160 °C for 2 hours. The yield is 64.8 %.
When you are dealing with this chemical, you should be very careful. This chemical is irritating to eyes, respiratory system and skin. Therefore, you should wear suitable protective clothing. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1) SMILES: Fc1c(F)c(F)c(F)c(O)c1O
(2) InChI: InChI=1/C6H2F4O2/c7-1-2(8)4(10)6(12)5(11)3(1)9/h11-12H
(3) InChIKey: AQSZAISVBFUJQG-UHFFFAOYAO
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