Trimethylarsine oxide supplier

Name
TRIMETHYLARSINE OXIDE
EINECS
CAS No. 4964-14-1
Article Data11
CAS DataBase
Density
Solubility
Melting Point
Formula C3H9 As O
Boiling Point 170.7 °C at 760 mmHg
Molecular Weight 136.025
Flash Point 56.4 °C
Transport Information
Appearance
Safety Low toxicity by ingestion. Mutation data reported. When heated to decomposition it emits toxic vapors of As.
Risk Codes R11; R23/25; R50/53
Molecular Structure
Hazard Symbols
Synonyms Trimethylarsineoxide; Trimethylarsinoxide
PSA 17.07000
LogP 1.25180

Synthetic route

: sodium (methyl)(aquo)cobyrinate perchlorate

: 4964-14-1
trimethylarsine oxide

Conditions

Conditions	Yield
With GLUTATHIONE; arsenic(III) trioxide at 100℃; for 2h; pH=8; aq. buffer;	99%

: methylcobalamin

: arsenic(III) trioxide

: 4964-14-1
trimethylarsine oxide

Conditions

Conditions	Yield
With GLUTATHIONE In water at 100℃; for 2h; pH=8; Product distribution / selectivity; Tris-HCl buffer solution;	97%

: methylcobalamine

: 4964-14-1
trimethylarsine oxide

Conditions

Conditions	Yield
With GLUTATHIONE; arsenic(III) trioxide at 100℃; for 2h; pH=8; aq. buffer;	97%

: methylcobalamin

: arsenic(III) trioxide

A: monomethylarsinic acid

B: 418758-51-7
cacodyloxide

C: 4964-14-1
trimethylarsine oxide

Conditions

Conditions	Yield
With GLUTATHIONE In water at 100℃; for 2h; pH=8; Product distribution / selectivity; Tris-HCl buffer solution;	A 6% B 14% C 79%
With GLUTATHIONE In water at 100℃; for 2h; pH=8; Product distribution / selectivity; Tris-HCl buffer solution;	A 41% B 30% C 15%

...Expand

: 593-88-4
trimethylarsine

: 4964-14-1
trimethylarsine oxide

Conditions

Conditions	Yield
With sulfuric acid at 150 - 250℃;
With oxygen
With diethyl ether; bromine Behandlung des Reaktionsprodukts mit wss.K2CO3-Loesung;

: 593-88-4
trimethylarsine

A: 4964-14-1
trimethylarsine oxide

B: 75-60-5
Dimethylarsinic acid

Conditions

Conditions	Yield
With air
With diethyl ether

: 503-80-0
bis-{dimethylarsenic}-oxide

: 4964-14-1
trimethylarsine oxide

Conditions

Conditions	Yield
With water; oxygen

: 503-80-0
bis-{dimethylarsenic}-oxide

: 74-88-4
methyl iodide

: 4964-14-1
trimethylarsine oxide

Conditions

Conditions	Yield
With methanol; sodium hydroxide

: 593-88-4
trimethylarsine

: 7664-93-9
sulfuric acid

: 4964-14-1
trimethylarsine oxide

Conditions

Conditions	Yield
at 250℃;

: 593-88-4
trimethylarsine

oxygen: oxygen

: 4964-14-1
trimethylarsine oxide

: 67-56-1
methanol

: 503-80-0
bis-{dimethylarsenic}-oxide

: 74-88-4
methyl iodide

sodium hydroxide: sodium hydroxide

: 4964-14-1
trimethylarsine oxide

...Expand

: 593-88-4
trimethylarsine

air: air

A: 4964-14-1
trimethylarsine oxide

B: 75-60-5
Dimethylarsinic acid

...Expand

: (4-carboxy-phenyl)-trimethyl-arsonium betaine

alcoholic KOH-solution: alcoholic KOH-solution

A: 4964-14-1
trimethylarsine oxide

B: 65-85-0
benzoic acid

...Expand

: methylcobalamin

: 75-60-5
Dimethylarsinic acid

: 4964-14-1
trimethylarsine oxide

Conditions

Conditions	Yield
With GLUTATHIONE In water at 37℃; for 22h; pH=7.6; Product distribution / selectivity; Tris-HCl buffer solution;

: 4964-14-1
trimethylarsine oxide

: 64-69-7
Iodoacetic acid

: 64436-13-1
arsenobetaine

Conditions

Conditions	Yield
With GLUTATHIONE at 37℃; for 2h; aq. buffer;	99%
With methylcobalamin; GLUTATHIONE In water at 37℃; for 94h; pH=7.6; Product distribution / selectivity; Tris-HCl buffer solution;

: 148556-51-8, 125940-11-6, 7590-35-4
tin(IV) fluoride bis(acetonitrile)

: 4964-14-1
trimethylarsine oxide

: 883143-74-6, 882872-02-8
[SnF4((CH3)3AsO)2]

Conditions

Conditions	Yield
In dichloromethane all manipulations under N2 atm.; Sn compd. suspended in CH2Cl2, ligand added, stirred for 2 h at room temp.; filtered, recrystd. from hot CH2Cl2, dried in vac.; elem. anal.;	92%

: 7647-18-9
antimony(V) chloride

: 4964-14-1
trimethylarsine oxide

: 37979-82-1
SbCl5(OAs(CH3)3)

Conditions

Conditions	Yield
In tetrachloromethane; dichloromethane under N2; soln. of ligand (sublimed in vac. before use) in CH2Cl2 added to stirred soln. of SbCl5 (molar ratio 1:1) in CCl4; concd. in vac.; filtered; ppt. dried; elem. anal.;	80%

: scandium(III) chloride hexahydrate

: 4964-14-1
trimethylarsine oxide

: Sc[(CH3)3AsO]6(3+)*3Cl(1-)=Sc[(CH3)3AsO]6Cl3

Conditions

Conditions	Yield
In ethanol mixed in boiling ethanol; concd., filtered, dried.(vac.), elem. anal.;	71%

: scandium bromide hexahydrate

: 4964-14-1
trimethylarsine oxide

: Sc[(CH3)3AsO]6(3+)*3Br(1-)=Sc[(CH3)3AsO]6Br3

Conditions

Conditions	Yield
In ethanol mixed in boiling ethanol; concd., filtered, dried.(vac.), elem. anal.;	62%

: lanthanum(III) nitrate hexahydrate

: 4964-14-1
trimethylarsine oxide

: La((CH3)3AsO)6(3+)*3NO3(1-)=[La((CH3)3AsO)6](NO3)3

Conditions

Conditions	Yield
In acetone boiling solns. of La(NO3)3*6H2O in acetone added to soln. of Me3AsO; refrigerated overnight; solid filtered off; dried in vac.; elem. anal.;	55%

: 4964-14-1
trimethylarsine oxide

: scandium iodide heptahydrate

: 7732-18-5
water

: Sc[(CH3)3AsO]6(3+)*3I(1-)*3H2O=Sc[(CH3)3AsO]6I3*3H2O

Conditions

Conditions	Yield
In ethanol mixed in warm (60°C) ethanol, stirred for 1 h; filtered, dried.(vac.), elem. anal.;	53%

...Expand

: yttrium(lll) nitrate hexahydrate

: 4964-14-1
trimethylarsine oxide

: 7732-18-5
water

: Y((CH3)3AsO)6(3+)*3NO3(1-)*H2O=[Y((CH3)3AsO)6](NO3)3*H2O

Conditions

Conditions	Yield
In ethanol solns. of Y(NO3)36H2O and Me3AsO in ice-cold ethanol mixted; stirred for 1 h; soln. conctd. in vac. to 10 cm*3 and refrigerated overnight; solid filtered off; dried in vac.; elem. anal.;	53%

...Expand

: yttrium(III) chloride hexahydrate

: 4964-14-1
trimethylarsine oxide

: Y(OAs(CH3)3)6(3+)*3Cl(1-)=[Y(OAs(CH3)3)6]Cl3

Conditions

Conditions	Yield
In ethanol compd. dissolved in boiling ethanol, a soln. of ligand added; solvent removed (vac.), ppt. dissolved (acetone), standed; elem. anal.;	43%

: scandium(III) nitrate hydrate

: 4964-14-1
trimethylarsine oxide

: Sc((CH3)3AsO)6(3+)*3NO3(1-)=[Sc((CH3)3AsO)6](NO3)3

Conditions

Conditions	Yield
In ethanol solns. of Sc(NO3)35H2O and Me3AsO in ice-cold ethanol mixted; stirred for 1 h; soln. conctd. in vac. to 10 cm*3 and refrigerated overnight; solid filtered off; dried in vac.; elem. anal.;	38%

: lanthanum(III) nitrate hexahydrate

: 4964-14-1
trimethylarsine oxide

: 385825-72-9
La((CH3)3AsO)2(H2O)(NO3)3

Conditions

Conditions	Yield
In ethanol boiling soln. of La(NO3)3*6H2O treated with soln. of Me3AsO; refrigerated overnight; solid filtered off; dried in vac.; elem. anal.;	20%

: 4964-14-1
trimethylarsine oxide

: mercury dichloride

: trimethylhydroxidearsonium trichloromercurate(II)

Conditions

Conditions	Yield
In water in acidic aq. soln.;

: (Nb(OCH3)5)2

: 4964-14-1
trimethylarsine oxide

: 36500-14-8
Nb(OCH3)5(CH3)3AsO

Conditions

Conditions	Yield
In acetonitrile equilibrium react.;; detected by PMR-measurements;;
In acetonitrile equilibrium react.;; detected by PMR-measurements;;

: 4964-14-1
trimethylarsine oxide

: 10025-82-8
indium(III) chloride

: 104002-66-6
(Me3AsO)3(indium trichloride)2

Conditions

Conditions	Yield
In ethanol ppt. from ethanol or acetone, extn. into boiling acetone;
In acetone mixing acetone solns. of InCl3 (1 mmol) and (CH3)3AsO (2 mmol) under anhydrous conditions; addn. of petroleum ether, pptn.; recrystn. from acetone; elem anal.;

: 4964-14-1
trimethylarsine oxide

: 10026-08-1
thorium tetrachloride

: thorium tetrachloride * 6 trimethylarsine oxide

Conditions

Conditions	Yield
In acetone anhydrous thorium tetrachloride in ice-cold acetone is added dropwise to an acetone soln. of (CH3)3AsO, stoichiometric quantity of (CH3)3AsO used;
In acetone dry N2-atmosphere; pptn. on dropwise addn. of filtered soln. of metal compd. to stoich. amt. of ligand; filtration, washing (Me2CO), drying (vac.); elem. anal.;

Trimethylarsine oxide Chemical Properties

IUPAC Name: Dimethylarsorylmethane
Molecular Formula: C₃H₉AsO
Molecular Weight: 136.04
Boiling Point: 170.7 °C at 760 mmHg
Flash Point: 56.4 °C
Freely Rotating Bonds: 0
Polar Surface Area: 17.07 Å²
Enthalpy of Vaporization: 39.03 kJ/mol
Vapour Pressure: 1.93 mmHg at 25°C
The Cas Register Number of Trimethylarsine oxide is 4964-14-1.The chemical synonyms of Trimethylarsine oxide (CAS NO.4964-14-1) are Arsorane, trimethyl-, oxide ; Trimethylarsane oxide ; (CH3)3As=O ; Arsine oxide, trimethyl- ; Arsine, trimethyl-, oxide ; C052920 ; Trimethyl Arsine Oxide ; Trimethylarsine oxide .The molecular structure of Trimethylarsine oxide (CAS NO.4964-14-1) is.

Trimethylarsine oxide Uses

Trimethylarsine oxide (CAS NO.4964-14-1) is used as pharmaceutical intermediate.

Trimethylarsine oxide Toxicity Data With Reference

1.		cyt-hmn-fbr 3700 µmol/L		MUREAV Mutation Research. 357 (1996),123.
2.		orl-mus LD50:10,600 mg/kg		JAFCAU Journal of Agricultural and Food Chemistry. 45 (1997),449.

Trimethylarsine oxide Safety Profile

Low toxicity by ingestion. Mutation data reported. When heated to decomposition it emits toxic vapors of As.
Hazard Codes: Toxic T, Dangerous N
Risk Statements: 11-23/25-50/53
R11: Highly flammable.
R23/25: Toxic by inhalation and if swallowed.
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 3/7-9-23-45-61-60-28-20/21
S3/7: Keep container tightly closed in a cool place .
S9: Keep container in a well-ventilated place.
S23: Do not breathe vapour.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
S60: This material and its container must be disposed of as hazardous waste.
S28: After contact with skin, wash immediately with plenty of soap-suds.
S20/21: When using, do not eat, drink or smoke .
RIDADR: 1992
RTECS: CH8800000
HazardClass: 4.2
PackingGroup: I

Product Name

TRIMETHYLARSINE OXIDE

Synthetic route

Trimethylarsine oxide Chemical Properties

Trimethylarsine oxide Uses

Trimethylarsine oxide Toxicity Data With Reference

Trimethylarsine oxide Safety Profile

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