The Tween 80,with the CAS registry number 61791-14-8, is also known as Polyoxyethylene sorbitan monooleate;Sorbimacrogol oleate 300; Sorbital 0 20. It belongs to the product categories of Organics;Catalyst and assistant;assistant. What's more,Its systematic name is Polyoxyethylene sorbitan monooleate. The Tween 80 is Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives,complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.
Uses of Tween 80:
(1).Polysorbate 80 is often used in ice cream to prevent milk proteins from completely coating the fat droplets.
(2).Polysorbate 80 is also used as an emulsifier in the manufacture of medications for parenteral administration, most notably in the popular anti-arrhythmic amiodarone.
Safety and Storage of the Tween 80:
The Tween 80 is moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.When you contact it avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes,avoid ingestion and inhalation.As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.And it Store in a cool, dry place. Store in a tightly closed container. Store at around 20°C.
The toxicity data of Tween 80 as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | intravenous | 500mg/kg (500mg/kg) | CARDIAC: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978. |
dog | LDLo | intravenous | 500mg/kg (500mg/kg) | CARDIAC: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978. |
mammal (species unspecified) | LD50 | intravenous | 5800mg/kg (5800mg/kg) | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 459, 1991. | |
mammal (species unspecified) | LD50 | oral | 25gm/kg (25000mg/kg) | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 459, 1991. | |
mouse | LD50 | intraperitoneal | 7600mg/kg (7600mg/kg) | Pharmacology and Therapeutics. Vol. 5, Pg. 467, 1979. | |
mouse | LD50 | intravenous | 4500mg/kg (4500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 666, 1968. | |
mouse | LD50 | oral | 25gm/kg (25000mg/kg) | Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962. | |
rat | LD50 | intraperitoneal | 6804mg/kg (6804mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 804, 1985. | |
rat | LD50 | intravenous | 1790mg/kg (1790mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 254, 1974. | |
rat | LD50 | oral | 34500uL/kg (34.5mL/kg) | Food Research. Vol. 21, Pg. 348, 1956. |
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