Tricine supplier | CasNO.5704-04-1

Name
Tricine
EINECS 227-193-6
CAS No. 5704-04-1
Article Data4
CAS DataBase
Density 1.449 g/cm³
Solubility water: 4 M at 20 °C, clear, colorless
Melting Point 186-188 °C (dec.)
Formula C₆H₁₃NO₅
Boiling Point 500.9 °C at 760 mmHg
Molecular Weight 179.173
Flash Point 256.7 °C
Transport Information
Appearance White/clear crystalline powder
Safety 26-36-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine;N-[Tris(hydroxymethyl)methyl]glycine;NSC 369995;
PSA 110.02000
LogP -2.23280

Synthetic route

: sodium [99Tc]pertechnetate

: 139-13-9
nitrilotriacetic acid

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: (99m)Tc(HYNIC-Lys(OMe)-NIC)(tricine)

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In water at 100℃; for 0.166667h; pH=5.0; Succinate buffer;	95%

...Expand

: 1-(N-(6-(2-(2-sulfonatobenzaldehyde)hydrazono)nicotinyl))-6-(nicotinoyl) hexanediamine

: sodium [99Tc]pertechnetate

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: (99m)Tc(HYNIC-HD-NIC)(tricine)

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In ethanol; water at 100℃; for 0.166667h; pH=5.0;	95%

...Expand

: HYNIC-Lys(OMe)-His

: sodium [99Tc]pertechnetate

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: (99m)Tc(HYNIC-Lys(OMe)-His)(tricine)

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In water at 100℃; for 0.25h; pH=5.0; Succinate buffer;	95%

...Expand

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 27668-52-6
octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride

: disodium 7-(2-((carboxymethyl)amino)-3-hydroxy-2-(hydroxymethyl)propoxy)-7-(3-(dimethyl(octadecyl)ammonio)propyl)-4,4,10,10-tetrakis(hydroxymethyl)-6,8-dioxa-3,11-diaza-7-silatridecanedioate chloride

Conditions

Conditions	Yield
Stage #1: N-[tris(hydroxymethyl)methyl]glycine; octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride In N,N-dimethyl-formamide at 145℃; Stage #2: With sodium methylate In N,N-dimethyl-formamide	89%

: [Re(carbonyl)3(water)3]Br

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 7732-18-5
water

: 121-44-8
triethylamine

: [HNEt3][Re(CO)3(κ3-NH2,O,CO2-tricine)][Re(CO)3(κ3-NH2,OH,CO2-tricine)]*2H2O

Conditions

Conditions	Yield
In water Re(CO)3(H2O)3Br (0.371 mmol), tricine (0.0445 mmol), NEt3 (1.12 mmol) inH2O refluxed (0.5 h); solvent removed; washed with acetone; elem. anal.;	88%

...Expand

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 3H3N*3H(1+)*[CrMo6O18(OH)6](3-)

: 3H3N*3H(1+)*[HOOCCH2NHC(CH2O)3]CrMo6O18(OH)3(3-)

Conditions

Conditions	Yield
In water at 130℃; for 12h;	88%

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: cobalt(II) nitrate

: 2382-96-9
2-sulfanyl-1,3-benzoxazole

: [Co[(HOCH2)3CNCH2COO][C7H4NO(S)]2](2-)*2H(1+)=H2[Co[(HOCH2)3CNCH2COO][C7H4NO(S)]2]

Conditions

Conditions	Yield
With KOH In ethanol Co-salt in H2O added slowly to tricine in EtOH with stirring, mercapto-comp. in EtOH added dropwise with stirring, pH ajusted to 8 with 0.1 M KOH, refluxed for 5 h; evapd., cooled, filtered, washed with H2O and EtOH, dried in vac. over P4H10, elem. anal.;	55%

...Expand

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 7732-18-5
water

: 149-30-4
2-Mercaptobenzothiazole

: nickel(II) nitrate

: [Ni[(HOCH2)3CNCH2COO][C7H4NS(S)]2(H2O)2](2-)*2H(1+)=H2[Ni[(HOCH2)3CNCH2COO][C7H4NS(S)]2(H2O)2]

Conditions

Conditions	Yield
With KOH In ethanol Ni-salt in H2O added slowly to tricine in EtOH with stirring, mercapto-comp. in EtOH added dropwise with stirring, pH ajusted to 8 with 0.1 M KOH, refluxed for 5 h; evapd., cooled, filtered, washed with H2O and EtOH, dried in vac. over P4H10, elem. anal.;	53%

...Expand

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: copper(II) nitrate

: 134469-07-1
Benzimidazol-2-thiol

: [Cu[(HOCH2)3CNCH2COO][C7H5N2(S)]2](2-)*2H(1+)=H2[Cu[(HOCH2)3CNCH2COO][C7H5N2(S)]2]

Conditions

Conditions	Yield
With KOH In ethanol Cu-salt in H2O added slowly to tricine in EtOH with stirring, mercapto-comp. in EtOH added dropwise with stirring, pH ajusted to 8 with 0.1 M KOH, refluxed for 5 h; evapd., cooled, filtered, washed with H2O and EtOH, dried in vac. over P4H10, elem. anal.;	52%

...Expand

: 148-24-3
8-quinolinol

: nickel(II) nitrate hexahydrate

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 7732-18-5
water

: H(1+)*Ni((HOCH2)3CNCH2CO2)(C5H3NC4H3O)(H2O)2(1-)*H2O=H[Ni((HOCH2)3CNCH2CO2)(C5H3NC4H3O)(H2O)2]H2O

Conditions

Conditions	Yield
With KOH In ethanol; water soln. of nitrate salt in water added slowly to soln. of tricine in C2H5OH with stirring, soln. of hydroxyquinoline in C2H5OH added dropwise withstirring, adjusting pH to 8 by aq. KOH, mixt. refluxed for 5 h; mixt. evapd., cooled, ternary complex filtered off, washed (H2O, C2H5OH), dried (vac., P4O10); elem. anal.;	51%

...Expand

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 7732-18-5
water

: 134469-07-1
Benzimidazol-2-thiol

: nickel(II) nitrate

: [Ni[(HOCH2)3CNCH2COO][C7H5N2(S)]2(H2O)2](2-)*2H(1+)=H2[Ni[(HOCH2)3CNCH2COO][C7H5N2(S)]2(H2O)2]

Conditions

Conditions	Yield
With KOH In ethanol Ni-salt in H2O added slowly to tricine in EtOH with stirring, mercapto-comp. in EtOH added dropwise with stirring, pH ajusted to 8 with 0.1 M KOH, refluxed for 5 h; evapd., cooled, filtered, washed with H2O and EtOH, dried in vac. over P4H10, elem. anal.;	51%

...Expand

: N-ε-(picolinyl)-N-α-(6-(2-(2-sulfonatobenzaldehyde)hydrazono)nicotinyl)lysine methyl ester

: sodium [99Tc]pertechnetate

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: (99m)Tc(HYNIC-Lys(OMe)-Pic)(tricine)

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In water at 100℃; for 0.166667h; pH=5.0;	50%

...Expand

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: ammonium pertechnetate

: C51H61BrClN8O14P

: 63995-70-0
trisodium tris(3-sulfophenyl)phosphine

: C75H84BrClN9O28P2S3(99)Tc

Conditions

Conditions	Yield
In dimethyl sulfoxide at 100℃; for 0.166667h; Microwave irradiation;	47%

...Expand

: 148-24-3
8-quinolinol

: cobalt(II) nitrate hexahydrate

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 7732-18-5
water

: H(1+)*Co((HOCH2)3CNCH2CO2)(C5H3NC4H3O)(H2O)2(1-)*H2O=H[Co((HOCH2)3CNCH2CO2)(C5H3NC4H3O)(H2O)2]H2O

Conditions

Conditions	Yield
With KOH In ethanol; water soln. of nitrate salt in water added slowly to soln. of tricine in C2H5OH with stirring, soln. of hydroxyquinoline in C2H5OH added dropwise withstirring, adjusting pH to 8 by aq. KOH, mixt. refluxed for 5 h; mixt. evapd., cooled, ternary complex filtered off, washed (H2O, C2H5OH), dried (vac., P4O10); elem. anal.;	46%

...Expand

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: cobalt(II) nitrate

: 134469-07-1
Benzimidazol-2-thiol

: [Co[(HOCH2)3CNCH2COO][C7H5N2(S)]2](2-)*2H(1+)=H2[Co[(HOCH2)3CNCH2COO][C7H5N2(S)]2]

Conditions

Conditions	Yield
With KOH In ethanol Co-salt in H2O added slowly to tricine in EtOH with stirring, mercapto-comp. in EtOH added dropwise with stirring, pH ajusted to 8 with 0.1 M KOH, refluxed for 5 h; evapd., cooled, filtered, washed with H2O and EtOH, dried in vac. over P4H10, elem. anal.;	46%

...Expand

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 100-52-7
benzaldehyde

: 99685-96-8, 161105-99-3, 161106-00-9, 111138-12-6, 133318-63-5, 134053-11-5, 134931-35-4, 134931-36-5, 139703-76-7, 145633-27-8, 175414-73-0, 175414-74-1, 175414-75-2, 175519-12-7, 175519-13-8, 175519-14-9, 175519-15-0, 136376-46-0, 144906-37-6, 144906-38-7, 151767-00-9, 152882-97-8, 152882-98-9, 152882-99-0, 153062-34-1, 154171-74-1, 154171-75-2, 154333-99-0, 154334-00-6, 154397-63-4, 154460-59-0, 199456-56-9, 108739-25-9, 120329-57-9, 120329-58-0
fullerene-C60

: C72H19NO3

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; toluene for 168000h; Heating;	45.8%

...Expand

: 50-00-0
formaldehyd

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: C14H29N2O12P

Conditions

Conditions	Yield
Stage #1: N-[tris(hydroxymethyl)methyl]glycine With hydrogenchloride; hypophosphorous acid In water at 20℃; for 1h; Stage #2: formaldehyd In water at 20℃; for 24h;	40%

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: [Fe3O(2-phenoxybenzoato)6(methanol)3][NO3]*3(methanol)

: 109-89-7
diethylamine

: 75-05-8
acetonitrile

: [Et2NH2][[Fe9O4(OH)2(N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine(-3H))2(2-phenoxybenzoato)12]*7(acetonitrile)*H2O

Conditions

Conditions	Yield
In acetonitrile ligand added to a soln. of Fe complex, (C2H5)2NH added, stirred overnight; filtered, crystd. upon vapor diffusion of Et2O; elem. anal.;	11%

...Expand

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 102586-88-9
2,3,4,5-tetrahydro-2-oxo-1,5-ethanolbenzazepine

: 104876-18-8
(N,N-dimethylamino)ethyl 1,2,3,4-tetrahydroquinoline-4-propanoate

Conditions

Conditions	Yield
In water at 25℃; Rate constant;

: N-ε-(2-(diphenylphosphino)benzoyl)-N-α-(6-(2-(2-sulfonatobenzaldehyde)hydrazono)nicotinyl)-lysine methyl ester

: 99mtechnetium pertechnetate

: 5704-04-1
N-[tris(hydroxymethyl)methyl]glycine

: 99mTc(HYNIC-Lys(OMe)-2-TPP)(tricine)

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride In Saline; ethanol; water at 95 - 100℃; for 0.166667 - 0.25h; pH=5.0; succinate buffer;

...Expand

Tricine Chemical Properties

IUPAC Name: 2-[[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
Synonyms: N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]glycine ; N-[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl]glycine ; N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine ; Glycine, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)- ; N-(2-hydroxy-1,1-bis[hydroxymethyl]ethyl)glycine ; N-(tri(hydroxymethyl)methyl)glycine ; N-(Trishydroxymethylmethyl)glycine
The Molecular Formula of Tricine (5704-04-1):C₆H₁₃NO₅
The Molecular Weight of Tricine (5704-04-1):179.1711 g/mol
The Molecular Structure of Tricine (5704-04-1):
Index of Refraction: 1.553
Molar Refractivity: 39.57 cm³
Molar Volume: 123.5 cm³
Surface Tension: 76.8 dyne/cm
Density: 1.449 g/cm³
Flash Point: 256.7 °C
Enthalpy of Vaporization: 88.63 kJ/mol
Boiling Point: 500.9 °C at 760 mmHg
Vapour Pressure: 3.92E-12 mmHg at 25°C

Tricine Uses

1. Tricine (5704-04-1) is an organic compound that is used in buffer solution.
2.It is also used in resuspension of cell pellet.

Tricine Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements :26-36-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3
F: 3

Product Name

Tricine

Synthetic route

Tricine Chemical Properties

Tricine Uses

Tricine Safety Profile

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