Thiacetazone supplier | CasNO.104-06-3

Name
THIACETAZONE
EINECS
CAS No. 104-06-3
Density 1.3g/cm³
Solubility
Melting Point 225-230 °C
Formula C10H12 N4 O S
Boiling Point °Cat760mmHg
Molecular Weight 236.297
Flash Point °C
Transport Information
Appearance
Safety Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. A tuberculostatic antibacterial agent. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Risk Codes 22
Molecular Structure
Hazard Symbols
Synonyms Acetamide,N-[4-[[(aminothioxomethyl)hydrazono]methyl]phenyl]- (9CI); Acetanilide, 4'-formyl-,4'-(thiosemicarbazone) (8CI); Acetanilide, 4'-formyl-, thiosemicarbazone (6CI);4-Acetylaminobenzaldehyde thiosemicarbazone; 4207RP; 4'-Formylacetanilidethiosemicarbazone; Aktivan; Ambathizon; Amithiozone; Amitiozon; Antib;Benthiozone; Benzothiozane; Benzothiozon; Berculon A; Berkazon; Conteben;Diasan; Diazan; Diazane; Domakol; Ilbion; Livazone; Mirizone Neustab; Mivizon;Myvizone; NSC 3550; Neotibil; Neustab; Novakol; Nuclon argentinian; Panrone;Parazone; SQ 2321; Sdt 1041; Seroden; Siocarbazone; Tb I; Tb I/698; Tebalon;Tebecure; Tebemar; Tebesone I; Tebethion; Tebethione; Tebezon; Thiacetazone;Thiacetone; Thibon; Thibone; Thioacetazon; Thioacetazone; Thiocarbazil;Thiocarbazyl; Thiomicid; Thionicid; Thioparamizon; Thioparamizone; Thiosemicarbazone;Thiosemicarbazone (pharmaceutical); Thiotebesin; Thiotebezin; Thiotebicina;Thizone; Tiacetazon; Tibicur; Tibion; Tibione; Tibizan; Tibon; Tibone;Tioacetazon; Tioatsetazon; Tiobicina; Tiocarone; Tiosecolo; Tubercazon;Tubigal; Tubin; p-Acetamidobenzaldehyde thiosemicarbazone;p-Acetylaminobenzaldehyde thiosemicarbazone
PSA 111.60000
LogP 1.97630

Synthetic route

: 4-acetylamino-benzaldehyde hydrazone

: 1147550-11-5
ammonium thiocyanate

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 6957-91-1
(E)-2-(4-aminobenzylidene)hydrazinecarbothioamide

: 108-24-7
acetic anhydride

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 122-85-0
para-acetamidobenzaldehyde

: 79-19-6
thiosemicarbazide

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 122-85-0
para-acetamidobenzaldehyde

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N2H4 View Scheme

: 15128-66-2
cis-anti-cis-Dicyclohexyl-18-crown-6

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: C20H36O6*2C10H12N4OS

Conditions

Conditions	Yield
In methanol; ethyl acetate	81%

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 108-24-7
acetic anhydride

: 107261-72-3
4-Acetyl-2-acetylamino-5-p-acetylaminophenyl-4,5-dihydro-1,3,4-thiadiazol

Conditions

Conditions	Yield
at 80 - 120℃;	56%

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 22592-41-2
4-acetylamino-benzaldehyde-semicarbazone

Conditions

Conditions	Yield
With oxygen; methylene blue In acetone for 1.66667h; Irradiation;	44%
With oxygen; methylene blue In methanol for 1.66667h; Product distribution; Mechanism; Irradiation; var. solvents; var. photosensitisers; var. singlet oxygen scavangers;	28%

: 10140-87-1
1,2-dichloroethyl acetate

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 100517-73-5
acetic acid-[4-(thiazol-2-ylhydrazono-methyl)-anilide]

Conditions

Conditions	Yield
With sodium acetate

: 57-57-8
β-Propiolactone

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 3-[(4-acetylamino-benzylidenehydrazono)-amino-methylsulfanyl]-propionic acid

: 6630-73-5
4-(chloroacetyl)antipyrine

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 96267-62-8
acetic acid-{4-[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-thiazol-2-ylhydrazonomethyl]-anilide}

Conditions

Conditions	Yield
With ethanol

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 90916-70-4
acetic acid-[4-(amino-[1,3,4]thiadiazol-2-yl)-anilide]

Conditions

Conditions	Yield
With water; iron(III) chloride

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 114164-09-9
N,N'''-bis-(4-acetylamino-benzylidene)-μ-disulfido-dicarboxamidrazone

Conditions

Conditions	Yield
With dibenzoyl peroxide

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 59643-83-3
1-(4-acetylamino-benzyl)-thiosemicarbazide

Conditions

Conditions	Yield
With ammonia; sodium; ammonium chloride unter Einleiten von CO2;
With sodium amalgam; sodium hydrogencarbonate unter Einleiten von CO2;

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 108-24-7
acetic anhydride

: 110175-75-2
4-diacetylamino-benzaldehyde-(4-acetyl thiosemicarbazone)

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 89-98-5
2-chloro-benzaldehyde

: 79-11-8
chloroacetic acid

: 111531-25-0
acetic acid-({4-[5-(2-chloro-benzyliden)-4-oxo-thiazolidin-2-ylidenehydrazono]-methyl}-anilide)

...Expand

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 122-85-0
para-acetamidobenzaldehyde

: 79-11-8
chloroacetic acid

: 115272-07-6
5-(4-acetylamino-benzylidene)-thiazolidine-2,4-dion-2-(4-acetylamino-benzylidenehydrazone)

Conditions

Conditions	Yield
With acetic acid

...Expand

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 99-81-0
4-Nitrophenacyl bromide

: 3-(4-acetylamino-benzylidenamino)-4-(4-nitro-phenyl)-3H-thiazol-2-one-imine

Conditions

Conditions	Yield
With ethanol

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 100-52-7
benzaldehyde

: 79-11-8
chloroacetic acid

: 102901-19-9
5,5'-benzylidene-bis-thiazolidine-2,4-dione-2,2'-bis-(4-acetylamino-benzylidenehydrazone)

Conditions

Conditions	Yield
With acetic acid

...Expand

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 100-52-7
benzaldehyde

: 79-11-8
chloroacetic acid

: 109568-33-4
acetic acid-{[4-(5-benzyliden-4-oxo-thiazolidin-2-ylidenehydrazono)-methyl]-anilide}

...Expand

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 100-44-7
benzyl chloride

: acetic acid-[4-(S-benzyl-isothiosemicarbazonomethyl)-anilide]

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 90-02-8
salicylaldehyde

: 79-11-8
chloroacetic acid

: 125544-42-5
5,5'-salicylidene-bis-thiazolidine-2,4-dione-2,2'-bis-(4-acetylamino-benzylidenehydrazone)

Conditions

Conditions	Yield
With acetic acid

...Expand

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 105-39-5
chloroacetic acid ethyl ester

: 95708-02-4
acetic acid-{[4-(4-oxo-thiazolidin-2-ylidenehydrazono)-methyl]-anilide}

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 78-95-5
chloroacetone

: 4-acetylamino-benzaldehyde-(4-methyl-thiazol-2-ylhydrazone)

: 14371-10-9
(E)-3-phenylpropenal

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 79-11-8
chloroacetic acid

: 113223-43-1
acetic acid-{4-[(5-trans-cinnamyliden-4-oxo-thiazolidin-2-ylidenehydrazono)-methyl]-anilide}

...Expand

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 79-11-8
chloroacetic acid

: 95708-02-4
acetic acid-{[4-(4-oxo-thiazolidin-2-ylidenehydrazono)-methyl]-anilide}

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 79-11-8
chloroacetic acid

: 119-67-5
o-carboxybenzaldehyde

: 2-[2-(4-acetylamino-benzylidenehydrazono)-4-oxo-thiazolidin-5-ylidenemethyl]-benzoic acid

...Expand

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 79-11-8
chloroacetic acid

: 119-67-5
o-carboxybenzaldehyde

: 2-{bis-[2-(4-acetylamino-benzylidenehydrazono)-4-oxo-thiazolidin-5-yl]-methyl}-benzoic acid

Conditions

Conditions	Yield
With acetic acid

...Expand

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 598-31-2
1-bromoacetone

: 4-acetylamino-benzaldehyde-(4-methyl-thiazol-2-ylhydrazone)

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 74-88-4
methyl iodide

: 94504-53-7
acetic acid-[4-(S-methyl-isothiosemicarbazonomethyl)-anilide]

: 104-06-3
N-(4-[2-(aminocarbonothionyl)hydrazono]methylphenyl)acetamide

: 534-07-6
1,3-Dichloroacetone

: 24698-85-9
4-acetylamino-benzaldehyde (4-chloromethyl-thiazol-2-yl)-hydrazone

Conditions

Conditions	Yield
In acetone for 1h; Heating;

Thiacetazone Chemical Properties

Chemistry informtion about Thiacetazone (CAS NO.104-06-3) is:
IUPAC Name: N-[4-[(E)-(Carbamothioylhydrazinylidene)Methyl]Phenyl]Acetamide
Synonyms: 4'-Formyl-Acetanilid4'-(Thiosemicarbazone) ; 4207 Rp ; 4207rp ; A 4081 ; Acetamide, N-(4-(((Aminothiomethyl)Hydrazono)Methylene)Phenyl)- ; Acetamide, N-[4-[[(Aminothioxomethyl)Hydrazono]Methyl]Phenyl]- ; Acetamide, N1-(4-{[2-(Aminocarbothioyl)Hydrazono]Methyl}Phenyl) ; Acetanilide, 4'-Formyl-, 4'-(Thiosemicarbazone)
Product Categories: Aromatic Aldehydes & Derivatives (substituted)
MF: C₁₀H₁₂N₄OS
MW: 236.29
EINECS: 203-170-6
Density: 1.3 g/cm³
Melting Point: 225-230 °C
Flash Point: °C
Boiling Point: °C at 760 mmHg
Vapour Pressure: mmHg at 25°C
Enthalpy of Vaporization: kJ/mol
Following is the molecular structure of Thiacetazone (CAS NO.104-06-3) is:

Thiacetazone Uses

Thiacetazone (CAS NO.104-06-3) is used in the treatment of tuberculosis; it has only weak activity against Mycobacterium tuberculosis and is only useful in preventing resistance to more powerful drugs like isoniazid and rifampicin. It is never used on its own to treat tuberculosis; it is used in a similar way to ethambutol. Thiacetazone is the only anti-TB drug that is ineffective when given intermittently. There is no advantage to using thioacetazone if the regimen used already contains ethambutol, but many countries in sub-Saharan Africa still use thioacetazone because it is extremely cheap. Use of Thiacetazone is declining because it can cause severe (sometimes fatal) skin reactions in HIV positive patients.

Thiacetazone Production

Raw materials is 4-Acetamidobenzaldehyde .

Thiacetazone Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	950mg/kg (950mg/kg)	behavioral: somnolence (general depressed activity) behavioral: coma lungs, thorax, or respiration: respiratory depression	Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 144, Pg. 1310, 1950.
mouse	LD50	subcutaneous	1gm/kg (1000mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 2, Pg. 764, 1950.

Thiacetazone Safety Profile

Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. A tuberculostatic antibacterial agent. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Hazard Codes:
Harmful Xn
Risk Statements:
R22:Harmful if swallowed.
Safety Statements:
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: AE3850000

Thiacetazone Specification

First Aid Measures:
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Handling and Storage:
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Product Name

THIACETAZONE

Synthetic route

Thiacetazone Chemical Properties

Thiacetazone Uses

Thiacetazone Production

Thiacetazone Toxicity Data With Reference

Thiacetazone Safety Profile

Thiacetazone Specification

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