Conditions | Yield |
---|---|
at 170 - 180℃; |
Conditions | Yield |
---|---|
im kuenstlichen Kreislaufversuch; |
(6-amino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-urea
uric Acid
Conditions | Yield |
---|---|
at 230℃; laesst sich auch durch trockenes Erhitzen; |
Conditions | Yield |
---|---|
at 185℃; |
Conditions | Yield |
---|---|
at 200℃; |
cyanoacetic acid
urea
A
uric Acid
B
N-(aminocarbonyl)-2-cyano-acetamide
Conditions | Yield |
---|---|
With bovine spleen-extract; oxygen |
Conditions | Yield |
---|---|
With oxygen In various solvent(s) Kinetics; Km, Ki,slope, Vmax; xanthine oxidase; | |
With bovine spleen-extract; oxygen | |
With oxygen |
Conditions | Yield |
---|---|
bei enzymatischen Oxydation; |
Conditions | Yield |
---|---|
With goose liver extract; oxygen at 38℃; bei pH 7.4 bis 7.6; | |
With chicken liverextract; oxygen at 38℃; bei pH 7.4 bis 7.6; | |
at 38℃; unter aeroben Bedingungen; |
Conditions | Yield |
---|---|
at 180℃; |
Conditions | Yield |
---|---|
With sodium azide; phosphate buffer; McIlvaine buffer; (E)-(3-methyl-1,3-benzothiazol-2-ylidene)hydrazine;hydrochloride; N,N-dimethyl-aniline; citric acid; xanthine oxidase; peroxidase 1.) pH=8.5; 2.) pH=3.5; 3.) standard assay of XO activity in serum; | |
With several organs of the rat; tissuesuspensionene different; methylene blue | |
With oxygen |
Conditions | Yield |
---|---|
With bovine spleen-extract; oxygen |
Conditions | Yield |
---|---|
Verfuetterung an Enten; |
Conditions | Yield |
---|---|
With alkali |
Conditions | Yield |
---|---|
With Chr-O(1-) In water at 20℃; Rate constant; Equilibrium constant; Irradiation; various substrate concentration, further reagent; pH 13.0; |
Conditions | Yield |
---|---|
With sodium dihydrogenphosphate; oxygen; palladium dichloride Rate constant; xanthine oxidase; var. conc. PdCl2; | |
With hydroxide In water Product distribution; Mechanism; Irradiation; pH = 6 10 11; OH(1-) radical was generated by photolysis of sulfate radical anion or photolysis of H2O2; add of 4-mercaptopyridine-N-oxide; intermedier radicals were determined by ESR; | |
With oxygen; xanthine oxidase In water at 283℃; Enzyme kinetics; Activation energy; Kinetics; Further Variations:; Temperatures; Oxidation; |
xanthin
A
pyrimidine-2,4,5,6(1H,3H)-tetraone
B
uric Acid
C
urea
Conditions | Yield |
---|---|
at 25℃; Product distribution; Mechanism; Rate constant; electrochemical oxidation; buffer (pH=2-6); various times, potentials and electrodes; |
Conditions | Yield |
---|---|
at 120℃; |
hydrogenchloride
2-methylsulfanyl-7,9-dihydro-1H-purine-6,8-dione
uric Acid
hydrogenchloride
(6-amino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-urea
uric Acid
Conditions | Yield |
---|---|
at 120℃; |
uric Acid
Conditions | Yield |
---|---|
With hydrogenchloride |
uric Acid
Conditions | Yield |
---|---|
With ammonium sulfide; potassium hydroxide In water at 180℃; for 6h; Microwave irradiation; | 89% |
Conditions | Yield |
---|---|
at 185℃; under 3750.38 Torr; for 5h; Inert atmosphere; Autoclave; | 85.9% |
In water at 160℃; under 760.051 Torr; | 82.4% |
Conditions | Yield |
---|---|
at 100℃; under 3750.38 Torr; for 24h; Inert atmosphere; Autoclave; | 82.3% |
Conditions | Yield |
---|---|
at 115℃; under 3750.38 Torr; for 18h; Inert atmosphere; Autoclave; | 82% |
Conditions | Yield |
---|---|
at 190℃; under 3750.38 Torr; for 8h; Inert atmosphere; Autoclave; | 81.5% |
Conditions | Yield |
---|---|
at 220℃; under 3750.38 Torr; for 48h; Inert atmosphere; Autoclave; | 80% |
Conditions | Yield |
---|---|
at 190℃; under 3750.38 Torr; for 2.5h; Inert atmosphere; Autoclave; | 79.2% |
uric Acid
A
parabanic acid
B
Oxalyldiurea
C
dehydro-allantoin
D
Allantoin
Conditions | Yield |
---|---|
With lithium hydroxide; iodine In water for 0.0833333h; excess of I2; | A n/a B n/a C 75% D n/a |
With lithium hydroxide; iodine In water for 0.0833333h; Mechanism; also with substituted uric acid; effect of amount of I2; 2H and 13C labelling experiment; |
Conditions | Yield |
---|---|
at 200℃; under 3750.38 Torr; for 2h; Inert atmosphere; Autoclave; | 75% |
uric Acid
dihydroxyuric acid
Conditions | Yield |
---|---|
With rose bengal In glycerol for 23h; Irradiation; | 74.71% |
With chlorine; acetic acid | |
pH=7; Electrochemical reaction; aq. phosphate buffer; | |
With Fe exchanged nanocrystalline ZSM-5 In aq. phosphate buffer pH=3.5; Kinetics; Electrochemical reaction; | |
With titanium dioxide nanorods with multi-walled carbon nanotubes pH=4; Electrochemical reaction; |
uric Acid
A
pyrimidine-2,4,5,6(1H,3H)-tetraone
B
urea
Conditions | Yield |
---|---|
With rose bengal; sodium hydroxide In glycerol for 36h; Irradiation; | A 72.18% B n/a |
Conditions | Yield |
---|---|
at 84℃; under 3750.38 Torr; for 2.5h; Inert atmosphere; Autoclave; | 71.4% |
Conditions | Yield |
---|---|
With lithium hydroxide; iodine In water at 4℃; equimolar amount of I2; | 70% |
With sodium hydroxide; oxygen; pyrographite | |
With water; ozone |
Conditions | Yield |
---|---|
at 84℃; under 3750.38 Torr; for 2h; Inert atmosphere; Autoclave; | 69.2% |
With alkaline solution at 100 - 110℃; |
uric Acid
1,5-diamino-3,7-dioxo-2,4,6,8-tetraazabicyclo-[3.3.0]octane
Conditions | Yield |
---|---|
With sodium persulfate; ammonia; water; sodium chloride at -8 - -5℃; for 2h; | 69% |
Stage #1: uric Acid With ammonium hydroxide; sodium persulfate; sodium chloride In water at -10℃; for 2h; Stage #2: With ammonium hydroxide In water at -10 - 20℃; for 1h; | 64% |
uric Acid
Conditions | Yield |
---|---|
With diammonium sulfide; water; potassium hydroxide at 0 - 180℃; for 8h; Sealed tube; | 63% |
uric Acid
cis-1,5-diamino-2,4,6,8-tetraazabicyclo-<3.3.0>octane-3,7-dione
Conditions | Yield |
---|---|
With ammonium hydroxide; potassium hexacyanoferrate(III) In water | 60% |
Conditions | Yield |
---|---|
With dihydrogen peroxide In not given oxidation of uric acid by alk. H2O2-soln.; | 50% |
Conditions | Yield |
---|---|
With rose bengal In acetic acid; glycerol for 38h; Irradiation; | A 45.11% B n/a |
uric Acid
A
5-Amino-4-iminoallantoin
B
cis-1,5-diamino-2,4,6,8-tetraazabicyclo-<3.3.0>octane-3,7-dione
Conditions | Yield |
---|---|
With ammonium hydroxide; potassium hexacyanoferrate(III) In water 1) r.t., 30 min, 2) 0 deg C, 1 h; | A 45% B 30% |
uric Acid
1H,4H-3a,6a-(epiminomethanoimino)imidazo[4,5-d]imidazole-2,5,8(3H,6H)-trione
Conditions | Yield |
---|---|
Stage #1: uric Acid With ammonium hydroxide; potassium hexacyanoferrate(III) In water at 0 - 20℃; for 6h; Stage #2: With 1,1'-carbonyldiimidazole In dimethyl sulfoxide at 20℃; for 72h; | 44% |
uric Acid
1-O-acetyl-2,3,4,6-tetra-O-benzoyl-α-D-glucopyranose
Conditions | Yield |
---|---|
Stage #1: uric Acid With N,O-bis-(trimethylsilyl)-acetamide In acetonitrile for 1h; Reflux; Inert atmosphere; Stage #2: 1-O-acetyl-2,3,4,6-tetra-O-benzoyl-α-D-glucopyranose With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 48h; Reflux; Inert atmosphere; | A 39% B 9% C 4% |
uric Acid
Conditions | Yield |
---|---|
With sodium persulfate; ammonia; water; sodium chloride at 2 - 10℃; | 36% |
Conditions | Yield |
---|---|
With potassium hydroxide; potassium permanganate In water for 4h; Product distribution; Mechanism; Ambient temperature; labelled 14C in position of 5; | A 26% B 14% |
Conditions | Yield |
---|---|
With potassium hydroxide; potassium permanganate In water for 4h; Ambient temperature; Yield given; | A n/a B 14% |
Conditions | Yield |
---|---|
With diethyl ether |
Conditions | Yield |
---|---|
With diethyl ether |
Conditions | Yield |
---|---|
mehrtaegigem Kochen; |
Conditions | Yield |
---|---|
at 155℃; |
Reported in EPA TSCA Inventory.
The Uric acid, with the CAS registry number 69-93-2 and EINECS registry number 200-720-7, has the systematic name of 7,9-dihydro-1H-purine-2,6,8(3H)-trione. It is a kind of off-white crystals, and the molecular formula of this chemical is C5H4N4O3.
The Uric acid is created when the body breaks down purine nucleotides. High concentrations of uric acid in blood serum can lead to a type of arthritis known as gout. About its solubilities: It is slightly soluble in water, and it exhibit greater solubility in hot water than cold, allowing for easy recrystallization. The solubility of the acid and its salts in ethanol is very low or negligible. In ethanol water mixtures, the solubilities are somewhere between the end values for pure ethanol and pure water.
The physical properties of Uric acid are as following: (1)ACD/LogP: -1.08; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.33; (4)ACD/LogD (pH 7.4): -2.67; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 3.46; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 7; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 64.17 Å2; (13)Index of Refraction: 1.721; (14)Molar Refractivity: 35.51 cm3; (15)Molar Volume: 89.7 cm3; (16)Polarizability: 14.07×10-24cm3; (17)Surface Tension: 94.3 dyne/cm; (18)Density: 1.87 g/cm3; (19)Flash Point: 475.7 °C; (20)Enthalpy of Vaporization: 129.69 kJ/mol; (21)Boiling Point: 863 °C at 760 mmHg; (22)Vapour Pressure: 2.63E-31 mmHg at 25°C.
Produce and uses of Uric acid: It can be produced by xanthine oxidase from xanthine and hypoxanthine, which in turn are produced from purine. Uric acid is released in hypoxic conditions. What's more, it is used as reagent in the determination of uricase and tungstate. With a wonderful moisture retention, it is often used in cosmetics.
You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin, and has danger of cumulative effects. Therefore, you had better take the following instructions: Avoid contacting with skin and eyes; Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C1\C2=C(/NC(=O)N1)NC(=O)N2
(2)InChI: InChI=1/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
(3)InChIKey: LEHOTFFKMJEONL-UHFFFAOYAN
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