Tyramine hydrochloride supplier

Name
Tyramine hydrochloride
EINECS 200-462-5
CAS No. 60-19-5
Article Data14
CAS DataBase
Density 1.103 g/cm3
Solubility
Melting Point 253-255 °C(lit.)
Formula C₈H₁₂ClNO
Boiling Point 325.2 °C at 760 mmHg
Molecular Weight 173.642
Flash Point 119.2 °C
Transport Information
Appearance off-white to light yellow powder
Safety 22-24/25-36-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Phenol,4-(2-aminoethyl)-, hydrochloride (9CI);Phenol, p-(2-aminoethyl)-,hydrochloride (8CI);2-(4-Hydroxyphenyl)ethylamine hydrochloride;4-Hydroxy-b-phenethylamine hydrochloride;4-Hydroxyphenethylamine hydrochloride;Mydrial;Tyrosam;Uteramin;p-Tyramine hydrochloride;
PSA 46.25000
LogP 2.39570

Synthetic route

: 14191-95-8
4-cyanomethylphenol

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; 1% Pd/C; hydrogen In ethanol; water under 2585.81 Torr; for 12h;	95%

: 2982-55-0
1-benzyloxy-4-(2-nitroethenyl)benzene

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol at 0℃; under 760 Torr;	94%

: p-hydroxyphenyl-α-isonitrosoacetophenone

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium In indication of hydrogen; water	85%

: C22H31NO

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In propan-1-ol at 190℃; for 0.0833333h; Microwave irradiation; Green chemistry;	81%

: C20H25NO2

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In propan-1-ol at 190℃; for 0.0833333h; Microwave irradiation; Green chemistry;	76%

: 60-18-4
L-tyrosine

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
Stage #1: L-tyrosine With (R)-Carvone In propan-1-ol at 190℃; under 11251.1 Torr; for 0.666667h; Sealed tube; Stage #2: With hydrogenchloride In propan-1-ol; water at 190℃; for 0.0833333h;	67%
Multi-step reaction with 2 steps 1: propan-1-ol / 20 - 190 °C / Green chemistry 2: hydrogenchloride / propan-1-ol / 0.67 h / 190 °C / Green chemistry View Scheme

: C18H23NO

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In propan-1-ol at 190℃; for 0.666667h; Temperature; Green chemistry;	67%

: 76457-44-8
anti-2-(p-Hydroxyphenyl)glyoxal-1-oxim

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
	66%

: C25H27Cl2NO

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In propan-1-ol at 190℃; for 0.0833333h; Microwave irradiation; Green chemistry;	64%

: p-hydroxyphenyl-α-isonitrosoacetophenone

: 64-17-5
ethanol

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium In water	2%

: 66648-43-9
(E)-N-feruloyltyramine

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 20h; Heating;	15 mg

: 2982-54-9
2-[4-(benzyloxy)phenyl]ethylamine hydrochloride

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal 1.) methanol, 2.) ethanol; Yield given. Multistep reaction;

: C8H11NO*C7H8N2O*2ClH

A: 60-19-5
tyramine hydrochloride

B: 29711-57-7
N-methylnicotinamide hydrochloride

Conditions

Conditions	Yield
at 28℃; Equilibrium constant; Thermodynamic data; association enthalpy: ΔH0 (kcal mol-1) = -2.4 (pH=1); -2.5 (pH=7);

: 148715-54-2
4-<2(E)-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)ethenyl>phenol

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal 1) EtOH, H2O, HOAc, 50 deg C, 50 psi, 4h, 2) EtOH; Yield given. Multistep reaction;

: primeveroside du 4-(-2-aminoethyl)phenol

A: 87-72-9, 608-45-7, 608-46-8, 608-47-9, 2460-44-8, 6748-95-4, 6763-34-4, 7261-26-9, 7283-06-9, 7283-07-0, 7296-55-1, 7296-56-2, 7296-58-4, 7296-59-5, 7296-60-8, 7296-61-9, 7296-62-0, 7322-30-7, 10257-31-5, 10257-32-6, 10257-33-7, 10257-34-8, 10257-35-9, 19982-83-3, 20242-88-0, 28697-53-2, 36562-42-2, 41546-41-2, 89299-64-9, 107655-34-5, 115794-06-4, 115794-07-5, 130550-15-1, 130606-21-2
D-Xylose

B: 2280-44-6
D-Glucose

C: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water Product distribution;

...Expand

: 74447-34-0
1-azido-2-(4-hydroxyphenyl)ethane

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 828 mg / potassium carbonate / methanol / Heating 2: 1.) lithium aluminium hydride, 2.) ethereal hydrogen chloride / 1.) ether, reflux, 1 h, 2.) methanol 3: 1.) hydrogen, 2.) ethereal hydrogen chloride / 1.) palladium-charcoal / 1.) methanol, 2.) ethanol View Scheme

: 74447-35-1
1-azido-2-(4-methylsulphonyloxyphenyl)ethane

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 310 mg / sodium hydroxide / methanol; H2O / 1 h / 70 °C 2: 828 mg / potassium carbonate / methanol / Heating 3: 1.) lithium aluminium hydride, 2.) ethereal hydrogen chloride / 1.) ether, reflux, 1 h, 2.) methanol 4: 1.) hydrogen, 2.) ethereal hydrogen chloride / 1.) palladium-charcoal / 1.) methanol, 2.) ethanol View Scheme

: 74447-33-9
1-(2'-azidoethyl)-4-(benzyloxy)benzene

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) lithium aluminium hydride, 2.) ethereal hydrogen chloride / 1.) ether, reflux, 1 h, 2.) methanol 2: 1.) hydrogen, 2.) ethereal hydrogen chloride / 1.) palladium-charcoal / 1.) methanol, 2.) ethanol View Scheme

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 99-93-4
4-Hydroxyacetophenone

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride

: 19745-72-3
ω-amino-4-hydroxyacetophenone hydrochloride

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; 12 % Pd/C; hydrogen In water at 20℃; Reagent/catalyst;

: 95932-41-5
tert-butyl (4-((tert-butoxycarbonyl)oxy)phenethyl)carbamate

: 60-19-5
tyramine hydrochloride

Conditions

Conditions	Yield
Stage #1: O,N-tert-butyloxycarbonylated tyramine With trifluoroacetic acid In dichloromethane Stage #2: With hydrogenchloride In methanol; diethyl ether regioselective reaction;

: 24424-99-5
di-tert-butyl dicarbonate

: 60-19-5
tyramine hydrochloride

: 64318-28-1
N-t-butoxycarbonyl-tyramine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;	100%
With sodium hydrogencarbonate In methanol; water	98%
With pyridine In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere;	95%

: 60-19-5
tyramine hydrochloride

: 73414-58-1
2-(3,5-dibromo-4-hydroxyphenyl)ethan-1-amine hydrobromide

Conditions

Conditions	Yield
With bromine In methanol at 60℃; for 14h;	100%
With bromine; potassium bromide In ethanol; water	91%
With bromine In methanol for 12h; Reflux;	91%
With bromine; acetic acid at 70℃; for 0.5h;	84%

: 108381-23-3
2-chloro-4,6-dimethylpyrimidine-5-carboxylic acid ethyl ester

: 60-19-5
tyramine hydrochloride

: 1400705-65-8
2-[2-(4-hydroxy-phenyl)ethylamino]-4,6-dimethyl-pyrimidine-5-carboxylc acid ethyl ester

Conditions

Conditions	Yield
With potassium acetate In ethanol at 150℃; for 1h; microwave irradiation;	100%

: 60-19-5
tyramine hydrochloride

: 134755-34-3
3,5-dibromo-4-hydroxy-β-phenethylamine

Conditions

Conditions	Yield
With bromine; acetic acid at 20℃; for 12h; Inert atmosphere;	100%

: 34619-03-9
tert-butyldicarbonate

: 60-19-5
tyramine hydrochloride

: 64318-28-1
N-t-butoxycarbonyl-tyramine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water at 20℃; for 3h;	98%

: 50-00-0
formaldehyd

: 60-19-5
tyramine hydrochloride

: 539-15-1
N,N-dimethyltyramine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate In methanol; water at 20℃;	98%

: 23911-25-3
ethylenediaminetetraacetic dianhydride

: 60-19-5
tyramine hydrochloride

: EDTA-bis(tyramide)

Conditions

Conditions	Yield
With triethylamine In dimethyl sulfoxide at 60℃; for 16h; Inert atmosphere;	97.17%

: 60-19-5
tyramine hydrochloride

: 108-24-7
acetic anhydride

: 1202-66-0
N-acetyltyramine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water at 20℃; for 0.25h;	95%
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 4h;	87%

: 60-19-5
tyramine hydrochloride

hyaluronic acid, 800-kDa: hyaluronic acid, 800-kDa

hyaluronic acid-tyramine conjugate: hyaluronic acid-tyramine conjugate

Conditions

Conditions	Yield
With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dimethyl sulfoxide at 20℃; for 48h; pH=6.8;	95%

: 51513-81-6
6-({6-[(tert-butoxycarbonyl)amino]hexanoyl}amino)hexanoic acid (2,5-dioxopyrrolidin-1-yl) ester

: 60-19-5
tyramine hydrochloride

: 1048007-85-7
C25H41N3O5

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane at 20℃; for 18h;	95%

: 60-19-5
tyramine hydrochloride

: 616-38-6
carbonic acid dimethyl ester

: 62372-08-1
4-hydroxyphenyl-2-ethylcarbamic acid methyl ester

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene for 16h; Reflux; chemoselective reaction;	95%

: 60-19-5
tyramine hydrochloride

: 501-53-1
benzyl chloroformate

: 29655-46-7
N-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylamine

Conditions

Conditions	Yield
With potassium carbonate In diethyl ether; water at 20℃; for 4h;	94%

: 60-19-5
tyramine hydrochloride

: 160208-44-6
7-Methoxy-2,4-dihydropyrrolo<4,3,2-de>quinolin-8(1H)-one

: makaluvamine D

Conditions

Conditions	Yield
With sodium hydrogencarbonate In methanol for 3h; Ambient temperature;	92%
In methanol for 14h; Ambient temperature;

: (1S,4S,5S,7R)-5-chloro-7-((6-chloro-9H-purin-9-yl)methyl)bicyclo[2.2.1]heptan-2-ol

: 60-19-5
tyramine hydrochloride

: (1S,4S,5S,7R)-5-chloro-7-((6-((4-hydroxyphenethyl)amino)-9H-purin-9-yl)methyl)bicyclo[2.2.1]heptan-2-ol

Conditions

Conditions	Yield
With triethylamine In ethanol at 20℃; for 144h;	91.5%

: 60-19-5
tyramine hydrochloride

: 246033-22-7
2-methyl-4,5-methylenedioxy-phenyl-sulfonyl chloride

: 246033-23-8
N-[2-(4-hydroxyphenyl)ethyl]-6-methyl-3,4-methylenedioxyphenylsulfonamido

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 2h; Substitution;	91%

: 60-19-5
tyramine hydrochloride

: 2937-50-0
Allyl chloroformate

: N-Aloc-tyramine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In chloroform; water at 0 - 22℃;	90%

: 60-19-5
tyramine hydrochloride

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

: 191097-29-7
4-[2-((N,N'-di-Boc)guanidino)ethyl]-phenol

Conditions

Conditions	Yield
With triethylamine; mercury dichloride In N,N-dimethyl-formamide at 4 - 20℃; Inert atmosphere;	90%

: 102767-61-3
4,4'-dihydroxy-3,3'-dimethoxy-β,β'-bicinnamic acid

: 60-19-5
tyramine hydrochloride

: cannabisin G

Conditions

Conditions	Yield
With triethylamine; dicyclohexyl-carbodiimide In tetrahydrofuran for 2h; Reflux;	86%

: 3-tert-butyl ethyl ferulate

: 60-19-5
tyramine hydrochloride

: 1246852-15-2
(E)-3-(3-tert-butyl-4-hydroxy-5-methoxyphenyl)-N-(2-(4-hydroxyphenyl)ethyl)-2-propenamide

Conditions

Conditions	Yield
Stage #1: 3-tert-butyl ethyl ferulate With 1-hydroxy-pyrrolidine-2,5-dione In acetonitrile for 0.0833333h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile for 24h; Cooling with ice; Stage #3: tyramine hydrochloride With triethylamine In acetonitrile at 20℃; for 7h;	85%
With triethylamine; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 2h;	82%

: 60-19-5
tyramine hydrochloride

: trans-7-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-6-methoxy-1,2-dihydronaphthalene-2,3-dicarboxylic acid

: (±)-canabisin D

Conditions

Conditions	Yield
Stage #1: trans-7-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-6-methoxy-1,2-dihydronaphthalene-2,3-dicarboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile for 4h; Cooling with ice; Stage #2: tyramine hydrochloride With triethylamine In acetonitrile at 20℃; for 18h;	85%

: 1121-60-4
pyridine-2-carbaldehyde

: 60-19-5
tyramine hydrochloride

: 4-(2-(pyridin-2-ylmethyleneamino)ethyl)phenol

Conditions

Conditions	Yield
Stage #1: tyramine hydrochloride With lithium hydroxide In methanol for 1h; Stage #2: pyridine-2-carbaldehyde In methanol at 25℃; for 12h; Cooling with ice;	85%

: 3898-94-0
ethyl N-[(4-methylbenzene)sulfonyl]ethanecarbohydrazonate

: 60-19-5
tyramine hydrochloride

: C17H21N3O3S

Conditions

Conditions	Yield
With triethylamine In ethanol for 24h; Reflux;	85%

: 60-19-5
tyramine hydrochloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 181050-97-5
2-{4-[(tert-butyl)(dimethyl)silyloxy]phenyl}ethanamine

Conditions

Conditions	Yield
Stage #1: tyramine hydrochloride; tert-butyldimethylsilyl chloride With 1H-imidazole In dichloromethane at 20℃; for 13h; Inert atmosphere; Stage #2: With water; sodium hydrogencarbonate In dichloromethane at 0℃; Inert atmosphere;	84%

: 90985-68-5
3-(4-acetoxy-3,5-dimethoxyphenyl)prop-2-enoic acid

: 60-19-5
tyramine hydrochloride

: 4-acetoxy-3,5-dimethoxy-N-(4'-hydroxyphenylethyl)-cinnamamide

Conditions

Conditions	Yield
Stage #1: 3-(4-acetoxy-3,5-dimethoxyphenyl)prop-2-enoic acid With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate In acetone at -10 - -5℃; for 1h; Stage #2: tyramine hydrochloride With N-ethyl-N,N-diisopropylamine In acetone at 20℃; for 24h;	84%

: 60-19-5
tyramine hydrochloride

: 90-02-8
salicylaldehyde

: 73428-20-3
2-(((4-hydroxyphenethyl)imino)methyl)phenol

Conditions

Conditions	Yield
Stage #1: tyramine hydrochloride With lithium hydroxide In methanol for 1h; Stage #2: salicylaldehyde In methanol at 25℃; for 12h;	83%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 60-19-5
tyramine hydrochloride

: 114865-17-7
(9H-fluoren-9-yl)methyl 4-hydroxyphenethylcarbamate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetonitrile at 20℃; Cooling with ice;	83%

Tyramine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

Tyramine hydrochloride Specification

The tyramine monochloride , with the CAS register number 60-19-5, has other names as 2-(3-indolyl)ethylamine hydrochloride ; 3-(2-aminoethyl)indole hcl;tryptamine hcl ; tryptamine hydrochloride ; timtec-bb sbb000359 ; 4-(2-aminoethyl)-phenohydrochloride ; p-(2-aminoethyl)-phenomonohydrochloride ; phenol,4-(2-aminoethyl)-,hydrochloride .

The characteristics of this chemical are as the following: (1)#H bond acceptors: 2 ; (2)#H bond donors: 3 ; (3)#Freely Rotating Bonds: 4 ; (4)Polar Surface Area: 12.47 ; (5)Index of Refraction: 1.577 ; (6)Molar Refractivity: 41.21 cm³ ; (7)Molar Volume: 124.3 cm³ ; (8)Polarizability: 16.34 ×10^-24cm³ ; (9)Surface Tension: 48.3 dyne/cm ; (10)Density: 1.103 g/cm³ ; (11)Flash Point: 119.2 °C ; (12)Enthalpy of Vaporization: 58.99 kJ/mol ; (13)Boiling Point: 325.2 °C at 760 mmHg ; (14)Vapour Pressure: 0.000123 mmHg at 25°C .

It is a off-white to light yellow powder and it is hygroscopic. Being a kind of irritant chemical to eyes, respiratory system and skin, it may cause inflammation to the skin or other mucous membranes. So while dealing with this chemcial, we need to be very careful. Wear suitable protective clothing and if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, avoid contact with skin and eyes and do not breathe dust. If you need more safety information, you could refer to the WGK Germany 3. When store it, you should keep it at RT. What's more, its product categories are including anilines, aromatic amines and nitro compounds;amines;aromatics.

In addition, you could refer to the following data information to get the molecular structure:
SMILES:Oc1ccc(cc1)CCN
InChI:InChI=1/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
InChIKey:DZGWFCGJZKJUFP-UHFFFAOYAB

Below are the toxicity information of this kind of chemical:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	subcutaneous	1044mg/kg (1044mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 339, 1933.
mouse	LD50	intraperitoneal	710mg/kg (710mg/kg)		Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974.
mouse	LD50	intravenous	208mg/kg (208mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	European Journal of Pharmacology. Vol. 9, Pg. 289, 1970.
mouse	LDLo	unreported	2750mg/kg (2750mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 126, 1916

Product Name

Tyramine hydrochloride

Synthetic route

Tyramine hydrochloride Consensus Reports

Tyramine hydrochloride Specification

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