Product Name

  • Name

    Thiazolidine

  • EINECS 208-002-5
  • CAS No. 504-78-9
  • Article Data30
  • CAS DataBase
  • Density 1.058 g/cm3
  • Solubility
  • Melting Point
  • Formula C3H7NS
  • Boiling Point 164.5 °C at 760 mmHg
  • Molecular Weight 89.1613
  • Flash Point 56.1 °C
  • Transport Information UN 1993 3/PG 3
  • Appearance clear colorless liquid
  • Safety 45-36/37/39-26
  • Risk Codes 34
  • Molecular Structure Molecular Structure of 504-78-9 (Thiazolidine)
  • Hazard Symbols CorrosiveC
  • Synonyms Thiazolidine
  • PSA 37.33000
  • LogP 0.60910

Synthetic route

formaldehyd
50-00-0

formaldehyd

2-mercaptoethylamine hydrochloride
156-57-0

2-mercaptoethylamine hydrochloride

1,3-thiazolidine
504-78-9

1,3-thiazolidine

formaldehyd
50-00-0

formaldehyd

Cysteamine
60-23-1

Cysteamine

1,3-thiazolidine
504-78-9

1,3-thiazolidine

Conditions
ConditionsYield
With phosphate buffer In water at 25℃; for 0.5h;
formaldehyd
50-00-0

formaldehyd

Cysteamine
60-23-1

Cysteamine

A

1,3-thiazolidine
504-78-9

1,3-thiazolidine

B

4,5-dihydro-thiazole
504-79-0

4,5-dihydro-thiazole

Conditions
ConditionsYield
With phosphate buffer at 25℃; for 0.5h; Mechanism; var. buffer systems; var. aldehydes; also in the presence of ethanol;
...Expand
1,3-thiazolidine
504-78-9

1,3-thiazolidine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl thiazolidine-3-carboxylate
148312-55-4

tert-butyl thiazolidine-3-carboxylate

Conditions
ConditionsYield
In tetrahydrofuran; water at 20℃; for 20h;100%
In tetrahydrofuran; water at 20℃; for 20h; Schlenk technique;99%
With dmap In acetonitrile for 3h; Ambient temperature;89%
In 1,4-dioxane; water86.2%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

2,6-Dichloro-4-morpholino-1,3,5-triazine
6601-22-5

2,6-Dichloro-4-morpholino-1,3,5-triazine

2-chloro-4-morpholino-6-(3-thiazolidinyl)-1,3,5-triazine

2-chloro-4-morpholino-6-(3-thiazolidinyl)-1,3,5-triazine

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide a) -5 deg C, 2 h, b) RT, 20 h;97%
With potassium carbonate In hexane; ethyl acetate; N,N-dimethyl-formamide97.2%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(S)-[1-(3-hydroxyadamantan-1-yl)-2-oxo-2-pyrrolidin-1-ylethyl]-carbamic acid tert-butyl ester
841302-34-9

(S)-[1-(3-hydroxyadamantan-1-yl)-2-oxo-2-pyrrolidin-1-ylethyl]-carbamic acid tert-butyl ester

(S)-[1-(3-hydroxyadamantan-1-yl)-2-oxo-2-thiazolidin-3-ylethyl]-carbamic acid tert-butyl ester
841302-35-0

(S)-[1-(3-hydroxyadamantan-1-yl)-2-oxo-2-thiazolidin-3-ylethyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In DMF (N,N-dimethyl-formamide) at 0℃; for 22h;95.7%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

benzoyl chloride
98-88-4

benzoyl chloride

N-benzoyl-1,3-thiazolidine
941599-07-1

N-benzoyl-1,3-thiazolidine

Conditions
ConditionsYield
In dichloromethane at 0℃; for 0.75h;95%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

2-chloro-5-cyano-6-ethoxy-4-phenylpyridine-3-carboxaldehyde
143815-60-5

2-chloro-5-cyano-6-ethoxy-4-phenylpyridine-3-carboxaldehyde

2-Ethoxy-5-formyl-4-phenyl-6-thiazolidin-3-yl-nicotinonitrile
143815-68-3

2-Ethoxy-5-formyl-4-phenyl-6-thiazolidin-3-yl-nicotinonitrile

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 0.166667h; Heating;93%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

trifluoroacetic acid
76-05-1

trifluoroacetic acid

N-Boc pyroglutamic acid-Wang resin

N-Boc pyroglutamic acid-Wang resin

(S)-2-Amino-5-oxo-5-thiazolidin-3-yl-pentanoic acid; compound with trifluoro-acetic acid

(S)-2-Amino-5-oxo-5-thiazolidin-3-yl-pentanoic acid; compound with trifluoro-acetic acid

Conditions
ConditionsYield
Stage #1: 1,3-thiazolidine; N-Boc pyroglutamic acid-Wang resin In tetrahydrofuran Addition;
Stage #2: trifluoroacetic acid In water for 2.5h; Hydrolysis;		93%
...Expand
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(S)-tert-butoxycarbonylamino-(trans-4-hydroxy-cyclohexyl)-acetic acid
336870-02-1

(S)-tert-butoxycarbonylamino-(trans-4-hydroxy-cyclohexyl)-acetic acid

(S)-[1-(4-hydroxy-cyclohexyl)-2-oxo-2-thiazolidin-3-yl-ethyl]-carbamic acid tert-butyl ester

(S)-[1-(4-hydroxy-cyclohexyl)-2-oxo-2-thiazolidin-3-yl-ethyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: (S)-tert-butoxycarbonylamino-(trans-4-hydroxy-cyclohexyl)-acetic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In Isopropyl acetate at 0℃; for 2h;
Stage #2: 1,3-thiazolidine In Isopropyl acetate at 0 - 20℃; for 18h;		93%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 12h;
1,3-thiazolidine
504-78-9

1,3-thiazolidine

3-((2R,3S,4R,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-propionic acid pentafluorophenyl ester
682349-94-6

3-((2R,3S,4R,5R,6R)-3,4,5-Triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-propionic acid pentafluorophenyl ester

Acetic acid (2R,3R,4R,5S,6R)-3,5-diacetoxy-2-acetoxymethyl-6-(3-oxo-3-thiazolidin-3-yl-propyl)-tetrahydro-pyran-4-yl ester

Acetic acid (2R,3R,4R,5S,6R)-3,5-diacetoxy-2-acetoxymethyl-6-(3-oxo-3-thiazolidin-3-yl-propyl)-tetrahydro-pyran-4-yl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃;92%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

N-(4-nitrobenzoyl)-1,3-thiazolidine

N-(4-nitrobenzoyl)-1,3-thiazolidine

Conditions
ConditionsYield
In dichloromethane at 0℃; for 0.75h;92%
With triethylamine In dichloromethane
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(E)-β-methylcinnamaldehyde
1196-67-4, 21878-52-4, 21866-70-6

(E)-β-methylcinnamaldehyde

(R)-3-phenyl-1-(thiazolidin-3-yl)butan-1-one

(R)-3-phenyl-1-(thiazolidin-3-yl)butan-1-one

Conditions
ConditionsYield
Stage #1: (E)-β-methylcinnamaldehyde With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; BF4(1-)*C21H22N3O(1+); 1,1'-biphenyl-2,2'-diyl hydrogen phosphate In toluene at 40℃; for 14h; Molecular sieve; Sealed tube; Inert atmosphere;
Stage #2: 1,3-thiazolidine In toluene at 20℃; for 10h; Molecular sieve; Sealed tube; Inert atmosphere; enantioselective reaction;		92%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

1-aminocyclohexanecarboxylic acid benzyl ester
102373-23-9

1-aminocyclohexanecarboxylic acid benzyl ester

1-[[(3-thiazolidinylcarbonyl)]amino]cyclohexanecarboxylic acid benzyl ester

1-[[(3-thiazolidinylcarbonyl)]amino]cyclohexanecarboxylic acid benzyl ester

Conditions
ConditionsYield
Stage #1: di-tert-butyl dicarbonate; 1-aminocyclohexanecarboxylic acid benzyl ester With dmap In dichloromethane at 20℃; for 0.666667h;
Stage #2: 1,3-thiazolidine With triethylamine In dichloromethane at 20℃; for 19h;		91%
...Expand
1,3-thiazolidine
504-78-9

1,3-thiazolidine

propargyl bromide
106-96-7

propargyl bromide

thiazolidino-3 propyne-1
85670-81-1

thiazolidino-3 propyne-1

Conditions
ConditionsYield
With sodium carbonate90%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 4h;
1,3-thiazolidine
504-78-9

1,3-thiazolidine

N-(4-chloro-6-methyl-pyrimidin-2-yl)-N'-(3-trifluoromethyl-phenyl)-guanidine

N-(4-chloro-6-methyl-pyrimidin-2-yl)-N'-(3-trifluoromethyl-phenyl)-guanidine

N-(4-methyl-6-thiazolidin-3-yl-pyrimidin-2-yl)-N'-(3-trifluoromethyl-phenyl)-guanidine

N-(4-methyl-6-thiazolidin-3-yl-pyrimidin-2-yl)-N'-(3-trifluoromethyl-phenyl)-guanidine

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane at 100℃; for 16h;90%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butanoic acid
59969-65-2

(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butanoic acid

(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenylbutanoic acid thiazolidide

(2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenylbutanoic acid thiazolidide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 4 - 20℃;90%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
114346-31-5

(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid

C32H35N3O5S
937207-80-2

C32H35N3O5S

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In tetrahydrofuran at 0 - 20℃; for 8h;90%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate
102195-80-2

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

(2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
401564-36-1

(2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester

Conditions
ConditionsYield
With acetic acid In methanol at 0 - 30℃; for 2.5h; Large scale;90%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid
1174039-19-0

(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

(R)-[3-oxo-3-[1-(thiazolidine-3-carbonyl)-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl]-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester
1174039-38-3

(R)-[3-oxo-3-[1-(thiazolidine-3-carbonyl)-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl]-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine In dichloromethane at 20℃; for 2h;89%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

carbon disulfide
75-15-0

carbon disulfide

2,3-bis(chloromethyl)-1,4-naphthoquinone
31581-11-0

2,3-bis(chloromethyl)-1,4-naphthoquinone

3-(thiazolidin-3-carbothioyl)thiomethyl-(1,4-dioxo-1,4-dihydronaphthalene-2-yl)methyl thiazolidin-3-carbodithioate

3-(thiazolidin-3-carbothioyl)thiomethyl-(1,4-dioxo-1,4-dihydronaphthalene-2-yl)methyl thiazolidin-3-carbodithioate

Conditions
ConditionsYield
Stage #1: 1,3-thiazolidine; carbon disulfide In acetonitrile at 20℃; for 0.5h;
Stage #2: 2,3-bis(chloromethyl)-1,4-naphthoquinone In acetonitrile at 20℃; for 48h;		88.8%
...Expand
1,3-thiazolidine
504-78-9

1,3-thiazolidine

1-Naphthylacetyl-thioproline
88329-34-4, 122230-50-6

1-Naphthylacetyl-thioproline

(1-Naphthyl)acetyl-Thiopro-thiazolidine
122230-45-9

(1-Naphthyl)acetyl-Thiopro-thiazolidine

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide88%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid
115962-35-1, 144069-68-1, 78879-20-6

(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid

3-(thiazolidine-3-carbonyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
460086-07-1

3-(thiazolidine-3-carbonyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 20℃; for 1.5h;88%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

phenylbutyric acid chloride
18496-54-3

phenylbutyric acid chloride

N-(4-phenylbutanoyl)thiazolidine
127401-86-9

N-(4-phenylbutanoyl)thiazolidine

Conditions
ConditionsYield
With sodium chloride; triethylamine In dichloromethane88%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

S-6-bromohexanoic acid N-α-methylbenzylamide
78461-93-5

S-6-bromohexanoic acid N-α-methylbenzylamide

S-6-(3-thiazolidinyl)hexanoic acid N-α-methylbenzylamide
78461-95-7

S-6-(3-thiazolidinyl)hexanoic acid N-α-methylbenzylamide

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol for 6h; Heating;87%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

R-6-bromohexanoic acid N-α-methylbenzylamide
78461-92-4

R-6-bromohexanoic acid N-α-methylbenzylamide

R-6-(3-thiazolidinyl)hexanoic acid N-α-methylbenzylamide
78461-94-6

R-6-(3-thiazolidinyl)hexanoic acid N-α-methylbenzylamide

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol for 6h; Heating;87%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(2S,4S)-1-tert-butoxycarbonyl-4-ethoxycarbonyl-2-pyrrolidinecarboxylic acid
898273-26-2

(2S,4S)-1-tert-butoxycarbonyl-4-ethoxycarbonyl-2-pyrrolidinecarboxylic acid

1-tert-butyl 3-ethyl (3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)-1,3-pyrrolidinedicarboxylate
1019637-84-3

1-tert-butyl 3-ethyl (3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)-1,3-pyrrolidinedicarboxylate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 19h;86%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

Boc-Cys(Npys)-OH

Boc-Cys(Npys)-OH

C17H24N4O5S3

C17H24N4O5S3

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In tetrahydrofuran at 0 - 20℃; for 4h;86%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

N-tert-butoxycarbonyl-4-oxo-L-proline
84348-37-8

N-tert-butoxycarbonyl-4-oxo-L-proline

(2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
401564-36-1

(2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In ethyl acetate at 2 - 7℃; for 2h; Large scale;86%
Stage #1: N-tert-butoxycarbonyl-4-oxo-L-proline With pivaloyl chloride; N-ethyl-N,N-diisopropylamine In ethyl acetate at 10℃; for 0.5h; Large scale;
Stage #2: 1,3-thiazolidine In ethyl acetate at 0 - 10℃; for 1h; Reagent/catalyst; Temperature; Solvent; Large scale;		86%
Stage #1: N-tert-butoxycarbonyl-4-oxo-L-proline With dicyclohexyl-carbodiimide In toluene at -10 - -5℃;
Stage #2: 1,3-thiazolidine With dmap In toluene at -6 - 5℃; for 1.33333h;		81.7%
With dmap; dicyclohexyl-carbodiimide In toluene at -6 - 5℃; for 1.33333h;81.7%
Stage #1: N-tert-butoxycarbonyl-4-oxo-L-proline With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In toluene at 0℃; for 3h; Large scale;
Stage #2: 1,3-thiazolidine With dmap at 0℃; for 2h; Reagent/catalyst; Large scale;		50 kg
1,3-thiazolidine
504-78-9

1,3-thiazolidine

benzene 1,3-dicarboxylic acid monomethyl ester
1877-71-0

benzene 1,3-dicarboxylic acid monomethyl ester

methyl 3-(thiazolidine-3-carbonyl)benzoate

methyl 3-(thiazolidine-3-carbonyl)benzoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 18h;85%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

C18H18N2O5S

C18H18N2O5S

C21H23N3O4S2

C21H23N3O4S2

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 24h;83%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

α-bromoacetophenone
70-11-1

α-bromoacetophenone

3-(benzoylmethyl)thiazolidine
133914-09-7

3-(benzoylmethyl)thiazolidine

Conditions
ConditionsYield
With potassium carbonate In ethanol82%
1,3-thiazolidine
504-78-9

1,3-thiazolidine

(S)-{trans-4-[(3-amino-pyrazine-2-carbonyl)-amino]-cyclohexyl}-tert-butoxycarbonylamino-acetic acid
867212-43-9

(S)-{trans-4-[(3-amino-pyrazine-2-carbonyl)-amino]-cyclohexyl}-tert-butoxycarbonylamino-acetic acid

(S)-(1-{trans-4-[(3-amino-pyrazine-2-carbonyl)-amino]-cyclohexyl}-2-oxo-2-thiazolidin-3-yl-ethyl)-carbamic acid tert-butyl ester
867212-44-0

(S)-(1-{trans-4-[(3-amino-pyrazine-2-carbonyl)-amino]-cyclohexyl}-2-oxo-2-thiazolidin-3-yl-ethyl)-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 4h;82%

Thiazolidine Specification

The Thiazolidine, with the CAS registry number 504-78-9 and EINECS registry number 208-002-5, has the systematic name and IUPAC name of 1,3-thiazolidine. It is a kind of clear colorless liquid, and belongs to the following product categories: Heterocyclic Compounds; Building Blocks; Heterocyclic Building Blocks; Thiazolines/Thiazolidines. And the molecular formula of the chemical is C3H7NS.

The characteristics of Thiazolidine are as followings: (1)ACD/LogP: -0.12; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.03; (4)ACD/LogD (pH 7.4): -1.57; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 28.54 Å2; (13)Index of Refraction: 1.513; (14)Molar Refractivity: 25.34 cm3; (15)Molar Volume: 84.2 cm3; (16)Polarizability: 10.04×10-24cm3; (17)Surface Tension: 37.5 dyne/cm; (18)Density: 1.058 g/cm3; (19)Flash Point: 56.1 °C; (20)Enthalpy of Vaporization: 40.1 kJ/mol; (21)Boiling Point: 164.5 °C at 760 mmHg; (22)Vapour Pressure: 1.96 mmHg at 25°C. 

It may be synthesized by a condensation reaction between a thiol and an aldehyde or ketone. The reaction is reversible. Therefore,many thiazolidines are labile towards hydrolysis in aqueous solution. Hydrolysis of the thiazolidine generates the thiol and aldehyde or ketone from which it was synthesized.

Uses of Thiazolidine: It can react with 4-cyano-benzenediazonium; tetrafluoroborate to produce 3-(p-cyanophenylazo)-1,3-thiazolidine. This reaction will need the menstruum acetone and H2O. The reaction time is 0.5 hours with temperature of 0°C, and the yield is about 37%.

You should be cautious while dealing with this chemical. It may cause burns. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: S1CCNC1
(2)InChI: InChI=1/C3H7NS/c1-2-5-3-4-1/h4H,1-3H2
(3)InChIKey: OGYGFUAIIOPWQD-UHFFFAOYAA

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 800mg/kg (800mg/kg)   Farmaco, Edizione Scientifica. Vol. 36, Pg. 740, 1981.

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